LOCUS       NM_014647               7730 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens meiosis regulator and mRNA stability factor 1 (MARF1),
            transcript variant 1, mRNA.
ACCESSION   NM_014647
VERSION     NM_014647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7730)
  AUTHORS   Brothers,W.R., Fakim,H., Kajjo,S. and Fabian,M.R.
  TITLE     P-bodies directly regulate MARF1-mediated mRNA decay in human cells
  JOURNAL   Nucleic Acids Res 50 (13), 7623-7636 (2022)
   PUBMED   35801873
  REMARK    GeneRIF: P-bodies directly regulate MARF1-mediated mRNA decay in
            human cells.
REFERENCE   2  (bases 1 to 7730)
  AUTHORS   Brothers,W.R., Hebert,S., Kleinman,C.L. and Fabian,M.R.
  TITLE     A non-canonical role for the EDC4 decapping factor in regulating
            MARF1-mediated mRNA decay
  JOURNAL   Elife 9, e54995 (2020)
   PUBMED   32510323
  REMARK    GeneRIF: A non-canonical role for the EDC4 decapping factor in
            regulating MARF1-mediated mRNA decay.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7730)
  AUTHORS   Nishimura,T., Fakim,H., Brandmann,T., Youn,J.Y., Gingras,A.C.,
            Jinek,M. and Fabian,M.R.
  TITLE     Human MARF1 is an endoribonuclease that interacts with the DCP1:2
            decapping complex and degrades target mRNAs
  JOURNAL   Nucleic Acids Res 46 (22), 12008-12021 (2018)
   PUBMED   30364987
  REMARK    GeneRIF: Human MARF1 is an endoribonuclease that interacts with the
            DCP1:DCP2 decapping complex and degrades target mRNAs.
REFERENCE   5  (bases 1 to 7730)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   6  (bases 1 to 7730)
  AUTHORS   Su,Y.Q., Sun,F., Handel,M.A., Schimenti,J.C. and Eppig,J.J.
  TITLE     Meiosis arrest female 1 (MARF1) has nuage-like function in
            mammalian oocytes
  JOURNAL   Proc Natl Acad Sci U S A 109 (46), 18653-18660 (2012)
   PUBMED   23090997
REFERENCE   7  (bases 1 to 7730)
  AUTHORS   Su,Y.Q., Sugiura,K., Sun,F., Pendola,J.K., Cox,G.A., Handel,M.A.,
            Schimenti,J.C. and Eppig,J.J.
  TITLE     MARF1 regulates essential oogenic processes in mice
  JOURNAL   Science 335 (6075), 1496-1499 (2012)
   PUBMED   22442484
REFERENCE   8  (bases 1 to 7730)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 7730)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   10 (bases 1 to 7730)
  AUTHORS   Dunster,K., Lai,F.P. and Sentry,J.W.
  TITLE     Limkain b1, a novel human autoantigen localized to a subset of
            ABCD3 and PXF marked peroxisomes
  JOURNAL   Clin Exp Immunol 140 (3), 556-563 (2005)
   PUBMED   15932519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064914.1, BC137165.1, AB007890.3 and DB360504.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014647.3.
