LOCUS       NM_002356               4296 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens myristoylated alanine rich protein kinase C substrate
            (MARCKS), mRNA.
ACCESSION   NM_002356
VERSION     NM_002356.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4296)
  AUTHORS   Kokesh,K.J., Bala,N., Dogan,Y.E., Nguyen,V.L., Costa,M. and Alli,A.
  TITLE     Mycobacterium avium inhibits protein kinase C and MARCKS
            phosphorylation in human cystic fibrosis and non-cystic fibrosis
            cells
  JOURNAL   PLoS One 19 (10), e0308299 (2024)
   PUBMED   39413095
  REMARK    GeneRIF: Mycobacterium avium inhibits protein kinase C and MARCKS
            phosphorylation in human cystic fibrosis and non-cystic fibrosis
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4296)
  AUTHORS   Li,Y., Wang,Z., Yang,J., Sun,Y., He,Y., Wang,Y., Chen,X., Liang,Y.,
            Zhang,N., Wang,X., Zhao,W., Hu,G. and Yang,Q.
  TITLE     CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and
            metastasis of TNBC via enhancing CaM-dependent MARCKS translocation
            and PI3K/AKT/mTOR activation
  JOURNAL   Mol Cancer 23 (1), 102 (2024)
   PUBMED   38755678
  REMARK    GeneRIF: CircTRIM1 encodes TRIM1-269aa to promote chemoresistance
            and metastasis of TNBC via enhancing CaM-dependent MARCKS
            translocation and PI3K/AKT/mTOR activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4296)
  AUTHORS   Chen,Z., Zhang,W., Selmi,C., Ridgway,W.M., Leung,P.S.C., Zhang,F.
            and Gershwin,M.E.
  TITLE     The myristoylated alanine-rich C-kinase substrates (MARCKS): A
            membrane-anchored mediator of the cell function
  JOURNAL   Autoimmun Rev 20 (11), 102942 (2021)
   PUBMED   34509657
  REMARK    GeneRIF: The myristoylated alanine-rich C-kinase substrates
            (MARCKS): A membrane-anchored mediator of the cell function.
            Review article
REFERENCE   4  (bases 1 to 4296)
  AUTHORS   Ren,X., Ju,Y., Wang,C., Wei,R., Sun,H. and Zhang,Q.
  TITLE     MARCKS on Tumor-Associated Macrophages is Correlated with Immune
            Infiltrates and Poor Prognosis in Hepatocellular Carcinoma
  JOURNAL   Cancer Invest 39 (9), 756-768 (2021)
   PUBMED   34279157
  REMARK    GeneRIF: MARCKS on Tumor-Associated Macrophages is Correlated with
            Immune Infiltrates and Poor Prognosis in Hepatocellular Carcinoma.
REFERENCE   5  (bases 1 to 4296)
  AUTHORS   Liu,J., Chen,S.J., Hsu,S.W., Zhang,J., Li,J.M., Yang,D.C., Gu,S.,
            Pinkerton,K.E. and Chen,C.H.
  TITLE     MARCKS cooperates with NKAP to activate NF-kB signaling in
            smoke-related lung cancer
  JOURNAL   Theranostics 11 (9), 4122-4136 (2021)
   PUBMED   33754052
  REMARK    GeneRIF: MARCKS cooperates with NKAP to activate NF-kB signaling in
            smoke-related lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4296)
  AUTHORS   Herget,T., Brooks,S.F., Broad,S. and Rozengurt,E.
  TITLE     Relationship between the major protein kinase C substrates acidic
            80-kDa protein-kinase-C substrate (80K) and myristoylated
            alanine-rich C-kinase substrate (MARCKS). Members of a gene family
            or equivalent genes in different species
  JOURNAL   Eur J Biochem 209 (1), 7-14 (1992)
   PUBMED   1396720
REFERENCE   7  (bases 1 to 4296)
  AUTHORS   Sakai,K., Hirai,M., Kudoh,J., Minoshima,S. and Shimizu,N.
