LOCUS       NM_005911               2817 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens methionine adenosyltransferase 2A (MAT2A), mRNA.
ACCESSION   NM_005911
VERSION     NM_005911.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Jiang,C., Liu,J., He,S., Xu,W., Huang,R., Pan,W., Li,X., Dai,X.,
            Guo,J., Zhang,T., Inuzuka,H., Wang,P., Asara,J.M., Xiao,J. and
            Wei,W.
  TITLE     PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing
            via Arg-methylation of NPRL2
  JOURNAL   Cell Metab 35 (12), 2183-2199 (2023)
   PUBMED   38006878
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Hunter,O.V., Ruiz,J.C., Flaherty,J.N. and Conrad,N.K.
  TITLE     Functional analysis of 3'-UTR hairpins supports a two-tiered model
            for posttranscriptional regulation of MAT2A by METTL16
  JOURNAL   RNA 29 (11), 1725-1737 (2023)
   PUBMED   37567786
  REMARK    GeneRIF: Functional analysis of 3'-UTR hairpins supports a
            two-tiered model for posttranscriptional regulation of MAT2A by
            METTL16.
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Herre,C., Nshdejan,A., Klopfleisch,R., Corte,G.M. and
            Bahramsoltani,M.
  TITLE     Expression of vimentin, TPI and MAT2A in human dermal microvascular
            endothelial cells during angiogenesis in vitro
  JOURNAL   PLoS One 17 (4), e0266774 (2022)
   PUBMED   35482724
  REMARK    GeneRIF: Expression of vimentin, TPI and MAT2A in human dermal
            microvascular endothelial cells during angiogenesis in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Ma,M., Kong,P., Huang,Y., Wang,J., Liu,X., Hu,Y., Chen,X., Du,C.
            and Yang,H.
  TITLE     Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis
            in gastric cancer
  JOURNAL   Free Radic Biol Med 181, 288-299 (2022)
   PUBMED   35182729
  REMARK    GeneRIF: Activation of MAT2A-ACSL3 pathway protects cells from
            ferroptosis in gastric cancer.
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Bailey,J., Douglas,H., Masino,L., de Carvalho,L.P.S. and Argyrou,A.
  TITLE     Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but
            Not Regulated by Mat2B
  JOURNAL   Biochemistry 60 (47), 3621-3632 (2021)
   PUBMED   34780697
  REMARK    GeneRIF: Human Mat2A Uses an Ordered Kinetic Mechanism and Is
            Stabilized but Not Regulated by Mat2B.
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Mao,Z., Liu,S., Cai,J., Huang,Z.Z. and Lu,S.C.
  TITLE     Cloning and functional characterization of the 5'-flanking region
            of human methionine adenosyltransferase 2A gene
  JOURNAL   Biochem Biophys Res Commun 248 (3), 479-484 (1998)
   PUBMED   9703951
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   De La Rosa,J., Ostrowski,J., Hryniewicz,M.M., Kredich,N.M.,
            Kotb,M., LeGros,H.L. Jr., Valentine,M. and Geller,A.M.
  TITLE     Chromosomal localization and catalytic properties of the
            recombinant alpha subunit of human lymphocyte methionine
            adenosyltransferase
  JOURNAL   J Biol Chem 270 (37), 21860-21868 (1995)
   PUBMED   7665609
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Horikawa,S. and Tsukada,K.
  TITLE     Molecular cloning and developmental expression of a human kidney
            S-adenosylmethionine synthetase
  JOURNAL   FEBS Lett 312 (1), 37-41 (1992)
   PUBMED   1426236
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Okada,G., Teraoka,H. and Tsukada,K.
  TITLE     Multiple species of mammalian S-adenosylmethionine synthetase.
            Partial purification and characterization
  JOURNAL   Biochemistry 20 (4), 934-940 (1981)
   PUBMED   7213623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC322518.1, BC001686.2 and
            AC016753.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005911.5.
