LOCUS       NM_001005415            1380 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 2 (MARCHF2),
            transcript variant 2, mRNA.
ACCESSION   NM_001005415
VERSION     NM_001005415.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Ni,D., Qi,Z., Wang,Y., Man,Y., Pang,J., Tang,W., Chen,J., Li,J. and
            Li,G.
  TITLE     KLF15-activated MARCH2 boosts cell proliferation and
            epithelial-mesenchymal transition and presents diagnostic
            significance for hepatocellular carcinoma
  JOURNAL   Exp Cell Res 440 (1), 114117 (2024)
   PUBMED   38848952
  REMARK    GeneRIF: KLF15-activated MARCH2 boosts cell proliferation and
            epithelial-mesenchymal transition and presents diagnostic
            significance for hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Seo,T., Lowery,A.M., Xu,H., Giang,W., Troyanovsky,S.M.,
            Vincent,P.A. and Kowalczyk,A.P.
  TITLE     MARCH family E3 ubiquitin ligases selectively target and degrade
            cadherin family proteins
  JOURNAL   PLoS One 19 (5), e0290485 (2024)
   PUBMED   38722959
  REMARK    GeneRIF: MARCH family E3 ubiquitin ligases selectively target and
            degrade cadherin family proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Ito,K., Harada,I., Martinez,C., Sato,K., Lee,E., Port,E.,
            Byerly,J.H., Nayak,A., Tripathi,E., Zhu,J. and Irie,H.Y.
  TITLE     MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses
            Triple-negative Breast Cancer Metastases
  JOURNAL   Cancer Res Commun 4 (3), 946-957 (2024)
   PUBMED   38457262
  REMARK    GeneRIF: MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase,
            Suppresses Triple-negative Breast Cancer Metastases.
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Yu,C., Bai,Y., Tan,W., Bai,Y., Li,X., Zhou,Y., Zhai,J., Xue,M.,
            Tang,Y.D., Zheng,C. and Liu,Q.
  TITLE     Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein
            cleavage via targeting furin P domain
  JOURNAL   J Med Virol 96 (2), e29445 (2024)
   PUBMED   38299743
  REMARK    GeneRIF: Human MARCH1, 2, and 8 block Ebola virus envelope
            glycoprotein cleavage via targeting furin P domain.
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Chathuranga,K., Kim,T.H., Lee,H., Park,J.S., Kim,J.H.,
            Chathuranga,W.A.G., Ekanayaka,P., Choi,Y.J., Lee,C.H., Kim,C.J.,
            Jung,J.U. and Lee,J.S.
  TITLE     Negative regulation of NEMO signaling by the ubiquitin E3 ligase
            MARCH2
  JOURNAL   EMBO J 39 (21), e105139 (2020)
   PUBMED   32935379
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 1380)
  AUTHORS   Fukuda,H., Nakamura,N. and Hirose,S.
  TITLE     MARCH-III Is a novel component of endosomes with properties similar
            to those of MARCH-II
  JOURNAL   J Biochem 139 (1), 137-145 (2006)
   PUBMED   16428329
REFERENCE   9  (bases 1 to 1380)
  AUTHORS   Nakamura,N., Fukuda,H., Kato,A. and Hirose,S.
  TITLE     MARCH-II is a syntaxin-6-binding protein involved in endosomal
            trafficking
  JOURNAL   Mol Biol Cell 16 (4), 1696-1710 (2005)
   PUBMED   15689499
  REMARK    GeneRIF: Depletion of MARCH-II by small interfering RNA perturbed
            the trans-Golgi network (TGN) localization of syntaxin 6 and
            TGN38/46
REFERENCE   10 (bases 1 to 1380)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI546028.1, AF151074.1, CN363445.1, BC032624.1 and BC015910.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001005415.1.
            
            Summary: MARCH2 is a member of the MARCH family of membrane-bound
            E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin
            (see MIM 191339) to target lysines in substrate proteins, thereby
            signaling their vesicular transport between membrane compartments.
