LOCUS       NM_001199706            4462 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens microtubule associated tyrosine carboxypeptidase 2
            (MATCAP2), transcript variant 3, mRNA.
ACCESSION   NM_001199706
VERSION     NM_001199706.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4462)
  AUTHORS   Nicot,S., Gillard,G., Impheng,H., Joachimiak,E., Urbach,S.,
            Mochizuki,K., Wloga,D., Juge,F. and Rogowski,K.
  TITLE     A family of carboxypeptidases catalyzing alpha- and beta-tubulin
            tail processing and deglutamylation
  JOURNAL   Sci Adv 9 (37), eadi7838 (2023)
   PUBMED   37703372
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006960.1, DC403204.1, BC144032.1 and BE463421.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001199706.1.
            
            Transcript Variant: This variant (3) lacks two exons from the 5'
            end and contains an alternate 5' exon and an additional in-frame
            exon, as compared to variant 1. The resulting isoform (3) has a
            shorter and distinct N-terminus and an additional internal segment,
            as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.155416.1,
                                           SRR1660803.36868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440378.6/ ENSP00000390837.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC006960.1         63499-63505         c
            8-102               DC403204.1         1-95
            103-2044            BC144032.1         1-1942
            2045-4339           AC006960.1         20540-22834         c
            4340-4462           BE463421.1         9-131               c
FEATURES             Location/Qualifiers
     source          1..4462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2"
     gene            1..4462
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="microtubule associated tyrosine carboxypeptidase 2"
                     /db_xref="GeneID:23366"
                     /db_xref="HGNC:HGNC:22206"
                     /db_xref="MIM:619896"
     exon            1..325
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1854
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     putative tyrosine carboxypeptidase MATCAP2; tubulin
                     metallocarboxypeptidase 2"
                     /codon_start=1
                     /product="putative tyrosine carboxypeptidase MATCAP2
                     isoform 3"
                     /protein_id="NP_001186635.1"
                     /db_xref="CCDS:CCDS56484.1"
                     /db_xref="GeneID:23366"
                     /db_xref="HGNC:HGNC:22206"
                     /db_xref="MIM:619896"
                     /translation="MLESIRVTEKLHWPEQELAKKSILNAEDSLIIDNKRSISHLSSG
                     VLKDIFTTGTSSYNVLLQSKEEKKYHSQKQSSSTYSKRCRKPSKSPNTSRSKDPRRMK
                     ALVPVTSSGTWYCLERRPAVFVTSSVSSPVKFTHDISVTGNGIVLPPKPKSKVKWCHF
                     STLPKPKPQLSRSFEKGDDFSGKKFCILTAIKPTNLEKEKLRFFKSDYTYNPQFEYAN
                     PALPSVLAKHSHASDRFLKQSINIMELTLQKYGSYEKFEQATGGSLLSKTRIWSHVRK
                     YMMKEGCLGEIVVHLTEDLLSRASMTVVNGCPTLTINVSTAREHWLEGMLRHEIGTHY
                     FRGINNLQQPWNSWTGRKKHELKPNNPTEEGLASIHSVLFRKDPFLWRAALLYYTVYQ
                     ASQMSFCELFKDIGRFVKDPNTRWDYCVRAKRGWTDTSQPGCFSKDQVYLDGILQILR
