LOCUS       NM_015112               5737 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens microtubule associated serine/threonine kinase 2
            (MAST2), transcript variant 1, mRNA.
ACCESSION   NM_015112
VERSION     NM_015112.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5737)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 5737)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5737)
  AUTHORS   Morange,P.E., Peiretti,F., Gourhant,L., Proust,C., Soukarieh,O.,
            Pulcrano-Nicolas,A.S., Saripella,G.V., Stefanucci,L., Lacroix,R.,
            Ibrahim-Kosta,M., Lemarie,C.A., Frontini,M., Alessi,M.C.,
            Tregouet,D.A. and Couturaud,F.
  TITLE     A rare coding mutation in the MAST2 gene causes venous thrombosis
            in a French family with unexplained thrombophilia: The Breizh MAST2
            Arg89Gln variant
  JOURNAL   PLoS Genet 17 (1), e1009284 (2021)
   PUBMED   33465109
  REMARK    GeneRIF: A rare coding mutation in the MAST2 gene causes venous
            thrombosis in a French family with unexplained thrombophilia: The
            Breizh MAST2 Arg89Gln variant.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5737)
  AUTHORS   Rodriguez-Garcia,M.E., Cotrina-Vinagre,F.J., Gomez-Cano,M.L.A.,
            Martinez de Aragon,A., Martin-Hernandez,E. and Martinez-Azorin,F.
  TITLE     MAST1 variant causes mega-corpus-callosum syndrome with cortical
            malformations but without cerebellar hypoplasia
  JOURNAL   Am J Med Genet A 182 (6), 1483-1490 (2020)
   PUBMED   32198973
  REMARK    GeneRIF: MAST1 variant causes mega-corpus-callosum syndrome with
            cortical malformations but without cerebellar hypoplasia.
REFERENCE   5  (bases 1 to 5737)
  AUTHORS   Jiao,Y., Li,Y., Jiang,P., Fu,Z. and Liu,Y.
  TITLE     High MAST2 mRNA expression and its role in diagnosis and prognosis
            of liver cancer
  JOURNAL   Sci Rep 9 (1), 19865 (2019)
   PUBMED   31882722
  REMARK    GeneRIF: High MAST2 mRNA expression and its role in diagnosis and
            prognosis of liver cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5737)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   7  (bases 1 to 5737)
  AUTHORS   Adey,N.B., Huang,L., Ormonde,P.A., Baumgard,M.L., Pero,R.,
            Byreddy,D.V., Tavtigian,S.V. and Bartel,P.L.
  TITLE     Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both
            inhibits and stimulates PDZ binding
  JOURNAL   Cancer Res 60 (1), 35-37 (2000)
   PUBMED   10646847
REFERENCE   8  (bases 1 to 5737)
  AUTHORS   Lumeng,C., Phelps,S., Crawford,G.E., Walden,P.D., Barald,K. and
            Chamberlain,J.S.
  TITLE     Interactions between beta 2-syntrophin and a family of
            microtubule-associated serine/threonine kinases
  JOURNAL   Nat Neurosci 2 (7), 611-617 (1999)
   PUBMED   10404183
REFERENCE   9  (bases 1 to 5737)
  AUTHORS   Walden,P.D. and Millette,C.F.
  TITLE     Increased activity associated with the MAST205 protein kinase
            complex during mammalian spermiogenesis
  JOURNAL   Biol Reprod 55 (5), 1039-1044 (1996)
   PUBMED   8902215
REFERENCE   10 (bases 1 to 5737)
  AUTHORS   Walden,P.D. and Cowan,N.J.
  TITLE     A novel 205-kilodalton testis-specific serine/threonine protein
            kinase associated with microtubules of the spermatid manchette
  JOURNAL   Mol Cell Biol 13 (12), 7625-7635 (1993)
   PUBMED   8246979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603882.13, AB047005.1, BC065499.1, CN297081.1 and AL540100.3.
