LOCUS       NM_014975               4853 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens microtubule associated serine/threonine kinase 1
            (MAST1), mRNA.
ACCESSION   NM_014975
VERSION     NM_014975.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Karapurkar,J.K., Colaco,J.C., Suresh,B., Tyagi,A., Woo,S.H.,
            Jo,W.J., Ko,N., Singh,V., Hong,S.H., Oh,S.J., Kim,K.S. and
            Ramakrishna,S.
  TITLE     USP28 promotes tumorigenesis and cisplatin resistance by
            deubiquitinating MAST1 protein in cancer cells
  JOURNAL   Cell Mol Life Sci 81 (1), 145 (2024)
   PUBMED   38498222
  REMARK    GeneRIF: USP28 promotes tumorigenesis and cisplatin resistance by
            deubiquitinating MAST1 protein in cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Zhang,C., Yuan,L., Zou,Q., Shao,C., Jia,Y., Li,J., Liao,Y.,
            Zhao,X., Wen,W., Jing,X., Yang,G., Wang,W., Jiang,H. and Yao,S.
  TITLE     CircMAST1 inhibits cervical cancer progression by hindering the
            N4-acetylcytidine modification of YAP mRNA
  JOURNAL   Cell Mol Biol Lett 29 (1), 25 (2024)
   PUBMED   38331765
  REMARK    GeneRIF: CircMAST1 inhibits cervical cancer progression by
            hindering the N4-acetylcytidine modification of YAP mRNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Ding,W., Lu,Y., Zhou,A., Chen,Y., Wang,Z., Wang,L. and Tian,Y.
  TITLE     Mast1 mediates radiation-induced gastric injury via the P38 MAPK
            pathway
  JOURNAL   Exp Cell Res 409 (2), 112913 (2021)
   PUBMED   34774870
  REMARK    GeneRIF: Mast1 mediates radiation-induced gastric injury via the
            P38 MAPK pathway.
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Pan,C., Kang,J., Hwang,J.S., Li,J., Boese,A.C., Wang,X., Yang,L.,
            Boggon,T.J., Chen,G.Z., Saba,N.F., Shin,D.M., Magliocca,K.R.,
            Jin,L. and Kang,S.
  TITLE     Cisplatin-mediated activation of glucocorticoid receptor induces
            platinum resistance via MAST1
  JOURNAL   Nat Commun 12 (1), 4960 (2021)
   PUBMED   34400618
  REMARK    GeneRIF: Cisplatin-mediated activation of glucocorticoid receptor
            induces platinum resistance via MAST1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Jing,T., Ma,J., Zhao,H., Zhang,J., Jiang,N. and Ma,D.
  TITLE     MAST1 modulates neuronal differentiation and cell cycle exit via
            P27 in neuroblastoma cells
  JOURNAL   FEBS Open Bio 10 (6), 1104-1114 (2020)
   PUBMED   32291963
  REMARK    GeneRIF: MAST1 modulates neuronal differentiation and cell cycle
            exit via P27 in neuroblastoma cells.
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   Tripathy,R., Leca,I., van Dijk,T., Weiss,J., van Bon,B.W.,
            Sergaki,M.C., Gstrein,T., Breuss,M., Tian,G., Bahi-Buisson,N.,
            Paciorkowski,A.R., Pagnamenta,A.T., Wenninger-Weinzierl,A.,
            Martinez-Reza,M.F., Landler,L., Lise,S., Taylor,J.C., Terrone,G.,
            Vitiello,G., Del Giudice,E., Brunetti-Pierri,N., D'Amico,A.,
            Reymond,A., Voisin,N., Bernstein,J.A., Farrelly,E., Kini,U.,
            Leonard,T.A., Valence,S., Burglen,L., Armstrong,L., Hiatt,S.M.,
            Cooper,G.M., Aldinger,K.A., Dobyns,W.B., Mirzaa,G., Pierson,T.M.,
            Baas,F., Chelly,J., Cowan,N.J. and Keays,D.A.
  TITLE     Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with
            Cerebellar Hypoplasia and Cortical Malformations
  JOURNAL   Neuron 100 (6), 1354-1368 (2018)
   PUBMED   30449657
  REMARK    GeneRIF: This report showed that de novo MAST1 substitutions are
            present in patients with autism and microcephaly, raising the
            prospect that mutations in this gene give rise to a spectrum of
            neurodevelopmental diseases.
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Robinson,D.R., Kalyana-Sundaram,S., Wu,Y.M., Shankar,S., Cao,X.,
            Ateeq,B., Asangani,I.A., Iyer,M., Maher,C.A., Grasso,C.S.,
            Lonigro,R.J., Quist,M., Siddiqui,J., Mehra,R., Jing,X.,
            Giordano,T.J., Sabel,M.S., Kleer,C.G., Palanisamy,N., Natrajan,R.,
            Lambros,M.B., Reis-Filho,J.S., Kumar-Sinha,C. and Chinnaiyan,A.M.
