LOCUS       NM_052858               2914 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MARVEL domain containing 3 (MARVELD3), transcript
            variant 2, mRNA.
ACCESSION   NM_052858
VERSION     NM_052858.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2914)
  AUTHORS   Li,S., Qi,S., Li,Y., Zhang,C., Sun,L., Liu,C. and Wang,H.
  TITLE     MARVELD3 inhibits the epithelial-mesenchymal transition and cell
            migration by suppressing the Wnt/beta-catenin signaling pathway in
            non-small cell lung cancer cells
  JOURNAL   Thorac Cancer 14 (12), 1045-1058 (2023)
   PUBMED   36924014
  REMARK    GeneRIF: MARVELD3 inhibits the epithelial-mesenchymal transition
            and cell migration by suppressing the Wnt/beta-catenin signaling
            pathway in non-small cell lung cancer cells.
REFERENCE   2  (bases 1 to 2914)
  AUTHORS   Li,Y., Li,T., Zhou,D., Wei,J., Li,Z., Li,X., Jia,S., Ouyang,Q.,
            Qi,S., Chen,Z., Zhang,B., Yu,J., Jia,J., Xu,A. and Huang,J.
  TITLE     Role of tight junction-associated MARVEL protein marvelD3 in
            migration and epithelial-mesenchymal transition of hepatocellular
            carcinoma
  JOURNAL   Cell Adh Migr 15 (1), 249-260 (2021)
   PUBMED   34338154
  REMARK    GeneRIF: Role of tight junction-associated MARVEL protein marvelD3
            in migration and epithelial-mesenchymal transition of
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2914)
  AUTHORS   Steed,E., Elbediwy,A., Vacca,B., Dupasquier,S., Hemkemeyer,S.A.,
            Suddason,T., Costa,A.C., Beaudry,J.B., Zihni,C., Gallagher,E.,
            Pierreux,C.E., Balda,M.S. and Matter,K.
  TITLE     MarvelD3 couples tight junctions to the MEKK1-JNK pathway to
            regulate cell behavior and survival
  JOURNAL   J Cell Biol 204 (5), 821-838 (2014)
   PUBMED   24567356
  REMARK    GeneRIF: MarvelD3 couples tight junctions to the MEKK1-JNK pathway
            to regulate cell behavior and survival.
REFERENCE   4  (bases 1 to 2914)
  AUTHORS   Cording,J., Berg,J., Kading,N., Bellmann,C., Tscheik,C.,
            Westphal,J.K., Milatz,S., Gunzel,D., Wolburg,H., Piontek,J.,
            Huber,O. and Blasig,I.E.
  TITLE     In tight junctions, claudins regulate the interactions between
            occludin, tricellulin and marvelD3, which, inversely, modulate
            claudin oligomerization
  JOURNAL   J Cell Sci 126 (Pt 2), 554-564 (2013)
   PUBMED   23203797
REFERENCE   5  (bases 1 to 2914)
  AUTHORS   Timmann,C., Thye,T., Vens,M., Evans,J., May,J., Ehmen,C.,
            Sievertsen,J., Muntau,B., Ruge,G., Loag,W., Ansong,D., Antwi,S.,
            Asafo-Adjei,E., Nguah,S.B., Kwakye,K.O., Akoto,A.O., Sylverken,J.,
            Brendel,M., Schuldt,K., Loley,C., Franke,A., Meyer,C.G.,
            Agbenyega,T., Ziegler,A. and Horstmann,R.D.
  TITLE     Genome-wide association study indicates two novel resistance loci
            for severe malaria
  JOURNAL   Nature 489 (7416), 443-446 (2012)
   PUBMED   22895189
REFERENCE   6  (bases 1 to 2914)
  AUTHORS   Kojima,T., Takasawa,A., Kyuno,D., Ito,T., Yamaguchi,H., Hirata,K.,
            Tsujiwaki,M., Murata,M., Tanaka,S. and Sawada,N.
  TITLE     Downregulation of tight junction-associated MARVEL protein marvelD3
            during epithelial-mesenchymal transition in human pancreatic cancer
            cells
  JOURNAL   Exp Cell Res 317 (16), 2288-2298 (2011)
   PUBMED   21763689
  REMARK    GeneRIF: MarvelD3 is transcriptionally downregulated in
            Snail-induced epithelial-mesenchymal transition during the
            progression for the pancreatic cancer.
REFERENCE   7  (bases 1 to 2914)
  AUTHORS   Raleigh,D.R., Marchiando,A.M., Zhang,Y., Shen,L., Sasaki,H.,
            Wang,Y., Long,M. and Turner,J.R.