            
            On Nov 22, 2018 this sequence version replaced NM_015112.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB047005.1, SRR7346977.2905302.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361297.7/ ENSP00000354671.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL603882.13        52674-52674
            2-68                AB047005.1         1-67
            69-69               AL603882.13        52742-52742
            70-3022             BC065499.1         43-2995
            3023-3494           CN297081.1         70-541
            3495-3922           AL540100.3         40-467
            3923-4935           AB047005.1         3922-4934
            4936-5737           BC065499.1         4906-5707
FEATURES             Location/Qualifiers
     source          1..5737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..5737
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /note="microtubule associated serine/threonine kinase 2"
                     /db_xref="GeneID:23139"
                     /db_xref="HGNC:HGNC:19035"
                     /db_xref="MIM:612257"
     exon            1..461
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..5681
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule associated testis specific serine/threonine
                     protein kinase; microtubule-associated
                     serine/threonine-protein kinase 2"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 2 isoform 1"
                     /protein_id="NP_055927.2"
                     /db_xref="CCDS:CCDS41326.1"
                     /db_xref="GeneID:23139"
                     /db_xref="HGNC:HGNC:19035"
                     /db_xref="MIM:612257"
                     /translation="MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQR
                     LEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGN
                     LASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELS
                     LPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSF
                     VPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKH
                     FSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEER
                     LAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEK
                     LLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKE
                     GQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPS
                     EEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTF
                     AENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALE
                     YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLD
                     KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD
                     EIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKA
                     EFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSM
                     ERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESS
                     HTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGP
                     VTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRL
                     LSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDS
                     SPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPA
                     SEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKG
                     SYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGP
                     GSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLH
                     GLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKL
                     HLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSE
                     LKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQK
                     QEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDP
                     RSLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDP
                     IPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRA
                     SPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWL
                     WESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKH
                     RDLALVPDELLKQT"
     exon            462..609
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            610..752
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            753..784
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            785..876
