LOCUS       NM_023009               1546 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1, mRNA.
ACCESSION   NM_023009
VERSION     NM_023009.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Rong,W., Shao,S., Pu,Y., Ji,Q. and Zhu,H.
  TITLE     Circulating extracellular vesicle-derived MARCKSL1 is a potential
            diagnostic non-invasive biomarker in metastatic colorectal cancer
            patients
  JOURNAL   Sci Rep 13 (1), 9957 (2023)
   PUBMED   37340044
  REMARK    GeneRIF: Circulating extracellular vesicle-derived MARCKSL1 is a
            potential diagnostic non-invasive biomarker in metastatic
            colorectal cancer patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Zhao,Y., Xie,X., Tian,L., Liu,F., Sun,Y., Lu,H., Zhao,X. and Mao,Y.
  TITLE     MARCKSL1 interacted with F-actin to promote esophageal squamous
            cell carcinoma mobility by modulating the formation of invadopodia
  JOURNAL   Cancer Med 12 (3), 3299-3312 (2023)
   PUBMED   35894387
  REMARK    GeneRIF: MARCKSL1 interacted with F-actin to promote esophageal
            squamous cell carcinoma mobility by modulating the formation of
            invadopodia.
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Jiang,M., Qi,F., Zhang,K., Zhang,X., Ma,J., Xia,S., Chen,L., Yu,Z.,
            Chen,J. and Chen,D.
  TITLE     MARCKSL1-2 reverses docetaxel-resistance of lung adenocarcinoma
            cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b
  JOURNAL   Mol Cancer 21 (1), 150 (2022)
   PUBMED   35864549
  REMARK    GeneRIF: MARCKSL1-2 reverses docetaxel-resistance of lung
            adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and
            elevate miR-200b.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Li,F., Zhao,J., Wang,L., Chi,Y., Huang,X. and Liu,W.
  TITLE     METTL14-Mediated miR-30c-1-3p Maturation Represses the Progression
            of Lung Cancer via Regulation of MARCKSL1 Expression
  JOURNAL   Mol Biotechnol 64 (2), 199-212 (2022)
   PUBMED   34586620
  REMARK    GeneRIF: METTL14-Mediated miR-30c-1-3p Maturation Represses the
            Progression of Lung Cancer via Regulation of MARCKSL1 Expression.
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Jia,J., Liu,Y., Yang,X., Wu,Z., Xu,X., Kang,F. and Liu,Y.
  TITLE     IncRNA TYMSOS Promotes Epithelial-Mesenchymal Transition and
            Metastasis in Thyroid Carcinoma through Regulating MARCKSL1 and
            Activating the PI3K/Akt Signaling Pathway
  JOURNAL   Crit Rev Eukaryot Gene Expr 33 (1), 1-14 (2022)
   PUBMED   36374807
  REMARK    GeneRIF: IncRNA TYMSOS Promotes Epithelial-Mesenchymal Transition
            and Metastasis in Thyroid Carcinoma through Regulating MARCKSL1 and
            Activating the PI3K/Akt Signaling Pathway.
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Jordanova,A., Irobi,J., Thomas,F.P., Van Dijck,P., Meerschaert,K.,
            Dewil,M., Dierick,I., Jacobs,A., De Vriendt,E., Guergueltcheva,V.,
            Rao,C.V., Tournev,I., Gondim,F.A., D'Hooghe,M., Van Gerwen,V.,
            Callaerts,P., Van Den Bosch,L., Timmermans,J.P., Robberecht,W.,
            Gettemans,J., Thevelein,J.M., De Jonghe,P., Kremensky,I. and
            Timmerman,V.
  TITLE     Disrupted function and axonal distribution of mutant tyrosyl-tRNA
            synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
  JOURNAL   Nat Genet 38 (2), 197-202 (2006)
   PUBMED   16429158
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Yue,L., Lu,S., Garces,J., Jin,T. and Li,J.
  TITLE     Protein kinase C-regulated dynamitin-macrophage-enriched
            myristoylated alanine-rice C kinase substrate interaction is
            involved in macrophage cell spreading
  JOURNAL   J Biol Chem 275 (31), 23948-23956 (2000)
   PUBMED   10827182
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Stumpo,D.J., Eddy,R.L. Jr., Haley,L.L., Sait,S., Shows,T.B.,
            Lai,W.S., Young,W.S. 3rd, Speer,M.C., Dehejia,A., Polymeropoulos,M.
            and Blackshear,P.J.
  TITLE     Promoter sequence, expression, and fine chromosomal mapping of the
            human gene (MLP) encoding the MARCKS-like protein: identification
            of neighboring and linked polymorphic loci for MLP and MACS and use
            in the evaluation of human neural tube defects
  JOURNAL   Genomics 49 (2), 253-264 (1998)
   PUBMED   9598313
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Verghese,G.M., Johnson,J.D., Vasulka,C., Haupt,D.M., Stumpo,D.J.
            and Blackshear,P.J.
