LOCUS       NM_000429               3384 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens methionine adenosyltransferase 1A (MAT1A), mRNA.
ACCESSION   NM_000429
VERSION     NM_000429.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Shen,S., Liu,R., Huang,J., Sun,Y., Tan,Q., Luo,Q. and Liu,R.
  TITLE     MAT1A activation of glycolysis to promote NSCLC progression depends
            on stabilizing CCND1
  JOURNAL   Cell Death Dis 15 (10), 768 (2024)
   PUBMED   39438468
  REMARK    GeneRIF: MAT1A activation of glycolysis to promote NSCLC
            progression depends on stabilizing CCND1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Fan,W., Cao,D., Yang,B., Wang,J., Li,X., Kitka,D., Li,T.W.H.,
            You,S., Shiao,S., Gangi,A., Posadas,E., Di Vizio,D., Tomasi,M.L.,
            Seki,E., Mato,J.M., Yang,H. and Lu,S.C.
  TITLE     Hepatic prohibitin 1 and methionine adenosyltransferase alpha1
            defend against primary and secondary liver cancer metastasis
  JOURNAL   J Hepatol 80 (3), 443-453 (2024)
   PUBMED   38086446
  REMARK    GeneRIF: Hepatic prohibitin 1 and methionine adenosyltransferase
            alpha1 defend against primary and secondary liver cancer
            metastasis.
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Pham,V.N., Bruemmer,K.J., Toh,J.D.W., Ge,E.J., Tenney,L.,
            Ward,C.C., Dingler,F.A., Millington,C.L., Garcia-Prieto,C.A.,
            Pulos-Holmes,M.C., Ingolia,N.T., Pontel,L.B., Esteller,M.,
            Patel,K.J., Nomura,D.K. and Chang,C.J.
  TITLE     Formaldehyde regulates S-adenosylmethionine biosynthesis and
            one-carbon metabolism
  JOURNAL   Science 382 (6670), eabp9201 (2023)
   PUBMED   37917677
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Barbier-Torres,L., Murray,B., Yang,J.W., Wang,J., Matsuda,M.,
            Robinson,A., Binek,A., Fan,W., Fernandez-Ramos,D., Lopitz-Otsoa,F.,
            Luque-Urbano,M., Millet,O., Mavila,N., Peng,H., Ramani,K.,
            Gottlieb,R., Sun,Z., Liangpunsakul,S., Seki,E., Van Eyk,J.E.,
            Mato,J.M. and Lu,S.C.
  TITLE     Depletion of mitochondrial methionine adenosyltransferase alpha1
            triggers mitochondrial dysfunction in alcohol-associated liver
            disease
  JOURNAL   Nat Commun 13 (1), 557 (2022)
   PUBMED   35091576
  REMARK    GeneRIF: Depletion of mitochondrial methionine adenosyltransferase
            alpha1 triggers mitochondrial dysfunction in alcohol-associated
            liver disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Chen,P.M., Tsai,C.H., Huang,C.C., Hwang,H.H., Li,J.R., Liu,C.C.,
            Ko,H.A. and Chiang,E.I.
  TITLE     Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches
            Protein-Associated Translation Process and Worsens Hepatocellular
            Carcinoma Prognosis
  JOURNAL   Int J Mol Sci 23 (1), 481 (2022)
   PUBMED   35008908
  REMARK    GeneRIF: Downregulation of Methionine Cycle Genes MAT1A and GNMT
            Enriches Protein-Associated Translation Process and Worsens
            Hepatocellular Carcinoma Prognosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Surtees,R., Leonard,J. and Austin,S.
  TITLE     Association of demyelination with deficiency of cerebrospinal-fluid
            S-adenosylmethionine in inborn errors of methyl-transfer pathway
  JOURNAL   Lancet 338 (8782-8783), 1550-1554 (1991)
   PUBMED   1683972
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Horikawa,S. and Tsukada,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNA encoding the
            human liver S-adenosylmethionine synthetase
  JOURNAL   Biochem Int 25 (1), 81-90 (1991)
   PUBMED   1772450
REFERENCE   8  (bases 1 to 3384)
  AUTHORS   Gahl,W.A., Finkelstein,J.D., Mullen,K.D., Bernardini,I.,
            Martin,J.J., Backlund,P., Ishak,K.G., Hoofnagle,J.H. and Mudd,S.H.
  TITLE     Hepatic methionine adenosyltransferase deficiency in a 31-year-old
            man
  JOURNAL   Am J Hum Genet 40 (1), 39-49 (1987)
   PUBMED   3812486
REFERENCE   9  (bases 1 to 3384)
  AUTHORS   Okada,G., Teraoka,H. and Tsukada,K.
