LOCUS       NM_001199867            5151 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens microtubule affinity regulating kinase 4 (MARK4),
            transcript variant 1, mRNA.
ACCESSION   NM_001199867
VERSION     NM_001199867.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5151)
  AUTHORS   Ma,F., Yao,J., Niu,X., Zhang,J., Shi,D. and Da,M.
  TITLE     MARK4 promotes the malignant phenotype of gastric cancer through
            the MAPK/ERK signaling pathway
  JOURNAL   Pathol Res Pract 261, 155471 (2024)
   PUBMED   39079384
  REMARK    GeneRIF: MARK4 promotes the malignant phenotype of gastric cancer
            through the MAPK/ERK signaling pathway.
REFERENCE   2  (bases 1 to 5151)
  AUTHORS   Li,Y., Cheng,M., Jin,J., Zhang,D., Zhang,S., Bai,Y. and Xu,J.
  TITLE     Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells
            apoptosis by activating Mark4 in vascular calcification
  JOURNAL   Aging (Albany NY) 16 (3), 2438-2456 (2024)
   PUBMED   38301049
  REMARK    GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth
            muscle cells apoptosis by activating Mark4 in vascular
            calcification.
REFERENCE   3  (bases 1 to 5151)
  AUTHORS   Samra,S., Sharma,M., Vaseghi-Shanjani,M., Del Bel,K.L., Byres,L.,
            Lin,S., Dalmann,J., Salman,A., Mwenifumbo,J., Modi,B.P.,
            Biggs,C.M., Boelman,C., Clarke,L.A., Lehman,A. and Turvey,S.E.
  TITLE     Gain-of-function MARK4 variant associates with pediatric
            neurodevelopmental disorder and dysmorphism
  JOURNAL   HGG Adv 5 (1), 100259 (2023)
   PUBMED   38041405
  REMARK    GeneRIF: Gain-of-function MARK4 variant associates with pediatric
            neurodevelopmental disorder and dysmorphism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5151)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 5151)
  AUTHORS   Natarajan,S.R., Ponnusamy,L. and Manoharan,R.
  TITLE     MARK2/4 promotes Warburg effect and cell growth in non-small cell
            lung carcinoma through the AMPKalpha1/mTOR/HIF-1alpha signaling
            pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (7), 119242 (2022)
   PUBMED   35192892
  REMARK    GeneRIF: MARK2/4 promotes Warburg effect and cell growth in
            non-small cell lung carcinoma through the
            AMPKalpha1/mTOR/HIF-1alpha signaling pathway.
REFERENCE   6  (bases 1 to 5151)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 5151)
  AUTHORS   Trinczek,B., Brajenovic,M., Ebneth,A. and Drewes,G.
  TITLE     MARK4 is a novel microtubule-associated proteins/microtubule
            affinity-regulating kinase that binds to the cellular microtubule
            network and to centrosomes
  JOURNAL   J Biol Chem 279 (7), 5915-5923 (2004)
   PUBMED   14594945
  REMARK    GeneRIF: MARK4 is likely to be directly involved in microtubule
            organization in neuronal cells
REFERENCE   8  (bases 1 to 5151)
  AUTHORS   Beghini,A., Magnani,I., Roversi,G., Piepoli,T., Di Terlizzi,S.,
            Moroni,R.F., Pollo,B., Fuhrman Conti,A.M., Cowell,J.K.,
            Finocchiaro,G. and Larizza,L.
  TITLE     The neural progenitor-restricted isoform of the MARK4 gene in
            19q13.2 is upregulated in human gliomas and overexpressed in a
            subset of glioblastoma cell lines
  JOURNAL   Oncogene 22 (17), 2581-2591 (2003)
   PUBMED   12735302
  REMARK    GeneRIF: Normally expressed in neural progenitors, re-expressed in
            gliomas and may become a target of amplification upon chr. 19
            rearrangement.
REFERENCE   9  (bases 1 to 5151)
  AUTHORS   Kato,T., Satoh,S., Okabe,H., Kitahara,O., Ono,K., Kihara,C.,
            Tanaka,T., Tsunoda,T., Yamaoka,Y., Nakamura,Y. and Furukawa,Y.
  TITLE     Isolation of a novel human gene, MARKL1, homologous to MARK3 and
            its involvement in hepatocellular carcinogenesis
  JOURNAL   Neoplasia 3 (1), 4-9 (2001)
   PUBMED   11326310
REFERENCE   10 (bases 1 to 5151)
  AUTHORS   Drewes,G., Ebneth,A., Preuss,U., Mandelkow,E.M. and Mandelkow,E.
