LOCUS       NM_178450               3946 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 3 (MARCHF3),
            mRNA.
ACCESSION   NM_178450 XM_938009
VERSION     NM_178450.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3946)
  AUTHORS   Zhou,J., Tu,D., Peng,R., Tang,Y., Deng,Q., Su,B., Wang,S., Tang,H.,
            Jin,S., Jiang,G., Wang,Q., Jin,X., Zhang,C., Cao,J. and Bai,D.
  TITLE     RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and
            metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma
  JOURNAL   Cell Commun Signal 21 (1), 224 (2023)
   PUBMED   37626338
  REMARK    GeneRIF: RNF173 suppresses RAF/MEK/ERK signaling to regulate
            invasion and metastasis via GRB2 ubiquitination in Hepatocellular
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3946)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3946)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3946)
  AUTHORS   Leclair,H.M., Andre-Gregoire,G., Treps,L., Azzi,S., Bidere,N. and
            Gavard,J.
  TITLE     The E3 ubiquitin ligase MARCH3 controls the endothelial barrier
  JOURNAL   FEBS Lett 590 (20), 3660-3668 (2016)
   PUBMED   27616439
  REMARK    GeneRIF: Report shows that silencing MARCH3 protects the
            endothelial barrier and upregulates OCLN in MARCH3-depleted cells.
            MARCH3 silencing results in the strengthening of cell-cell contacts
            and inactivates FoxO1.
REFERENCE   5  (bases 1 to 3946)
  AUTHORS   Fatehchand,K., Ren,L., Elavazhagan,S., Fang,H., Mo,X.,
            Vasilakos,J.P., Dietsch,G.N., Hershberg,R.M., Tridandapani,S. and
            Butchar,J.P.
  TITLE     Toll-like Receptor 4 Ligands Down-regulate Fcgamma Receptor IIb
            (FcgammaRIIb) via MARCH3 Protein-mediated Ubiquitination
  JOURNAL   J Biol Chem 291 (8), 3895-3904 (2016)
   PUBMED   26694610
  REMARK    GeneRIF: LPS activation of TLR4 significantly increased MARCH3
            expression and that siRNA against MARCH3 prevented the decrease in
            FcgammaRIIb following LPS treatment.
REFERENCE   6  (bases 1 to 3946)
  AUTHORS   Fukuda,H., Nakamura,N. and Hirose,S.
  TITLE     MARCH-III Is a novel component of endosomes with properties similar
            to those of MARCH-II
  JOURNAL   J Biochem 139 (1), 137-145 (2006)
   PUBMED   16428329
REFERENCE   7  (bases 1 to 3946)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455278.1, BC047569.1,
            AC093532.2 and AC137794.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178450.4.
            
            Summary: This gene encodes a member of the membrane-associated
            RING-CH (MARCH) family. The encoded protein is an E3
            ubiquitin-protein ligase that may be involved in regulation of the
            endosomal transport pathway. [provided by RefSeq, Mar 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.62941.1,
                                           SRR1803613.34973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308660.6/ ENSP00000309141.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               DB455278.1         191-470
            281-1358            BC047569.1         281-1358
            1359-2400           AC093532.2         78602-79643         c
            2401-3946           AC137794.2         1-1546
FEATURES             Location/Qualifiers
     source          1..3946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..3946
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="membrane associated ring-CH-type finger 3"
                     /db_xref="GeneID:115123"
                     /db_xref="HGNC:HGNC:28728"
