LOCUS       NM_002377              10881 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens MAS1 proto-oncogene, G protein-coupled receptor
            (MAS1), transcript variant 1, mRNA.
ACCESSION   NM_002377
VERSION     NM_002377.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10881)
  AUTHORS   Chen,S., Lu,Z., Zhao,Y., Xia,L., Liu,C., Zuo,S., Jin,M., Jia,H.,
            Li,S., Zhang,S., Yang,B., Wang,Z., Li,J., Wang,F. and Yang,C.
  TITLE     Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among
            MYC+CD63+ Endothelial Cells, MMP12+ Macrophages, and Monocytes in
            Acetaminophen-Induced Liver Injury
  JOURNAL   Adv Sci (Weinh) 11 (16), e2306066 (2024)
   PUBMED   38350725
  REMARK    GeneRIF: Myeloid-Mas Signaling Modulates Pathogenic Crosstalk among
            MYC[+]CD63[+] Endothelial Cells, MMP12[+] Macrophages, and
            Monocytes in Acetaminophen-Induced Liver Injury.
REFERENCE   2  (bases 1 to 10881)
  AUTHORS   Clark,C.R. and Khalil,R.A.
  TITLE     Regulation of vascular angiotensin II type 1 and type 2 receptor
            and angiotensin-(1-7)/MasR signaling in normal and hypertensive
            pregnancy
  JOURNAL   Biochem Pharmacol 220, 115963 (2024)
   PUBMED   38061417
  REMARK    GeneRIF: Regulation of vascular angiotensin II type 1 and type 2
            receptor and angiotensin-(1-7)/MasR signaling in normal and
            hypertensive pregnancy.
            Review article
REFERENCE   3  (bases 1 to 10881)
  AUTHORS   Rukavina Mikusic,N.L. and Gironacci,M.M.
  TITLE     Mas receptor endocytosis and signaling in health and disease
  JOURNAL   Prog Mol Biol Transl Sci 194, 49-65 (2023)
   PUBMED   36631200
  REMARK    GeneRIF: Mas receptor endocytosis and signaling in health and
            disease.
REFERENCE   4  (bases 1 to 10881)
  AUTHORS   Choopani,S. and Nematbakhsh,M.
  TITLE     Sex Difference in MasR Expression and Functions in the Renal System
  JOURNAL   J Renin Angiotensin Aldosterone Syst 2022, 1327839 (2022)
   PUBMED   36148474
  REMARK    GeneRIF: Sex Difference in MasR Expression and Functions in the
            Renal System.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10881)
  AUTHORS   Zhang,T., Li,Z., Dang,H., Chen,R., Liaw,C., Tran,T.A.,
            Boatman,P.D., Connolly,D.T. and Adams,J.W.
  TITLE     Inhibition of Mas G-protein signaling improves coronary blood flow,
            reduces myocardial infarct size, and provides long-term
            cardioprotection
  JOURNAL   Am J Physiol Heart Circ Physiol 302 (1), H299-H311 (2012)
   PUBMED   22003054
  REMARK    GeneRIF: Activation of Mas during myocardial infarction contributes
            to ischemia-reperfusion injury and suggest that inhibition of
            Mas-G(q) signaling may provide a new therapeutic strategy directed
            at cardioprotection.
REFERENCE   6  (bases 1 to 10881)
  AUTHORS   Pinheiro,S.V. and Simoes E Silva,A.C.
  TITLE     Angiotensin converting enzyme 2, Angiotensin-(1-7), and receptor
            MAS axis in the kidney
  JOURNAL   Int J Hypertens 2012, 414128 (2012)
   PUBMED   22518283
REFERENCE   7  (bases 1 to 10881)
  AUTHORS   Santos,R.A., Simoes e Silva,A.C., Maric,C., Silva,D.M.,
            Machado,R.P., de Buhr,I., Heringer-Walther,S., Pinheiro,S.V.,
            Lopes,M.T., Bader,M., Mendes,E.P., Lemos,V.S.,
            Campagnole-Santos,M.J., Schultheiss,H.P., Speth,R. and Walther,T.
