LOCUS       NM_001040715            3386 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens microtubule associated tyrosine carboxypeptidase 1
            (MATCAP1), transcript variant 2, mRNA.
ACCESSION   NM_001040715 XM_929083 XM_933410 XM_933414 XM_933425 XM_933430
            XM_933435 XM_933438 XM_933442 XM_933445 XM_933447 XM_941971
            XM_945589 XM_945591 XM_945592 XM_945593 XM_945594 XM_945596
            XM_945598 XM_945599 XM_945600
VERSION     NM_001040715.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3386)
  AUTHORS   Nicot,S., Gillard,G., Impheng,H., Joachimiak,E., Urbach,S.,
            Mochizuki,K., Wloga,D., Juge,F. and Rogowski,K.
  TITLE     A family of carboxypeptidases catalyzing alpha- and beta-tubulin
            tail processing and deglutamylation
  JOURNAL   Sci Adv 9 (37), eadi7838 (2023)
   PUBMED   37703372
REFERENCE   2  (bases 1 to 3386)
  AUTHORS   Landskron,L., Bak,J., Adamopoulos,A., Kaplani,K., Moraiti,M., van
            den Hengel,L.G., Song,J.Y., Bleijerveld,O.B., Nieuwenhuis,J.,
            Heidebrecht,T., Henneman,L., Moutin,M.J., Barisic,M., Taraviras,S.,
            Perrakis,A. and Brummelkamp,T.R.
  TITLE     Posttranslational modification of microtubules by the MATCAP
            detyrosinase
  JOURNAL   Science 376 (6595), eabn6020 (2022)
   PUBMED   35482892
REFERENCE   3  (bases 1 to 3386)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX460002.2, BC080183.1, BC007594.1 and AC074143.5.
            
            On Nov 24, 2018 this sequence version replaced NM_001040715.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.45613.1,
                                           SRR1803615.105694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563902.2/ ENSP00000456838.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BX460002.2         18-77
            61-390              BX460002.2         79-408
            391-925             BC080183.1         1-535
            926-2614            BC007594.1         137-1825
            2615-2930           AC074143.5         144691-145006       c
            2931-3383           BC007594.1         2134-2586
            3384-3386           AC074143.5         144235-144237       c
FEATURES             Location/Qualifiers
     source          1..3386
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..3386
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /note="microtubule associated tyrosine carboxypeptidase 1"
                     /db_xref="GeneID:653319"
                     /db_xref="HGNC:HGNC:34408"
                     /db_xref="MIM:619978"
     exon            1..702
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1328
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             759..2174
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /EC_number="3.4.17.17"
                     /note="isoform 1 is encoded by transcript variant 2;
                     KIAA0895 like; microtubule-associated tyrosine
                     carboxypeptidase; tubulin metallocarboxypeptidase 1"
                     /codon_start=1
                     /product="microtubule-associated tyrosine carboxypeptidase
                     1 isoform 1"
                     /protein_id="NP_001035805.1"
                     /db_xref="CCDS:CCDS42177.1"
                     /db_xref="GeneID:653319"
                     /db_xref="HGNC:HGNC:34408"
                     /db_xref="MIM:619978"
                     /translation="MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQS
                     LALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPP
                     GRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHY
                     TYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLT
                     KCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEG
                     MLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWR
                     AALLYYTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQV
                     YLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQ
                     LEHIMATNRLDEAELGRLLPD"
     exon            1329..1472
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1605
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1911
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2009
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..3386
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3386