  TITLE     Molecular cloning and chromosomal mapping of a cDNA encoding human
            80K-L protein: major substrate for protein kinase C
  JOURNAL   Genomics 14 (1), 175-178 (1992)
   PUBMED   1427823
REFERENCE   8  (bases 1 to 4296)
  AUTHORS   Hartwig,J.H., Thelen,M., Rosen,A., Janmey,P.A., Nairn,A.C. and
            Aderem,A.
  TITLE     MARCKS is an actin filament crosslinking protein regulated by
            protein kinase C and calcium-calmodulin
  JOURNAL   Nature 356 (6370), 618-622 (1992)
   PUBMED   1560845
REFERENCE   9  (bases 1 to 4296)
  AUTHORS   Harlan,D.M., Graff,J.M., Stumpo,D.J., Eddy,R.L. Jr., Shows,T.B.,
            Boyle,J.M. and Blackshear,P.J.
  TITLE     The human myristoylated alanine-rich C kinase substrate (MARCKS)
            gene (MACS). Analysis of its gene product, promoter, and
            chromosomal localization
  JOURNAL   J Biol Chem 266 (22), 14399-14405 (1991)
   PUBMED   1860846
REFERENCE   10 (bases 1 to 4296)
  AUTHORS   Graff,J.M., Stumpo,D.J. and Blackshear,P.J.
  TITLE     Characterization of the phosphorylation sites in the chicken and
            bovine myristoylated alanine-rich C kinase substrate protein, a
            prominent cellular substrate for protein kinase C
  JOURNAL   J Biol Chem 264 (20), 11912-11919 (1989)
   PUBMED   2473066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY144763.1, BC013004.2,
            FO393415.1 and BU678392.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002356.6.
            
            Summary: The protein encoded by this gene is a substrate for
            protein kinase C. It is localized to the plasma membrane and is an
            actin filament crosslinking protein. Phosphorylation by protein
            kinase C or binding to calcium-calmodulin inhibits its association
            with actin and with the plasma membrane, leading to its presence in
            the cytoplasm. The protein is thought to be involved in cell
            motility, phagocytosis, membrane trafficking and mitogenesis.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10522.1, SRR1163655.61791.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612661.2/ ENSP00000478061.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY144763.1         11-27
            18-865              BC013004.2         1-848
            866-3704            FO393415.1         87193-90031
            3705-4296           BU678392.1         17-608              c
FEATURES             Location/Qualifiers
     source          1..4296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..4296
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="myristoylated alanine rich protein kinase C
                     substrate"
                     /db_xref="GeneID:4082"
                     /db_xref="HGNC:HGNC:6759"
                     /db_xref="MIM:177061"
     exon            1..503
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1400
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="phosphomyristin; myristoylated alanine-rich protein
                     kinase C substrate (MARCKS, 80K-L); protein kinase C
                     substrate, 80 kDa protein, light chain"
                     /codon_start=1
                     /product="myristoylated alanine-rich C-kinase substrate"