                     YRDTIDFHLLTALGKVSYEDVDRLKGLAVTENMRVPHFLQDHGRYMEHLEKIMEVNEL
                     TDRELKDLI"
     exon            326..1014
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1158
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1291
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1597
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1695
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..4462
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="hexamer: AATAAA"
     regulatory      4369..4374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="hexamer: AAGAAA"
     polyA_site      4393
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="major polyA site"
     polyA_site      4397
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
     regulatory      4443..4448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
                     /note="hexamer: ATTATA"
     polyA_site      4443
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
     polyA_site      4462
                     /gene="MATCAP2"
                     /gene_synonym="KIAA0895; TMCP2"
ORIGIN      
        1 gtttcctagc aaccggcgga gcggctacgt cacggtggca ggttctaagc gctgctgggc
       61 accgtaaggc cgccgtgtgt accttccagt agctacgggc tggtggaagc gctgctcaca
      121 gtcagtgtcg gtacgtcttc gtccgccctt accctcctta tcctgctcca ggtagcggag
      181 agccgcctcc cgccgcgccc ccgccaccga ggcccgggtc agaggctaga ggccgcccgc
      241 ccctgcgcgg ccctttcccc tgagcccgcg gagcccgccg ccccgggcct cggggcgacg
      301 atgctggagt ccattcgcgt gacggaaaag cttcactggc ctgagcaaga acttgctaag
      361 aagtctattc taaatgcaga agattcattg atcattgaca acaaaagaag catttcacat
      421 ttgtcctcgg gagtgctaaa agacattttc acaactggaa ccagtagtta caatgtccta
      481 ctacagagca aggaggaaaa aaagtatcat tcacaaaaac agtcttcctc cacctactcc
      541 aaaagatgta gaaaacccag caaatctcct aacacttctc gtagcaaaga tcctcgcagg
      601 atgaaagccc tggtgcctgt gacaagcagt ggtacttggt actgcctgga gaggcggcct
      661 gctgtttttg tcactagttc agtgtcaagt cctgtaaagt ttacacatga tatctctgtt
      721 acagggaatg gcatagtact gccacctaaa cccaaaagca aggtcaagtg gtgccatttc
      781 tccactcttc caaagccaaa gcctcagctg tctagaagct ttgaaaaggg agatgacttt
      841 tctgggaaga aattttgtat attgactgct ataaaaccca ccaacttaga gaaagaaaaa
      901 ctgagattct tcaaatctga ctatacctac aatcctcagt ttgagtatgc caatcctgct
      961 ctgccaagcg tattagctaa gcatagccac gcatctgacc gatttcttaa gcagtctatc
     1021 aatattatgg aactgacttt acagaaatat ggaagttatg aaaaatttga acaagccact
     1081 ggtggtagct tgctctctaa aactcgaatc tggagtcacg ttaggaagta catgatgaag
     1141 gaaggctgcc taggggagat tgtagttcat ctcactgagg acctgctttc ccgagcgtca
     1201 atgacagtag taaatggatg tccgactctg actatcaatg tgtccactgc acgtgagcat
     1261 tggctggagg gaatgctgag gcatgaaata ggtacacatt attttcgagg tattaacaac
     1321 ctccagcagc catggaacag ttggactgga cgtaaaaaac atgagctaaa gccaaataat
     1381 cccacagagg aaggactagc aagcattcac agtgttctgt ttagaaaaga ccctttttta
     1441 tggagggctg ccctcctcta ctacactgtt tatcaagcca gccaaatgtc tttttgtgaa
     1501 ctctttaaag atattggcag gtttgtcaag gaccccaata caagatggga ttattgtgta
     1561 cgggccaaga ggggatggac tgatacttcc caaccagggt gttttagtaa agaccaggta
     1621 tacttggatg gaattcttca aatcctccga tacagagata ccatagactt ccatctgctg
     1681 actgctctcg ggaaggtttc ttatgaagat gtggatcgct taaaaggatt ggcagttacc
     1741 gaaaacatga gggtccctca tttcctgcag gaccatggcc gatatatgga acacttagag
