LOCUS       NM_001172303            4132 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens microtubule associated serine/threonine kinase like
            (MASTL), transcript variant 1, mRNA.
ACCESSION   NM_001172303
VERSION     NM_001172303.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4132)
  AUTHORS   Marzec,K.A., Rogers,S., McCloy,R., Parker,B.L., James,D.E.,
            Watkins,D.N. and Burgess,A.
  TITLE     SILAC kinase screen identifies potential MASTL substrates
  JOURNAL   Sci Rep 12 (1), 10568 (2022)
   PUBMED   35732702
  REMARK    GeneRIF: SILAC kinase screen identifies potential MASTL substrates.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4132)
  AUTHORS   Fatima,I., Barman,S., Uppada,J., Chauhan,S., Rauth,S.,
            Rachagani,S., Ponnusamy,M.P., Smith,L., Talmon,G., Singh,A.B.,
            Batra,S.K. and Dhawan,P.
  TITLE     MASTL regulates EGFR signaling to impact pancreatic cancer
            progression
  JOURNAL   Oncogene 40 (38), 5691-5704 (2021)
   PUBMED   34331012
  REMARK    GeneRIF: MASTL regulates EGFR signaling to impact pancreatic cancer
            progression.
REFERENCE   3  (bases 1 to 4132)
  AUTHORS   Monsivais,D., Vasquez,Y.M., Chen,F., Zhang,Y., Chandrashekar,D.S.,
            Faver,J.C., Masand,R.P., Scheurer,M.E., Varambally,S., Matzuk,M.M.
            and Creighton,C.J.
  TITLE     Mass-spectrometry-based proteomic correlates of grade and stage
            reveal pathways and kinases associated with aggressive human
            cancers
  JOURNAL   Oncogene 40 (11), 2081-2095 (2021)
   PUBMED   33627787
  REMARK    GeneRIF: Mass-spectrometry-based proteomic correlates of grade and
            stage reveal pathways and kinases associated with aggressive human
            cancers.
REFERENCE   4  (bases 1 to 4132)
  AUTHORS   An,C.X., Xie,S.P., Li,H.L., Hu,Y.H., Niu,R., Zhang,L.J., Jiang,Y.,
            Li,Q. and Zhou,Y.N.
  TITLE     Knockdown of Microtubule Associated Serine/threonine Kinase Like
            Expression Inhibits Gastric Cancer Cell Growth and Induces
            Apoptosis by Activation of ERK1/2 and Inactivation of NF-kappaB
            Signaling
  JOURNAL   Curr Med Sci 41 (1), 108-117 (2021)
   PUBMED   33582914
  REMARK    GeneRIF: Knockdown of Microtubule Associated Serine/threonine
            Kinase Like Expression Inhibits Gastric Cancer Cell Growth and
            Induces Apoptosis by Activation of ERK1/2 and Inactivation of
            NF-kappaB Signaling.
REFERENCE   5  (bases 1 to 4132)
  AUTHORS   Fatima,I., Singh,A.B. and Dhawan,P.
  TITLE     MASTL: A novel therapeutic target for Cancer Malignancy
  JOURNAL   Cancer Med 9 (17), 6322-6329 (2020)
   PUBMED   32692487
  REMARK    GeneRIF: MASTL: A novel therapeutic target for Cancer Malignancy.
            Review article
REFERENCE   6  (bases 1 to 4132)
  AUTHORS   Burgess,A., Vigneron,S., Brioudes,E., Labbe,J.C., Lorca,T. and
            Castro,A.
  TITLE     Loss of human Greatwall results in G2 arrest and multiple mitotic
            defects due to deregulation of the cyclin B-Cdc2/PP2A balance
  JOURNAL   Proc Natl Acad Sci U S A 107 (28), 12564-12569 (2010)
   PUBMED   20538976
REFERENCE   7  (bases 1 to 4132)
  AUTHORS   Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
            Rowley,J.D. and Wang,S.M.