            
            Summary: This gene encodes a putative peroxisomal protein that
            appears to be conserved across Euteleostomi. In humans, it may be
            autoantigenic. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137165.1, SRR1803612.107373.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396368.8/ ENSP00000379654.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BC064914.1         13-58
            47-5946             BC137165.1         1-5900
            5947-7729           AB007890.3         5045-6827
            7730-7730           DB360504.1         19-19               c
FEATURES             Location/Qualifiers
     source          1..7730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..7730
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /note="meiosis regulator and mRNA stability factor 1"
                     /db_xref="GeneID:9665"
                     /db_xref="HGNC:HGNC:29562"
                     /db_xref="MIM:614593"
     exon            1..137
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            138..339
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..5424
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     limkain-b1; protein phosphatase 1, regulatory subunit 34;
                     meiosis arrest female protein 1; meiosis arrest female 1"
                     /codon_start=1
                     /product="meiosis regulator and mRNA stability factor 1
                     isoform 1"
                     /protein_id="NP_055462.2"
                     /db_xref="CCDS:CCDS10562.2"
                     /db_xref="GeneID:9665"
                     /db_xref="HGNC:HGNC:29562"
                     /db_xref="MIM:614593"
                     /translation="MMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPH
                     SPQTKEYMENKKVAVELKDVPSPLHAGSKLFPAVPLPDIRSLQQPKIQLSSVPKVSCC
                     AHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSL
                     QNASARNNLAGIASDFPSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGC
                     TSAGYFPCSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLKGSLYCEDCLN
                     KPARNSIIDAAKVWPNIPPPNTQPAPLAVPLCNGCGTKGTGKETTLLLATSLGKAASK
                     FGSPEVAVAGQVLENLPPIGVFWDIENCSVPSGRSATAVVQRIREKFFKGHREAEFIC
                     VCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLVS
                     TDVNFALELSDLRHRHGFHIILVHKNQASEALLHHANELIRFEEFISDLPPRLPLKMP
                     QCHTLLYVYNLPANKDGKSVSNRLRRLSDNCGGKVLSITGCSAILRFINQDSAERAQK
                     RMENEDVFGNRIIVSFTPKNRELCETKSSNAIADKVKSPKKLKNPKLCLIKDASEQSS
                     SAKATPGKGSQANSGSATKNTNVKSLQELCRMESKTGHRNSEHQQGHLRLVVPTHGNS
                     SAAVSTPKNSGVAEPVYKTSQKKENLSARSVTSSPVEKKDKEETVFQVSYPSAFSKLV
                     ASRQVSPLLASQSWSSRSMSPNLLNRASPLAFNIANSSSEADCPDPFANGADVQVSNI
                     DYRLSRKELQQLLQEAFARHGKVKSVELSPHTDYQLKAVVQMENLQDAIGAVNSLHRY
                     KIGSKKILVSLATGAASKSLSLLSAETMSVLQDAPACCLPLFKFTDIYEKKFGHKLNV
                     SDLYKLTDTVAIREQGNGRLVCLLPSSQARQSPLGSSQSHDGSSTNCSPIIFEELEYH