            MARCH2 reduces surface accumulation of several glycoproteins and
            appears to regulate early endosome-to-trans-Golgi network (TGN)
            trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et
            al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 4. Variants 1, 2, and 4-7 all encode the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1388149.1,
                                           SRR3476690.846630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215555.7/ ENSP00000215555.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BI546028.1         17-104
            89-116              AF151074.1         1-28
            117-1052            AF151074.1         300-1235
            1053-1110           CN363445.1         345-402
            1111-1111           BC032624.1         1398-1398
            1112-1346           BC032624.1         1400-1634
            1347-1380           BC015910.1         1161-1194
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1380
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /note="membrane associated ring-CH-type finger 2"
                     /db_xref="GeneID:51257"
                     /db_xref="HGNC:HGNC:28038"
                     /db_xref="MIM:613332"
     exon            1..116
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            117..344
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..909
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2;
                     membrane-associated RING-CH protein II;
                     membrane-associated ring finger (C3HC4) 2, E3 ubiquitin
                     protein ligase; membrane associated ring finger 2; E3
                     ubiquitin-protein ligase MARCH2; RING finger protein 172;
                     membrane-associated RING finger protein 2; RING-type E3
                     ubiquitin transferase MARCHF2; E3 ubiquitin-protein ligase
                     MARCHF2; RING-type E3 ubiquitin transferase MARCH2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF2 isoform 1"
                     /protein_id="NP_001005415.1"
                     /db_xref="CCDS:CCDS12202.1"
                     /db_xref="GeneID:51257"
                     /db_xref="HGNC:HGNC:28038"
                     /db_xref="MIM:613332"
                     /translation="MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRD
                     GRLLSTVIRALDTPSDGPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSN
                     TSYCELCHTEFAVEKRPRPLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCL
                     RGAQDHLRLHSQLEAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKI
                     READSPEGPQHSPLAAGLLKKVAEETPV"
     exon            345..540
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            541..750
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1380
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="MARCHF2"
                     /gene_synonym="HSPC240; MARCH-II; MARCH2; RNF172"
                     /note="major polyA site"
ORIGIN      
        1 ggacgcaggt gccggccgga gcggagctag tggcgccgac gggccgggcc gggccgggac
       61 cggggccgag gcgaaccgag gggcctgtgc ggccgcccgg cccggccgcg gatcaggctc
      121 ctggaaccat gggcctcagg ccctgaggat acggggctcc cggtggccat gacgacgggt
      181 gactgctgcc acctccccgg ctccctgtgt gactgctccg gcagccctgc cttctccaag
      241 gtcgtggagg ctacgggcct cggaccgccc cagtatgtgg cacaggtgac ttcaagggat
      301 ggccggctcc tctccaccgt catccgtgcc ttggacacac cgagtgatgg tcctttctgc
      361 cggatctgcc atgagggagc gaacggggag tgcttgctgt ccccgtgtgg ctgcaccggc
      421 acgctgggtg ccgtgcataa gagctgtctg gagaagtggc tttcctcatc taacaccagc
      481 tactgcgagc tgtgccacac ggagtttgca gtggagaaac ggcctcgacc cctcacagag
      541 tggctgaagg acccggggcc gcggacggag aagcggacac tgtgctgcga catggtgtgt
      601 ttcctgttca tcacaccgct ggccgccatc tcaggctggt tgtgcctgcg cggggcccag
      661 gaccacctcc ggctccacag ccagctggag gccgtgggtc tcattgccct caccatcgcc
      721 ctcttcacca tctatgtcct ctggacgctg gtctccttcc gctaccactg ccagctgtac
      781 tccgagtgga gaaagaccaa ccagaaagtt cgcctgaaga tccgggaggc ggacagcccc
      841 gagggccccc agcattctcc actggcagct ggactcctga agaaggtggc agaggagaca
      901 ccagtatgaa tgctgggctc tccggaccct gcagcagaga ggccagaggt agctggtgat
      961 accctgtcct gtggaaggac ttccacttca acacttccac ttcaacagtt cccgcacggc
     1021 ctgaacgctt cttaggccaa gagacaccat gcagagccta gtctgtgatc ctgtgtgaag
     1081 atattttcag ggtttttttt tttttttttt tgcatatgga ggacaggtgg acatggtcct
     1141 gagctctgga cggagcaggc accctgatct cattctgagg tccacatggc accttctggg
     1201 ccagcagctg tggccggtgt atcaagggcg cccttaaagc tggaacattc cagcaagctt
     1261 cttgcgcttc tctgcacccg gcaggcccac tttcctggca ccctcgactt tatataaaag
     1321 ttgcactgcg tttcaaaaac ccacccctga atgaataaaa ggagccctgg ctggacaaaa
//