  TITLE     Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled
            receptor Mas
  JOURNAL   Proc Natl Acad Sci U S A 100 (14), 8258-8263 (2003)
   PUBMED   12829792
REFERENCE   8  (bases 1 to 10881)
  AUTHORS   Hanley,M.R.
  TITLE     Molecular and cell biology of angiotensin receptors
  JOURNAL   J Cardiovasc Pharmacol 18 Suppl 2, S7-S13 (1991)
   PUBMED   1725048
  REMARK    Review article
REFERENCE   9  (bases 1 to 10881)
  AUTHORS   Hanley,M.R., Cheung,W.T., Hawkins,P., Poyner,D., Benton,H.P.,
            Blair,L., Jackson,T.R. and Goedert,M.
  TITLE     The mas oncogene as a neural peptide receptor: expression,
            regulation and mechanism of action
  JOURNAL   Ciba Found Symp 150, 23-38 (1990)
   PUBMED   2197067
  REMARK    Review article
REFERENCE   10 (bases 1 to 10881)
  AUTHORS   Rabin,M., Birnbaum,D., Young,D., Birchmeier,C., Wigler,M. and
            Ruddle,F.H.
  TITLE     Human ros1 and mas1 oncogenes located in regions of chromosome 6
            associated with tumor-specific rearrangements
  JOURNAL   Oncogene Res 1 (2), 169-178 (1987)
   PUBMED   3329713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB475311.1 and AL035691.17.
            
            On Jul 16, 2019 this sequence version replaced NM_002377.3.
            
            Summary: This gene encodes a class I seven-transmembrane
            G-protein-coupled receptor. The encoded protein is a receptor for
            angiotensin-(1-7) and preferentially couples to the Gq protein,
            activating the phospholipase C signaling pathway. The encoded
            protein may play a role in multiple processes including
            hypotension, smooth muscle relaxation and cardioprotection by
            mediating the effects of angiotensin-(1-7). [provided by RefSeq,
            May 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.126128.1,
                                           SRR1803613.139969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674077.2/ ENSP00000501180.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               DB475311.1         18-470
            454-10881           AL035691.17        95640-106067        c
FEATURES             Location/Qualifiers
     source          1..10881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..10881
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /note="MAS1 proto-oncogene, G protein-coupled receptor"
                     /db_xref="GeneID:4142"
                     /db_xref="HGNC:HGNC:6899"
                     /db_xref="MIM:165180"
     exon            1..146
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /inference="alignment:Splign:2.1.0"
     exon            147..353
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /inference="alignment:Splign:2.1.0"
     exon            354..10881
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1367
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /note="Mas-related G protein-coupled receptor A; MAS1
                     oncogene"