                     EPVCRQHCSNKDFSEHEFDPDSYKIPFVILSLKTFAPQVHSLLQTHEGTVPLLSFPDC
                     YIAEFGDLEVVQENQGGVPLEHFITCVPGVNIATAQNGIKVVKWIHNKPPPPNTDPWL
                     LRSKSPVGNPQLIQFSREVIDLLKSQPSCVIPISHFIPSYHHHFAKQCRVSDYGYSKL
                     IELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQDLLKLLKSQASKQVIVREFSQAY
                     HWCFSKDWDVTEYGVCELIDIVSEIPDTTICLSQQDNEMVICIPKRERTQDEIERTKQ
                     FSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELFEAIPDTLQVL
                     ECGEEKILTLTEVERFKALAAQFVKLLRSQKDNCLMMTDLLTEYAKTFGYTFRLQDYD
                     VSSISALTQKLCHVVKVADIESGRQIQLINRKSLRSLTAQLLVLLMSWEGTTHLSVEE
                     LKRHYESTHNTPLNPCEYGFMTLTELLKSLPYLVEVFTNDKMEECVKLTSLYLFAKNV
                     RSLLHTYHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVWIKGHGHK
                     RIVVLKNDMKSRLSSLSLSPANHENQPSEGERILEVPESHTASELKLGADGSGPSHTE
                     QELLRLTDDSPVDLLCAPVPSCLPSPQLRPDPVILQSADLIQFEERPQEPSEIMILNQ
                     EEKMEIPIPGKSKTLTSDSSSSCISAAVPVPPCPSSETSESLLSKDPVESPAKKQPKN
                     RVKLAANFSLAPITKL"
     exon            340..1026
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1201
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1428
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1546
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1719
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..2148
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2306
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2465
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2655
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2834
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2915
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3152
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3272
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3448
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3669
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3812
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3946
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4149
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4377
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4608
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4821
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..4882
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..5008
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            5009..5179
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..7730
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7706..7711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /note="hexamer: AATAAA"
     polyA_site      7730
                     /gene="MARF1"
                     /gene_synonym="KIAA0430; LKAP; LMKB; PPP1R34"
                     /note="major polyA site"
ORIGIN      
        1 gcggaagcgg aagtgaaggg tgcgcttggc ggcggcggcg ggagctgcgg agtcgggaat
       61 caaaacaaag ggcctggggg gggcgggggg aaggcggcgg ggccggaatg tgagcggagg
      121 tggagccggc ggcagagggt ggaagaatga aagaaaagaa agatgaaagg atgttgaatc
      181 actttgcatg gctgtatgat ggaaggaaac ggaactgaga actcctgcag tagaacacgt