                     /db_xref="MIM:613333"
     exon            1..209
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            210..453
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1027
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /EC_number="2.3.2.27"
                     /note="membrane-associated RING-CH protein III; E3
                     ubiquitin-protein ligase MARCH3; RING finger protein 173;
                     membrane-associated ring finger (C3HC4) 3, E3 ubiquitin
                     protein ligase; membrane associated ring finger 3;
                     RING-type E3 ubiquitin transferase MARCH3; RING-type E3
                     ubiquitin transferase MARCHF3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF3"
                     /protein_id="NP_848545.1"
                     /db_xref="CCDS:CCDS4141.1"
                     /db_xref="GeneID:115123"
                     /db_xref="HGNC:HGNC:28728"
                     /db_xref="MIM:613333"
                     /translation="MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQV
                     SAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLE
                     HWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLAT
                     ISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTN
                     QRVILLIPKSVNVPSNQPSLLGLHSVKRNSKETVV"
     exon            454..658
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            659..868
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /inference="alignment:Splign:2.1.0"
     exon            869..3946
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="hexamer: ATTAAA"
     polyA_site      1424
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="major polyA site"
     regulatory      1775..1780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="major polyA site"
     regulatory      2189..2194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="hexamer: AATAGA"
     polyA_site      2207
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
     regulatory      3922..3927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
                     /note="hexamer: AATAAA"
     polyA_site      3946
                     /gene="MARCHF3"
                     /gene_synonym="MARCH-III; MARCH3; RNF173"
ORIGIN      
        1 actcgttgag caggtccgtg aattgtcagc gcgctgtggg cgactgtgtg gccgcggcgg
       61 ccgccaggct tgccgcactc cccctgaggt gcccgccgga accaatgtgc cctggtccac
      121 tgggccgtga gcagccaccg actgggggca acttggcact tagaaccgca gcagggacgt
      181 cggtttgcta tcgggactcg gcgaggacga tggaaatcct gtatgaatgt ggaagccatt
      241 agcagagtaa ttgctgtctg ttaccatgac aaccagccgc tgcagtcacc tgcccgaagt
      301 cctgccagac tgcaccagct cagctgcacc cgtggtgaag acggtggagg attgtggcag
      361 cctagtgaat gggcagccgc agtatgtcat gcaagtttca gccaaggacg ggcagctgct
      421 gtcaacagta gtgcggactc ttgccaccca gagccccttc aatgaccggc cgatgtgcag
      481 gatctgccac gagggcagca gccaagagga cttgctctct ccatgtgaat gtacagggac
      541 cttggggaca attcatcgga gctgcctgga gcactggctg tcatcctcaa acaccagcta
      601 ctgtgaactc tgccacttca ggtttgcagt cgagcgcaaa cccaggccgt tagtggagtg
      661 gctgagaaac cctggccccc agcatgagaa gcggactctg tttggcgaca tggtgtgctt
      721 cttgtttata actcccctgg ccaccatctc gggctggctg tgcctgcggg gcgccgtgga
      781 ccacctgcac tttagtagtc ggctggaagc cgtcggactg attgcactca ctgtcgcact
      841 cttcactatt tacctctttt ggacactagt gtcatttagg taccactgtc gattgtacaa
      901 cgagtggcgt cggaccaatc agagggtgat tctcctcatt ccaaagtctg tcaatgtacc
      961 ttctaaccag ccgtccttgc tgggcctcca ttcggtcaag aggaactcaa aggagacagt
     1021 tgtttgatgt ttgtatggtt ggttggttgt ttgattcatt gtttggggtt tggaagtgtc
