LOCUS       NP_443090                401 aa            linear   PRI 29-APR-2025
DEFINITION  MARVEL domain-containing protein 3 isoform 2 [Homo sapiens].
ACCESSION   NP_443090
VERSION     NP_443090.4
DBSOURCE    REFSEQ: accession NM_052858.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 401)
  AUTHORS   Li,S., Qi,S., Li,Y., Zhang,C., Sun,L., Liu,C. and Wang,H.
  TITLE     MARVELD3 inhibits the epithelial-mesenchymal transition and cell
            migration by suppressing the Wnt/beta-catenin signaling pathway in
            non-small cell lung cancer cells
  JOURNAL   Thorac Cancer 14 (12), 1045-1058 (2023)
   PUBMED   36924014
  REMARK    GeneRIF: MARVELD3 inhibits the epithelial-mesenchymal transition
            and cell migration by suppressing the Wnt/beta-catenin signaling
            pathway in non-small cell lung cancer cells.
REFERENCE   2  (residues 1 to 401)
  AUTHORS   Li,Y., Li,T., Zhou,D., Wei,J., Li,Z., Li,X., Jia,S., Ouyang,Q.,
            Qi,S., Chen,Z., Zhang,B., Yu,J., Jia,J., Xu,A. and Huang,J.
  TITLE     Role of tight junction-associated MARVEL protein marvelD3 in
            migration and epithelial-mesenchymal transition of hepatocellular
            carcinoma
  JOURNAL   Cell Adh Migr 15 (1), 249-260 (2021)
   PUBMED   34338154
  REMARK    GeneRIF: Role of tight junction-associated MARVEL protein marvelD3
            in migration and epithelial-mesenchymal transition of
            hepatocellular carcinoma.
REFERENCE   3  (residues 1 to 401)
  AUTHORS   Steed,E., Elbediwy,A., Vacca,B., Dupasquier,S., Hemkemeyer,S.A.,
            Suddason,T., Costa,A.C., Beaudry,J.B., Zihni,C., Gallagher,E.,
            Pierreux,C.E., Balda,M.S. and Matter,K.
  TITLE     MarvelD3 couples tight junctions to the MEKK1-JNK pathway to
            regulate cell behavior and survival
  JOURNAL   J Cell Biol 204 (5), 821-838 (2014)
   PUBMED   24567356
  REMARK    GeneRIF: MarvelD3 couples tight junctions to the MEKK1-JNK pathway
            to regulate cell behavior and survival.
REFERENCE   4  (residues 1 to 401)
  AUTHORS   Cording,J., Berg,J., Kading,N., Bellmann,C., Tscheik,C.,
            Westphal,J.K., Milatz,S., Gunzel,D., Wolburg,H., Piontek,J.,
            Huber,O. and Blasig,I.E.
  TITLE     In tight junctions, claudins regulate the interactions between
            occludin, tricellulin and marvelD3, which, inversely, modulate
            claudin oligomerization
  JOURNAL   J Cell Sci 126 (Pt 2), 554-564 (2013)
   PUBMED   23203797
REFERENCE   5  (residues 1 to 401)
  AUTHORS   Timmann,C., Thye,T., Vens,M., Evans,J., May,J., Ehmen,C.,
            Sievertsen,J., Muntau,B., Ruge,G., Loag,W., Ansong,D., Antwi,S.,
            Asafo-Adjei,E., Nguah,S.B., Kwakye,K.O., Akoto,A.O., Sylverken,J.,
            Brendel,M., Schuldt,K., Loley,C., Franke,A., Meyer,C.G.,
            Agbenyega,T., Ziegler,A. and Horstmann,R.D.
  TITLE     Genome-wide association study indicates two novel resistance loci
            for severe malaria
  JOURNAL   Nature 489 (7416), 443-446 (2012)
   PUBMED   22895189
REFERENCE   6  (residues 1 to 401)
  AUTHORS   Kojima,T., Takasawa,A., Kyuno,D., Ito,T., Yamaguchi,H., Hirata,K.,
            Tsujiwaki,M., Murata,M., Tanaka,S. and Sawada,N.