      241 ggatggcttc aacaagataa tgatgctaag ccatggcttt ggaaattctc taattgcttt
      301 tctcgtcctg agcagacgct gccacatagt ccccaaacga aagagtacat ggagaacaag
      361 aaagttgctg tggaactaaa ggatgtacca tcaccccttc atgctggctc taagcttttt
      421 ccagcagtcc cacttcctga tattcgttct cttcagcagc ctaaaataca gctttcttct
      481 gtccccaaag taagctgctg tgctcattgc cctaatgaac cctccacttc gccaatgcgt
      541 tttggtggtg gtggtggcgg tagcggaggt accagtagct tgattcaccc gggcgcactg
      601 ttagactcgc aaagcaccag gacaatcacg tgtcaggtag ggtcagggtt tgctttccag
      661 tctgcatctt cactccagaa tgcctcagct aggaacaatt tggcaggcat tgcaagtgac
      721 tttcccagca tgtgtctaga gagtaacctg tcttcctgca aacacctgcc ctgttgtgga
      781 aaactccact tccagtcatg tcatggtaat gtgcacaagc tgcatcagtt tccgagtctg
      841 cagggctgca cctccgctgg ctatttcccc tgttctgatt tcacaagcgg ggctccaggg
      901 catttggaag agcacatttc acagtcggag ctaacgcctc acttgtgcac caactctttg
      961 caccttaatg tggtacctcc ggtttgttta aagggctcac tttactgcga agactgtcta
     1021 aacaagccag caagaaatag cataatcgat gcggctaaag tctggccaaa tataccacct
     1081 ccaaatactc aacctgcacc tcttgctgtc cctctgtgta atggctgtgg aaccaaagga
     1141 acagggaagg agaccacgtt gttattggcg accagtctag gcaaagctgc ttcaaaattt
     1201 gggtcaccag aagttgcagt agctggacag gtgctagaaa acttaccccc cattggagtt
     1261 ttttgggata ttgaaaactg ctccgttccc tctggccggt cagcaactgc tgttgtgcaa
     1321 agaatccgtg agaagttttt taaaggccac agagaagcag aattcatctg tgtatgtgac
     1381 atcagtaaag aaaacaagga agttattcaa gagctgaata attgccaggt aaccgttgcc
     1441 cacatcaatg ctactgcaaa gaatgccgct gatgataaac tgcggcagag tctccgcaga
     1501 tttgcaaata cacacactgc tccagccaca gtggttcttg tgtcaactga tgtcaatttt
     1561 gcattggaac ttagtgacct gagacacagg catggtttcc acattatttt ggtccataaa
     1621 aaccaggcct cagaagcact gctgcatcat gctaacgagc tgatcagatt tgaagagttc
     1681 atttccgact tgccccccag gttaccacta aaaatgccac agtgccacac tctgctctat
     1741 gtttataacc taccagcaaa taaggatggc aagagcgtca gcaacaggct cagacgcctg
     1801 tccgataatt gtggtgggaa agtgctgagt atcacaggct gcagtgcaat tctccgcttc
     1861 ataaaccaag atagtgcaga gcgcgctcag aagcgaatgg aaaacgaaga tgtctttggt
     1921 aataggatca ttgtgtcatt tactccaaaa aatagagaac tctgtgaaac aaagagttca
     1981 aatgcaattg ctgataaagt gaagtctccc aaaaaactta agaatccaaa attgtgcctc
     2041 atcaaagatg caagtgaaca atcttccagt gccaaagcca cgcctggaaa agggtcacag
     2101 gcaaattctg gatctgctac aaaaaataca aatgttaaaa gtttacagga gctgtgccgc
     2161 atggagtcaa aaactggtca tagaaacagt gagcaccagc aaggtcacct gaggctggtc
     2221 gtacccactc acggtaactc aagtgctgca gtgtcgacgc cgaaaaactc gggggtggca
     2281 gaacccgttt acaaaaccag tcagaaaaag gagaacctca gtgcccgaag tgttaccagt
     2341 tctcctgtag agaaaaaaga taaagaggag actgtattcc aagtgagtta cccgtctgct
     2401 tttagcaagt tagttgcatc caggcaagtc agtcctctgc tcgcatctca gtcttggtct
     2461 tctaggagta tgtctccaaa ccttttaaac agagcatccc cgcttgcttt caacattgca
     2521 aattcgagca gcgaagccga ctgcccagac ccatttgcaa atggtgctga tgtccaagtc
     2581 agcaacatag actacagatt atcccggaag gagctgcagc agctcctgca ggaagcattt
     2641 gccaggcatg gcaaggtgaa gagtgttgag ctcagccccc atacagatta tcaactcaag
     2701 gctgttgtgc aaatggaaaa cttacaagat gcgatcggtg cagtgaatag cctccacaga