  TITLE     Functionally recurrent rearrangements of the MAST kinase and Notch
            gene families in breast cancer
  JOURNAL   Nat Med 17 (12), 1646-1651 (2011)
   PUBMED   22101766
  REMARK    GeneRIF: Overexpression of MAST1 or MAST2 gene fusions has a
            proliferative effect both in vitro and in vivo in breast cancer
            cell lines.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Deribe,Y.L., Wild,P., Chandrashaker,A., Curak,J., Schmidt,M.H.H.,
            Kalaidzidis,Y., Milutinovic,N., Kratchmarova,I., Buerkle,L.,
            Fetchko,M.J., Schmidt,P., Kittanakom,S., Brown,K.R., Jurisica,I.,
            Blagoev,B., Zerial,M., Stagljar,I. and Dikic,I.
  TITLE     Regulation of epidermal growth factor receptor trafficking by
            lysine deacetylase HDAC6
  JOURNAL   Sci Signal 2 (102), ra84 (2009)
   PUBMED   20029029
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4853)
  AUTHORS   Yano,R., Yap,C.C., Yamazaki,Y., Muto,Y., Kishida,H., Okada,D. and
            Hashikawa,T.
  TITLE     Sast124, a novel splice variant of syntrophin-associated
            serine/threonine kinase (SAST), is specifically localized in the
            restricted brain regions
  JOURNAL   Neuroscience 117 (2), 373-381 (2003)
   PUBMED   12614677
  REMARK    GeneRIF: Discusses cloning of Sast124, the rat ortholog of MAST1.
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Lumeng,C., Phelps,S., Crawford,G.E., Walden,P.D., Barald,K. and
            Chamberlain,J.S.
  TITLE     Interactions between beta 2-syntrophin and a family of
            microtubule-associated serine/threonine kinases
  JOURNAL   Nat Neurosci 2 (7), 611-617 (1999)
   PUBMED   10404183
  REMARK    GeneRIF: Discusses cloning of Sast, the mouse ortholog of human
            MAST1.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA769770.1, AB023190.1,
            AC020934.9 and BM681304.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014975.2.
            
            Summary: This gene is a member of the microtubule-associated
            serine/threonine kinase (MAST) family. The protein encoded by this
            gene has an N-terminal serine/threonine kinase domain followed by a
            postsynaptic density protein-95/discs large/zona occludens-1 (PDZ)
            domain. In mouse and rat, the orthologous protein associates with
            the cytoskeleton and can bind both beta-2-syntrophin and neuronal
            nitric oxide synthase (nNOS) through its PDZ domain. In mouse and
            rat, this protein also co-localizes with dystrophin- and
            utrophin-associated protein complexes (DAPC/UAPC) in the vascular
            endothelium of the central nervous system. [provided by RefSeq, May
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251472.9/ ENSP00000251472.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA769770.1         71-89
            20-657              AB023190.1         1-638
            658-658             AC020934.9         82807-82807
            659-1068            AB023190.1         640-1049
            1069-1069           AC020934.9         87253-87253
            1070-4662           AB023190.1         1051-4643
            4663-4853           BM681304.1         18-208              c
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..4853
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /note="microtubule associated serine/threonine kinase 1"
                     /db_xref="GeneID:22983"
                     /db_xref="HGNC:HGNC:19034"
                     /db_xref="MIM:612256"
     exon            1..141
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..4771
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /EC_number="2.7.11.1"
                     /note="syntrophin associated serine/threonine kinase;
                     syntrophin-associated serine/threonine-protein kinase"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_055790.1"
                     /db_xref="CCDS:CCDS32921.1"
                     /db_xref="GeneID:22983"
                     /db_xref="HGNC:HGNC:19034"
                     /db_xref="MIM:612256"
                     /translation="MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSP
                     TLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTN
                     TPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSR
                     SLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLS
                     FIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVK
                     KLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDP
                     FPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVR
                     HRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMV
                     MEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSM
                     GHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGK
                     PVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSL
                     LQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRY
                     HHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREP
                     STKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRF
                     SALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGEGTSSAGDSEAT
                     DRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVIKSAS
                     ATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITIQR
                     SGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHG
                     MVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQES
                     KKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPD
                     SAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPL
                     SPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLK
                     RVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL
                     GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPG
                     GRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPI
                     VVEPARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGP
                     RSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAV
                     PPAGLTKKGVSSPAPPGP"
     exon            142..230
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            231..306
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            307..385
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            386..546
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            547..622
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            623..832
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            833..934
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1067
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1135
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1215
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1424
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1563
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1696
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1862
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1964
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2087
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2197
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2376
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2624
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2831
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3061
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3184
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3321
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3509
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..4853
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4829..4834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /note="hexamer: AATAAA"
     polyA_site      4853
                     /gene="MAST1"
                     /gene_synonym="MCCCHCM; SAST"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgccg cctccgccgc tgctgccgca cctgccacca tgtcgccgcc gccgggtcat
       61 gtctgactct ctctggaccg cgctttctaa tttctcgatg ccctccttcc ccggcggcag
      121 tatgttccgc cgcaccaaga gctgccgcac cagtaatcgg aaaagcctca tcctgaccag
      181 cacttcaccc acgctaccga gaccccactc cccgctgcca ggtcacctag gcagcagtcc
      241 cctggacagc ccccgaaact tctcccccaa cacccccgcc cacttctcgt ttgcctcctc
      301 ccgaagggcg gacggacgcc ggtggtctct ggcctcgctc ccttcatctg gctatggcac
      361 caacacgccc agttccaccg tctcgtcctc ctgctcctcc caggagcgcc ttcaccagct
      421 gccctaccag cccacggtgg acgagctcca cttcctctcc aaacacttcg ggagcaccga
      481 gagcatcaca gacgaggatg gtggccgtcg ctccccagcc gtgcggcccc gctcacggag
      541 cctcagcccc gggcgctccc cctcctccta cgacaacgag atcgtgatga tgaatcacgt
      601 ctacaaggag aggttcccga aggccactgc gcagatggag gagaagctgc gcgactttac
      661 ccgcgcctac gaacccgaca gcgttctgcc tctggccgat ggcgtgctca gcttcatcca
      721 ccaccagatc atcgagctgg cccgggactg cctgaccaag tcccgtgacg gcctcatcac
      781 cacggtctac ttctatgaat tgcaggagaa cctggagaag ctccttcaag acgcctatga
      841 acgctctgag agcttggagg tggccttcgt tactcagctg gtgaagaagt tgcttattat
      901 catctcacgc cctgcgaggc tgctggagtg cctggaattc aaccccgagg agttctacca
      961 cctgctggag gcggccgaag gacacgccaa ggagggccac cttgtgaaga cggacatccc
     1021 ccgctacatc atccgccagc tgggcctcac ccgtgacccc tttccagatg tggtgcatct
