LOCUS       NM_006770               1810 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens macrophage receptor with collagenous structure
            (MARCO), mRNA.
ACCESSION   NM_006770
VERSION     NM_006770.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1810)
  AUTHORS   Gu,C., Wiest,M., Zhang,W., Halder,K., Zurawski,S., Zurawski,G.,
            Joo,H. and Oh,S.
  TITLE     Cancer Cells Promote Immune Regulatory Function of Macrophages by
            Upregulating Scavenger Receptor MARCO Expression
  JOURNAL   J Immunol 211 (1), 57-70 (2023)
   PUBMED   37212598
  REMARK    GeneRIF: Cancer Cells Promote Immune Regulatory Function of
            Macrophages by Upregulating Scavenger Receptor MARCO Expression.
REFERENCE   2  (bases 1 to 1810)
  AUTHORS   Su,Z., Luo,L., Wu,X., Wei,B., Wang,L., Liu,F. and Cai,B.
  TITLE     Association of the MARCO polymorphism rs6761637 with hepatocellular
            carcinoma susceptibility and clinical characteristics
  JOURNAL   Immunol Res 70 (3), 400-407 (2022)
   PUBMED   35364781
  REMARK    GeneRIF: Association of the MARCO polymorphism rs6761637 with
            hepatocellular carcinoma susceptibility and clinical
            characteristics.
REFERENCE   3  (bases 1 to 1810)
  AUTHORS   Xing,Q., Feng,Y., Sun,H., Yang,S., Sun,T., Guo,X., Ji,F., Wu,B. and
            Zhou,D.
  TITLE     Scavenger receptor MARCO contributes to macrophage phagocytosis and
            clearance of tumor cells
  JOURNAL   Exp Cell Res 408 (2), 112862 (2021)
   PUBMED   34626585
  REMARK    GeneRIF: Scavenger receptor MARCO contributes to macrophage
            phagocytosis and clearance of tumor cells.
REFERENCE   4  (bases 1 to 1810)
  AUTHORS   Wang,L., Yang,H.Y., Zang,C.X., Shang,J.M., Liu,H., Zhang,Z.H.,
            Yuan,F.Y., Ju,C., Li,F.Y., Bao,X.Q. and Zhang,D.
  TITLE     TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting
            with the SRCR Domain
  JOURNAL   Mol Neurobiol 58 (11), 5743-5755 (2021)
   PUBMED   34398403
  REMARK    GeneRIF: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by
            Interacting with the SRCR Domain.
REFERENCE   5  (bases 1 to 1810)
  AUTHORS   Chen,A.X., Gartrell,R.D., Zhao,J., Upadhyayula,P.S., Zhao,W.,
            Yuan,J., Minns,H.E., Dovas,A., Bruce,J.N., Lasorella,A.,
            Iavarone,A., Canoll,P., Sims,P.A. and Rabadan,R.
  TITLE     Single-cell characterization of macrophages in glioblastoma reveals
            MARCO as a mesenchymal pro-tumor marker
  JOURNAL   Genome Med 13 (1), 88 (2021)
   PUBMED   34011400
  REMARK    GeneRIF: Single-cell characterization of macrophages in
            glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1810)
  AUTHORS   Seta,N., Granfors,K., Sahly,H., Kuipers,J.G., Song,Y.W., Baeten,D.,
            Veys,E.M., Maksymowych,W., Marker-Hermann,E., Gu,J., Huang,F.,
            Kirveskari,J. and Yu,D.T.
  TITLE     Expression of host defense scavenger receptors in
            spondylarthropathy
  JOURNAL   Arthritis Rheum 44 (4), 931-939 (2001)
   PUBMED   11315932
REFERENCE   7  (bases 1 to 1810)
  AUTHORS   Elshourbagy,N.A., Li,X., Terrett,J., Vanhorn,S., Gross,M.S.,
            Adamou,J.E., Anderson,K.M., Webb,C.L. and Lysko,P.G.
  TITLE     Molecular characterization of a human scavenger receptor, human
            MARCO
  JOURNAL   Eur J Biochem 267 (3), 919-926 (2000)
   PUBMED   10651831
REFERENCE   8  (bases 1 to 1810)
  AUTHORS   Kangas,M., Brannstrom,A., Elomaa,O., Matsuda,Y., Eddy,R.,
            Shows,T.B. and Tryggvason,K.