  TITLE     Tight junction-associated MARVEL proteins marveld3, tricellulin,
            and occludin have distinct but overlapping functions
  JOURNAL   Mol Biol Cell 21 (7), 1200-1213 (2010)
   PUBMED   20164257
  REMARK    GeneRIF: marvelD3, occludin, and tricellulin define the tight
            junction-associated MARVEL protein family
REFERENCE   8  (bases 1 to 2914)
  AUTHORS   Steed,E., Rodrigues,N.T., Balda,M.S. and Matter,K.
  TITLE     Identification of MarvelD3 as a tight junction-associated
            transmembrane protein of the occludin family
  JOURNAL   BMC Cell Biol 10, 95 (2009)
   PUBMED   20028514
  REMARK    GeneRIF: MarvelD3 co-localises with occludin at tight junctions in
            intestinal and corneal epithelial cells.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2914)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009097.9.
            
            On Jun 2, 2019 this sequence version replaced NM_052858.5.
            
            Transcript Variant: This variant (2) uses an alternate exon at its
            3' terminus, compared to variant 1, which results in a protein
            (isoform 2) with a shorter and distinct C-terminus, compared to
            isoform 1. There is no support for the protein predicted to be
            encoded by this variant.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013376.2, SRR7346977.789467.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268485.8/ ENSP00000268485.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC009097.9         86965-87477
            514-641             AC009097.9         90148-90275
            642-2914            AC009097.9         94974-97246
FEATURES             Location/Qualifiers
     source          1..2914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..2914
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /note="MARVEL domain containing 3"
                     /db_xref="GeneID:91862"
                     /db_xref="HGNC:HGNC:30525"
                     /db_xref="MIM:614094"
     exon            1..513
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1252
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     MARVEL (membrane-associating) domain containing 3; MARVEL
                     domain-containing protein 3"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 3 isoform 2"
                     /protein_id="NP_443090.4"
                     /db_xref="CCDS:CCDS10904.1"
                     /db_xref="GeneID:91862"
                     /db_xref="HGNC:HGNC:30525"
                     /db_xref="MIM:614094"
                     /translation="MEDPSGAREPRARPRERDPGRRPHPDQGRTHDRPRDRPGDPRRK
                     RSSDGNRRRDGDRDPERDQERDGNRDRNRDRERERERERDPDRGPRRDTHRDAGPRAG
                     EHGVWEKPRQSRTRDGARGLTWDAAAPPGPAPWEAPEPPQPQRKGDPGRRRPESEPPS
                     ERYLPSTPRPGREEVEYYQSEAEGLLECHKCKYLCTGRACCQMLEVLLNLLILACSSV
                     SYSSTGGYTGITSLGGIYYYQFGGAYSGFDGADGEKAQQLDVQFYQLKLPMVTVAMAC
                     SGALTALCCLFVAMGVLRVPWHCPLLLVTEGLLDMLIAGGYIPALYFYFHYLSAAYGS
                     PVCKERQALYQSKGYSGFGCSFHGADIGAGIFAALGIVVFALGAVLAIKGYRKVRKLK
                     EKPAEMFEF"
     exon            514..641
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..2914
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /note="hexamer: AATAAA"
     polyA_site      2654
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /note="major polyA site"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /note="hexamer: AATAAA"
     polyA_site      2914
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
ORIGIN      
        1 gttgttgccc tcaggtcgct cccgggcggg gacacggaac ccggccatgg aagatccgtc