                     /gene="MATCAP1"
                     /gene_synonym="KIAA0895L; TMCP1"
                     /note="major polyA site"
ORIGIN      
        1 gtacgtcatc ggcgacggct cccgccggct gggcgtccgg tggccggtgt agcagagcgg
       61 gagcggcggg cggcgagcag aggagctaac aggtgggggc acggcacgcg gacggacccc
      121 cccaaaggcc gggaggaggc gcgcgacgcg acctttcctg atctcccgga gaagcctcca
      181 ctccattgtc tcctggcccc accctccatt gggcacgccc ttcaccttat cccccaccac
      241 ttattggctg caggtcacgc ccctcctcta tttctggttc cccattggct cttcaccttg
      301 tcctctccgg ggcttctctc cgcacaggcc acaccctctc atttgtcact agaccccgcc
      361 ttaatagtgg ggggctcctc ccccatccat ccttcattca ttatgcaccc agtgctgggt
      421 gcttggtaca cgggggtgaa tcagacccca ttcctgcctt cggggagttc aggggattgt
      481 gggaggacac ggacctagac tccaacagtg acagctctga gtaaagaagt cgccgaagca
      541 gtgggacact agacgcgggg aaggcttcct ggaggaagtg aggcctaaac tgagccttga
      601 agaatggtta agagtttgct ccaggaatat attgcaaagg cattcttggc ggaaggaccc
      661 gagacgtgaa aaaaacaggc gtattctggt aatttcgagg agaggtcgac agtgtgggga
      721 gttggagtga cccggctgga tgtgaccccc aggacagaat ggtgctggac tcaggggctc
      781 aggcgtatga tcaggcaccc cccagcccgc ctaccagtcc cccatccctg cgccataggc
      841 tgaagccctc agaccgagat gggccaccac tgtacccctg gtctcagtcc ctggccttgc
      901 ccctggctct ggcagtcccc ccagcgctgc agccccagcc tgagcagcag ccgttctcac
      961 agatgctcct gggccaccgt ggccacatgc gtcgcagtga gagcacctac tctgtaaata
     1021 gtactggccg gcgggggcgt ggcaccctgg gacggcctcc acctggacgg ggacggaacc
     1081 caggtggggg caccctgcgg cctgcagcct ccctgcctca cattgctaag actcaaaggg
     1141 atgcaggcca tattgccagc aagagcccct gcatgttggt ggccctgcgg ccaaccaaca
     1201 tggaccgtga gcgagacaag ttcttccagt cccattacac ctacaatcca cagtttgagt
     1261 accaggagcc catgcccacg gctgtgctgg aaaagtactg cgaggcctct ggacagttca
     1321 tccatcaggc agttggcatc attgaggctg ttctggagaa gtttggaacc tatgaacact
     1381 ttgaggctgc cactgggggg cagctgctca ccaagtgcca gatatggtcg attgtgcgca
     1441 aatacatgca gaaggagggc tgcgctgggg aggttgtggt gcagctgagt gaggacctgc
     1501 tgtcccaggc agtgatgatg gtggagaaca gccggcccac attggcgatc aacctgaccg
     1561 gagcccgcca gtactggttg gagggcatgc tgcggcatga gataggcacc cactacctgc
     1621 ggggcgtgaa caacgcgcgc cagccgtggc acaacgcgga gggccggctg cggtacgggc
     1681 tgcggccggc gaaccccacg gaggagggcc tggccagcct gcacagcgtg ctgttccgca
     1741 agcagccgtt cctgtggcgc gctgcactgc tctactacac catccaccgc gccgcgcgca
     1801 tgtccttccg tcagctcttc caggacctgg agcgctacgt gcaggacgcc gatgtgcgct
     1861 gggagtactg cgtgcgcgcc aagcgcggcc agaccgacac ctcgctgcca ggttgtttca
     1921 gcaaggacca ggtgtacctg gacggcatcg tgcgcattct gcgacatcgc cagaccatcg
     1981 atttcccgtt gctgacctca ctgggcaagg tgtcctatga ggatgtggac cacctgcggc
     2041 cccatggggt gctggataat acccgggtgc cccacttcat gcaggacttg gcacgctacc
     2101 ggcagcagct ggagcacatc atggccacca accggctgga tgaggcggag ctgggtcgcc
     2161 tgctacccga ctgatgtccg ttgagggctg cagtcagagg ccctggacag aagctccaga
     2221 taggccccta gaacatgaag cagtttgctc tgtgcgtcca cggcctaggt gtttcttggg
     2281 ggtgttggga gggcaggagc attccttgag gaggagtggc aacatcaaag tgtttgtgtc
     2341 ccttgccagc ctccctgggg tctggggacc tgcagcagca tgtctggcaa actgagtcgc
     2401 cctcctgcct ccagctctct gttgagcaga gggaaggcat gggggcagga agagagctga
     2461 gcattgatgg ggatgggggt ggtttgggaa tagaaacttg ttcttgcatg agatggcttt
     2521 ggttgtccca gtactccagt ctctcccttc ccttacctgg ccccttggtg ctccttcagc
     2581 atttgtgctg tctacctctc actgggtcct ggtgggggtc gggctccctt ctcctggggt
     2641 gattgatggc ctgagcctgg ggtcctggta gtagagaccc agctggcctg gggtctgctt
     2701 tccgacattt tgcctctctc actggtcatg tatttattcc atatttatat ggtctacttc
     2761 ctgtggctgg gagcagcagc tcctgaaggt tccgtggggg tgcggggggt tggacaggac
     2821 actccttctt ggaaggcacc aattttccca gccccactcc cattacacac acacacacac
     2881 acacacacac acacacacac acacacacac acacacacac acacacacac tgattcaggc
     2941 cttgagagtc aagcccaaga gctcccttgg ccctgttccc cactccctcc actggcctct
     3001 gctgttcctg tctttgctca caccctcaca gctgctctct ggcagaggtt ggcatagcct
     3061 aggagcagct gcaattgcac ctgagggaca ggccctagag tttggtggcc caagtcctga
     3121 acccctctta gaccaggtga ggtgcagagg tggttgctgc ttccagtttc ccttcagact
     3181 tagctgtgtg aaccccactc ctatcctttg gccttagttt tcccatctgt aaaactcaga
     3241 aacgcagttg gaaagtcctt attcatttag taagcgaata tattataata tgtatagagc
     3301 gccttttgtg taagtcactg gtcagaatcc tcactgagct cccagtccag agagaagcca
     3361 gacaattaaa acagtaatga caatga
//