                     /codon_start=1
                     /product="proto-oncogene Mas"
                     /protein_id="NP_002368.1"
                     /db_xref="CCDS:CCDS5272.1"
                     /db_xref="GeneID:4142"
                     /db_xref="HGNC:HGNC:6899"
                     /db_xref="MIM:165180"
                     /translation="MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISP
                     VGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHY
                     YTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALS
                     CLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNT
                     WASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSAN
                     PFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV"
     regulatory      9944..9949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /note="hexamer: AATAAA"
     polyA_site      9965
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /note="major polyA site"
     regulatory      10859..10864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
                     /note="hexamer: AATAAA"
     polyA_site      10881
                     /gene="MAS1"
                     /gene_synonym="MAS; MGRA"
ORIGIN      
        1 gattccttca gagatgagag gctgcagcca tccttcgaga tgttgggacc ggagaccctg
       61 caggctggct gggcattgat gccccagatg tgaaggggca gccaacctgt tggccacgtc
      121 tgacccttcc tgagcaaatg acaccaacat ctctttcgtg agaagaaaga gaggagggaa
      181 gatgctctgt gatgctgcca gtaatgctga ccagtcgtgg tgctgtcacc tccttggctg
      241 tctttgcaat ctgttcccaa ctgaggtttc cattgcagtg taactgacca ctccaggggc
      301 cactgagggc tgtcaggatg agctatccct ccaccccagg ctgtcactgc cagaaaatta
      361 cctgaagagt tccaacctga ggcctcctca tggatgggtc aaacgtgaca tcatttgttg
      421 ttgaggaacc cacgaacatc tcaactggca ggaacgcctc agtcgggaat gcacatcggc
      481 aaatccccat cgtgcactgg gtcattatga gcatctcccc agtggggttt gttgagaatg
      541 ggattctcct ctggttcctg tgcttccgga tgagaagaaa tcccttcact gtctacatca
      601 cccacctgtc tatcgcagac atctcactgc tcttctgtat tttcatcttg tctatcgact
      661 atgctttaga ttatgagctt tcttctggcc attactacac aattgtcaca ttatcagtga
      721 cttttctgtt tggctacaac acgggcctct atctgctgac ggccattagt gtggagaggt
      781 gcctgtcagt cctttacccc atctggtacc gatgccatcg ccccaagtac cagtcggcat
      841 tggtctgtgc ccttctgtgg gctctttctt gcttggtgac caccatggag tatgtcatgt
      901 gcatcgacag agaagaagag agtcactctc ggaatgactg ccgagcagtc atcatcttta
      961 tagccatcct gagcttcctg gtcttcacgc ccctcatgct ggtgtccagc accatcttgg
     1021 tcgtgaagat ccggaagaac acgtgggctt cccattcctc caagctttac atagtcatca
     1081 tggtcaccat cattatattc ctcatcttcg ctatgcccat gagactcctt tacctgctgt
     1141 actatgagta ttggtcgacc tttgggaacc tacaccacat ttccctgctc ttctccacaa
     1201 tcaacagtag cgccaaccct ttcatttact tctttgtggg aagcagtaag aagaagagat
     1261 tcaaggagtc cttaaaagtt gttctgacca gggctttcaa agatgaaatg caacctcggc
     1321 gccagaaaga caattgtaat acggtcacag ttgagactgt cgtctaagaa ctgtgaggga
