LOCUS       NM_001128918            3481 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens microtubule affinity regulating kinase 3 (MARK3),
            transcript variant 1, mRNA.
ACCESSION   NM_001128918
VERSION     NM_001128918.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Aparicio-Bautista,D.I., Jimenez-Ortega,R.F., Becerra-Cervera,A.,
            Aquino-Galvez,A., de Leon-Suarez,V.P., Casas-Avila,L., Salmeron,J.,
            Hidalgo-Bravo,A., Rivera-Paredez,B. and Velazquez-Cruz,R.
  TITLE     Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and
            GEMIN2 (rs2277458) variants with bone mineral density and serum
            25-hidroxivitamin D levels in Mexican Mestizo women
  JOURNAL   Front Endocrinol (Lausanne) 15, 1392063 (2024)
   PUBMED   38715801
  REMARK    GeneRIF: Interaction between MARK3 (rs11623869), PLCB4 (rs6086746)
            and GEMIN2 (rs2277458) variants with bone mineral density and serum
            25-hidroxivitamin D levels in Mexican Mestizo women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Machino,H., Kaneko,S., Komatsu,M., Ikawa,N., Asada,K., Nakato,R.,
            Shozu,K., Dozen,A., Sone,K., Yoshida,H., Kato,T., Oda,K., Osuga,Y.,
            Fujii,T., von Keudell,G., Saloura,V. and Hamamoto,R.
  TITLE     The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a
            tumor suppressor in high-grade serous ovarian carcinoma
  JOURNAL   Commun Biol 5 (1), 39 (2022)
   PUBMED   35017636
  REMARK    GeneRIF: The metabolic stress-activated checkpoint LKB1-MARK3 axis
            acts as a tumor suppressor in high-grade serous ovarian carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   Li,M.G., Katsura,K., Nomiyama,H., Komaki,K., Ninomiya-Tsuji,J.,
            Matsumoto,K., Kobayashi,T. and Tamura,S.
  TITLE     Regulation of the interleukin-1-induced signaling pathways by a
            novel member of the protein phosphatase 2C family (PP2Cepsilon)
  JOURNAL   J Biol Chem 278 (14), 12013-12021 (2003)
   PUBMED   12556533
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Sun,T.Q., Lu,B., Feng,J.J., Reinhard,C., Jan,Y.N., Fantl,W.J. and
            Williams,L.T.
  TITLE     PAR-1 is a Dishevelled-associated kinase and a positive regulator
            of Wnt signalling
  JOURNAL   Nat Cell Biol 3 (7), 628-636 (2001)
   PUBMED   11433294
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Peng,C.Y., Graves,P.R., Ogg,S., Thoma,R.S., Byrnes,M.J. 3rd, Wu,Z.,
            Stephenson,M.T. and Piwnica-Worms,H.
  TITLE     C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and
            promotes 14-3-3 protein binding
  JOURNAL   Cell Growth Differ 9 (3), 197-208 (1998)
   PUBMED   9543386
REFERENCE   9  (bases 1 to 3481)
  AUTHORS   Ono,T., Kawabe,T., Sonta,S. and Okamoto,T.
  TITLE     Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 101-102 (1997)
   PUBMED   9533022
REFERENCE   10 (bases 1 to 3481)
  AUTHORS   Meller,N., Liu,Y.C., Collins,T.L., Bonnefoy-Berard,N., Baier,G.,
            Isakov,N. and Altman,A.
  TITLE     Direct interaction between protein kinase C theta (PKC theta) and
            14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition
            of PKC theta translocation and function
  JOURNAL   Mol Cell Biol 16 (10), 5782-5791 (1996)
   PUBMED   8816492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA707357.1, AL133367.4,
            AF465413.1, BX248250.1 and BC024773.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001128918.2.