     2761 tacaaaattg gcagcaaaaa gatcctggtc tcacttgcca ccggggctgc cagcaaatca
     2821 ctctctttac tgagtgcaga aacaatgtct gttcttcagg atgcccctgc ctgttgcctg
     2881 cctctgttta aatttacaga tatctatgaa aaaaagtttg gacacaagtt gaatgtgtca
     2941 gatctatata aattaacaga cacggtcgca atccgtgaac aaggaaacgg acggctggtg
     3001 tgtctcctac ccagcagtca ggcccgccag agccccttgg ggtcttccca gtcacacgac
     3061 ggctcctcca cgaattgcag cccaattata tttgaagagt tagaatatca cgagcctgtc
     3121 tgcagacagc attgttccaa taaggatttc agcgaacatg aatttgatcc agactcttac
     3181 aagattcctt ttgtgattct ttctttgaag acatttgcgc cccaggttca cagtcttctc
     3241 cagacccacg agggcaccgt gcctttattg agctttccag attgttacat tgcagagttt
     3301 ggcgatctag aagtagtgca agaaaaccaa ggaggtgttc ccttagaaca cttcattacc
     3361 tgtgttccag gtgtaaacat tgccactgct cagaatggca tcaaagtggt taaatggatt
     3421 cacaacaagc ccccgcctcc caacactgac ccttggcttc tgcgttcgaa gagtcctgta
     3481 ggtaaccccc agctgatcca gttcagtaga gaagtgattg acttgctgaa aagccagcca
     3541 tcttgtgtca tacccatcag tcatttcatc ccatcctatc accatcattt tgcaaagcag
     3601 tgccgagtgt cagactacgg atactccaag ctgattgagt tattagaagc agtgcctcat
     3661 gtattgcaga ttcttggaat gggctccaaa cgtctgctga cccttaccca cagggcccag
     3721 gtgaagcgct ttactcagga tttactaaaa cttctcaaat cccaggccag caaacaggtc
     3781 attgtgagag aattctcaca ggcttatcac tggtgtttct caaaggactg ggatgtcact
     3841 gaatatggtg tttgtgagtt gattgacatc gtatcagaga ttccagacac aaccatctgc
     3901 ttgtcccaac aagataatga aatggtgatt tgtatcccca aaagagaacg cactcaggat
     3961 gaaatagaaa ggacaaaaca gttctccaag gatgtcgttg atttgctgcg tcaccaaccc
     4021 catttccgga tgccctttaa taaatttatc ccttcttacc atcaccactt tggccggcag
     4081 tgcaaacttg cgtactatgg gtttaccaaa ctacttgaac tttttgaagc catacctgat
     4141 actttacaag tattggaatg tggagaagaa aagatcctta ctctgacaga ggtggagcgg
     4201 ttcaaagctc tagctgccca gtttgttaaa ctccttcggt cccaaaaaga taactgcctt
     4261 atgatgacag atctccttac agaatatgct aaaacttttg gttatacatt tcgtctccaa
     4321 gactatgatg tcagttccat ttcggcttta actcagaaac tctgccatgt cgtgaaggtt
     4381 gccgatatag aatctggcag acagattcag ctgatcaacc gaaagtctct gcgatctctc
     4441 actgcccagt tgctggtatt gttgatgtct tgggaaggaa ccacccatct ttctgttgag
     4501 gagctcaaga gacattacga aagtacccac aacactcccc ttaacccctg tgaatatgga
     4561 ttcatgacct tgaccgaact gctgaagagc ctgccatact tggttgaggt tttcactaat
     4621 gataagatgg aagaatgtgt gaagctcaca agtctgtatt tgtttgcaaa gaatgtgcgg
     4681 tctttacttc atacttacca ctaccagcag attttccttc atgagttttc catggcctat
     4741 accaagtatg tcggagaaac tctgcagccc aagacctacg gccacagcag cgtggaggag
     4801 ctcttgggag caattccaca ggtggtctgg ataaaaggac atggtcataa gagaattgta
     4861 gtgttaaaaa atgacatgaa aagtcgtttg agttcactca gtctctcccc tgccaatcat
     4921 gaaaaccagc cctcggaggg cgagcgcatc ctggaggtgc ccgaatcgca cacagcctcg
     4981 gaactcaagc ttggagctga cggcagtggg cccagtcaca cagagcagga gcttctccgc
     5041 ctgaccgacg actcccccgt cgacctcctg tgtgcgcctg tcccctcgtg cctgccgtcc
     5101 cctcagctga gaccagaccc cgttatcctc caatctgctg atctcattca gtttgaggag
     5161 cgccctcaag agccttctga aattatgatt ttaaaccaag aagaaaaaat ggagattcca