  TITLE     The transcriptome of human CD34+ hematopoietic stem-progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
   PUBMED   19416867
REFERENCE   8  (bases 1 to 4132)
  AUTHORS   Gandhi,M.J., Cummings,C.L. and Drachman,J.G.
  TITLE     FLJ14813 missense mutation: a candidate for autosomal dominant
            thrombocytopenia on human chromosome 10
  JOURNAL   Hum Hered 55 (1), 66-70 (2003)
   PUBMED   12890928
  REMARK    GeneRIF: A novel missense mutation in the human gene FLJ14813 is
            associated with autosomal dominant thrombocytopenia
            GeneRIF: A paper that narrows the identity of the gene for
            autosomal dominant thrombocytopenia (THC2) to FLJ14813. The
            mutation is present in all affected people across three generations
            while is absent in unaffected family members & 94 random blood
            donors.
REFERENCE   9  (bases 1 to 4132)
  AUTHORS   Drachman,J.G., Jarvik,G.P. and Mehaffey,M.G.
  TITLE     Autosomal dominant thrombocytopenia: incomplete megakaryocyte
            differentiation and linkage to human chromosome 10
  JOURNAL   Blood 96 (1), 118-125 (2000)
   PUBMED   10891439
REFERENCE   10 (bases 1 to 4132)
  AUTHORS   Savoia,A., Del Vecchio,M., Totaro,A., Perrotta,S., Amendola,G.,
            Moretti,A., Zelante,L. and Iolascon,A.
  TITLE     An autosomal dominant thrombocytopenia gene maps to chromosomal
            region 10p
  JOURNAL   Am J Hum Genet 65 (5), 1401-1405 (1999)
   PUBMED   10521306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160291.31.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 2, 2019 this sequence version replaced NM_001172303.2.
            
            Summary: This gene encodes a microtubule-associated
            serine/threonine kinase. Mutations at this locus have been
            associated with autosomal dominant thrombocytopenia, also known as
            thrombocytopenia-2. Alternatively spliced transcript variants have
            been described for this locus. [provided by RefSeq, Feb 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1056087.1, BC009107.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375940.9/ ENSP00000365107.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AL160291.31        27654-27914
            262-399             AL160291.31        30851-30988
            400-539             AL160291.31        31921-32060
            540-628             AL160291.31        33396-33484
            629-735             AL160291.31        37366-37472
            736-886             AL160291.31        37691-37841
            887-1059            AL160291.31        39404-39576
            1060-2199           AL160291.31        42246-43385
            2200-2341           AL160291.31        45420-45561
            2342-2455           AL160291.31        53255-53368
            2456-2557           AL160291.31        53782-53883
            2558-4132           AL160291.31        58681-60255
FEATURES             Location/Qualifiers
     source          1..4132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..4132
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /note="microtubule associated serine/threonine kinase
                     like"
                     /db_xref="GeneID:84930"
                     /db_xref="HGNC:HGNC:19042"
                     /db_xref="MIM:608221"
     exon            1..261
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2715
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase greatwall; greatwall
                     protein kinase; greatwall kinase homolog"
                     /codon_start=1
                     /product="serine/threonine-protein kinase greatwall
                     isoform 1"
                     /protein_id="NP_001165774.1"
                     /db_xref="CCDS:CCDS53502.1"
                     /db_xref="GeneID:84930"