            
            Summary: The protein encoded by this gene is activated by
            phosphorylation and in turn is involved in the phosphorylation of
            tau proteins MAP2 and MAP4. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.154392.1,
                                           SRR1803613.163292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429436.7/ ENSP00000411397.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               DA707357.1         52-463
            413-413             AL133367.4         150463-150463       c
            414-474             DA707357.1         465-525
            475-1029            AF465413.1         370-924
            1030-1030           AL133367.4         79146-79146         c
            1031-2908           AF465413.1         926-2803
            2909-3467           BX248250.1         1330-1888
            3468-3481           BC024773.1         3270-3283
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32-q32.33"
     gene            1..3481
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="microtubule affinity regulating kinase 3"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
     exon            1..666
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..2877
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     EMK-2; C-TAK1; ELKL motif kinase 2; protein kinase STK10;
                     ser/Thr protein kinase PAR-1; cdc25C-associated protein
                     kinase 1; MAP/microtubule affinity-regulating kinase 3;
                     serine/threonine-protein kinase p78"
                     /codon_start=1
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform a"
                     /protein_id="NP_001122390.2"
                     /db_xref="CCDS:CCDS45165.1"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
                     /translation="MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIA
                     SCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFR
                     EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR
                     QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPY
                     AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM
                     STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDI
                     MVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSD
                     LNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGI
                     SSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTY
                     VCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFH
                     GQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKR
                     LPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKV
                     LDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAF
                     KNIASKIANELKL"
     exon            667..858
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            859..912
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            913..961
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1027
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1098
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1155
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1392
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1512
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1612
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1725
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1879
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2097
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2201
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2459
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2486
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2531
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..3481
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="hexamer: ATTAAA"
     polyA_site      2932
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="major polyA site"
     regulatory      2989..2994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="hexamer: ATTAAA"
     polyA_site      3011
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="major polyA site"
     regulatory      3454..3459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="hexamer: ATTAAA"
     polyA_site      3481
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /note="major polyA site"