     1381 agttgtggat aaaaatggtg gaacacaggt catttttagt ttgtgcttgg aatatgactt
     1441 aagtatctcc taaatgtgat acagaagaac atctcatccc atatgcatga gatactaatt
     1501 aatgatgaaa ttgaactctt gtactgtatc ttctggaaat gacctgtcat ttctgtactt
     1561 gacaaagact ctatttcttt cagctctttt ggcagcatct taccatgaac cataaaaatg
     1621 acttttgcag gaagatttac agatgtgtac gggacaaggt aacaaaacta tttgttggaa
     1681 cttgaggagg cagcttgatg tagcaggaag aacaagggtc gcttcctgtg tgacctcagg
     1741 caagttgtta aacctctcag agcctcattt tctcactcat aaaatggttg cggcaatagt
     1801 ctatacctcc ttggtctgct gtgaagatga aatgagaaga tgaggcttgt aaagcacctg
     1861 gcacattgtg gatgttcaac aaatatcagt ctctcctcac tcccttcaat ggtagacaag
     1921 atataaattt ttgttttgta aagcacacac acacacacac acacacacac acacacacag
     1981 ctctatcatg tacagaagtt attatgtgtt tttacatgtt gaatgtaaat ttacgaaggt
     2041 cttctttttg cttgcagcat gaaagcattt catggcatta cacctctatt gaaaaacatc
     2101 gcggatgtta tgatctaaca agccatgtgc tagtgcatca tttcaggttg tgaagaaata
     2161 catttggcca ccagtagagg agtttctcat ggctcccctt ccctctgtgg gaatactaga
     2221 tgaaatgaaa gtctgtgttt tgaaatcctt tgattgcata aacattttta cgaatggagt
     2281 tgaatttatg acttcctggg ggtgactggg accttcctcc cccatgaaga ggtgggttat
     2341 ttgtagccag agttctcacc tgcagccaag tgcgggtctc tgcacctgtc tgcctcctct
     2401 cctcctgagg cttttttttt ttttttcatc acacctggaa ggaggctcag tggcaagggc
     2461 taatgaaaat gtggtcacat cctggaggac tctgatattt ttgctcatga cagatccttg
     2521 catgacttcc tcagaatctt tactcagcac tccagggggg gctctgcctc ttgcctgcca
     2581 tgagttgccc tccagacact gcacgtcctg ggttttagct gtgaagcccg tcgcatagct
     2641 atgtttattt ccttctgtcc cttctaggag ttccacaaaa gggcaatatg tcacatgatt
     2701 ctacaggttg taaaatgttc aagtccatag aaatgagccc gatagtattt attttaacca
     2761 tttgctcttt aaaaggtcag agaggcagtg atgtaattgt tctctgttgc tgcttgtcct
     2821 tccccatcct cttcctttct caaaagaaat gatgtggggc agcttcgctg ggggagagga
     2881 gtctgtcccc tcgagcaagg accccactgc cagccaagct tggatgcagg aggcttttca
     2941 gtgggtgaca acatctgatt cagaaacaag gcagctttgc tttcaggagc ccagatgggg
     3001 tgtggagcaa tgacatttag aatgatcttg tttttggttg aaaacagagc attttccctg
     3061 ggaaagaaca gaatatggag atcagagcaa ctcccctctg tttcctgtcc tctcctgtgt
     3121 gtgctgtgtg ctggcctctg gggtagggaa agggggccaa cctcgtctca tctctaaggg
     3181 gatcttagtc tcaaagagga ccctaaagac tatcagatac aaggaatttc tacctaagga
     3241 aaatatggtg aactaatagg aagcccctat ttattgtttt tctgcagata aagtggggaa
     3301 atcgaatgtg ataatgaata taaaaattat tctaaccttt taaaatgatg ccttaccaag
     3361 aggtaggagg taggattcag agtttggcag ggttataaag actaatttct ttctgtcttc
     3421 ccccaaaccc attcccaaag tgaactgtaa ggttaaaact ataacaagaa gatttaagta
     3481 aatttgcaaa tatgtagaga atactaaatc atttgtatcc tttaggcatt cagacaattt
     3541 gcctaagtca ttgtaggtta ctaggtgcca cttccgagaa ttccttgggg atggggagga
     3601 gattgtttgg ataatgcctg tcctaactga acgggaaggg tttgtagcat tcctactaca
     3661 aagattcatg cacagccttc tctgcagaac accatgatgt ggacaaggca aagacgggga