     5221 ataccaggaa agagcaaaac tctgacctct gactccagct cgtcctgcat ctcagcagct
     5281 gtccccgtgc ctccctgccc ctcctcggaa acctccgagt cactgctcag caaggacccc
     5341 gtggaaagcc cggccaaaaa gcaacccaaa aatagagtca aattggcagc caacttttcc
     5401 ttagcaccta taaccaagct ttaactccca tttggaatat agaattagga tgggaaaaca
     5461 ctgtctgatt ctgcacacaa aagtgggttt caaaaataca tccttttctg tgtcatgaaa
     5521 accccccgaa gccattgact tcatcttacc tgtgttctat catgtttttc ttttccattg
     5581 aacacagctt tgagctgaag tctttctttt cttcttcctt tttctttctt ttttcaatta
     5641 tttgaagaac ttgtggcatt tgttaaagaa tccttaatat attttaccaa atttttagta
     5701 actattatga aatacaatgg tgttccaaaa gaagaaagca ctaaaaactc aactagcagg
     5761 aagcggtttt gcttccattg agccacgtcg gtggtgtcat cctacatgta gcataataga
     5821 gtctctcagc ctttgcttac tggtgtttcc gacagtatta acccagtgcg tggcatgtct
     5881 ttgaagcaaa gcctgtcccg ctagcctgtg tgttcacaca ccaaaggaga agggtaggcg
     5941 aggggttcgg agtgtatttt caggttggaa tgtgaaggtt cctggcttcc atgtgacttg
     6001 taagtgtgcc ttgtttttta tttaaactat gtctgtagtt gacaaaagtg gcttcatcac
     6061 aaattttttt aaacgtttct actttggggt tccatttagg agctttctag aaagttgagg
     6121 atgtttgaag cttcccttct gtgttccagt ttgatatggg ttaggttaag gaaaaggaga
     6181 tggtctcgat gtcatggatt taaagtcagc atttggatta caacacacat tattgtgtgt
     6241 cgagaggcag cattggaaag agcctgattt tctaaaatat gcatcaagtg cataaattac
     6301 aaatcagagc tgagtgggga ggtgcttcag cagcagcggg atcaatacga tttccactgg
     6361 gaagagacag gaattctacc tacacatagg aaggccaagg ttgatccact taaccttgtt
     6421 attgtaattt taaagctggt atcggtagct gggaagcttt atgtgtgtgt atgtcagctc
     6481 agcatctttt aatcgtgtct gattttactc tcgttacttc tcgctgttgg aagcatctct
     6541 gggtttcttg tggcgtctgg tgtggaatgg ccttcctctc taggtgcctg aggtgtccgc
     6601 tgacgggtgg cctctcaccc ccctctagag aaacctgaca tttacaatgg attgtatttg
     6661 tccggcaaaa aaggcggatt cattcataga gcagaaagaa cctgttggcg taaggtcttc
     6721 cactagttag atggtttctt ttggggaaat gtttatattt ggtaacttct agaaagccag
     6781 aaaatggact ctgatttcat agcattttga taaaatgcca caaaataagg gctatagaga
     6841 gatttttaca agtcagattt tttgttcccc aaatctttta aatgaagcca gtgactccca
     6901 gttctcaaca catggcccca gtcaagacag aacaccatgg aaaaaaccct gtaagtatta
     6961 tggcactctc cgaatcctcc tgaaggcatt tcctctacag acatagtgtt acaggaagtg
     7021 aaatgcaaat gtgcaatttt ttttaaagga gcttttaaac aaagtaataa taattggtgt
     7081 tgagaacatc agttgcctta ttctaagatt tcataaggct gagtttgcac gcttggactt
     7141 cagttctgct agcatgtaaa gagtggtgga ctttaaaacc gtaagaggta tcattacaag
     7201 tcacctggaa cagactcaaa gaacaggttc tttgggcaac agacaaagaa gaatcaagtt
     7261 ctgtgctgtc ccgtgagtgt gtctgagtac cattcactgg agttgctgct taggtctggg
     7321 acgtgtgtgt gactcttaac aattgctgtc tgaaaatgag agagaagact tcggaagcac
     7381 attgtgttca taatgtactc cacaatggcc agtccaattg ctatctattt ttttatccag
     7441 aggcttaatt aaatgatgtg gtaaaatgat gtttgagcat taagacaatg taattcttta
     7501 tttctgggtg gaaagatata ccggattaaa tttatctgtt taaaaaaatg acaaaagtta
     7561 tcaccaaaac cccctttccc atcttgcact gtttgttttg gattgggttt gggggaaaga
     7621 gatgtttttc ttagttgtct actttgtttg aacacttttg ttgtggttca agtgctgttt
     7681 tgtgtgttgg gaccaaacag ttgtcaataa actttacaag cgagcatcta
//
