LOCUS       NM_031484               3213 bp    mRNA    linear   PRI 31-MAY-2021
DEFINITION  Homo sapiens MARVEL domain containing 1 (MARVELD1), mRNA.
ACCESSION   NM_031484 NR_026753 XR_041875 XR_041876 XR_041877
VERSION     NM_031484.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3213)
  AUTHORS   Xia L, Jin P, Tian W, Liang S, Tan L and Li B.
  TITLE     Up-regulation of MARVEL domain-containing protein 1 (MARVELD1)
            accelerated the malignant phenotype of glioma cancer cells via
            mediating JAK/STAT signaling pathway
  JOURNAL   Braz J Med Biol Res 54 (7), e10236 (2021)
   PUBMED   34008750
  REMARK    GeneRIF: Up-regulation of MARVEL domain-containing protein 1
            (MARVELD1) accelerated the malignant phenotype of glioma cancer
            cells via mediating JAK/STAT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3213)
  AUTHORS   Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, Yao Y, Dou P, Akhtar ML,
            Nie H, He J and Li Y.
  TITLE     MARVELD1 interacting with catalase regulates reactive oxygen
            species metabolism and mediates the sensitivity to chemotherapeutic
            drugs in epithelial tumors of the reproductive system
  JOURNAL   Mol Carcinog 58 (8), 1410-1426 (2019)
   PUBMED   31066116
  REMARK    GeneRIF: MARVELD1 may regulate tumor cell proliferation and
            sensitivity to chemotherapeutic drugs via reducing the exorbitant
            reactive oxygen species. The mechanism was that MARVELD1 interacted
            with catalase to maintain latter stability, and then ensure
            continuous reactive oxygen species scavenge.
REFERENCE   3  (bases 1 to 3213)
  AUTHORS   Yao Y, Shi M, Liu S, Li Y, Guo K, Ci Y, Liu W and Li Y.
  TITLE     MARVELD1 modulates cell surface morphology and suppresses
            epithelial-mesenchymal transition in non-small cell lung cancer
  JOURNAL   Mol Carcinog 55 (11), 1714-1727 (2016)
   PUBMED   26509557
  REMARK    GeneRIF: Study demonstrates that MARVELD1-mediated balance of
            integrin beta1 and beta4 regulates cell surface ultrastructure and
            epithelial-mesenchymal transition phenotype of non-small cell lung
            cancer (NSCLC).
REFERENCE   4  (bases 1 to 3213)
  AUTHORS   Wang ZY, Shi M and Li Y.
  TITLE     [Importin-beta1 plays a key role in the nucleocytoplasmic
            transportation process of MARVELD1]
  JOURNAL   Mol Biol (Mosk) 49 (3), 491-497 (2015)
   PUBMED   26107903
  REMARK    GeneRIF: Importin-beta1 mediates the non-classical
            nucleocytoplasmic transport of MARVELD1.
REFERENCE   5  (bases 1 to 3213)
  AUTHORS   Shi M, Wang S, Yao Y, Li Y, Zhang H, Han F, Nie H, Su J, Wang Z,
            Yue L, Cao J and Li Y.
  TITLE     Biological and clinical significance of epigenetic silencing of
            MARVELD1 gene in lung cancer
  JOURNAL   Sci Rep 4, 7545 (2014)
   PUBMED   25520033
  REMARK    GeneRIF: MARVELD1 silencing is an appealing diagnostic biomarker
            for lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3213)
  AUTHORS   Hu J, Li Y and Li P.
  TITLE     MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine
            Phosphorylation of UPF1
  JOURNAL   PLoS One 8 (6), e68291 (2013)
   PUBMED   23826386
  REMARK    GeneRIF: MARVELD1 substantially inhibits nonsense-mediated RNA
            decay by decreasing the pioneer round of translation but not
            steady-state translation, and is an important component of the
            molecular machinery containing UPF1 and Y14. MARVELD1 promotes the
            dissociation of SMG1 from UPF1, resulting in the repression of
            serine phosphorylation of UPF1, and subsequently blocks the
            recruitment of SMG5.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3213)
  AUTHORS   Yu Y, Zhang Y, Hu J, Zhang H, Wang S, Han F, Yue L, Qu Y, Zhang Y,
            Liang H, Nie H and Li Y.
  TITLE     MARVELD1 inhibited cell proliferation and enhance chemosensitivity
            via increasing expression of p53 and p16 in hepatocellular
            carcinoma
  JOURNAL   Cancer Sci 103 (4), 716-722 (2012)
   PUBMED   22320884
  REMARK    GeneRIF: Our findings suggest that MARVELD1 is a tumor suppressor
            by negatively regulating proliferation, tumor growth and
            chemosensitivity of HCC cells via increasing p53 and p16 in vitro
            and in vivo.
