LOCUS       NM_139355               2098 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens megakaryocyte-associated tyrosine kinase (MATK),
            transcript variant 1, mRNA.
ACCESSION   NM_139355
VERSION     NM_139355.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Chueh,A.C., Advani,G., Foroutan,M., Smith,J., Ng,N., Nandurkar,H.,
            Lio,D.S., Zhu,H.J., Chong,Y.P., Verkade,H., Fujita,D.J., Bjorge,J.,
            Basheer,F., Lim,J.P., Luk,I., Dhillon,A., Sakthianandeswaren,A.,
            Mouradov,D., Sieber,O., Hollande,F., Mariadason,J.M. and Cheng,H.C.
  TITLE     CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer
            tumour suppressor gene epigenetically silenced by promoter
            methylation
  JOURNAL   Oncogene 40 (17), 3015-3029 (2021)
   PUBMED   33767439
  REMARK    GeneRIF: CSK-homologous kinase (CHK/MATK) is a potential colorectal
            cancer tumour suppressor gene epigenetically silenced by promoter
            methylation.
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Reyniers,L., Del Giudice,M.G., Civiero,L., Belluzzi,E.,
            Lobbestael,E., Beilina,A., Arrigoni,G., Derua,R., Waelkens,E.,
            Li,Y., Crosio,C., Iaccarino,C., Cookson,M.R., Baekelandt,V.,
            Greggio,E. and Taymans,J.M.
  TITLE     Differential protein-protein interactions of LRRK1 and LRRK2
            indicate roles in distinct cellular signaling pathways
  JOURNAL   J Neurochem 131 (2), 239-250 (2014)
   PUBMED   24947832
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Leung,K.K., Hause,R.J. Jr., Barkinge,J.L., Ciaccio,M.F., Chuu,C.P.
            and Jones,R.B.
  TITLE     Enhanced prediction of Src homology 2 (SH2) domain binding
            potentials using a fluorescence polarization-derived c-Met, c-Kit,
            ErbB, and androgen receptor interactome
  JOURNAL   Mol Cell Proteomics 13 (7), 1705-1723 (2014)
   PUBMED   24728074
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Jhun,B.H., Rivnay,B., Price,D. and Avraham,H.
  TITLE     The MATK tyrosine kinase interacts in a specific and SH2-dependent
            manner with c-Kit
  JOURNAL   J Biol Chem 270 (16), 9661-9666 (1995)
   PUBMED   7536744
REFERENCE   7  (bases 1 to 2098)
  AUTHORS   Avraham,S., Jiang,S., Ota,S., Fu,Y., Deng,B., Dowler,L.L.,
            White,R.A. and Avraham,H.
  TITLE     Structural and functional studies of the intracellular tyrosine
            kinase MATK gene and its translated product
  JOURNAL   J Biol Chem 270 (4), 1833-1842 (1995)
   PUBMED   7530249
REFERENCE   8  (bases 1 to 2098)
  AUTHORS   Hamaguchi,I., Iwama,A., Yamaguchi,N., Sakano,S., Matsuda,Y. and
            Suda,T.
  TITLE     Characterization of mouse non-receptor tyrosine kinase gene, HYL
  JOURNAL   Oncogene 9 (11), 3371-3374 (1994)
   PUBMED   7936664
REFERENCE   9  (bases 1 to 2098)
  AUTHORS   McVicar,D.W., Lal,B.K., Lloyd,A., Kawamura,M., Chen,Y.Q., Zhang,X.,
            Staples,J.E., Ortaldo,J.R. and O'Shea,J.J.
  TITLE     Molecular cloning of lsk, a carboxyl-terminal src kinase (csk)
            related gene, expressed in leukocytes
  JOURNAL   Oncogene 9 (7), 2037-2044 (1994)
   PUBMED   7516063
REFERENCE   10 (bases 1 to 2098)
  AUTHORS   Okada,M., Nada,S., Yamanashi,Y., Yamamoto,T. and Nakagawa,H.
  TITLE     CSK: a protein-tyrosine kinase involved in regulation of src family
            kinases
  JOURNAL   J Biol Chem 266 (36), 24249-24252 (1991)
   PUBMED   1722201
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG396388.1, BM925586.1 and
            BC000114.1.
            
            On Nov 23, 2018 this sequence version replaced NM_139355.2.
            
            Summary: The protein encoded by this gene has amino acid sequence
            similarity to Csk tyrosine kinase and has the structural features
            of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic
            domain, a unique N terminus, lack of myristylation signals, lack of
            a negative regulatory phosphorylation site, and lack of an
            autophosphorylation site. This protein is thought to play a
            significant role in the signal transduction of hematopoietic cells.
            It is able to phosphorylate and inactivate Src family kinases, and
            may play an inhibitory role in the control of T-cell proliferation.