                     /db_xref="HGNC:HGNC:19042"
                     /db_xref="MIM:608221"
                     /translation="MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRG
                     AFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQS
                     ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPD
                     NMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSL
                     GFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVA
                     SNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEAL
                     GPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKC
                     FSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELV
                     DSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKEN
                     IVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNIS
                     MNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVE
                     NPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMD
                     ISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILG
                     TPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWP
                     EGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDD
                     ETDTSYFEARNTAQHLTVSGFSL"
     exon            262..399
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..539
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..628
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..735
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..886
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1059
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..2199
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2341
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2455
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2557
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..4132
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2985..2990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /note="major polyA site"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /note="hexamer: AATAAA"
     polyA_site      3099
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
     regulatory      4110..4115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
                     /note="hexamer: AATAAA"
     polyA_site      4132
                     /gene="MASTL"
                     /gene_synonym="GREATWALL; GW; GWL; MAST-L; THC2"
ORIGIN      
        1 actttgaacc cagttggcgg gagtggctgc tcgcggaggg gcagtgtctg cggggccgct
       61 gtatgctgtc cagcgatgga tcccaccgcg ggaagcaaga aggagcctgg aggaggcgcg
      121 gcgactgagg agggcgtgaa taggatcgca gtgccaaaac cgccctccat tgaggaattc
      181 agcatagtga agcccattag ccggggcgcc ttcgggaaag tgtatctggg gcagaaaggc
      241 ggcaaattgt atgcagtaaa ggttgttaaa aaagcagaca tgatcaacaa aaatatgact
      301 catcaggtcc aagctgagag agatgcactg gcactaagca aaagcccatt cattgtccat
      361 ttgtattatt cactgcagtc tgcaaacaat gtctacttgg taatggaata tcttattggg
      421 ggagatgtca agtctctcct acatatatat ggttattttg atgaagagat ggctgtgaaa
      481 tatatttctg aagtagcact ggctctagac taccttcaca gacatggaat catccacagg
      541 gacttgaaac cggacaatat gcttatttct aatgagggtc atattaaact gacggatttt
      601 ggcctttcaa aagttacttt gaatagagat attaatatga tggatatcct tacaacacca
      661 tcaatggcaa aacctagaca agattattca agaaccccag gacaagtgtt atcgcttatc
      721 agctcgttgg gatttaacac accaattgca gaaaaaaatc aagaccctgc aaacatcctt
      781 tcagcctgtc tgtctgaaac atcacagctt tctcaaggac tcgtatgccc tatgtctgta
      841 gatcaaaagg acactacgcc ttattctagc aaattactaa aatcatgtct tgaaacagtt
      901 gcctccaacc caggaatgcc tgtgaagtgt ctaacttcta atttactcca gtctaggaaa
      961 aggctggcca catccagtgc cagtagtcaa tcccacacct tcatatccag tgtggaatca
     1021 gaatgccaca gcagtcccaa atgggaaaaa gattgccagg aaagtgatga agcattgggc