                     /protein_id="NP_002347.5"
                     /db_xref="CCDS:CCDS5101.1"
                     /db_xref="GeneID:4082"
                     /db_xref="HGNC:HGNC:6759"
                     /db_xref="MIM:177061"
                     /translation="MGAQFSKTAAKGEAAAERPGEAAVASSPSKANGQENGHVKVNGD
                     ASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASP
                     VEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSF
                     KKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAP
                     GEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASA
                     AACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQEAQPECSPEAPPAEAAE"
     exon            504..4296
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="major polyA site"
     regulatory      4133..4138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="hexamer: AATAAA"
     polyA_site      4156
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
                     /note="hexamer: AATAAA"
     polyA_site      4296
                     /gene="MARCKS"
                     /gene_synonym="80K-L; MACS; PKCSL; PRKCSL"
ORIGIN      
        1 gcacttgggc gttggacccc gcatcttatt agcaaccagg gagatttctc cattttcctc
       61 ttgtctacag tgcggctaca aatctgggat ttttttatta cttctttttt tttcgaacta
      121 cacttgggct cctttttttg tgctcgactt ttccaccctt tttccctccc tcctgtgctg
      181 ctgctttttg atctcttcga ctaaaatttt tttatccgga gtgtatttaa tcggttctgt
      241 tctgtcctct ccaccacccc cacccccctc cctccggtgt gtgtgccgct gccgctgttg
      301 ccgccgccgc tgctgctgct gctcgccccg tcgttacacc aacccgaggc tctttgtttc
      361 ccctcttgga tctgttgagt ttctttgttg aagaagccag catgggtgcc cagttctcca
      421 agaccgcagc gaagggagaa gccgccgcgg agaggcctgg ggaggcggct gtggcctcgt
      481 cgccttccaa agcgaacgga caggagaatg gccacgtgaa ggtaaacggc gacgcttcgc
      541 ccgcggccgc cgagtcgggc gccaaggagg agctgcaggc caacggcagc gccccggccg
      601 ccgacaagga ggagcccgcg gccgccggga gcggggcggc gtcgccctcc gcggccgaga
      661 aaggtgagcc ggccgccgcc gctgcccccg aggccggggc cagcccggta gagaaggagg
      721 cccccgcgga aggcgaggct gccgagcccg gctcgcccac ggccgcggag ggagaggccg
      781 cgtcggccgc ctcctcgact tcttcgccca aggccgagga cggggccacg ccctcgccca
      841 gcaacgagac cccgaaaaaa aaaaagaagc gcttttcctt caagaagtct ttcaagctga
      901 gcggcttctc cttcaagaag aacaagaagg aggctggaga aggcggtgag gctgaggcgc
      961 ccgctgccga aggcggcaag gacgaggccg ccgggggcgc agctgcggcc gccgccgagg
     1021 cgggcgcggc ctccggggag caggcagcgg cgccgggcga ggaggcggca gcgggcgagg
     1081 agggggcggc gggtggcgac ccgcaggagg ccaagcccca ggaggccgct gtcgcgccag
     1141 agaagccgcc cgccagcgac gagaccaagg ccgccgagga gcccagcaag gtggaggaga
     1201 aaaaggccga ggaggccggg gccagcgccg ccgcctgcga ggccccctcc gccgccgggc
     1261 ccggcgcgcc cccggagcag gaggcagccc ccgcggagga gcccgcggcc gccgcagcct
     1321 cgtcagcctg cgcagccccc tcacaggagg cccagcccga gtgcagtcca gaagcccccc
     1381 cagcggaggc ggcagagtaa aagagcaagc ttttgtgaga taatcgaaga acttttctcc
     1441 cccgtttgtt tgttggagtg gtgccaggta ctggttttgg agaacttgtc tacaaccagg
     1501 gattgatttt aaagatgtct ttttttattt tacttttttt taagcaccaa attttgttgt
     1561 tttttttttt tctcccctcc ccacagatcc catctcaaat cattctgtta accaccattc
     1621 caacaggtcg aggagagctt aaacaccttc ttcctctgcc ttgtttctct tttatttttt
