LOCUS       NM_020814               4903 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 4 (MARCHF4),
            mRNA.
ACCESSION   NM_020814 XM_046685
VERSION     NM_020814.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4903)
  AUTHORS   Freilinger,T., Anttila,V., de Vries,B., Malik,R., Kallela,M.,
            Terwindt,G.M., Pozo-Rosich,P., Winsvold,B., Nyholt,D.R., van
            Oosterhout,W.P., Artto,V., Todt,U., Hamalainen,E.,
            Fernandez-Morales,J., Louter,M.A., Kaunisto,M.A., Schoenen,J.,
            Raitakari,O., Lehtimaki,T., Vila-Pueyo,M., Gobel,H., Wichmann,E.,
            Sintas,C., Uitterlinden,A.G., Hofman,A., Rivadeneira,F., Heinze,A.,
            Tronvik,E., van Duijn,C.M., Kaprio,J., Cormand,B., Wessman,M.,
            Frants,R.R., Meitinger,T., Muller-Myhsok,B., Zwart,J.A.,
            Farkkila,M., Macaya,A., Ferrari,M.D., Kubisch,C., Palotie,A.,
            Dichgans,M. and van den Maagdenberg,A.M.
  CONSRTM   International Headache Genetics Consortium
  TITLE     Genome-wide association analysis identifies susceptibility loci for
            migraine without aura
  JOURNAL   Nat Genet 44 (7), 777-782 (2012)
   PUBMED   22683712
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4903)
  AUTHORS   Bartee,E., Eyster,C.A., Viswanathan,K., Mansouri,M., Donaldson,J.G.
            and Fruh,K.
  TITLE     Membrane-Associated RING-CH proteins associate with Bap31 and
            target CD81 and CD44 to lysosomes
  JOURNAL   PLoS One 5 (12), e15132 (2010)
   PUBMED   21151997
  REMARK    GeneRIF: Membrane-Associated RING-CH proteins MARCH VIII and MARCH
            IV associate with Bap31 and target CD81 and CD44 to lysosomes
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4903)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098820.3, AB037820.1, BC098448.1, BC048793.1, AC012513.12 and
            AW051292.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020814.2.
            
            Summary: MARCH4 is a member of the MARCH family of membrane-bound
            E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin
            (see MIM 191339) to target lysines in substrate proteins, thereby
            signaling their vesicular transport between membrane compartments.
            MARCH4 reduces surface accumulation of several membrane
            glycoproteins by directing them to the endosomal compartment
            (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr
            2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098448.1, AB037820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273067.5/ ENSP00000273067.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AC098820.3         36650-37105         c
            457-2027            AB037820.1         1-1571
            2028-2774           BC098448.1         1-747
            2775-4258           BC048793.1         393-1876
            4259-4260           AC012513.12        137663-137664       c
            4261-4900           BC048793.1         1877-2516
            4901-4903           AW051292.1         20-22               c
FEATURES             Location/Qualifiers
     source          1..4903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..4903
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /note="membrane associated ring-CH-type finger 4"
                     /db_xref="GeneID:57574"
                     /db_xref="HGNC:HGNC:29269"
                     /db_xref="MIM:608208"
     exon            1..2739
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /inference="alignment:Splign:2.1.0"
     CDS             2224..3456
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /EC_number="2.3.2.27"
                     /note="membrane-associated RING-CH protein IV; E3
                     ubiquitin-protein ligase MARCH4; membrane-associated ring
                     finger (C3HC4) 4, E3 ubiquitin protein ligase; RING finger