  TITLE     Structure and chromosomal localization of the human and murine
            genes for the macrophage MARCO receptor
  JOURNAL   Genomics 58 (1), 82-89 (1999)
   PUBMED   10331948
REFERENCE   9  (bases 1 to 1810)
  AUTHORS   Elomaa,O., Sankala,M., Pikkarainen,T., Bergmann,U., Tuuttila,A.,
            Raatikainen-Ahokas,A., Sariola,H. and Tryggvason,K.
  TITLE     Structure of the human macrophage MARCO receptor and
            characterization of its bacteria-binding region
  JOURNAL   J Biol Chem 273 (8), 4530-4538 (1998)
   PUBMED   9468508
REFERENCE   10 (bases 1 to 1810)
  AUTHORS   Elomaa,O., Kangas,M., Sahlberg,C., Tuukkanen,J., Sormunen,R.,
            Liakka,A., Thesleff,I., Kraal,G. and Tryggvason,K.
  TITLE     Cloning of a novel bacteria-binding receptor structurally related
            to scavenger receptors and expressed in a subset of macrophages
  JOURNAL   Cell 80 (4), 603-609 (1995)
   PUBMED   7867067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013457.7.
            
            On Jul 1, 2020 this sequence version replaced NM_006770.3.
            
            Summary: The protein encoded by this gene is a member of the class
            A scavenger receptor family and is part of the innate antimicrobial
            immune system. The protein may bind both Gram-negative and
            Gram-positive bacteria via an extracellular, C-terminal, scavenger
            receptor cysteine-rich (SRCR) domain. In addition to short
            cytoplasmic and transmembrane domains, there is an extracellular
            spacer domain and a long, extracellular collagenous domain. The
            protein may form a trimeric molecule by the association of the
            collagenous domains of three identical polypeptide chains.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016004.1, AF035819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327097.5/ ENSP00000318916.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AC013457.7         9957-10160
            205-306             AC013457.7         36923-37024
            307-531             AC013457.7         37877-38101
            532-567             AC013457.7         39262-39297
            568-675             AC013457.7         42096-42203
            676-720             AC013457.7         42284-42328
            721-765             AC013457.7         45234-45278
            766-873             AC013457.7         45591-45698
            874-972             AC013457.7         49172-49270
            973-1008            AC013457.7         49384-49419
            1009-1107           AC013457.7         49919-50017
            1108-1170           AC013457.7         50111-50173
            1171-1215           AC013457.7         58352-58396
            1216-1314           AC013457.7         59540-59638
            1315-1359           AC013457.7         60195-60239
            1360-1536           AC013457.7         60887-61063
            1537-1810           AC013457.7         62150-62423
FEATURES             Location/Qualifiers
     source          1..1810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..1810
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /note="macrophage receptor with collagenous structure"
                     /db_xref="GeneID:8685"
                     /db_xref="HGNC:HGNC:6895"
                     /db_xref="MIM:604870"
     exon            1..204
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1670
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /note="scavenger receptor class A, member 2"
                     /codon_start=1
                     /product="macrophage receptor MARCO"
                     /protein_id="NP_006761.1"
                     /db_xref="CCDS:CCDS2124.1"
                     /db_xref="GeneID:8685"
                     /db_xref="HGNC:HGNC:6895"
                     /db_xref="MIM:604870"
                     /translation="MRNKKILKEDELLSETQQAAFHQIAMEPFEINVPKPKRRNGVNF
                     SLAVVVIYLILLTAGAGLLVVQVLNLQARLRVLEMYFLNDTLAAEDSPSFSLLQSAHP
                     GEHLAQGASRLQVLQAQLTWVRVSHEHLLQRVDNFTQNPGMFRIKGEQGAPGLQGHKG