  TITLE     MARK, a novel family of protein kinases that phosphorylate
            microtubule-associated proteins and trigger microtubule disruption
  JOURNAL   Cell 89 (2), 297-308 (1997)
   PUBMED   9108484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006126.1, AC005581.1 and
            AC005781.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001199867.1.
            
            Summary: This gene encodes a member of the microtubule
            affinity-regulating kinase family. These protein kinases
            phosphorylate microtubule-associated proteins and regulate the
            transition between stable and dynamic microtubules. The encoded
            protein is associated with the centrosome throughout mitosis and
            may be involved in cell cycle control. Expression of this gene is a
            potential marker for cancer, and the encoded protein may also play
            a role in Alzheimer's disease. Pseudogenes of this gene are located
            on both the short and long arm of chromosome 3. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB088047.1, AY057448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262891.9/ ENSP00000262891.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AC006126.1         42744-43112
            370-570             AC005581.1         9421-9621
            571-624             AC005581.1         13545-13598
            625-673             AC005581.1         13751-13799
            674-739             AC005581.1         15116-15181
            740-810             AC005581.1         15272-15342
            811-867             AC005581.1         16657-16713
            868-1104            AC005581.1         21904-22140
            1105-1224           AC005581.1         28355-28474
            1225-1324           AC005581.1         28948-29047
            1325-1434           AC005581.1         30806-30915
            1435-1594           AC005581.1         31007-31166
            1595-1812           AC005581.1         37879-38096
            1813-1916           AC005781.1         7648-7751
            1917-2195           AC005781.1         10975-11253
            2196-2240           AC005781.1         13110-13154
            2241-5151           AC005781.1         15673-18583
FEATURES             Location/Qualifiers
     source          1..5151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..5151
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /note="microtubule affinity regulating kinase 4"
                     /db_xref="GeneID:57787"
                     /db_xref="HGNC:HGNC:13538"
                     /db_xref="MIM:606495"
     exon            1..369
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2577
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAP/microtubule affinity-regulating kinase like 1;
                     epididymis secretory sperm binding protein; MARK4
                     serine/threonine protein kinase; MAP/microtubule
                     affinity-regulating kinase 4"
                     /codon_start=1
                     /product="MAP/microtubule affinity-regulating kinase 4
                     isoform 1"
                     /protein_id="NP_001186796.1"
                     /db_xref="CCDS:CCDS56097.1"
                     /db_xref="GeneID:57787"
                     /db_xref="HGNC:HGNC:13538"
                     /db_xref="MIM:606495"
                     /translation="MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRN
                     SIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQK
                     LFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARA
                     KFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGS
                     PPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVP
                     FYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKR
                     IEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSD
                     TTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEE
                     RLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTR
                     RNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIR
                     STFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLT
                     RRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATA
                     AARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFR
                     TLVTRISNDLEL"
     exon            370..570
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            571..624
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            625..673
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            674..739
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            740..810
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            811..867
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1104
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1224
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1324
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1434
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1594
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1812
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1916
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2195
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2240
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..5151
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3530..3535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /note="hexamer: AATAAA"
     polyA_site      3538
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /note="major polyA site"
     regulatory      5133..5138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
                     /note="hexamer: AGTAAA"
     polyA_site      5151
                     /gene="MARK4"
                     /gene_synonym="MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D"
ORIGIN      
        1 ctccctcccc agcccctcca ccgcctccct ccgccgccgc ttgggccggc tccgcgcccc
       61 ctccgcggcc cccgcccgcc cgcctgcccg ccgcccccat ggcgcccggg gtccccgctg
      121 cacggggcca ctaggaccct cggcgtccct tcccctcccc cgccctgccc cctctcccgc
      181 cgcgcggacc cgggcgttct cggcgcccag cttttgagct cgcgtcccca ggccggcggg
      241 gggggagggg aagagagggg accctgggac ccccgccccc cccacccggc cgcccctgcc
      301 ccccgggacc cggagaagat gtcttcgcgg acggtgctgg ccccgggcaa cgatcggaac
      361 tcggacacgc atggcacctt gggcagtggc cgctcctcgg acaaaggccc gtcctggtcc
      421 agccgctcac tgggtgcccg ttgccggaac tccatcgcct cctgtcccga ggagcagccc
      481 cacgtgggca actaccgcct gctgaggacc attgggaagg gcaactttgc caaagtcaag
      541 ctggctcggc acatcctcac tggtcgggag gttgccatca agattatcga caaaacccag
      601 ctgaatccca gcagcctgca gaagctgttc cgagaagtcc gcatcatgaa gggcctaaac
      661 caccccaaca tcgtgaagct ctttgaggtg attgagactg agaagacgct gtacctggtg
      721 atggagtacg caagtgctgg agaagtgttt gactacctcg tgtcgcatgg ccgcatgaag
      781 gagaaggaag ctcgagccaa gttccgacag attgtttcgg ctgtgcacta ttgtcaccag
      841 aaaaatattg tacacaggga cctgaaggct gagaacctct tgctggatgc cgaggccaac
      901 atcaagattg ctgactttgg cttcagcaac gagttcacgc tgggatcgaa gctggacacg
      961 ttctgcggga gccccccata tgccgccccg gagctgtttc agggcaagaa gtacgacggg
     1021 ccggaggtgg acatctggag cctgggagtc atcctgtaca ccctcgtcag cggctccctg
     1081 cccttcgacg ggcacaacct caaggagctg cgggagcgag tactcagagg gaagtaccgg
     1141 gtccctttct acatgtcaac agactgtgag agcatcctgc ggagattttt ggtgctgaac
     1201 ccagctaaac gctgtactct cgagcaaatc atgaaagaca aatggatcaa catcggctat
     1261 gagggtgagg agttgaagcc atacacagag cccgaggagg acttcgggga caccaagaga
     1321 attgaggtga tggtgggtat gggctacaca cgggaagaaa tcaaagagtc cttgaccagc
     1381 cagaagtaca acgaagtgac cgccacctac ctcctgctgg gcaggaagac tgaggagggt
     1441 ggggaccggg gcgccccagg gctggccctg gcacgggtgc gggcgcccag cgacaccacc
     1501 aacggaacaa gttccagcaa aggcaccagc cacagcaaag ggcagcggag ttcctcttcc
     1561 acctaccacc gccagcgcag gcatagcgat ttctgtggcc catcccctgc acccctgcac
     1621 cccaaacgca gcccgacgag cacgggggag gcggagctga aggaggagcg gctgccaggc
     1681 cggaaggcga gctgcagcac cgcggggagt gggagtcgag ggctgccccc ctccagcccc
     1741 atggtcagca gcgcccacaa ccccaacaag gcagagatcc cagagcggcg gaaggacagc
     1801 acgagcaccc ccaacaacct ccctcctagc atgatgaccc gcagaaacac ctacgtttgc