                     protein 174; membrane-associated RING finger protein 4;
                     membrane associated ring finger 4; RING-type E3 ubiquitin
                     transferase MARCH4; RING-type E3 ubiquitin transferase
                     MARCHF4; E3 ubiquitin-protein ligase MARCHF4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF4 precursor"
                     /protein_id="NP_065865.1"
                     /db_xref="CCDS:CCDS33376.1"
                     /db_xref="GeneID:57574"
                     /db_xref="HGNC:HGNC:29269"
                     /db_xref="MIM:608208"
                     /translation="MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRM
                     LFNDLKVFLLRRPPQAPLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPP
                     PVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRT
                     PLCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAIS
                     TKNPLQWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQIC
                     YGMYGFMDVVCIGLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNP
                     RTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHE
                     QRSPPGSSRELVMRVTTV"
     exon            2740..2895
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3088
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..4903
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4882..4887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /note="hexamer: AATAAA"
     polyA_site      4903
                     /gene="MARCHF4"
                     /gene_synonym="MARCH-IV; MARCH4; RNF174"
                     /note="major polyA site"
ORIGIN      
        1 acagttctct cctcctcttg ctccctctcc ctccagcttc ttttcctctc atcccctttc
       61 cctcctccat ccctccgcgg cgtctgcgtc aggcccccac gagcgtgacg cgcggggtct
      121 gggtgggagc tgtccactcg cccggggtgc tgaatgcagc agcggcggcc gcggcgccgg
      181 cggcggagat agccgagagc ctccctcgct gcaagaacct tgtttccagt tctcggacgg
      241 tcagctcgcc gccccgccac ctcccttcca gcaccacccc tttgggaatc gagccagtgg
      301 gggcagcggc gggtgctgag caacggcgga agacgagaca acacctggca gcagcctgga
      361 atctgatttg cttcctctcg gcttttataa gagatatatt tatatacggt tttggggagt
      421 cgcgaggacc aagctggagc caagtgccgg ctgcctccca cctcggccac actgcttcgc
      481 tcccccctcc ccaccttcag ctggcaccgc aaacaagcct tacctcgttg catctgcgag
      541 gagaggtagc aacagcgagc ctagccagcc agaggcggtg gagaggagga aggggcgggg
      601 tgggggggca gagagcgggc cgaggccgcc cttggtgggg gtagcggggg cagagctgcc
      661 gagcagaccc ggcagccgcc ctcctccgcc cccaccctcc agaagcactc ttgcctgaga
      721 accgaattat tccactagta ttatttcatt ttttattact ccccctcctc actccccagc
      781 cgcccccacc cccacgccgg cctcgcctct ggttgcatgg cagcgctgcc cgggcgcggg
      841 ggctcagggc tggcccccag ggaaggggga ggaggaggag gatcatgaag gccggagtcg
      901 cgaccgcgcc ggacggcggg cagcagccag aggacgagcc ggagcagccc ccgccccgga
      961 gacacccgga cgccgagcag cagtcgcctc cgccgccgca gcagcagctg cgggcgcggg
     1021 ccgacccgga gccggaggag gagggcgacc gcgacccaga ggaggaagag gaggagaagg
     1081 cgaggccact cgcccgcccg gacctgccct tctctcggct cttgcccctc gaccgaaggg
     1141 acctttgatg gaaccgaggg gagggcgcca cggatttgcc gactgcagca ggggtgggct
     1201 gggggctgag ataatgtaac cactcctttc tcctgttctc tcccacacgc ccctctcctc
     1261 tacccctatt ctctgctcca ctgccctctc accccggtac acacaccctt cctctagcca
     1321 ggatcttcat gctcaggaag gaggcgcctc tgcaagggtt aaacgatctt ttctttttct
     1381 cccatccttt ttccttccca aacctctatt ttacctccct tctcctaatt ggctttcccc
     1441 tcttcggtgt aaccctttgg ctgcggaggc aaagcacaag cccctagccc agtttcacct
     1501 gcaacacccc tcccccaccc aactgctctc ttaaaagcaa ctctggtgct tctgggggtt
     1561 aattgcccca gttttctgcc caggagaatt aaaacttctc ccaatcttct ctcctcccct
     1621 accttgactc ccccaacccc taccacctga gaaaaacgat cttttctctc tcacacatgc
     1681 agtcctcaat tcttcattga gctagttttc tctaagccca gctcaatcca ctccagattt
     1741 gatttacaat tgtccccacc cttttatata aaagaaagat ttctcactgc gtaggaattt