     1801 aagatcatgg aagtgaatga actgactgac agggaactga aagatcttat atagtaatta
     1861 gcgttctggc aaacatagct aagctatgcc tccatgtata ttaccagtta ggtgcagtta
     1921 gcaccagaag atttataaaa gaagaaagac tacttgtgtt ttctgaagaa gggtcttcag
     1981 tattcagcgg aatttttagg ttaagtacag atcttaaact atttccctaa aatgtttcta
     2041 taggttgcag ggggaagtta ttcctatttt ctgaatctcg acagagtcag atgaaaatac
     2101 tactgctgag catttttgaa gactcttggt caaattgcat gataaatttc tgcctgagca
     2161 gtaagcactg gcctagtgct tctgcctaaa tatggaggtc agctccaact ggagactggc
     2221 tgaattccat tgctgttcag actccaaagt tatattttat ttgataaata atggtaatta
     2281 ttctcctttg aaaaattagt tttgtgttgc tccaaaaagc tagctatata tctcagcttt
     2341 cttatttctt ttatatgttg agggatttta aagggagagg aaaagcaatt tgaaaatttt
     2401 tcattaagtg ttttatttta acattattgt ttcaccttat cagcttatag gaactaaatt
     2461 agagaatcac ctctttttgt ccggttatct cttaactatg ttttcatttg ctgaaacata
     2521 ttgtaccctt ttaaattttt tacagagttt taacgtcttt tccactgcat cctttataaa
     2581 aataagtaca aattccagag aggttttcct acacaaatac aaaataattg gggaagggct
     2641 actcaccttt tttatgaaac agaatatgta acaagcagag gacaaataga ctgacctggt
     2701 taaacgtagg ttctggatgt tgatgggtag cacctgcagt aaacttgacc atgctctgaa
     2761 aaaagaaatt tctgggtatt gatggtttat aaagccagct ttgtgctatt ggttcagtat
     2821 attttatcaa atctttgact tcatcaaccc agtaatgaca tagtttaaat tttaaaatga
     2881 gagttctgtt ttgctgtatt tctcctgcta gcctagcttt gtattttatc atcagcttca
     2941 gtatatactt gtatatatat acctggattc aaatggttct tcatacaact taatgatcag
     3001 aaagaatgct gctgtaaaca ccccactcaa gattgctgct ggaatttcta cccaaagctg
     3061 tctgagagtt tatctttacc tcagtgcagg cttaaataat ggtgctaata ctggtagata
     3121 tatactgtga agcctggttc acattcatgc tagaaaatga ttttgggaaa tcttttatag
     3181 gagaggttac atgatttttc tctttcacat atctagaagg acttgcctca aagaagaatg
     3241 ttgcagcaaa caggatatac tctagctggt gcccaaaggt tcttgcaaaa ccatgaatct
     3301 tgcttttagc agtaaagggc cagacacttt ggagcattga aaggccttag cccctgctcc
     3361 ccaactacgt gccatgctgg gtagtgtgta tcctgtacat ctgtgtgcca ggctggggca
     3421 gactgtgcca atgctcaccg aacactagaa tctgctctta cacctctagc atgtatctcg
     3481 ttgtagcaga gttgtgcact ttctcagcat tgtgtagtgt tttctaattg catctaaaaa
     3541 cttatcaaaa gtgattgtga aaacagtgtc ttagaagtat aaacagaaat ggcaatattt
     3601 atgtcctgtg attcaagccc aaaggttata aattcaactt tcacagggaa tagcactgct
     3661 aatcttactt tatgatttaa atataaagga aaatcacagc agccttaatt tcctgttggt
     3721 cggatcattt gcagcagttc tagttcctga cttttaaaat ggatgaaatt ttctctttgt
     3781 ctgatttgga aaaggaactg cttttttgcc ttactgcttt ggtataagga tgaaaaacat
     3841 gagcactctg cagacaaaat gaccttaaat cacattgatt aagatatttt aaaagttagc
     3901 agtgaaccaa aagtagtttc agattagcag aaataaagag ctttaagttt taaaagttga
     3961 gattgaatat ttaatgaaag tttattaatt ctttttccag gaatagcagt aaggtcagtt
     4021 tttttcccta aaataaaaag ttttaataaa cagaaaatta tagcaacagt acttaggaga
     4081 atagttgaag attgtattaa ttttaattat aatagttatt tgtcataggc tattgatgat
     4141 tagaatttca ttagttttgt ccactataat tttaaaaata gttgtgtcaa atacaaattc
     4201 tggtaaactg ttaggtttta acaccagaca gtattcaaag gaaattaatg tttgcaaaca
     4261 taaatccata gtcttcattt ctttatattg tcacctttgt aaaagtgttt aaaatttgta
     4321 ttgtttgttt tgtatatctt tgggcatctt gtgtctagct ataataaaaa gaaacggtgc
     4381 caaggttctc agatgaagtg tgtggctatg tatgcatgta acttggtttc tttgaaaacc
     4441 caattatatt tgtattgtgg tg
//