                     AMGMPGAPGPPGPPAEKGAKGAMGRDGATGPSGPQGPPGVKGEAGLQGPQGAPGKQGA
                     TGTPGPQGEKGSKGDGGLIGPKGETGTKGEKGDLGLPGSKGDRGMKGDAGVMGPPGAQ
                     GSKGDFGRPGPPGLAGFPGAKGDQGQPGLQGVPGPPGAVGHPGAKGEPGSAGSPGRAG
                     LPGSPGSPGATGLKGSKGDTGLQGQQGRKGESGVPGPAGVKGEQGSPGLAGPKGAPGQ
                     AGQKGDQGVKGSSGEQGVKGEKGERGENSVSVRIVGSSNRGRAEVYYSGTWGTICDDE
                     WQNSDAIVFCRMLGYSKGRALYKVGAGTGQIWLDNVQCRGTESTLWSCTKNSWGHHDC
                     SHEEDAGVECSV"
     exon            205..306
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            307..531
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            532..567
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            568..675
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            676..720
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            721..765
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            766..873
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            874..972
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1008
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1107
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1170
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1215
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1314
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1359
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1536
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1810
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /note="hexamer: AATAAA"
     polyA_site      1810
                     /gene="MARCO"
                     /gene_synonym="SCARA2; SR-A6"
                     /note="major polyA site"
ORIGIN      
        1 acaaccagct gcagtggttc gatgggaagg atctttctcc aagtggttcc tcttgagggg
       61 agcatttctg ctggctccag gactttggcc atctataaag cttggcaatg agaaataaga
      121 aaattctcaa ggaggacgag ctcttgagtg agacccaaca agctgctttt caccaaattg
      181 caatggagcc tttcgaaatc aatgttccaa agcccaagag gagaaatggg gtgaacttct
      241 ccctagctgt ggtggtcatc tacctgatcc tgctcaccgc tggcgctggg ctgctggtgg
      301 tccaagttct gaatctgcag gcgcggctcc gggtcctgga gatgtatttc ctcaatgaca
      361 ctctggcggc tgaggacagc ccgtccttct ccttgctgca gtcagcacac cctggagaac
      421 acctggctca gggtgcatcg aggctgcaag tcctgcaggc ccaactcacc tgggtccgcg
      481 tcagccatga gcacttgctg cagcgggtag acaacttcac tcagaaccca gggatgttca
      541 gaatcaaagg tgaacaaggc gccccaggtc ttcaaggtca caagggggcc atgggcatgc
      601 ctggtgcccc tggcccgccg ggaccacctg ctgagaaggg agccaagggg gctatgggac
      661 gagatggagc aacaggcccc tcgggacccc aaggcccacc gggagtcaag ggagaggcgg
      721 gcctccaagg accccagggt gctccaggga agcaaggagc cactggcacc ccaggacccc
      781 aaggagagaa gggcagcaaa ggcgatgggg gtctcattgg cccaaaaggg gaaactggaa
      841 ctaagggaga gaaaggagac ctgggtctcc caggaagcaa aggggacagg ggcatgaaag
      901 gagatgcagg ggtcatgggg cctcctggag cccaggggag taaaggtgac ttcgggaggc
      961 caggcccacc aggtttggct ggttttcctg gagctaaagg agatcaagga caacctggac
     1021 tgcagggtgt tccgggccct cctggtgcag tgggacaccc aggtgccaag ggtgagcctg
     1081 gcagtgctgg ctcccctggg cgagcaggac ttccagggag ccccgggagt ccaggagcca
     1141 caggcctgaa aggaagcaaa ggggacacag gacttcaagg acagcaagga agaaaaggag
     1201 aatcaggagt tccaggccct gcaggtgtga agggagaaca ggggagccca gggctggcag
     1261 gtcccaaggg agcccctgga caagctggcc agaagggaga ccagggagtg aaaggatctt
     1321 ctggggagca aggagtaaag ggagaaaaag gtgaaagagg tgaaaactca gtgtccgtca
     1381 ggattgtcgg cagtagtaac cgaggccggg ctgaagttta ctacagtggt acctggggga
     1441 caatttgcga tgacgagtgg caaaattctg atgccattgt cttctgccgc atgctgggtt
     1501 actccaaagg aagggccctg tacaaagtgg gagctggcac tgggcagatc tggctggata
     1561 atgttcagtg tcggggcacg gagagtaccc tgtggagctg caccaagaat agctggggcc
     1621 atcatgactg cagccacgag gaggacgcag gcgtggagtg cagcgtctga cccggaaacc
     1681 ctttcacttc tctgctcccg aggtgtcctc gggctcatat gtgggaaggc agaggatctc
     1741 tgaggagttc cctggggaca actgagcagc ctctggagag gggccattaa taaagctcaa
     1801 catcattggc
//