ORIGIN      
        1 ggctccgtga ggctctgagg tgccggggtg cggcggcggc agcggcggcc agcagggcgg
       61 aggctgaggc agcaagctcg ctagagaggg agaagcagtc gggcgcaggc gcctcctccg
      121 cagcccgctc catggtcggc gcccacagcc cgcggcggcc tgtcttgcgc tccacttcct
      181 tcacatcctc ctccgcctcc tcgttttcag gcgccgccgg cggcgctgtg tggaggcccg
      241 cgagctgaaa ttcgcggtgc gacgggaggg agtggagaag gaggtgaggg ggcccaggat
      301 cgcggggcgc cctgaggcaa ggggacgccg gcgggccgaa gcgcagcccg ccgcccgcag
      361 gctcggctcc gccactgccg ccctcccggt ctcctcgcct cggccgccga ggcagggaga
      421 gaatgagccc cgggacccgc cgggggacgg cccgggccag gcccgggatc tagacggccg
      481 tagggggaag ggagccgccc tccccacggc gccttttcgg aactgccgtg gactcgagga
      541 cgctggtcgc cggcctccta gggctgtgct gttttgtttt gaccctcgca ttgtgcagaa
      601 ttaaagtgca gtaaaatgtc cactaggacc ccattgccaa cggtgaatga acgagacact
      661 gaaaaccaca cgtcacatgg agatgggcgt caagaagtta cctctcgtac cagccgctca
      721 ggagctcggt gtagaaactc tatagcctcc tgtgcagatg aacaacctca catcggaaac
      781 tacagactgt tgaaaacaat cggcaagggg aattttgcaa aagtaaaatt ggcaagacat
      841 atccttacag gcagagaggt tgcaataaaa ataattgaca aaactcagtt gaatccaaca
      901 agtctacaaa agctcttcag agaagtaaga ataatgaaga ttttaaatca tcccaatata
      961 gtgaagttat tcgaagtcat tgaaactgaa aaaacactct acctaatcat ggaatatgca
     1021 agtggaggtg aagtatttga ctatttggtt gcacatggca ggatgaagga aaaagaagca
     1081 agatctaaat ttagacagat tgtgtctgca gttcaatact gccatcagaa acggatcgta
     1141 catcgagacc tcaaggctga aaatctattg ttagatgccg atatgaacat taaaatagca
     1201 gatttcggtt ttagcaatga atttactgtt ggcggtaaac tcgacacgtt ttgtggcagt
     1261 cctccatacg cagcacctga gctcttccag ggcaagaaat atgacgggcc agaagtggat
     1321 gtgtggagtc tgggggtcat tttatacaca ctagtcagtg gctcacttcc ctttgatggg
     1381 caaaacctaa aggaactgag agagagagta ttaagaggga aatacagaat tcccttctac
     1441 atgtctacag actgtgaaaa ccttctcaaa cgtttcctgg tgctaaatcc aattaaacgc
     1501 ggcactctag agcaaatcat gaaggacagg tggatcaatg cagggcatga agaagatgaa
     1561 ctcaaaccat ttgttgaacc agagctagac atctcagacc aaaaaagaat agatattatg
     1621 gtgggaatgg gatattcaca agaagaaatt caagaatctc ttagtaagat gaaatacgat
     1681 gaaatcacag ctacatattt gttattgggg agaaaatctt cagagctgga tgctagtgat
     1741 tccagttcta gcagcaatct ttcacttgct aaggttaggc cgagcagtga tctcaacaac
     1801 agtactggcc agtctcctca ccacaaagtg cagagaagtg tttcttcaag ccaaaagcaa
     1861 agacgctaca gtgaccatgc tggaccagct attccttctg ttgtggcgta tccgaaaagg
     1921 agtcagacca gcactgcaga tagtgacctc aaagaagatg gaatttcctc ccggaaatca
     1981 agtggcagtg ctgttggagg aaagggaatt gctccagcca gtcccatgct tgggaatgca
     2041 agtaatccta ataaggcgga tattcctgaa cgcaagaaaa gctccactgt ccctagtagt
     2101 aacacagcat ctggtggaat gacacgacga aatacttatg tttgcagtga gagaactaca
     2161 gctgatagac actcagtgat tcagaatggc aaagaaaaca gcactattcc tgatcagaga
     2221 actccagttg cttcaacaca cagtatcagt agtgcagcca ccccagatcg aatccgcttc
     2281 ccaagaggca ctgccagtcg tagcactttc cacggccagc cccgggaacg gcgaaccgca
     2341 acatataatg gccctcctgc ctctcccagc ctgtcccatg aagccacacc attgtcccag
     2401 actcgaagcc gaggctccac taatctcttt agtaaattaa cttcaaaact cacaaggaga
     2461 aacatgtcat tcaggtttat caaaaggctt ccaactgaat atgagaggaa cgggagatat
     2521 gagggctcaa gtcgcaatgt atctgctgag caaaaagatg aaaacaaaga agcaaagcct
     2581 cgatccctac gcttcacctg gagcatgaaa accactagtt caatggatcc cggggacatg
     2641 atgcgggaaa tccgcaaagt gttggacgcc aataactgcg actatgagca gagggagcgc
     2701 ttcttgctct tctgcgtcca cggagatggg cacgcggaga acctcgtgca gtgggaaatg
     2761 gaagtgtgca agctgccaag actgtctctg aacggggtcc ggtttaagcg gatatcgggg
     2821 acatccatag ccttcaaaaa tattgcttcc aaaattgcca atgagctaaa gctgtaaccc
     2881 agtgattatg atgtaaatta agtagcaatt aaagtgtttt cctgaacact gatggaaatg
     2941 tatagaataa tatttaggca ataacgtctg catcttctaa atcatgaaat taaagtctga
     3001 ggacgagagc acgcctggga gcgaaagctg gccttttttc tacgaatgca ctacattaaa
     3061 gatgtgcaac ctatgcgccc cctgccctac ttccgttacc ctgagagtcg gtgtgtggcc
     3121 ccatctccat gtgcctcccg tctgggtggg tgtgagagtg gacggtatgt gtgtgaagtg
     3181 gtgtatatgg aagcatctcc ctacactggc agccagtcat tactagtacc tctgcgggag
     3241 atcatccggt gctaaaacat tacagttgcc aaggaggaaa atactgaatg actgctaaga
     3301 attaacctta agaccagttc atagttaata caggtttaca gttcatgcct gtggttttgt
     3361 gtttgttgtt ttgtgttttt ttagtgcaaa aggtttaaat ttatagttgt gaacattgct
     3421 tgtgtgtgtt tttctaagta gattcacaag ataattaaaa attcactttt tctcagtaaa
     3481 a
//