     3721 agcggaagcc gctgtctatg tcataggaga aagagacacc gcataactac aacaccaggc
     3781 tgcacacaag tttgtttgac aagtgttagg aacaaaattg tgtggcagag gtcaccacag
     3841 caggggctct tcctgccacc cccatattgc atgcagcctc ttctgttccc tcccctgccc
     3901 actggggttt ctcctcagca ctcatcatgc catatatcga tttgcttatt tgctcgttct
     3961 ctgtctcttc acgctagact ataagctcct tgagggcagg gacgtagctt tgctcactgc
     4021 tgtagcccca gcttatttgc tgtgttggtc gaatccactg cacccctctc tgggctgttt
     4081 cctttgtaca tataaataga ctcaaattgc ttccacctaa ccagaagcca ttccttgccc
     4141 cacagccctt tccagtttct atctcccctc cctcccttcc ttccaaacca ccttctggaa
     4201 aggctcttcc acactcactg tcctgactct tgccacaatt cacccctcaa catcctgcca
     4261 tttgtcttgc agcctgacca tcatagagag attggtccag ataggaaggt gagtaacttc
     4321 cacagtgtca aatctgatgg gctgttttct acctatgcct tttgtggcat ttaataccca
     4381 cagtcttcct gaaattatct cttttcttgg attctagttt gctacatttt tctccagctc
     4441 tctttttgaa tcctatcttc ctgattggaa tcttctcact tctttcctcc ctcttctact
     4501 gctcctccct taaatggaca cattttccat aattcagtgg ctgggcctct gctctcctct
     4561 ttctgagaaa tctccctgga tcctgatcca taatcacctg cttattaatg aacctcaaat
     4621 agacatttgc tgaccagaac cctttgctgg gctccagtcc tgtgtgtcca atcatctaat
     4681 ggactttttg acccaatgtc ctgcaggtgc ttgtaaccca ttcatttccc caccgtttct
     4741 tttttctttt cttttctttt cctttttttt tttttttttt ttttttgaga cagagtcttg
     4801 ctctgttgcc ccagctggag tgcggtggcg tgatttcggc tcactgcaac ctccacctcc
     4861 caggttcaag caattctcct gcctcagcct cccaagtagc tgggattaca ggagtgagcc
     4921 actgcgccgg gcctgcccct attctttttt cagtgaagta caccgctggt caccctgtcc
     4981 cccttgctat gctattccct ttgcacagac tgctctacct ttttttaatc tagcaaactc
     5041 catttatcca tctacgtcca gctcaagcat tagagactca ggagagcctc tggaagctga
     5101 gttcctggat aaccgtgcca taccttttct ttcccagact ttccacatct ttcccttcct
     5161 cactctcagc aaatgatggc tggctcccct ttacacaagg ggaatagaag caaccggaag
     5221 aactcttcca gacatccccg ctgtcccctc tgctgaccta gctccatctt cttcatatca
     5281 gcctctcccc tgtgtgctca gggggaactc actatgcccc tccctggcta aggtgatacc
     5341 ctggctaaga tgctccaacc ccttcccctg ttgcctgccc gatggcattt cgccagcaat
     5401 tctccctctc tgtcctgcac catcaatttc agtccaggat aacggaggac agaattttca
     5461 ggaatcagga tggaggaggg ttggtgaaca gcaccactgg ccttgactag cctgctccct
     5521 gccacacata ctggttgttt ctctggagac agcattgtat gcactgagat gagcaactgg
     5581 agagccacca gcagccatcc cctctctttg tgcctcacag ctccagtgac tgatggagat
     5641 ggagatggga tcgttggctg ccttcatgga gttgtttaag gagcacttag aagatgcttt
     5701 acgggcatcc ctagaatttc accattagaa gagtagttct gttaggttga aatttgtctt
     5761 tttactcaac ctcttcttaa attaggaatc acttctggaa aggaaaacac atcaagccat
     5821 acatactttt tcctgtgctt tttctcatgg agaggagcag cacaagacaa gacacccagc
     5881 tgttcaggct gctgaatgag atggtgagga gtgggtggta gaagtgaaga aaggaggagg
     5941 tgggagcaat caagtatttg cttgcttgat tccacaaaca agaagcttct tttctcttta
     6001 acctaacatt tgactgttta actttgcaag gttatatggg aaaaaaaatc cttgatatga
     6061 aaacattagc aaatgtatca cttataaaat gggtaccatc aggcctcccc ctgcttagca