  TITLE     Multiple species of mammalian S-adenosylmethionine synthetase.
            Partial purification and characterization
  JOURNAL   Biochemistry 20 (4), 934-940 (1981)
   PUBMED   7213623
REFERENCE   10 (bases 1 to 3384)
  AUTHORS   Allsop,J. and Watts,R.W.
  TITLE     Methionine adenosyltransferase, cystathionine beta-synthase and
            cystathionine gamma-lyase activity of rat liver subcellular
            particles, human blood cells and mixed white cells from rat bone
            marrow
  JOURNAL   Clin Sci Mol Med Suppl 48 (6), 509-513 (1975)
   PUBMED   1056281
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM738684.1, BX496326.1,
            X69078.1 and BC018359.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000429.2.
            
            Summary: This gene catalyzes a two-step reaction that involves the
            transfer of the adenosyl moiety of ATP to methionine to form
            S-adenosylmethionine and tripolyphosphate, which is subsequently
            cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl
            groups for most biological methylations. The encoded protein is
            found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a
            third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations
            in this gene are associated with methionine adenosyltransferase
            deficiency. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018359.1, AK290820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267761, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372213.8/ ENSP00000361287.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BM738684.1         27-161
            136-527             BX496326.1         137-528
            528-2150            X69078.1           364-1986
            2151-2719           BC018359.1         2138-2706
            2720-2960           X69078.1           2556-2796
            2961-3384           BC018359.1         2948-3371
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..3384
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /note="methionine adenosyltransferase 1A"
                     /db_xref="GeneID:4143"
                     /db_xref="HGNC:HGNC:6903"
                     /db_xref="MIM:610550"
     exon            1..326
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1423
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /EC_number="2.5.1.6"
                     /note="MAT 1; MAT-I/III; adoMet synthetase 1; methionine
                     adenosyltransferase 1; methionine adenosyltransferase
                     I/III; adoMet synthase 1; methionine adenosyltransferase
                     I, alpha"
                     /codon_start=1
                     /product="S-adenosylmethionine synthase isoform type-1"
                     /protein_id="NP_000420.1"
                     /db_xref="CCDS:CCDS7365.1"
                     /db_xref="GeneID:4143"
                     /db_xref="HGNC:HGNC:6903"
                     /db_xref="MIM:610550"
                     /translation="MNGPVDGLCDHSLSEGVFMFTSESVGEGHPDKICDQISDAVLDA
                     HLKQDPNAKVACETVCKTGMVLLCGEITSMAMVDYQRVVRDTIKHIGYDDSAKGFDFK
                     TCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKL
                     NARMADLRRSGLLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEM
                     RRALKEQVIRAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGA
                     HGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFT
                     YGTSQKTERELLDVVHKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPRK
                     LVF"
     exon            327..404
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..527
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..640
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            641..784
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1003
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1186
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1320
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..3384
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3362..3367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /note="hexamer: AATAAA"
     polyA_site      3384
                     /gene="MAT1A"