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            877..952
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1031
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1186
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1262
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1472
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1574
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1707
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1769
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1855
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2064
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2203
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2336
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2502
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2604
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2727
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2837
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2992
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3276
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3471
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3698
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3821
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3958
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4152
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..5737
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5717..5722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /note="hexamer: AATATA"
     polyA_site      5737
                     /gene="MAST2"
                     /gene_synonym="MAST205; MTSSK"
                     /note="major polyA site"
ORIGIN      
        1 gtaggcaggc ggctgagccg gcggcgggtg gcctgcccaa cgtgtgctgg gtgggagaag
       61 gcgaggcgtc agcgatgctg tctcttccgt gaggagcgca gaggaggtcg cggcgccgga
      121 ggccccagaa ggctcgaagg cgccgcgggc tggggtcggt ggcttaggga gcccgtccgg
      181 ccatggtggc cgcgggtggt ggttggcgcg gctgcgctgc ggcccggggc agtgcggagc
      241 cgggacagtc gcggcgctga cgcccgcggg ccccagctgc agatatgaag cggagccgct
      301 gccgcgaccg accgcagccg ccgccgcccg accgccggga ggatggagtt cagcgggcag
      361 cggagctgtc tcagtctttg ccgccgcgcc ggcgagcgcc gcccgggagg cagcggctgg
      421 aggagcggac gggccccgcg gggcccgagg gcaaggagca ggatgtagta actggagtta
      481 gtcccctgct cttcaggaaa ctcagtaatc ctgacatatt ttcatccact ggaaaagtta
      541 aacttcagcg acaactgagt caggatgatt gtaagttatg gagaggaaac ctggccagct
      601 ctctatcggg taagcagctg ctccctttgt ccagcagtgt acatagcagt gtgggacagg
      661 tgacttggca gtcgtcagga gaagcatcaa acctggttcg aatgagaaac cagtcccttg
      721 gacagtctgc accttctctt actgctggcc tgaaggagtt gagccttcca agaagaggca
      781 gcttttgtcg gacaagtaac cgcaagagct tgattgtgac ctctagcaca tcacctacac
      841 taccacggcc acactcacca ctccatggcc acacaggtaa cagtcctttg gacagccccc
      901 ggaatttctc tccaaatgca cctgctcact tttcttttgt tcctgcccgt aggactgatg
      961 ggcggcgctg gtctttggcc tctttgccct cttcaggata tggaactaac actcctagct
     1021 ccactgtctc atcatcatgc tcctcacagg aaaagctgca tcagttgcct ttccagccta
     1081 cagctgatga gctgcacttt ttgacgaagc atttcagcac agagagcgta ccagatgagg
     1141 aaggacggca gtccccagcc atgcggcctc gctcccggag cctcagtccc ggacgatccc
     1201 cagtatcctt tgacagtgaa ataataatga tgaatcatgt ttacaaagaa agattcccaa
     1261 aggccaccgc acaaatggaa gagcgactag cagagtttat ttcctccaac actccagaca
     1321 gcgtgctgcc cttggcagat ggagccctga gctttattca tcatcaggtg attgagatgg
     1381 cccgagactg cctggataaa tctcggagtg gcctcattac atcacaatac ttctacgaac
     1441 ttcaagataa tttggagaaa cttttacaag atgctcatga gcgctcagag agctcagaag
     1501 tggcttttgt gatgcagctg gtgaaaaagc tgatgattat cattgcccgc ccagcacgtc
     1561 tcctggaatg cctggagttt gaccctgaag agttctacca ccttttagaa gcagctgagg
     1621 gccacgccaa agagggacaa gggattaaat gtgacattcc ccgctacatc gttagccagc
     1681 tgggcctcac ccgggatccc ctagaagaaa tggcccagtt gagcagctgt gacagtcctg
     1741 acactccaga gacagatgat tctattgagg gccatggggc atctctgcca tctaaaaaga
     1801 caccctctga agaggacttc gagaccatta agctcatcag caatggcgcc tatggggctg
     1861 tatttctggt gcggcacaag tccacccggc agcgctttgc catgaagaag atcaacaagc
     1921 agaacctgat cctacggaac cagatccagc aggccttcgt ggagcgtgac atactgactt
     1981 tcgctgagaa cccctttgtg gtcagcatgt tctgctcctt tgataccaag cgccacttgt
     2041 gcatggtgat ggagtacgtt gaagggggag actgtgccac tctgctgaag aatattgggg
     2101 ccctgcctgt ggacatggtg cgtctatact ttgcggaaac tgtgctggcc ctggagtact
     2161 tacacaacta tggcatcgtg caccgtgacc tcaagcctga caacctccta attacatcca