REFERENCE   8  (bases 1 to 3213)
  AUTHORS   Zeng F, Tian Y, Shi S, Wu Q, Liu S, Zheng H, Yue L and Li Y.
  TITLE     Identification of mouse MARVELD1 as a microtubule associated
            protein that inhibits cell cycle progression and migration
  JOURNAL   Mol Cells 31 (3), 267-274 (2011)
   PUBMED   21347699
REFERENCE   9  (bases 1 to 3213)
  AUTHORS   Wang S, Li Y, Han F, Hu J, Yue L, Yu Y, Zhang Y, He J, Zheng H, Shi
            S, Fu X and Wu H.
  TITLE     Identification and characterization of MARVELD1, a novel nuclear
            protein that is down-regulated in multiple cancers and silenced by
            DNA methylation
  JOURNAL   Cancer Lett 282 (1), 77-86 (2009)
   PUBMED   19364627
  REMARK    GeneRIF: MARVELD1 protein is located in nucleus instead of cell
            membrane in several different tumors, in males and in females.
REFERENCE   10 (bases 1 to 3213)
  AUTHORS   Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L,
            Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE,
            Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles
            J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD,
            Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H,
            Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,
            Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee
            CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner
            L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S,
            Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E,
            Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C,
            Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK,
            Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird
            G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE,
            McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson
            T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan
            S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou
            T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore
            N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J,
            Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead
            SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK,
            Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T,
            Doucette-Stamm L, Beck S, Smith DR and Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC004995.1 and AI347102.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031484.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062544.1, BC004995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285605.8/ ENSP00000441365.1
            NMD candidate          :: PMID: 19364627
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3211              BC004995.1         7-3217
            3212-3213           AI347102.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..3213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..3213
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /note="MARVEL domain containing 1"
                     /db_xref="GeneID:83742"
                     /db_xref="HGNC:HGNC:28674"
                     /db_xref="MIM:616970"
     exon            1..2256
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..669
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /note="MARVEL (membrane-associating) domain containing 1;
                     putative MARVEL domain-containing protein 1; occludin"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 1"
                     /protein_id="NP_113672.1"
                     /db_xref="GeneID:83742"
                     /db_xref="HGNC:HGNC:28674"
                     /db_xref="MIM:616970"
                     /translation="MLPPPPRQPPPQARAARGAVRLQRPFLRSPLGVLRLLQLLAGAA
                     FWITIATSKYQGPVHFALFVSVLFWLLTLGLYFLTLLGKHELVPVLGSRWLMVNVAHD
                     VLAAALYGAATGIMSDQMQRHSYCNLKDYPLPCAYHAFLAAAVCGGVCHGLYLLSALY
                     GCGRRCQGKQEVA"
     exon            2257..3213
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /note="hexamer: GATAAA"
     polyA_site      3213
                     /gene="MARVELD1"