     6121 ccagagtctc tctcactgcc tcatctacag ttttgtggat cagtcttgtg atgcctgaga
     6181 gtcaatgtgc aaactgtcct cgaactttaa ttgatgatct tgacaaacat tcaggattct
     6241 gtgaaggagg taagagaggt gtcacagaac tgctaaaata cacttcaact attgataaaa
     6301 gagcatggag cagagttaga ccggttagca gctgaatcag aggtaaataa acaaggatga
     6361 tgatgagatg ggagcttcca aaaagaagcg ttttaatatc aaatgttgaa gagaggctct
     6421 tgggaaaact gctgaagtct ttagatattt ttgcaaaaat tacccacttt ttgatgttca
     6481 gcaaaagtaa ccattaagta aagacagaaa aattggctgg gtacggtggc tcatgcctgt
     6541 aatcccagca ctttgggagg ctgaggtgag cagatcacct gaggtcagga gtttgagacc
     6601 agcctggcca acatggtgaa accccatctc tgctgaaaat acaaaaatta gctgggtgtg
     6661 gtggtgggca cctgtaatcc cagctacttg ggaggctgag gcaggagaat tgcttgaacc
     6721 tgggaggcgg aggttgcagt aagctgagat cgcaccactg ctctccagcc tgggtgatag
     6781 agtgagactc cgtctcaaaa aaaagaaaaa ttatgccaaa aaattaagta cttttgtggc
     6841 ttaaaagaac aatgtattgt catttctcaa ggctccatgg gttgattgag ttcagtttct
     6901 catttggcgt ctcttgtagt tgtagtgagt tgttggctga ggcagaagcc acctgaaggc
     6961 ttgactaggc agggcaatcg aggtggtaca ctcacaaggc tggtcatttc ctggggctca
     7021 gctggaaagg tggaccagag ttcctacaca aggccctttg atgtggtttg ggtttcttac
     7081 aacatggtga ttgtgttctg gaaggaagtc tcctgagact tagcttttcc taaaggccaa
     7141 aaatcagcta ttggggtctc atttgcttaa aattattggc atgttgttga aattataatg
     7201 agttttagta aagcaaaatt aaaacaattt tcatgatttt aatttcactt ttttcatgat
     7261 tttctatgaa attttggtcc tcattttaac aagattcctt tttaacaatc ttttactaaa
     7321 accagtcatt catggataag gagatcctct tacactaatt atttaaatgt gtacatatac
     7381 atgttaatac aaagggttga attgttaaag caaattcaga gtgacttaca gatcttaccc
     7441 aacatgaaac taatgattca aatgataaga ggcaagtgcc aggcacaaat gaaacactct
     7501 tttctggagg agaccaacag ttttaattat ttctggggtt tttttggtca aatttctcat
     7561 gttgcttcta gattgttttc caaatgtcat ttagttttct atctgtactt tttgtgattc
     7621 tctgaattct ctgtcagaca tttcggagat cttcaattct tctgggtcca ttgctacagc
     7681 tttgttatct cttttgatgt tgtcgttttc ccctgagttt tcacagtcct tgcacttcac
     7741 gtcgatcccc gtgcaattga gaagatagtc acctctgaca gttttttaag ggttcttggt
     7801 ggtgtcagag ctttgctact tagtattgga acttaaactc tggtctgttg tttcttcctg
     7861 ttctgagtga gacttgcggt gagcactgga acttaaacat tgccctggaa ctatattgct
     7921 gctctgtcaa catttcccag ttcagggaag atgtaagtgg gtatcagaac ttaatcttga
     7981 gctttttgtt gtttccaggc caggggaggg ctctcgagta tacctaggct cgtggaaaat
     8041 gcagccaggg atttggacct ccctgtggat tgtgccagcc agtcccttca ccatggtgtc
     8101 cccactgatc agagctcaga gtgcaccagt acaccagttg ctgcaatcag tgcttggctt
     8161 tttgtcccca gttcacccca ggtcattcag ctatcctggc attcccagtg gttcctgtgg
     8221 gacggggcca gagtgggtgt cccatgaaga tgaccagatc agtggggaga taaaatgctc
     8281 acctgtaatt ctctcctgtc accttggaaa ccatggatct agagacattc tctgagtgac
     8341 actatgccag ctgggagtgg tggcacagtc cgaattgatt gtttctctta ccagttctgg
     8401 cttctttcaa ttctgtggac ctagggggtt tctcagcttc tccccaaagt tctggtgaat
     8461 tcagggtggt gttcttgtct ttgaatagtt ggaatctatt tctgtggggg gaatggttcc