            
            Summary: The protein encoded by this gene catalyzes the production
            of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is
            the key methyl donor in cellular processes. [provided by RefSeq,
            Jun 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.267421.1,
                                           SRR3476690.387103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306434.8/ ENSP00000303147.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC322518.1         32-44
            14-2816             BC001686.2         1-2803
            2817-2817           AC016753.9         112240-112240
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..2817
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /note="methionine adenosyltransferase 2A"
                     /db_xref="GeneID:4144"
                     /db_xref="HGNC:HGNC:6904"
                     /db_xref="MIM:601468"
     exon            1..211
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1308
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /EC_number="2.5.1.6"
                     /note="methionine adenosyltransferase II, alpha; MAT 2;
                     MAT-II; adoMet synthetase 2; methionine
                     adenosyltransferase 2; adoMet synthase 2; testicular
                     tissue protein Li 121"
                     /codon_start=1
                     /product="S-adenosylmethionine synthase isoform type-2"
                     /protein_id="NP_005902.1"
                     /db_xref="CCDS:CCDS1977.1"
                     /db_xref="GeneID:4144"
                     /db_xref="HGNC:HGNC:6904"
                     /db_xref="MIM:601468"
                     /translation="MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDA
                     HLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYK
                     TCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKL
                     NAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEM
                     RDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGA
                     HGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFH
                     YGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKK
                     LKY"
     exon            212..289
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..412
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..525
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..669
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..888
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1071
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1205
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..2817
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1705
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /note="major polyA site"
     polyA_site      1982
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /note="major polyA site"
     polyA_site      1988
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
                     /note="hexamer: AATAAA"
     polyA_site      2817
                     /gene="MAT2A"
                     /gene_synonym="MATA2; MATII; SAMS2"
ORIGIN      
        1 gttcgctccg cgccgcccgc ctgctacgag tagaacgctg tccgcagctt gcgcatttcg
       61 cagccgctgc cgcctcgccg ctgctccttc gtaaggccac ttccgcacac cgacaccaac
      121 atgaacggac agctcaacgg cttccacgag gcgttcatcg aggagggcac attccttttc
      181 acctcagagt cggtcgggga aggccaccca gataagattt gtgaccaaat cagtgatgct
      241 gtccttgatg cccaccttca gcaggatcct gatgccaaag tagcttgtga aactgttgct
      301 aaaactggaa tgatccttct tgctggggaa attacatcca gagctgctgt tgactaccag
      361 aaagtggttc gtgaagctgt taaacacatt ggatatgatg attcttccaa aggttttgac
      421 tacaagactt gtaacgtgct ggtagccttg gagcaacagt caccagatat tgctcaaggt
      481 gttcatcttg acagaaatga agaagacatt ggtgctggag accagggctt aatgtttggc
      541 tatgccactg atgaaactga ggagtgtatg cctttaacca ttgtcttggc acacaagcta
      601 aatgccaaac tggcagaact acgccgtaat ggcactttgc cttggttacg ccctgattct
      661 aaaactcaag ttactgtgca gtatatgcag gatcgaggtg ctgtgcttcc catcagagtc
      721 cacacaattg ttatatctgt tcagcatgat gaagaggttt gtcttgatga aatgagggat
      781 gccctaaagg agaaagtcat caaagcagtt gtgcctgcga aataccttga tgaggataca
      841 atctaccacc tacagccaag tggcagattt gttattggtg ggcctcaggg tgatgctggt
      901 ttgactggac gcaaaatcat tgtggacact tatggcggtt ggggtgctca tggaggaggt
      961 gccttttcag gaaaggatta taccaaggtc gaccgttcag ctgcttatgc tgctcgttgg
     1021 gtggcaaaat cccttgttaa aggaggtctg tgccggaggg ttcttgttca ggtctcttat
     1081 gctattggag tttctcatcc attatctatc tccattttcc attatggtac ctctcagaag
     1141 agtgagagag agctattaga gattgtgaag aagaatttcg atctccgccc tggggtcatt
     1201 gtcagggatc tggatctgaa gaagccaatt tatcagagga ctgcagccta tggccacttt
     1261 ggtagggaca gcttcccatg ggaagtgccc aaaaagctta aatattgaaa gtgttagcct
     1321 tttttcccca gacttgttgg cgtaggctac agagaagcct tcaagctctg agggaaaggg
     1381 ccctccttcc taaattttcc tgtcctcttt cagctcctga ccagttgcag tcactctagt
     1441 caatgacatg aattttagct tttgtggggg actgtaagtt gggcttgcta ttctgtccct
     1501 aggtgttttg ttcaccatta taatgaattt agtgagcata ggtgatccat gtaactgcct
     1561 agaaacaaca ctgtagtaaa taatgctttg aaattgaacc tttgtgccct atcacccaac
     1621 gctccaaagt cataattgca ttgactttcc ccaccagatg ctgaaaatgt ccttgtgatg
     1681 tgcacgtaaa gtacttgtag ttccacttat agcctctgtc tggcaatgcc acagccctgt
     1741 cagcatgaat ttgtaatgtc ttgagctcta ttatgaatgt gaagccttcc ccttatcctc
     1801 cctgtaactt gatccatttc taattatgta gctctttgtc agggagtgtt ccctatccaa
     1861 tcaatcttgc atgtaacgca agttcccagt tggagctcca gcctgacatc aaaaaaggca
     1921 gttaccatta aaccatctcc ctggtgctta tgctcttaat tgccacctct aacagcacca
     1981 aatcaaaatc tctccacttt cagctgtctt ttggaggacg tacgtaataa ggttttaatt
     2041 tagtaaacca atcctatgca tggtttcagc actagccaaa cctcaccaac tcctagttct
     2101 agaaaaacag gcacttggca gccttgtgat gtcatacaga gaagtcacag ggcagtacct
     2161 gagggtctgt aggttgcaca ctttggtacc agataacttt tttttttctt tataagaaag
     2221 cctgagtact ccacactgca caataactcc tcccagggtt ttaactttgt tttattttca
     2281 aaaccaggtc caatgagctt tctgaacagc tggtgtagct acagagaaac cagcttcctt
     2341 cagagagcag tgcttttggc ggggaggagg aaatcccttc atacttgaac gttttctaat
     2401 tgcttattta ttgtattctg gggtatggcg taagtacaga gaagccatca cctcagatgg
     2461 cagcttttaa aagatttttt ttttttctct caacaccatg attcctttaa caacatgttt
     2521 ccagcattcc caggtaggcc aaggtgtcct acagaaaaac cttgggttag acctacaggg
     2581 ggtctggctg gtgttaacag aagggagggc agagctggtg cggctggcca tggagaaagc
     2641 tgacttggct ggtgtggtac agagaagcca gcttgtttac atgcttattc catgactgct
     2701 tgccctaagc agaaagtgcc tttcaggatc tatttttgga ggtttattac gtatgtctgg
     2761 ttctcaattc caacagttta atgaagatct aaataaaatg ctaggttcta ccttaac
//