       61 gggggctcgc gagccccggg cccggccgag agagcgggac ccgggacggc gcccccaccc
      121 agaccaaggc cgcacccacg atcgaccgcg ggaccgaccc ggggacccgc gcaggaagcg
      181 aagcagcgac gggaaccggc gaagggacgg ggaccgggac ccggagagag accaggagag
      241 ggacgggaac cgcgaccgga accgggaccg ggagagggag agagagaggg aaagagaccc
      301 ggaccgaggc ccccgccggg acacacacag ggacgcgggc cctcgcgcag gtgaacacgg
      361 agtttgggaa aaaccgcgcc aaagccggac gcgggacgga gcccggggac tgacctggga
      421 cgcagccgcg cctcctgggc ccgcgccctg ggaagccccg gagccgccgc agccgcagag
      481 gaagggagac cccgggcgcc gcagacccga aagtgaaccc ccttcggaga gatatctgcc
      541 ctcgaccccc aggcctggac gagaggaggt ggaatattac cagtcagagg cggaaggact
      601 cctggaatgc cacaaatgca aatacttgtg cactgggaga gcctgctgcc aaatgctgga
      661 ggttctcctg aacttgctga tcctggcctg cagctctgtg tcttacagtt ccacaggggg
      721 ctacacgggc atcaccagct tggggggcat ttactactat cagttcggag gggcttacag
      781 tggctttgat ggtgctgacg gggagaaggc ccagcaactg gatgtccagt tctaccagct
      841 aaagctgccc atggtcactg tggcaatggc ctgtagtgga gccctcacag ccctctgctg
      901 cctcttcgtt gccatgggtg tcctgcgggt cccgtggcat tgtccactgt tgctggtgac
      961 cgaaggcttg ttggacatgc tcatcgcggg ggggtacatc ccggccttgt acttctactt
     1021 ccactacctc tctgctgcct atggctctcc tgtgtgtaaa gagaggcagg cgctgtacca
     1081 aagcaaaggc tacagcggtt tcggctgcag tttccacgga gcagatatag gagctggaat
     1141 ctttgctgcc ctgggcattg tggtctttgc cctgggggct gtcctggcca taaagggcta
     1201 ccgaaaagtt aggaagctaa aagagaagcc agcagaaatg tttgaatttt aagggtttct
     1261 aaaacgctct gacagatgca agtggtggtg gaaggtagtc tgagccactg cctttcccaa
     1321 gaatcccttg ttgtggaagt ttccagtgct ggaaaagcag cgagccagcg ttggtgtggt
     1381 gggcggagct cccagtcgca tggagcggtg ttcatggatg caacagaccc tggcttctgg
     1441 agtcctctgt gagtgaggga ccaatcaaaa ttatttttca aaaagcaaaa aaatggccgg
     1501 cctcggcggc tcacacctgt aaccccagca ctttgggagg ctgaggtggg tggatcactt
     1561 gaggtcagga gctcgagacc agcttggcca acatggtgag cccccgtctc tactaaaata
     1621 caaaaaaatt agccaggcgt ggtggcgggc gcctgtaatc ccagctactt gggaggctga
     1681 ggcaggagaa tcgcttgaat ctgggaggcg gagattgcag tgagccgaga tcccgccact
     1741 gcactccagc ccaggtgaca gagcgagact ccatctcaaa aaaaaaaaaa agcaaaaaaa
     1801 ctggacccca agagccacaa ggaaaaagca tgtactacaa cagagtgcac ctcttcattc
     1861 agtaaaggga ggtcaccaag agaatttgat gaaccttacc ttcaaagttc ctgggcacag
     1921 tggctcacac ctgtaatccc agagctttgg gaggctgagg taggaggatt gcttgaaccc
     1981 aggagttcaa gtttgcagtg cgctatgatt gtcccactac actctagcct gagcaacaga
     2041 ccaagaccgt attgccaaaa taccaaaaaa aaaaaaagtt catggagagc cacatagaca
     2101 tgagaccaca cttcagcctg aatttttcta aaacacagtt gtctcaagca gattactcca
     2161 cacgtttttc cacactgaac tctccagtcc ttccacttcc ttaattctgc aaatggaggg
     2221 ggtggggact cttgggaaac tactcctgta aaattgaagt tggaggtagg cgtgggctga
     2281 ggaaagagga atcagattaa ttctctgggt tgcaaagagg ctattctgca agccccttac
     2341 agtggccctg aaagctcaat aagtgttttg tacctcttgt aaatgtgcca ttgtgtgaag
     2401 cattaaaccc aacatctaga attcaggatt catccagaat aaaaggatgt aaaatctttc
     2461 ccaacagaag agtgttactt ttggtcagac aacttcatgg gttcttactg cacattaaat
     2521 tatgacttat ggaacattgc aatatattct cggtccttaa gttatgactt atggaacatt
     2581 acaatatatt ctcggtccaa gtgagtaagt tctttgcttt atgtgaatcc aataaaaaat
     2641 ccaaagaatt ttaatttgga gttgatgtcc tctttacaat acatttataa tattctctta
     2701 aatacagaca atttttcaca tttaaaaggt gagttccatt tgagtttaga aaaggaaata
     2761 tatatataca tgcttgtata tgattggaaa atttcttgaa gaataacatc agaaagtatt
     2821 aagttttgct tttgaagaga aggggacttt tcatttatac atggcttgac tgcacatgta
     2881 ttaattttag aaaaataaaa agtaaaaaag ttga
//
