LOCUS       NP_001122390             753 aa            linear   PRI 03-APR-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform a [Homo
            sapiens].
ACCESSION   NP_001122390
VERSION     NP_001122390.2
DBSOURCE    REFSEQ: accession NM_001128918.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 753)
  AUTHORS   Aparicio-Bautista,D.I., Jimenez-Ortega,R.F., Becerra-Cervera,A.,
            Aquino-Galvez,A., de Leon-Suarez,V.P., Casas-Avila,L., Salmeron,J.,
            Hidalgo-Bravo,A., Rivera-Paredez,B. and Velazquez-Cruz,R.
  TITLE     Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and
            GEMIN2 (rs2277458) variants with bone mineral density and serum
            25-hidroxivitamin D levels in Mexican Mestizo women
  JOURNAL   Front Endocrinol (Lausanne) 15, 1392063 (2024)
   PUBMED   38715801
  REMARK    GeneRIF: Interaction between MARK3 (rs11623869), PLCB4 (rs6086746)
            and GEMIN2 (rs2277458) variants with bone mineral density and serum
            25-hidroxivitamin D levels in Mexican Mestizo women.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 753)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 753)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (residues 1 to 753)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (residues 1 to 753)
  AUTHORS   Machino,H., Kaneko,S., Komatsu,M., Ikawa,N., Asada,K., Nakato,R.,
            Shozu,K., Dozen,A., Sone,K., Yoshida,H., Kato,T., Oda,K., Osuga,Y.,
            Fujii,T., von Keudell,G., Saloura,V. and Hamamoto,R.
  TITLE     The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a
            tumor suppressor in high-grade serous ovarian carcinoma
  JOURNAL   Commun Biol 5 (1), 39 (2022)
   PUBMED   35017636
  REMARK    GeneRIF: The metabolic stress-activated checkpoint LKB1-MARK3 axis
            acts as a tumor suppressor in high-grade serous ovarian carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 753)
  AUTHORS   Li,M.G., Katsura,K., Nomiyama,H., Komaki,K., Ninomiya-Tsuji,J.,
            Matsumoto,K., Kobayashi,T. and Tamura,S.
  TITLE     Regulation of the interleukin-1-induced signaling pathways by a
            novel member of the protein phosphatase 2C family (PP2Cepsilon)
  JOURNAL   J Biol Chem 278 (14), 12013-12021 (2003)
   PUBMED   12556533
REFERENCE   7  (residues 1 to 753)
  AUTHORS   Sun,T.Q., Lu,B., Feng,J.J., Reinhard,C., Jan,Y.N., Fantl,W.J. and
            Williams,L.T.
  TITLE     PAR-1 is a Dishevelled-associated kinase and a positive regulator
            of Wnt signalling
  JOURNAL   Nat Cell Biol 3 (7), 628-636 (2001)
   PUBMED   11433294
REFERENCE   8  (residues 1 to 753)
  AUTHORS   Peng,C.Y., Graves,P.R., Ogg,S., Thoma,R.S., Byrnes,M.J. 3rd, Wu,Z.,
            Stephenson,M.T. and Piwnica-Worms,H.
  TITLE     C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and
            promotes 14-3-3 protein binding
  JOURNAL   Cell Growth Differ 9 (3), 197-208 (1998)
   PUBMED   9543386
REFERENCE   9  (residues 1 to 753)
  AUTHORS   Ono,T., Kawabe,T., Sonta,S. and Okamoto,T.
  TITLE     Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 101-102 (1997)
   PUBMED   9533022
REFERENCE   10 (residues 1 to 753)
  AUTHORS   Meller,N., Liu,Y.C., Collins,T.L., Bonnefoy-Berard,N., Baier,G.,
            Isakov,N. and Altman,A.
  TITLE     Direct interaction between protein kinase C theta (PKC theta) and
            14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition
            of PKC theta translocation and function
  JOURNAL   Mol Cell Biol 16 (10), 5782-5791 (1996)
   PUBMED   8816492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA707357.1, AL133367.4,
            AF465413.1, BX248250.1 and BC024773.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 11, 2014 this sequence version replaced NP_001122390.1.
            
            Summary: The protein encoded by this gene is activated by
            phosphorylation and in turn is involved in the phosphorylation of
            tau proteins MAP2 and MAP4. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.154392.1,
                                           SRR1803613.163292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429436.7/ ENSP00000411397.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.32-q32.33"
     Protein         1..753
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform a"
                     /EC_number="2.7.11.1"
                     /note="EMK-2; C-TAK1; ELKL motif kinase 2; protein kinase
                     STK10; ser/Thr protein kinase PAR-1; cdc25C-associated
                     protein kinase 1; MAP/microtubule affinity-regulating
                     kinase 3; serine/threonine-protein kinase p78"
                     /calculated_mol_wt=84298
     Region          1..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27448.5)"
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Region          55..307
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,83,85,116,132..135,139,141..142,144,
                     177..178,180,182..183,185,195..196,199,212..217,219,
                     249..252,254)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,83,85,116,132..135,139,182..183,185,
                     195..196)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,139,141,177..178,180,182,199,213..217,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            195..217
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Site            211
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by LKB1.
                     /evidence=ECO:0000269|PubMed:14976552; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Region          325..367
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q03141; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Region          370..600
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27448.5)"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q03141; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            400
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            419
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            469
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            540
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q03141; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            549
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18220336,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (P27448.5)"
     Site            564
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCZ.
                     /evidence=ECO:0000269|PubMed:15084291; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            583
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            598
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Site            601
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Region          632..655
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P27448.5)"
     Site            643
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (P27448.5)"
     Region          654..751
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(656,659,729,731..732)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..753
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="NM_001128918.3:616..2877"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS45165.1"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr evaikiidkt qlnptslqkl frevrimkil nhpnivklfe
      121 vietektlyl imeyasggev fdylvahgrm kekearskfr qivsavqych qkrivhrdlk
      181 aenllldadm nikiadfgfs neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg
      241 vilytlvsgs lpfdgqnlke lrervlrgky ripfymstdc enllkrflvl npikrgtleq
      301 imkdrwinag heedelkpfv epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat
      361 ylllgrksse ldasdsssss nlslakvrps sdlnnstgqs phhkvqrsvs ssqkqrrysd
      421 hagpaipsvv aypkrsqtst adsdlkedgi ssrkssgsav ggkgiapasp mlgnasnpnk
      481 adiperkkss tvpssntasg gmtrrntyvc serttadrhs viqngkenst ipdqrtpvas
      541 thsissaatp drirfprgta srstfhgqpr errtatyngp paspslshea tplsqtrsrg
      601 stnlfsklts kltrrnmsfr fikrlpteye rngryegssr nvsaeqkden keakprslrf
      661 twsmkttssm dpgdmmreir kvldanncdy eqrerfllfc vhgdghaenl vqwemevckl
      721 prlslngvrf krisgtsiaf kniaskiane lkl
//