     8521 agagaatctt ctattctgcc atcttgttga gctctcccaa aatgtcccct tctcctacat
     8581 tggcacacgc tttggtttca cattgactga tgagttttga gcaacgtata caaagaaaca
     8641 ttgttctcaa aggaaactgg tgaagtttgg gggtgcctcc attttgcacg ttgttcatta
     8701 cacaagtaga atatacttat gtgactaccc gtaccctttc tccagcctcc ctgccccata
     8761 aacctataaa tcccaaattt atttataata gacaatcttg acagattagg tatatcctgc
     8821 tggaaatagg actagttcac tgagtataac gtttctacag agcagtctga ttgaggtctt
     8881 cagcatcttt gcaaggtgcc ctggttgagg ttattgttcc gcaggcactc ctgtggggaa
     8941 ggagtgattt gcaggcttca tgctgacatt acctgtatgg tacattttgg ccaacaccag
     9001 cctgttaatg cctgaggcag aggcctctgg aatgagaaaa caggactgga agcctgccta
     9061 cttagtagct tggcaagtgt caacaagtta atctctgtga ctggtgactt agttggagtt
     9121 ccacccaaag cagatcctga gacaaggatt tagtgcaagt aattcatgtg gccatcatcc
     9181 agaggagcat gggagaaagt ggggaattta gacagggaaa ggaggaagtt agcaaagggt
     9241 gagtgaagga gaacaagggc ccaggacagt gaggccccac ctcagaactg ccctcctgga
     9301 agggcgaagg agccgtggcg ccgaccccca cctcctgccc ctcaataggg agcatcactc
     9361 cccgacgtca actcccagct cttcctggcc tgccctgtgc tcaggccgag catggcctaa
     9421 agcagggaat atgtctaggc agagtgacac agggagccat gggcaggtac aggatctacc
     9481 tgcaagtgac tacaggggtg gcttcagggc tgaccaatgg catctgctat catggaatta
     9541 aagtaaccta ccccacgaag tagctgtgcc aagtaagtga aataatgcac aaggaaattc
     9601 tgtgtaaact ttcaagcatc aagcaaatgt tagttatttc ttgaggacgt tatgtaaagt
     9661 gatataagcc aggcccggaa ggacaaagac tgtatgattc cactcatatg aggggcttag
     9721 agttgtcaga ttcatagaga cagaaggtag aatggtggtg gccgggggct ggagggagga
     9781 gggagtgggg agttagtgtt tagtaggaac tgaatttcag tttgaggaga tgaaaatgtt
     9841 ctggggatct attgcacaac aatggacatg tagctaaccc cactgtactg tattcttaaa
     9901 aatgtttcag atggtaaatt ttatgttatg tatattttac cacaataaag aagtgagtta
     9961 ttgtactttc aaggcactcg gtgtgtttct caggatgctg ggcagcccat ggccccgaga
    10021 caggtgccaa gtcaatactt gggtgatgaa ggatgaagac aaacctcctc ttcatcttca
    10081 ctccagtgag tggagcactg gcactgttgc cagtgagagg caaagacacg aggccaattc
    10141 aacaacccac ctcaaacctg tatttgcaag tgagtgcaga ctcccctgat tccaatgaag
    10201 ctgctgttga gggccggata gcagccactc ttggctttgc gggccgtaca gtctgtgctg
    10261 caatgacaac tctgtgggtg tgtgaaagca gacactgctt agatgaacga ggatggcggc
    10321 acgccaacaa attcattatg gacactaaaa attgaatttc atgtaatttt catgtcatag
    10381 aaattctttc ttttcccctt caaccattta aaaatgtaaa aaaactattc tcagcttgtg
    10441 ggttttacaa aaacaggtgg cagccagatt tggtagtggc cggactttgc cacctccagc
    10501 ctggagtgtt ttgggaattc cccattctga aatggtctcc agtgtggctg cagcacgtcc
    10561 atttgacaat cctgacctcg gtggtggcaa atcttccttg tttcctggtg gatttaactt
    10621 tgcagaagga ccagcagaca tcctgaccca aacctgatgg atgagattgg tgtaaagtgg
    10681 agaaattctg ttttggatta atcacaagga gatttaaaaa acgagagatt ttctgtagta
    10741 agtacattgc ctgtaaatag aattccaatt ctacatgctc agggaccatt ttgttcactt
    10801 gtatcaaact atattctctg gattcagagg gaattattgg aacttttcag agatcaggaa
    10861 taaaatgttc atgcatgaga a
//