     1081 ggaggaacag gacagtggtg gttccaacac ccctgagcaa gacgatctct ctgagggccg
     1141 cagcagcaag gccaagaaac cgccggggga gaatgacttc gataccatca agctcataag
     1201 caacggtgcc tacggcgctg tctacctggt gcggcaccgc gacacgcggc agcgctttgc
     1261 catgaaaaag atcaacaagc agaacttgat cctccgcaac cagatccagc aggcctttgt
     1321 ggagcgcgat atcctcacct tcgccgagaa cccgtttgtg gtcggcatgt tctgctcctt
     1381 tgagactcgg cgccacctct gcatggtcat ggaatatgtg gaaggcggcg actgtgccac
     1441 cctgctgaag aatattggag cgctgcccgt agagatggcc cgcatgtact ttgctgagac
     1501 ggtgctagcc ctggagtatt tgcacaacta tggcatcgtg caccgcgacc tcaagcctga
     1561 caacctcctt atcacctcca tgggtcacat caagctcaca gatttcggcc tctccaagat
     1621 ggggctcatg agcctcacca ccaacttata tgaaggccac atcgagaagg acgcccgaga
     1681 gttcctggac aaacaggtgt gtgggacccc agagtacatc gcgcccgagg tcatcctgcg
     1741 tcaaggctac ggcaagccag tggactggtg ggctatgggg atcatcctct acgagttcct
     1801 ggtgggctgt gtgcccttct tcggagacac accagaggag ctatttggac aggtcatcag
     1861 tgatgacatc ctgtggcccg agggggatga ggccctacct acggaggccc aactcctcat
     1921 atccagcctc ctgcagacca accctctggt caggcttggg gcaggcggcg cttttgaggt
     1981 gaagcagcac agtttctttc gagacctgga ctggacaggg ctgctgaggc agaaggccga
     2041 gttcatcccc cacctagagt cggaagatga cactagctac tttgacaccc gctcagacag
     2101 gtatcaccac gtgaactcct atgacgagga tgacacgacg gaggaggagc ccgtggaaat
     2161 ccgccagttc tcttcctgct ctccgcgctt cagcaaggtg tatagcagca tggagcagct
     2221 gtcgcagcac gagcccaaga ccccagtagc agctgcaggg agcagcaagc gggagccgag
     2281 caccaagggc cccgaggaga aggtggccgg caagcgggag gggctgggcg gcctgaccct
     2341 gcgtgagaag acctggagag ggggctctcc ggagatcaag cgattctccg cgtccgaggc
     2401 cagtttcctg gagggagagg ccagtccccc tttgggcgcc cgccgccgtt tctcggcgct
     2461 gctggagccc agccgcttca gcgcccccca agaggacgag gatgaggccc ggctgcgcag
     2521 gcctccccgg cccagctccg accccgcggg atccctggat gcacgggccc ccaaagagga
     2581 gactcaaggg gaaggcacct ccagcgccgg ggactccgag gccactgacc gtccacgccc
     2641 aggtgacctc tgcccaccct cgaaggatgg ggatgcatca ggcccaaggg ctaccaatga
     2701 cttggttctg cgccgggcgc ggcaccagca gatgtcaggg gatgtggcag tagagaagag
     2761 gccttctcga actgggggca aagtcatcaa atcagcctca gccactgcct tatctgtcat
     2821 gattcctgca gtggacccac atggaagttc accccttgct agtcccatgt ctccacgatc
     2881 tctgtcctcc aacccatcct cacgggactc ctcacccagc cgggactact caccagctgt
     2941 cagtgggctc cgctccccca tcaccatcca gcgctcgggc aagaagtatg gcttcacact
     3001 gcgtgccatc cgtgtctaca tgggtgacac ggatgtctat agtgtccacc acattgtctg
     3061 gcatgtggag gaaggaggcc cagcccagga ggcaggactc tgtgctgggg acctcatcac
     3121 ccacgtgaat ggggagcctg tgcatggcat ggtgcatcct gaggtcgtgg agctgatcct
     3181 taagagtggc aacaaggtag cagtgaccac aacgcccttc gaaaatacct ctatccgcat
     3241 tggtcccgca aggcgcagca gctacaaggc taaaatggct cggaggaaca agcgaccctc
     3301 cgccaaggag ggccaggaga gcaagaagcg cagctccctc ttccggaaga tcacgaagca
     3361 gtcgaacctg ctgcatacta gccgctcgct gtcgtcgctg aaccgctcgc tgtcatccag
     3421 cgatagtctc ccgggctcgc ctacgcacgg gctgccggcg cgctcgccca cgcacagcta
     3481 ccgctccacg cctgactccg cctacctagg cgcctcatcc cagagcagct ccccagcctc
     3541 gagcacgccc aactcgcctg cgtcgtcggc gtcgcaccac attcggccca gcacgctgca
     3601 cggactgtcg ccaaagctcc atcgccagta ccgctctgcg cgatgcaagt cggccggcaa
     3661 catccctcta tcgccgctgg cacacacgcc gtcccccacg caggcgtcac cgccgccact
     3721 gccgggccac acggtgggca gctcgcacac tactcagagc ttcccggcca aactgcactc
     3781 atcgcctccc gtcgtgcgcc cgcgccccaa gagtgccgag ccccctcgct cgccgctcct
     3841 caagcgcgtg cagtcggccg agaagctggg agcctctttg agtgcggaca agaagggcgc
     3901 gctgcgcaaa cacagcctcg aggtgggcca cccggatttc cgcaaggact tccatggcga
     3961 gctggcgctg catagccttg ccgagtccga cggtgagacg cccccagtcg agggccttgg
     4021 cgcgccccgg caggtcgccg tccgccgcct gggccgacag gagtcacctt tgagcctggg
     4081 cgcggacccg ttgctgcccg agggtgcctc caggccacca gtgtcgagca aggagaagga
     4141 atccccgggg ggcgccgagg cgtgcacccc accccgcgcg acgacccccg gtggccggac
     4201 cctggagcgg gacgtcggct gcacgcggca tcagagcgtg cagacggagg atggcactgg
     4261 cgggatggcc agggctgtgg ccaaggcggc gctgagcccg gtgcaggaac acgagacagg
     4321 ccggcgcagc agctctggcg aggcgggcac acccctggta cccattgtcg tagagcctgc
     4381 gcggcccggg gctaaggctg tggtgcctca gcctctgggc gcggactcca aggggttgca
     4441 ggaacccgca cccctggcgc cttccgtgcc cgaggccccc cggggccggg agcgctgggt
     4501 gttggaggtg gtggaggagc gcaccacgct gagcggtcct cgctccaagc ccgcctcccc
     4561 aaagctctcc ccggagcccc agacaccctc cctagcccca gcgaagtgca gtgcacccag
     4621 cagtgcagtg accccagtcc cacccgcatc cctcttgggc tcaggcacca agcctcaagt
     4681 ggggctgacc tcccggtgcc ctgctgaagc tgtgccccca gcaggcctga ccaaaaaagg
     4741 agtgtccagt cccgcacccc cgggaccata gccaaggggg tcatcggccc cgcgctgtac
     4801 agcctccgta tacatatgta cacatataaa taaagtgcgt ccgtgctgcg tga
//