                     /gene_synonym="bA548K23.8; GB14; MARVD1; MRVLDC1"
                     /note="major polyA site"
ORIGIN      
        1 aggagaggaa gagaggacta agaggggagc aaggcgagga ggccgcggcg ggcgcagcgg
       61 gcacctgggc cgtgctgccc ccgcgagcaa ggcgccgcca ttccgctgct cggggcgccg
      121 ccgccgccgc caccgcgccc aggggccatg ctcccgccgc ccccgcgcca gccgccgccc
      181 caggcgcgtg cggcccgcgg cgcggtgcgc ctgcagcggc ccttcctgcg cagcccgctg
      241 ggcgtgttgc ggctgctgca gctgctggcc ggcgctgcct tctggatcac tatcgccacc
      301 agcaagtacc agggccccgt gcacttcgcg ctcttcgtgt ccgtgctctt ctggctgctc
      361 accctgggcc tctacttcct cacgctgctg ggcaagcacg agctggtccc cgtgctgggc
      421 tcgcgctggc tcatggtcaa cgtggcgcac gatgtgctgg cggccgcgct ctacggcgcc
      481 gccaccggca tcatgagcga ccagatgcag cgccacagct actgcaacct caaggattac
      541 ccgctcccct gcgcctacca cgccttcctg gcggccgccg tctgcggcgg cgtctgccac
      601 ggcctctacc tgctttcggc gctctatggc tgcgggcgtc gctgccaggg caagcaggag
      661 gtggcgtgag gccgcccgcg cccgccgcgg ccccgatcgg ggcgggggaa tccccggaga
      721 ccagcctcct taatcccttc ccccgccgcc gccccgcgcg ggtgcgccct ggcaccctct
      781 ccctgccctc cagcgtttcc actgtcgccc gcgcccggga accctgacgc tcagctcccg
      841 cccgacggca gcgccgccgc cgcccagaat cccagcccag aatcccgacc gccgcgccgg
      901 acgcgccgtc tcccgggaca agcgcaggct gcgatccgag gggctgacac acactcgcag
      961 acgagccgcc ccgaggcgaa acctcgcggt tcctcttccc ttccctgctg agactaagac
     1021 gtggacaggg gccgcgcaga tccgggggag gctcccaaat tggaaccagg cttctggctg
     1081 cccccttccc tcccgccccg tggtcggaag agcactccct tccctggccc ctcatccagc
     1141 ctccggtgct gtaaaacgca ggcgctgggc cgcgggcgga gctgaggaca ggccttggct
     1201 ggtcccagga tgagcgacga gtttggtttt agctggggat tgtgctggca tcctgcgaag
     1261 ctcctcccag ccggtctctc tgtgctcggt tgtcttgggg tggggcccat ccgccgaggt
     1321 ggggaccgat aggagaagcc ggtgggttgt acccttacac ttgtggagtc tcctcttgcc
     1381 tctacctact ccgcctttgt ccttaaggtt tttgcaggcc agtgccaaac acacactaac
     1441 tgtcctggcc tctccgtgac acaagtctct tcccagcctt cctcacaggc ttctgccgcc
     1501 cccctcatct ccaccctccc ccatatctgt ttgcattagg agttccacga ccatggtgga
     1561 atgttaaggt gaaccccacc ccttcttaca gatggggacc cagagcctgc tcttgggaac
     1621 agccagagta agattggaac ccagacttgc agtccagcgc tgtttgcatt aaaagggtgg
     1681 gtgagtcagg acccctggct caggagccgc ctctcctaaa agagggtttc aaggccaaat
     1741 gggtttgtca acggtgctgt ctccctttct tggagatgct cattagctta tcaaagactg
     1801 agaagtcccg ctgttacaga aataatttag tttgctgtat taactgctcc tgggcctgga
     1861 gcagtattcc caccttaaga ttcccagcat ccctgtgctg tcccggctct cattcatgcc
     1921 gaagggccca acccattggc tgtgttctgt ttgaagattt ggggggcgcc ttctctttct
     1981 tccccaggga attctctagc agagggaggg gacccacccc agtgaggaag tagattgctg
     2041 cctctagcca gagacctgaa ctggggaatt tgaacattcc tttacattgt tggagaaatg
     2101 aagccaaagt tattcagatg gttttcccag gctaaaggaa agtcacctgc aagagatccc
     2161 ggcactgatc tggagcagct gacagggtgg gtctccctta ccaaagagaa gaaccactct
     2221 ctggcgctgg ggtgacctgc tggctgggcc tgtaaggttt ccatgttgct gaggccatgg
     2281 agattcccag agctggtcac accgaccgct ctcagggccc gctgccctgg gctggcaaca
     2341 ccattctggc cttggcctgc agaagctttc agagtcttca ctggcagtag ggggagatgg
     2401 ggagaggaat gatctctgcc cagccccttc ctttccaaac catgcaatgg aagagcccag
     2461 atgggtgaag attgattttg ccttaactca agagaattcc tgttctcctt gtgctatgat
     2521 ttggacacaa gattctggat acctggaact tagctgtgta ctcctgtacc ctaaacagtg
     2581 gatttgagtt ccagcgttta ttcttttttc cttttttcag atcaccatct aagttacatc
     2641 tttagctcag gtccatcctt ctcaagatct ccttcttagc cccccagccc ctggtgctgt
     2701 ctgtggtcag gtgaccttac tcaggagcag atatctcctt ggccgccatg gagcctcatc
     2761 catccacacg tgcctgtagc attccagagc tcactgccct tctagatgtg ccttcccgct
     2821 tggcttccag cggcttgtgc tcactctgtc tgccaggtat gagaagaaca cgtaagaccg
     2881 ccaccacact caccctccct caaggccctg tgccataggg gtggccaccc gacctgcccc
     2941 cagaactttt ggatactgga ggcagttgca taggtctccc tctctgggca ccaggactca
     3001 gtccagccca agactactct gggcagctcc catcccagtc tggggccatt tgcagactca
     3061 ggaaaggatt tctacagtgt tctataaaag ccaaaagaga gagtgggttt gggaagagtg
     3121 agggtggttg gggagagggg accgatgtgc ctcattgttt agtggtgatt acaaatatgc
     3181 ttttctggat aaagtttggt tgtttgctct tgg
//