     1081 ccaacaatga tgagttggaa tgcagttgaa aagttatgcg caaaatctgc aaatgccatt
     1141 gagacgaaag gtttcaataa aaaggatctg gagttagctc tttctcccat tcataacagc
     1201 agtgcccttc ccaccactgg acgctcttgt gtaaaccttg ctaaaaaatg cttctctggg
     1261 gaagtttctt gggaagcagt agaactggat gtaaataata taaatatgga cactgacaca
     1321 agtcagttag gtttccatca gtcaaatcag tgggctgtgg attctggtgg gatatctgaa
     1381 gagcaccttg ggaaaagaag tttaaaaaga aattttgagt tggttgactc cagtccttgt
     1441 aaaaaaatta tacagaataa aaaaacttgt gtagagtata agcataacga aatgacaaat
     1501 tgttatacaa atcaaaatac aggcttaaca gttgaagtgc aggaccttaa gctatcagtg
     1561 cacaaaagtc aacaaaatga ctgtgctaat aaggagaaca ttgtcaattc ttttactgat
     1621 aaacaacaaa caccagaaaa attacctata ccaatgatag caaaaaacct tatgtgtgaa
     1681 ctcgatgaag actgtgaaaa gaatagtaag agggactact taagttctag ttttctatgt
     1741 tctgatgatg atagagcttc taaaaatatt tctatgaact ctgattcatc ttttcctgga
     1801 atttctataa tggaaagtcc attagaaagt cagcccttag attcagatag aagcatcaaa
     1861 gaatcctctt ttgaagaatc aaatattgaa gatccactta ttgtaacacc agattgccaa
     1921 gaaaagacct caccaaaagg tgtcgagaac cctgctgtac aagagagtaa ccaaaaaatg
     1981 ttaggtcctc ctttggaggt gctgaaaacg ttagcctcta aaagaaatgc tgttgctttt
     2041 cgaagtttta acagtcatat taatgcatcc aataactcag aaccatccag aatgaacatg
     2101 acttctttag atgcaatgga tatttcgtgt gcctacagtg gttcatatcc catggctata
     2161 acccctactc aaaaaagaag atcctgtatg ccacatcagc agaccccaaa tcagatcaag
     2221 tcgggaactc cataccgaac tccgaagagt gtgagaagag gggtggcccc cgttgatgat
     2281 gggcgaattc taggaacccc agactacctt gcacctgagc tgttactagg cagggcccat
     2341 ggtcctgcgg tagactggtg ggcacttgga gtttgcttgt ttgaatttct aacaggaatt
     2401 ccccctttca atgatgaaac accacaacaa gtattccaga atattctgaa aagagatatc
     2461 ccttggccag aaggtgaaga aaagttatct gataatgctc aaagtgcagt agaaatactt
     2521 ttaaccattg atgatacaaa gagagctgga atgaaagagc taaaacgtca tcctctcttc
     2581 agtgatgtgg actgggaaaa tctgcagcat cagactatgc ctttcatccc ccagccagat
     2641 gatgaaacag atacctccta ttttgaagcc aggaatactg ctcagcacct gactgtatct
     2701 ggatttagtc tgtagcacaa aaattttcct tttagtctag ccttgtgtta tagaatgaac
     2761 ttgcataatt atatactcct taatactaga ttgatctaag ggggaaagat cattatttaa
     2821 cctagttcaa tgtgctttta atgtacgtta cagctttcac agagttaaaa ggctgaaagg
     2881 aatatagtca gtaatttatc ttaacctcaa aactgtatat aaatcttcaa agcttttttc
     2941 atttatttat tttgtttatt gcactttatg aaaactgaag catcaataaa attagaggac
     3001 actattgaga gtgagccact agcttgattt tctttctcct ctgatttcag ttcactgttc
     3061 agtttagcat taaaataata aaataatcat acagttccat ttgattgtaa tttacttgca
     3121 tatgattacc ttcaaaagct gtgttcttga gggcaatcat ttaaggccat acttgtgacc
     3181 tcagaaatgc agctggaagg ccgggcgcag tggctcacgc atgtaatccc agcactgtgg
     3241 gaggccgagg caggctgatc ttgaggtcag gagttcaaga ccatcctggc caacataatg
     3301 aaaccccatc tctactgtaa atacacaaat tagccgggca tgttggtggg cgcctgtagt
     3361 cccagctact ctggaggctg aggcaggaga atcgctggaa cccaggagga ggaggttgtg
     3421 gtgagccaag atcgtgccac tgcactccag cctgggcaac agaacaagac tccgtctcaa
     3481 aaaaataaag gcagctggaa aattccttca cttagtaact cctttgggga ataaggaata
     3541 aacaaaaaga ctaaggcttt cacttacttt actaatgata cggttttgcc accttaattt
     3601 ctattggtgc gtagtccaca atatgtattt gtttaaaatg gtactggagg acgggtgcga
     3661 tggctcatgc ctgtaatccc ggcactttgg gaggctgagg caggcaagtc gcttgaggcc
     3721 tggagtttga gaccagcctg gccaacatgg caaaacctgg tctctactaa aaatagaaaa
     3781 attagccagg tatggtgacg cacacctgta gtcccagcta cttgggaggc tgaggcatga
     3841 gaatcgcttg aacccaggag gtggagattg cagtgagctg agatcacatc actgcatttc
     3901 agcctgggca acagaatgag actcagtctc aaaaaaaaaa aaaatactac tggaacaatt
     3961 aggtgtgata taatgtagca atttgaatag cttgttcaat tttaatagaa aatgtgatgc
     4021 tttacatctt attgtcattt atttaaaaca tgcaacatta tcagaaacag attggtcctt
     4081 aaaaaacaaa acataatttt cttttgctta ataaatataa ctatcacaag ta
//