            This protein might be involved in signaling in some cases of breast
            cancer. Three alternatively spliced transcript variants that encode
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000114.1, SRR1163655.683456.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310132.11/ ENSP00000308734.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BG396388.1         37-86
            51-726              BM925586.1         72-747
            727-2098            BC000114.1         762-2133
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2098
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:4145"
                     /db_xref="HGNC:HGNC:6906"
                     /db_xref="MIM:600038"
     exon            1..213
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            214..436
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1888
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /EC_number="2.7.10.2"
                     /note="isoform a is encoded by transcript variant 1;
                     tyrosine-protein kinase CTK; protein kinase HYL;
                     hematopoietic consensus tyrosine-lacking kinase;
                     tyrosylprotein kinase; hydroxyaryl-protein kinase;
                     Csk-type protein tyrosine kinase; HYL tyrosine kinase;
                     tyrosine kinase MATK; leukocyte carboxyl-terminal src
                     kinase related; Csk-homologous kinase;
                     megakaryocyte-associated tyrosine-protein kinase; CSK
                     homologous kinase"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein kinase
                     isoform a"
                     /protein_id="NP_647612.1"
                     /db_xref="CCDS:CCDS12114.1"
                     /db_xref="GeneID:4145"
                     /db_xref="HGNC:HGNC:6906"
                     /db_xref="MIM:600038"
                     /translation="MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPT
                     RRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAA
                     GALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCV
                     SFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKS
                     AEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDE
                     TAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL
                     HVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTA
                     PEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCP
                     GPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP"
     exon            437..496
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            497..610
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            611..726
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            727..946
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1040
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1106
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1206
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1291
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1365
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1561
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1648
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2098
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2077..2082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /note="hexamer: GATAAA"
     polyA_site      2098
                     /gene="MATK"
                     /gene_synonym="CHK; CTK; HHYLTK; HYL; HYLTK; Lsk"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggccg gcgctaggac ccgcgggggc ctcccaggcc gcggcgcctc ccgctttccc
       61 ccactccccg acccttcttc gcccccaaaa tgaggaaacg gagcaactcg ctccaagttg
      121 tgcagccggg accgcctcgg ggtgtgcagc cggctcgcgg aggccctcct gggggcgggc
      181 gcggggcgcg gctcgggggc gccccctgag cagaaaacag gaagaaccag gctcggtcca
      241 gtggcaccca gctccctacc tcctgtgcca gccgactggc ctgtggcagg ccattcccag
      301 cgtccccgac tgtgaccact tgctcagtgt gcctctcacc tgcctcagtt tccctctggg
      361 ggcgatggcg gggcgaggct ctctggtttc ctggcgggca tttcacggct gtgattctgc
      421 tgaggaactt ccccgggtga gcccccgctt cctccgagcc tggcaccccc ctcccgtctc
      481 agccaggatg ccaacgaggc gctgggcccc gggcacccag tgtatcacca aatgcgagca
      541 cacccgcccc aagccagggg agctggcctt ccgcaagggc gacgtggtca ccatcctgga
      601 ggcctgcgag aacaagagct ggtaccgcgt caagcaccac accagtggac aggaggggct
      661 gctggcagct ggggcgctgc gggagcggga ggccctctcc gcagacccca agctcagcct
      721 catgccgtgg ttccacggga agatctcggg ccaggaggct gtccagcagc tgcagcctcc
      781 cgaggatggg ctgttcctgg tgcgggagtc cgcgcgccac cccggcgact acgtcctgtg
      841 cgtgagcttt ggccgcgacg tcatccacta ccgcgtgctg caccgcgacg gccacctcac
      901 aatcgatgag gccgtgttct tctgcaacct catggacatg gtggagcatt acagcaagga
      961 caagggcgct atctgcacca agctggtgag accaaagcgg aaacacggga ccaagtcggc
     1021 cgaggaggag ctggccaggg cgggctggtt actgaacctg cagcatttga cattgggagc
     1081 acagatcgga gagggagagt ttggagctgt cctgcagggt gagtacctgg ggcaaaaggt
     1141 ggccgtgaag aatatcaagt gtgatgtgac agcccaggcc ttcctggacg agacggccgt
     1201 catgacgaag atgcaacacg agaacctggt gcgtctcctg ggcgtgatcc tgcaccaggg
     1261 gctgtacatt gtcatggagc acgtgagcaa gggcaacctg gtgaactttc tgcggacccg
     1321 gggtcgagcc ctcgtgaaca ccgctcagct cctgcagttt tctctgcacg tggccgaggg
     1381 catggagtac ctggagagca agaagcttgt gcaccgcgac ctggccgccc gcaacatcct
     1441 ggtctcagag gacctggtgg ccaaggtcag cgactttggc ctggccaaag ccgagcggaa
     1501 ggggctagac tcaagccggc tgcccgtcaa gtggacggcg cccgaggctc tcaaacacgg
     1561 gaagttcacc agcaagtcgg atgtctggag ttttggggtg ctgctctggg aggtcttctc
     1621 atatggacgg gctccgtacc ctaaaatgtc actgaaagag gtgtcggagg ccgtggagaa
     1681 ggggtaccgc atggaacccc ccgagggctg tccaggcccc gtgcacgtcc tcatgagcag
     1741 ctgctgggag gcagagcccg cccgccggcc acccttccgc aaactggccg agaagctggc
     1801 ccgggagcta cgcagtgcag gtgccccagc ctccgtctca gggcaggacg ccgacggctc
     1861 cacctcgccc cgaagccagg agccctgacc ccacccggtg gggcccttgg ccccagagga
     1921 ccgagagagt ggagagtgcg gcgtgggggc actgaccagg cccaaggagg gtccaggcgg
     1981 gcaagtcatc ctcctggtgc ccacagcagg ggctggccca cgtagggggc tctgggcggc
     2041 ccgtggacac cccagacctg cgaaggatga tcgcccgata aagacggatt ctaaggac
//