                     /gene_synonym="MAT; MATA1; SAMS; SAMS1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcaagct ggagggaggg acacatcccg tgttccatcc actccctccc ttctcagcag
       61 tcctcgcctg ttctcacgtg ctcacaggca gttaggcaga agtgatcccc gtggctctgc
      121 caaagacaag cctgttgggt tgaaagaaga agaagaagaa gaaaaaaaaa ctcaggcaaa
      181 gtcacagcct caaaattgtt cactgaaaga agcgtgagtg gagaagtgtg agaagatgaa
      241 tggaccggtg gatggcttgt gtgaccactc tctaagtgaa ggagtcttca tgttcacatc
      301 ggagtctgtg ggagagggac acccggataa gatctgtgac cagatcagtg atgcagtgct
      361 ggatgcccat ctcaagcaag accccaatgc caaggtggcc tgtgagacag tgtgcaagac
      421 cggcatggtg ctgctgtgtg gtgagatcac ctcaatggcc atggtggact accagcgggt
      481 ggtgagggac accatcaagc acatcggcta cgatgactca gccaagggct ttgacttcaa
      541 gacttgcaac gtgctggtgg ctttggagca gcaatcccca gatattgccc agtgcgtcca
      601 tctggacaga aatgaggagg atgtgggggc aggagatcag ggtttgatgt tcggctatgc
      661 taccgacgag acagaggagt gcatgcccct caccatcatc cttgctcaca agctcaacgc
      721 ccggatggca gacctcaggc gctccggcct cctcccctgg ctgcggcctg actctaagac
      781 tcaggtgaca gttcagtaca tgcaggacaa tggcgcagtc atccctgtgc gcatccacac
      841 catcgtcatc tctgtgcagc acaacgaaga catcacgctg gaggagatgc gcagggccct
      901 gaaggagcaa gtcatcaggg ccgtggtgcc ggccaagtac ctggacgaag acaccgtcta
      961 ccacctgcag cccagtgggc ggtttgtcat cggaggtccc cagggggatg cgggtgtcac
     1021 tggccgtaag attattgtgg acacctatgg cggctggggg gctcatggtg gtggggcctt
     1081 ctctgggaag gactacacca aggtagaccg ctcagctgca tatgctgccc gctgggtggc
     1141 caagtctctg gtgaaagcag ggctctgccg gagagtgctt gtccaggttt cctatgccat
     1201 tggtgtggcc gagccgctgt ccatttccat cttcacctac ggaacctctc agaagacaga
     1261 gcgagagctg ctggatgtgg tgcataagaa cttcgacctc cggccgggcg tcattgtcag
     1321 ggatttggac ttgaagaagc ccatctacca gaagacagca tgctacggcc atttcggaag
     1381 aagcgagttc ccatgggagg ttcccaggaa gcttgtattt tagagccagg gggagctggg
     1441 cctggtctca ccctggaggc acctggtggc catgctcctc ttccccagac gcctggctgc
     1501 tgatcgcctt ccccacccac caaccctcag ggcaaagcca ggtccctctc atttagcctg
     1561 tcctgtcatc atcatggcca gctggaggca ggggcttcct ggtgctggag gttggatctt
     1621 gatgtaagga tgggcatggt gttctcctgc tgctccctca gactggggca atgttaattt
     1681 agtggaaaag gcacccccgt caagagtgaa ttccctcact cgtctccccc aacagctgga
     1741 ccctgaccag ctccccctcc ctccccttgc ctgtgccagg tgaggtcagc acatctcaac
     1801 aggcctcagg gctccttgtg ggcctgggct cctggacccc cctttcacag gcagccagtg
     1861 ccctgagcca gggtctccag aaagccccac ccaggccagg catgtggcag gggttagagc
     1921 aggactgatg tctcctaagc acctgtaatg tgcgagggac ccagctaata actgatctcg
     1981 ttttttcttc actgcaacat gatgaggtag taccttttat atcccattta tagatggggg
     2041 aaagcaaagc acagagagtc tggataactt ccacagggtc ccacagccac gtgtttagac
     2101 ctagatgtat aactaggagc tttgactcag gagcctgtga cataccccct cccccaccgt
     2161 tgtctcatgc cagtaacagg ctcaaacaat gacaaagcag attcagaaat gaggccatgg
     2221 actctgtcct gaaggcctga ggttactgga aattagggga ttaacccact agctcttgtt
     2281 gagccgtggg caattgtctg aaaagtgaag acagaaccac agggctattt tgtttgcttc
     2341 atgtgtccca gaagatgact gagggtgagt tggcttacct ggcccatcag ggtaggctgg
     2401 agttagggac tgaccagcag ctttagaatc ccagccccct gaccactcag agacatgcag
     2461 agattgggtt tttggacttc tggggtaagt ggtctaagtc cagtccagtc ctatctgggc
     2521 ttcctggagc agaagcagca acttgtccta gcacagatgg ccagcccctt agacagaggc
     2581 cctcaagtct ttctctttcc ctggtccctt gtatcccctg caggctgagt gcatttggag
     2641 ggagtgagtg gccctttcgg atccagggag gctggtccta tggcctcatg ttaaataggc
     2701 ggggcttgcc ttctggtgtt ggacaagctt ctgagacgtc atgaggagat tctgcctttg
     2761 ccaggtgact gtctggggag cgggtctgct cccaaggggc ctgagcagtc cttggcctgc
     2821 taaggtcttg gaacttgcct gcctttccat ccatggccag cagcacctgc cctacctgcc
     2881 ccacttgtcc ttagcctgga cctctgacag cagcatctct accttctccc cagctcccag
     2941 gaccacaggc tcaggcaggg gcctccatgg gccccagggg aacactgggg acttggcctc
     3001 tctctagggt acatggtgct gggagaggca gcccaggaag tctcatctgg ggagcaggca
     3061 gccagcatct gggccttggc ctggagcaca aagaccctgg ctttcatttt ctctcaggtg
     3121 aaaggaaatt aaggcaacaa aagaagcccg gctcctggtc acctaggaag cctcagattc
     3181 cttcccatgg agggagggag tggtttgcag gtggccaagt tcctctaact tggctcacac
     3241 tcgacatgaa aattcagaat tttatacttt ccctaccctc tagagaaata agatcttttt
     3301 tgtcagtttg tttgtatgaa actaaagcct ttatttgtta atagttcctg ctaaaacaat
     3361 gaataaaaac tcaaggagca acta
//