     1861 acagaacgcc cgggggctga gcgcccgtca ctgttgccaa atgggaaaga aaacagctca
     1921 ggcaccccac gggtgccccc tgcctccccc tccagtcaca gcctggcacc cccatcaggg
     1981 gagcggagcc gcctggcacg tggttccacc atccgcagca ccttccatgg tggccaggtc
     2041 cgggaccggc gggcaggggg tgggggtggt gggggtgtgc agaatgggcc ccctgcctct
     2101 cccacactgg cccatgaggc tgcacccctg cccgccgggc ggccccgccc caccaccaac
     2161 ctcttcacca agctgacctc caaactgacc cgaagggtcg cagacgaacc tgagagaatc
     2221 gggggacctg aggtcacaag ttgccatcta ccttgggatc aaacggaaac cgccccccgg
     2281 ctgctccgat tcccctggag tgtgaagctg accagctcgc gccctcctga ggccctgatg
     2341 gcagctctgc gccaggccac agcagccgcc cgctgccgct gccgccagcc acagccgttc
     2401 ctgctggcct gcctgcacgg gggtgcgggc gggcccgagc ccctgtccca cttcgaagtg
     2461 gaggtctgcc agctgccccg gccaggcttg cggggagttc tcttccgccg tgtggcgggc
     2521 accgccctgg ccttccgcac cctcgtcacc cgcatctcca acgacctcga gctctgagcc
     2581 accacggtcc cagggccctt actcttcctc tcccttgtcg ccttcacttc tacaggaggg
     2641 gaaggggcca gggaggggat tctcccttta tcatcacctc agtttccctg aattatattt
     2701 gggggcaaag attgtcccct ctgctgttct ctggggccgc tcagcacaga agaaggatga
     2761 gggggctcag cggggggagc tggcaccttc ctggagcctc cagccagtcc tgtcctccct
     2821 cgccctacca agagggcacc tgaggagact ttggggacag ggcaggggca gggagggaaa
     2881 ctgaggaaat cttccattcc tcccaacagc tcaaaattag gccttgggca ggggcaggga
     2941 gagctgctga gcctaaagac tggagaatct gggggactgg gagtgggggt cagagaggca
     3001 gattccttcc cctcccgtcc cctcacgctc aaacccccac ttcctgcccc aggctggcgc
     3061 ggggcacttt gtacaaatcc ttgtaaatac cccacaccct cccctctgca aaggtctctt
     3121 gaggagctgc cgctgtcacc tacggttttt aagttattac accccgaccc tcctcctgtc
     3181 agccccctca cctgcagcct gttgcccaat aaatttaaga gagtcccccc ctccccaatg
     3241 ctgaccctag gattttcctt ccctgccctc acctgcaaat gagttaaaga agaggcgtgg
     3301 gaatccaggc agtggttttt cctttcggag cctcggtttt ctcatctgca gaatgggagc
     3361 ggtgggggtg ggaaggtaag gatggtcgtg gaagaaggca ggatggaact cggcctcatc
     3421 cccgaggccc cagttcctat atcgggcccc ccattcatcc actcacactc ccagccacca
     3481 tgttacactg gactctaagc cacttcttac tccagtagta aatttattca ataaacaatc
     3541 attgacccat gcctactcca tgccaggccc agtgctggac acagagacat gaagctctgt
     3601 ctgtgggaga cagggattct gacacagaca ccggacaaac cattgtcttg gggagcccag
     3661 aagagaaagt gggcagggtg gggtcattgg ggaagatgct ctagaggaat taatgctgga
     3721 atggggtgtt gaaggatgag taggagttag ttaggcattg agtttgccct gggcaaaagc
     3781 ccagaagtgg gagtatgtgg tatatcttca gagaactggg taatttcagt gtggctgctg
     3841 tgttgggcat ggatggagaa tcagcaagag aaatgctgta ttaggactaa taatccatct
     3901 acgctgctta agcaaaaagg tatttgttgg tttatgttac ttaatagtcc aggggcacct
     3961 ggcttcaggt aggtttgatc caggcatcag gccattgcat ctattttttc agtgtaagtt
     4021 gaattctagt aatttttatc aagtaagggc tcctttcctg gtggcacaga tgacttcagc
     4081 agttagaagt ttctatccct ccagctttct gcagcagaaa gaccctcatt gtcagtttcc
     4141 cagcaaaagt cccagggcag actctcattg gcccaaatgg gccatgtgat tttctctaaa
     4201 ccaatcactg tgactctaga gtggccagac tcagagctgc acttagtagg ggttcctcaa
     4261 aggaaggtca agtgtcatga gcaggagaaa aggcatggga gctggacaga ttatagtggt
     4321 tgaagtctgt gcagtacaga agggcggagc ttattcacac agcacctttg gggccaaaat
     4381 gaataagctg gactttctcc ccatggcact ggggaaccat ggaagttcag ggaacttcag
     4441 ggaagaggct tggtcaattc ctgagagcat cctctgtgct ggggacacag tggtaatcaa
     4501 gacagcccca acactgccct catagagctc acagtccaat ggaggaggca gatgtgtcct
     4561 caggcagcga ctgggcaggg ctggtatagg ggagtccaga ggtgatgcct gcctcagcca
     4621 gggagggctt cctggaggag aaggagccag ctagacatgg ataggagtgc gttttaggca
     4681 cagcaaatgg cacatacaag ggccagggag caagagagag gacaggtcct caacaaatgg
     4741 catgtgactt tgtaagtgta gaattgctgt gaggtatggg gctaggggcg tcagtagggc
     4801 cttgaaggtt atggacaggg gcctgggctt tcttccaagg gcactggggg agccatggca
     4861 aggttgtagg tagggtagag atgggcgggt ttgtgctatg tgcagggtgg aagggaggga
     4921 agttgacagg tcagaagatc aggaaagagg tcggggctgg acagatgggg agagcgcaga
     4981 tagatttaag agagtcctgt gaggcaaagt gggcaggacc tggtaacagg tgtctggact
     5041 gtggctttgg ctggctcaga aggtccccac tggcgtgtgt ggtctatgta gcctctgggt
     5101 gtggagctgg gatcttcaac tggggacagt acagtaaaga acatcacagc a
//