     2221 tggggcacat caagctcacg gactttggac tgtccaaaat tggcctcatg agtctgacaa
     2281 cgaacttgta tgagggtcat attgaaaagg atgcccggga attcctggac aagcaggtat
     2341 gcgggacccc agaatacatt gcgcctgagg tgatcctgcg ccagggctat gggaagccag
     2401 tggactggtg ggccatgggc attatcctgt atgagttcct ggtgggctgc gtcccttttt
     2461 ttggagatac tccggaggag ctctttgggc aggtgatcag tgatgagatt gtgtggcctg
     2521 agggtgatga ggcactgccc ccagacgccc aggacctcac ctccaaactg ctccaccaga
     2581 accctctgga gagacttggc acaggcagtg cctatgaggt gaagcagcac ccattcttta
     2641 ctggtctgga ctggacagga cttctccgcc agaaggctga atttattcct cagttggagt
     2701 cagaggatga tactagctat tttgacaccc gctcagagcg ataccaccac atggactcgg
     2761 aggatgagga agaagtgagt gaggatggct gccttgagat ccgccagttc tcttcctgct
     2821 ctccaaggtt caacaaggtg tacagcagca tggagcggct ctcactgctc gaggagcgcc
     2881 ggacaccacc cccgaccaag cgcagcctga gtgaggagaa ggaggaccat tcagatggcc
     2941 tggcagggct caaaggccga gaccggagct gggtgattgg ctcccctgag atattacgga
     3001 agcggctgtc ggtgtctgag tcatcccaca cagagagtga ctcaagccct ccaatgacag
     3061 tgcgacgccg ctgctcaggc ctcctggatg cgcctcggtt cccggagggc cctgaggagg
     3121 ccagcagcac cctcaggagg caaccacagg agggtatatg ggtcctgaca cccccatctg
     3181 gagagggggt atctgggcct gtcactgaac actcagggga gcagcggcca aagctggatg
     3241 aggaagctgt tggccggagc agtggttcca gtccagctat ggagacccga ggccgtggga
     3301 cctcacagct ggctgaggga gccacagcca aggccatcag tgacctggct gtgcgtaggg
     3361 cccgccaccg gctgctctct ggggactcaa cagagaagcg cactgctcgc cctgtcaaca
     3421 aagtgatcaa gtccgcctca gccacagccc tctcactcct cattccttcg gaacaccaca
     3481 cctgctcccc gttggccagc cccatgtccc cacattctca gtcgtccaac ccatcatccc
     3541 gggactcttc tccaagcagg gacttcttgc cagcccttgg cagcatgagg cctcccatca
     3601 tcatccaccg agctggcaag aagtatggct tcaccctgcg ggccattcgc gtctacatgg
     3661 gtgactccga tgtctacacc gtgcaccata tggtgtggca cgtggaggat ggaggtccgg
     3721 ccagtgaggc agggcttcgt caaggtgacc tcatcaccca tgtcaatggg gaacctgtgc
     3781 atggcctggt gcacacggag gtggtagagc tgatcctgaa gagtggaaac aaggtggcca
     3841 tttcaacaac tcccctggag aacacatcca ttaaagtggg gccagctcgg aagggcagct
     3901 acaaggccaa gatggcccga aggagcaaga ggagccgcgg caaggatggg caagaaagca
     3961 gaaaaaggag ctccctgttc cgcaagatca ccaagcaagc atccctgctc cacaccagcc
     4021 gcagcctttc ttcccttaac cgctccttgt catcagggga gagtgggcca ggctctccca
     4081 cacacagcca cagcctttcc ccccgatctc ccactcaagg ctaccgggtg acccccgatg
     4141 ctgtgcattc agtgggaggg aattcatcac agagcagctc ccccagctcc agcgtgccca
     4201 gttccccagc cggctctggg cacacacggc ccagctccct ccacggtctg gcacccaagc
     4261 tccaacgcca gtaccgctct ccacggcgca agtcagcagg cagcatccca ctgtcaccac
     4321 tggcccacac cccttctccc ccacccccaa cagcttcacc tcagcggtcc ccatcgcccc
     4381 tgtctggcca tgtagcccag gcctttccca caaagcttca cttgtcacct cccctgggca
     4441 ggcaactctc acggcccaag agtgcggagc caccccgttc accactactc aagagggtgc
     4501 agtcggctga gaaactggca gcagcacttg ccgcctctga gaagaagcta gccacttctc
     4561 gcaagcacag ccttgacctg ccccactctg aactaaagaa ggaactgccg cccagggaag
     4621 tgagccctct ggaggtagtt ggagccagga gtgtgctgtc tggcaagggg gccctgccag
     4681 ggaagggggt gctgcagcct gctccctcac gggccctagg caccctccgg caggaccgag
     4741 ccgaacgacg ggagtcgctg cagaagcaag aagccattcg tgaggtggac tcctcagagg
     4801 acgacaccga ggaagggcct gagaacagcc agggtgcaca ggagctgagc ttggcacctc
     4861 acccagaagt gagccagagt gtggccccta aaggagcagg agagagtggg gaagaggatc
     4921 ctttcccgtc cagagaccct aggagcctgg gcccaatggt cccaagccta ttgacaggga
     4981 tcacactggg gcctcccaga atggaaagtc ccagtggtcc ccacaggagg ctcgggagcc
     5041 cacaagccat tgaggaggct gccagctcct cctcagcagg ccccaaccta ggtcagtctg
     5101 gagccacaga ccccatccct cctgaaggtt gctggaaggc ccagcacctc cacacccagg
     5161 cactaacagc actttctccc agcacttcgg gactcacccc caccagcagt tgctctcctc
     5221 ccagctccac ctctgggaag ctgagcatgt ggtcctggaa atcccttatt gagggcccag
     5281 acagggcatc cccaagcaga aaggcaacca tggcaggtgg gctagccaac ctccaggatt
     5341 tggaaaacac aactccagcc cagcctaaga acctgtctcc cagggagcag gggaagacac
     5401 agccacctag tgcccccaga ctggcccatc catcttatga ggatcccagc cagggctggc
     5461 tatgggagtc tgagtgtgca caagcagtga aagaggatcc agccctgagc atcacccaag
     5521 tgcctgatgc ctcaggtgac agaaggcagg acgttccatg ccgaggctgc cccctcaccc
     5581 agaagtctga gcccagcctc aggaggggcc aagaaccagg gggccatcaa aagcatcggg
     5641 atttggcatt ggttccagat gagcttttaa agcaaacata gcagttgttt gccatttctt
     5701 gcactcagac ctgtgtaata tatgctcctg gaaacca
//