     1681 attttttcgc atcagtatta atgtttttgc atactttgca tctttattca aaagtgtaaa
     1741 ctttctttgt caatctatgg acatgcccat atatgaagga gatgggtggg tcaaaaaggg
     1801 atatcaaatg aagtgatggg gtcacaatgg ggaaattgaa gtggtgcata acattgccaa
     1861 aatagtgtgc cactagaaat ggtgtaaagg ctgtcttttt ttttttttta aaagaaaagt
     1921 tattaccatg tattttgtga ggcaggttta caacactaca agtcttgagt taagaaggaa
     1981 agaggaaaaa agaaaaaaca ccaataccca gatttaaaaa aaaaaaaacg atcatagtct
     2041 taggagttca tttaaaccat aggaactttt cacttatctc atgttagctg taccagtcag
     2101 tgattaagta gaactacaag ttgtataggc tttattgttt attgctggtt tatgacctta
     2161 ataaagtgta attatgtatt accagcaggg tgtttttaac tgtgactatt gtataaaaac
     2221 aaatcttgat atccagaagc acatgaagtt tgcaactttc caccctgccc atttttgtaa
     2281 aactgcagtc atcttggacc ttttaaaaca caaattttaa actcaaccaa gctgtgataa
     2341 gtggaatggt tactgtttat actgtggtat gtttttgatt acagcagata atgctttctt
     2401 ttccagtcgt ctttgagaat aaaggaaaaa aaatcttcag atgcaatggt tttgtgtagc
     2461 atcttgtcta tcatgttttg taaatactgg agaagctttg accaatttga cttagagatg
     2521 gaatgtaact ttgcttacaa aaattgctat taaactcctg cttaaggtgt tctaattttc
     2581 tgtgagcaca ctaaaagcga aaaataaatg tgaataaaat gtacaaattt gttgtgtttt
     2641 tttatgttct aataatactg agacttctag gtcttaggtt aatttttagg aagatcttgc
     2701 atgccatcag gagtaaattt tattgtggtt cttaatctga agttttcaag ctctgaaatt
     2761 cataatccgc agtgtcagat tacgtagagg aagatcttac aacatttcca tgtcaaatct
     2821 gttaccattt attggcattt agttttcatt taagaattga acataattat ttttattgta
     2881 gctatatagc atgtcagatt aaatcattta caacaaaagg ggtgtgaacc taagactatt
     2941 taaatgtctt atgagaaaat ttcataaagc cattctcttg tcattcaggt ccagaaacaa
     3001 attttaaact gagtgagagt ctatagaatc catactgcag atgggtcatg aaatgtgacc
     3061 aaatgtgttt caaaaattga tggtgtatta cctgctattg taattgctta gtgcttggct
     3121 aatttccaaa ttattgcata atatgttcta ccttaagaaa acaggtttat gtaacaaagt
     3181 aatggtgttg aatggatgat gtcagttcat gggcctttag catagtttta agcatccttt
     3241 tttttttttt tttttgaaag tgtgttagca tcttgttact caaaggataa gacagacaat
     3301 aatacttcac tgaatcttaa taatctttac tagtttacct cctctgctct ttgccacccg
     3361 ataactggat atcttttcct tcaaaggacc ctaaactgat tgaaatttaa gatatgtatc
     3421 aaaaacatta tttcatttaa tgcacatctg ttttgctgtt tttgagcagt gtgcagttta
     3481 gggttcatga taaatcattg aaccacatgt gtaacaactg aatgccaaat cttaaactca
     3541 ttagaaaaat aacaaattag gttttgacac gcattcttaa ttggaataat ggatcaaaaa
     3601 tagtggttca tgaccttacc aaacaccctt gctactaata aaatcaaata acacttagaa
     3661 gggtatgtat ttttagttag ggtttcttga tcttggagga tgtttgaaag ttaaaaattg
     3721 aatttggtaa ccaaaggact gatttatggg tctttcctat cttaaccaac gttttcttag
     3781 ttacctagat ggccaagtac agtgcctggt atgtagtaag actcagtaaa aaagtggatt
     3841 tttaaaaata actcccaaag tgaatagtca aaaatcctgt tagcaaactg ttatatattg
     3901 ctaagtttgt tcttttaaca gctggaattt attaagatgc attattttga ttttattcac
     3961 tgcctaaaac actttgggtg gtattgatgg agttggtgga ttttcctcca agtgattaaa
     4021 tgaaatttga cgtatctttt catccaaagt tttgtacatc atgttttcta acggaaaaaa
     4081 atgttaatat ggcttttttg tattactaaa aatagctttg agattaagga aaaataaata
     4141 actcttgtac agttcagtat tgtctattaa atctgtattg gcagtatgta taatggcatt
     4201 tgctgtggtt acaaaatact tcctctgggt tataataatc atttgatcca attcctattg
     4261 cttgtaaaat aaagttttac cagttgatat aatcaa
//