  TITLE     Protein kinase C-mediated phosphorylation and calmodulin binding of
            recombinant myristoylated alanine-rich C kinase substrate (MARCKS)
            and MARCKS-related protein
  JOURNAL   J Biol Chem 269 (12), 9361-9367 (1994)
   PUBMED   8132675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI879076.1, BC007904.2 and
            N70661.1.
            
            On Nov 22, 2018 this sequence version replaced NM_023009.6.
            
            Summary: This gene encodes a member of the myristoylated
            alanine-rich C-kinase substrate (MARCKS) family. Members of this
            family play a role in cytoskeletal regulation, protein kinase C
            signaling and calmodulin signaling. The encoded protein affects the
            formation of adherens junction. Alternative splicing results in
            multiple transcript variants. Pseudogenes of this gene are located
            on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun
            2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein coding.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066915.1, SRR3476690.130069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329421.8/ ENSP00000362638.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AI879076.1         5-13
            10-1471             BC007904.2         1-1462
            1472-1546           N70661.1           11-85               c
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..1546
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /note="MARCKS like 1"
                     /db_xref="GeneID:65108"
                     /db_xref="HGNC:HGNC:7142"
                     /db_xref="MIM:602940"
     exon            1..287
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..788
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /note="macrophage myristoylated alanine-rich C kinase
                     substrate; mac-MARCKS; MARCKS-like protein 1"
                     /codon_start=1
                     /product="MARCKS-related protein"
                     /protein_id="NP_075385.1"
                     /db_xref="CCDS:CCDS361.1"
                     /db_xref="GeneID:65108"
                     /db_xref="HGNC:HGNC:7142"
                     /db_xref="MIM:602940"
                     /translation="MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKG
                     EGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSG
                     LSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAE
                     ASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE"
     exon            288..1546
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1528..1533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /note="hexamer: AATAAA"
     polyA_site      1546
                     /gene="MARCKSL1"
                     /gene_synonym="F52; MACMARCKS; MLP; MLP1; MRP"
                     /note="major polyA site"
ORIGIN      
        1 ggcattctgg cgcggagcgg agcggcggcg ggcgcagcta gcgggtcggc cgcggagcgg
       61 aggtgcagct cggcttcccc cggcacccct ccccctcggg cgccagcccc acccctccgc
      121 cggccgggcc gaccccgccg tactatcccc tgcggcgcga gcccggggcg gctccaagcg
      181 ccccccagca gacccccatc atgggcagcc agagctccaa ggctccccgg ggcgacgtga
      241 ccgccgagga ggcagcaggc gcttcccccg cgaaggccaa cggccaggag aatggccacg
      301 tgaaaagcaa tggagactta tcccccaagg gtgaagggga gtcgccccct gtgaacggaa
      361 cagatgaggc agccggggcc actggcgatg ccatcgagcc agcaccccct agccagggtg
      421 ctgaggccaa gggggaggtc ccccccaagg agacccccaa gaagaagaag aaattctctt
      481 tcaagaagcc tttcaaattg agcggcctgt ccttcaagag aaatcggaag gagggtgggg
      541 gtgattcttc tgcctcctca cccacagagg aagagcagga gcagggggag atcggtgcct
      601 gcagcgacga gggcactgct caggaaggga aggccgcagc cacccctgag agccaggaac
      661 cccaggccaa gggggcagag gctagtgcag cctcagaaga agaggcaggg ccccaggcta
      721 cagagccatc cactccctcg gggccggaga gtggccctac accagccagc gctgagcaga
      781 atgagtagct aggtaggggc aggtgggtga tctctaagct gcaaaaactg tgctgtcctt
      841 gtgaggtcac tgcctggacc tggtgccctg gctgccttcc tgtgcccaga aaggaagggg
      901 ctattgcctc ctcccagcca cgttcccttt cctcctctcc ctcctgtgga ttctcccatc
      961 agccatctgg ttctcctctt aaggccagtt gaagatggtc ccttacagct tcccaagtta
     1021 ggttagtgat gtgaaatgct cctgtccctg gccctacctc cttccctgtc cccacccctg
     1081 cataaggcag ttgttggttt tcttccccaa ttcttttcca agtaggtttt gtttacccta
     1141 ctccccaaat ccctgagcca gaagtggggt gcttatactc ccaaaccttg agtgtccagc
     1201 cttcccctgt tgtttttagt ctcttgtgct gtgcctagtg gcacctgggc tggggaggac
     1261 actgccccgt ctaggttttt ataaatgtct tactcaagtt caaacctcca gcctgtgaat
     1321 caactgtgtc tcttttttga cttggtaagc aagtattagg ctttggggtg gggggaggtc
     1381 tgtaatgtga aacaacttct tgtctttttt tctcccactg ttgtaaataa cttttaatgg
     1441 ccaaacccca gatttgtact tttttttttt ttctaactgc taaaaccatt ctcttccacc
     1501 tggttttact gtaacatttg gaaaaggaat aaatgtcgtc ccttta
//