     1801 gagaagaacc caataatcct ttcctgggga acttttaaac aattcgacat tgatttaaac
     1861 aattcgacag aggctctagt ggcccctcca ccacgcttct tcaatccctc tgctcctacc
     1921 agtgtcctca ggtcaaaagc agaaaggaga cacactgaac aaagttggag gttggggtgg
     1981 gtgtgtgagg gcaagaaaaa cttttttgtt attgggcttt ccaggtggag ttcagaacca
     2041 gtgactcaca cttctcagtc ctgggagcaa tttatttgct acttggaggg gttgtaagaa
     2101 aagccagtga gaaagcagac tccccccaca acacagatcc actgtggacc cccaaaacct
     2161 gtcctgtccc cctcttttaa gactccagcc acccctcttg ggctctctac ttccacgggg
     2221 cacatgctga tgcccctgtg tgggctgctc tggtggtggt ggtgctgctg ctccggctgg
     2281 tactgctatg gattgtgtgc cccagccccc cagatgttgc gccaccaggg tctcctcaag
     2341 tgccgctgcc gcatgctctt caatgacctg aaggttttct tactgcggcg ccctcctcaa
     2401 gcgcccctgc ccatgcacgg cgacccccag ccccccggtt tggcggccaa caacaccctt
     2461 ccggctctgg gcgccggggg gtgggcaggc tggaggggcc cccgagaagt ggtgggcagg
     2521 gagccccctc ctgtgccacc tccacccccc ttgccacctt cttctgtgga agatgactgg
     2581 ggtggcccag ccacagagcc acctgcctcg ctgctcagca gtgcctcctc agatgacttc
     2641 tgtaaggaga agaccgagga tcgctactca ctgggcagca gcttggacag tggtatgagg
     2701 accccactct gccgcatctg cttccagggg ccagaacagg gggagctgct gagcccatgc
     2761 cgctgtgatg gctcggtcaa gtgcacacac cagccttgcc tcatcaagtg gatcagcgag
     2821 cggggctgct ggagctgcga gctgtgctac tacaagtacc acgtcatcgc cataagcaca
     2881 aaaaatcctc tgcagtggca ggccatctct ctgacggtca ttgagaaggt tcaggttgca
     2941 gccgccatcc tgggctccct cttcctcatc gccagtattt cttggctcat ctggtcaact
     3001 ttcagcccct cggcaagatg gcagcgccaa gaccttctct tccagatctg ctacgggatg
     3061 tatggcttca tggacgtggt gtgcataggt ctcatcatcc atgaaggacc ctcggtgtac
     3121 cgcatcttta aacggtggca ggctgtcaac cagcagtgga aagtgctgaa ctatgacaag
     3181 acaaaagacc tggaggatca aaaggcagga ggcaggacca acccccggac ctcctcatcc
     3241 acccaggcca atatcccctc ctcggaagag gagaccgcag gcacccctgc ccctgagcag
     3301 ggccctgccc aggctgccgg ccacccctca ggccctctgt cccatcacca ctgtgcttat
     3361 accatcctgc acatcctgag tcacttgaga cctcatgaac agcgaagtcc cccaggcagc
     3421 agccgagagc tggtcatgag agtcacgaca gtgtgagagc agaggcccgg aaggaaggcc
     3481 atgaccacca ctgagggccc ggagcagggt ggggaggtgc agtggcaccc ccagagccaa
     3541 cagagggagc aggcagaggg tgggggacct ggcgggagcc ctggggtagt gtcagagcgg
     3601 gagtgaggct ggtgcaggag cagttctgct atttccaatc agtcaatgcc actctccaca
     3661 acaacaatga aaaccaacac caactcaaca acaaagtgca atacaggctg aacctggccc
     3721 aacagaaaaa ccctgcccca atgcacctgc aggcaaggta cccgaagaag cagaggctga
     3781 gggcaggcaa agcctgtgtg actgtggcag tgccggaggc caagggggcc aagaggaaaa
     3841 gcatctgtgg tctgctctgc tctcaccctg tttggttttg tttctcctgg ggctgtgttc
     3901 tgcaggcagc cagaaaagga ggaggcacgg gtgagctggc agggacacac tgcctttggg
     3961 gctcctgggc tcatttggat gggcaagatt cgctgacaaa tggctgtggg gatggtgggg
     4021 tggatggtca gggagggatg ctcagggagg gatatgctgg tgtgagcagc cagagggaga
     4081 gtgtgtctcc ttcctgaagg aacttccaaa tggaactccc gatttcaggt gggctaaaag
     4141 agggcttagg tttggaaaag ggtgtccttc tgtgcccttg ttaatttatt ttatagtgat
     4201 ttggttcaaa gatgtttaca ggacacacac acacacacac acacacacac acacacacac
     4261 ccctagagaa aagtacagat ttccagtgga tatttcaagc acagttctgc tgctgtggct
     4321 tcagctttgg aagctgtcaa tcccggagca actttcccaa ctacccaacc ccaccatggc
     4381 caggacatgt gcaatgccag ccccttcttg tcttggcaca tgcacagacc cagtcccctc
     4441 acggtagggc acccctgacc tacgggcttc caagagagca gctgcagtgg ttgggaggag
     4501 cttgaccagt gtgccccaag gagtggagta gagcccaatc taagtattcc ttgctgcttg
     4561 gaaccctccc tgtttggaac cctccccaaa gaggcagtca ggctgatgct cagtgctttg
     4621 tgctccctgc tccttcccgc gtagccaggt gggcccaagg gtgcctggca gggagcacta
     4681 cccctggacc cctcctgctc gctctgggga ccctgccagg gaaggccact gggtgttcac
     4741 ctgcaaagtt tctggttgtc actgcacagt ggtcgcgtca tccatgggta ttaaaaggac
     4801 actgtcaagt acttttttaa actagttttt agggtttttt aaaactctct gttgtttgta
     4861 atattctctt aaaagcttga aaataaaact tctttcccta cca
//