     1081 tgcactgggg tcatgcactg agcgaccccc aagcccttcc ttaagcctgt gggtctaaga
     1141 acatccagag catattagca catcactcca agcaacaacc tccgccagaa gaaagcaaat
     1201 gctgttttac ttcaaatgat ggatgctgca atcatatgat atttgctaag ctgccaaaca
     1261 tgtttattta gcagatactg tatggaattt tctgaacacc tctttaacgt atgaggaagg
     1321 ttgtcctgct acggatgcaa ttcaattctt ccttttttat tactatttca aacacacaca
     1381 catatatata tatattaaac ttagatgata atcaaaatca aaaagtcaac gtaaaaactg
     1441 gtttcttggt ttggttgggt cttatttgag ttagtttgtt tctcagtttc tcgtatggat
     1501 tctttggggt actttggtag cctgagtggt ctttttcatc tctttcgcgt ccattactca
     1561 aggagacagc ataacagatg cagaacaagt catatttgaa gaatgttttg tactaaactt
     1621 catttaatta ttcagttttt aaagggaaaa agggcgtgag ctcacacagt gagctgttta
     1681 tttaaatatc attaaggaga aaaaaaaata tggtgagaag ctcgctcctt tcaacttgtt
     1741 tggtactgac agctgataga agctattttc taataataaa catccagtgt gtgaaagaca
     1801 aaacccactg attgcaatac tcttttttta atgataaaac ctgtgaagtt tcccaaagca
     1861 ggttttaaaa ggaaaaaaag gaaaagcaaa aaggttgctg ttctcactcc catctcattt
     1921 agtgcatgtc ttaattcggg attcgtaatg aattggagga tcattagaca tttctaggaa
     1981 ccctagacct gttttgcatg tcaattagca ttcccattgc tctattgaat ttctagcttg
     2041 acaggtagat gtggcaaaaa aaaaaaaaaa aaaaaaagcc tgtcctagca gccctgcact
     2101 tattctaaga cccctttgtc tgattcttta aaaaggagcc ccacacagtg ccttccccca
     2161 accatgagcc aattctgtca cagtccgaaa tagacttttt ctaagggttt cgtgtccctc
     2221 ttttatccgt cgcagtgtaa agggtctgat ccgcagcctg cattgtgcgc gcaccgaggc
     2281 aggagcggat gtcttctgag gagagcgctg gctggggttg actctcaggc tcccggctgt
     2341 ccgcccgccc acacgcagcg aggaggggcg gagccctgct tccggaatgc ttaaaatatg
     2401 gaattctaga acatgaccca cattctgagt atcactccag catctgcctt gtgttccaag
     2461 tgggaaaacg agaagtgcaa aggaacaggc agcgaggagg gtagcgattt ttgtctgcaa
     2521 attgatggag ctgatgcagg tgtccccttt gtaggcgagc cctccattca ctggctgctc
     2581 ccagcgctgc ctggggaggg aaacagctgt actgctctcc gctgcaaaac tcagatgtgc
     2641 tttatggctt gtgacaatag atttcctccc caccacgctt cactgggaca cttcaattcc
     2701 agtaatatat gtctcagccc ttctgtttac tgcgccctgc tcacccccct gggctgtcat
     2761 tagctgcacc accatcaacc gtttcttaat tgaccttttt aaaatgctgg acatcaccgg
     2821 ctgcacgcag ctgccacaca ttaaatttcc agagcaaaga gtccaacttg gtagctggtg
     2881 aattgcagcc ctgtaatata cttaataaat gacgtccacc cagccttagt ccctgagctg
     2941 tcaggtgaac ccgtgacacg tctcaactga atggcacaac attcatgaga ggaccatacc
     3001 ccttctccct gtttcttgca tgaattaagg aagcagcgga tttccaggat gatttcctgt
     3061 caaggttggc tgcagagaat tcctgccatc ttggttcatg agatgagata tgacatcatc
     3121 aaaggcagcc aggtcccagg ccgttcaatg gggatcctgc attaggaagg gtttgcacat
     3181 taaaactgtg cctgtgccac acctctttcc ttcgtgtttg catccctgcc ctgtgaagta
     3241 aaacagagtc caagatgcaa ggagtagatt gtgtgtgggg tggtgaaagg acacccctgg
     3301 cagccaggca gagcatcagt gcctcccttc ccaggtcacc agcttgggac ctccttgtga
     3361 gaggctctga tctccatcag catcagggcc cataggggat tctgaactct tggaggatat
     3421 ttcatcccct ccaagccttg ccccatggaa agggctacac ctcctgcagg aaggggtgcc
     3481 ttttgttaac aggtattaat gggtacagag gcaccatgca gcctaccagc acccttgcta
     3541 gcctagtcct cttcctgtgc ttctttttga aagatcaaga atgaagagga agagatgagg
     3601 agtgggggtc ctttacctaa aggaccctcg tggttcattg cttctcttta actgactttt
     3661 taaaaaaact ccctcttcca cactccttgc tgtgattctg tcctaatcat ttttcttgag
     3721 aatgtcatgt agagataaat gtgtgtcaca gtgaagccag aaggtgaatt aacaactaag
     3781 acaaatccag catgctcttg cctgccctgc atatgtgctc atttggggaa ggacggagga
     3841 cacagagcat cgacacaaat tctacagctc ctcagagaac acagcagaga ctcagatgag
     3901 ctgtaaaatc cattaaggaa aaataaatgg catgatttgg aagtta
//