  TITLE     Downregulation of tight junction-associated MARVEL protein marvelD3
            during epithelial-mesenchymal transition in human pancreatic cancer
            cells
  JOURNAL   Exp Cell Res 317 (16), 2288-2298 (2011)
   PUBMED   21763689
  REMARK    GeneRIF: MarvelD3 is transcriptionally downregulated in
            Snail-induced epithelial-mesenchymal transition during the
            progression for the pancreatic cancer.
REFERENCE   7  (residues 1 to 401)
  AUTHORS   Raleigh,D.R., Marchiando,A.M., Zhang,Y., Shen,L., Sasaki,H.,
            Wang,Y., Long,M. and Turner,J.R.
  TITLE     Tight junction-associated MARVEL proteins marveld3, tricellulin,
            and occludin have distinct but overlapping functions
  JOURNAL   Mol Biol Cell 21 (7), 1200-1213 (2010)
   PUBMED   20164257
  REMARK    GeneRIF: marvelD3, occludin, and tricellulin define the tight
            junction-associated MARVEL protein family
REFERENCE   8  (residues 1 to 401)
  AUTHORS   Steed,E., Rodrigues,N.T., Balda,M.S. and Matter,K.
  TITLE     Identification of MarvelD3 as a tight junction-associated
            transmembrane protein of the occludin family
  JOURNAL   BMC Cell Biol 10, 95 (2009)
   PUBMED   20028514
  REMARK    GeneRIF: MarvelD3 co-localises with occludin at tight junctions in
            intestinal and corneal epithelial cells.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 401)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009097.9.
            
            On Jun 22, 2013 this sequence version replaced NP_443090.3.
            
            Transcript Variant: This variant (2) uses an alternate exon at its
            3' terminus, compared to variant 1, which results in a protein
            (isoform 2) with a shorter and distinct C-terminus, compared to
            isoform 1. There is no support for the protein predicted to be
            encoded by this variant.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013376.2, SRR7346977.789467.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268485.8/ ENSP00000268485.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     Protein         1..401
                     /product="MARVEL domain-containing protein 3 isoform 2"
                     /note="MARVEL (membrane-associating) domain containing 3;
                     MARVEL domain-containing protein 3"
                     /calculated_mol_wt=44780
     Region          1..173
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96A59.3)"
     Region          <18..>117
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Site            227..247
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96A59.3)"
     Site            272..292
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96A59.3)"
     Site            301..321
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96A59.3)"
     Site            361..381
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96A59.3)"
     CDS             1..401
                     /gene="MARVELD3"
                     /gene_synonym="MARVD3; MRVLDC3"
                     /coded_by="NM_052858.6:47..1252"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS10904.1"
                     /db_xref="GeneID:91862"
                     /db_xref="HGNC:HGNC:30525"
                     /db_xref="MIM:614094"
ORIGIN      
        1 medpsgarep rarprerdpg rrphpdqgrt hdrprdrpgd prrkrssdgn rrrdgdrdpe
       61 rdqerdgnrd rnrdrerere rerdpdrgpr rdthrdagpr agehgvwekp rqsrtrdgar
      121 gltwdaaapp gpapweapep pqpqrkgdpg rrrpesepps erylpstprp greeveyyqs
      181 eaegllechk ckylctgrac cqmlevllnl lilacssvsy sstggytgit slggiyyyqf
      241 ggaysgfdga dgekaqqldv qfyqlklpmv tvamacsgal talcclfvam gvlrvpwhcp
      301 lllvteglld mliaggyipa lyfyfhylsa aygspvcker qalyqskgys gfgcsfhgad
      361 igagifaalg ivvfalgavl aikgyrkvrk lkekpaemfe f
//
