LOCUS       NM_001102562            1757 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 11 (MARCHF11),
            mRNA.
ACCESSION   NM_001102562 XM_496738 XM_941081
VERSION     NM_001102562.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Lai,W.Y., Chuang,T.P., Borenas,M., Lind,D.E., Hallberg,B. and
            Palmer,R.H.
  TITLE     Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression
            via MARCH11 to promote neuroblastoma cell growth
  JOURNAL   Cell Death Differ 31 (7), 910-923 (2024)
   PUBMED   38858548
  REMARK    GeneRIF: Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2
            expression via MARCH11 to promote neuroblastoma cell growth.
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Morokuma,Y., Nakamura,N., Kato,A., Notoya,M., Yamamoto,Y.,
            Sakai,Y., Fukuda,H., Yamashina,S., Hirata,Y. and Hirose,S.
  TITLE     MARCH-XI, a novel transmembrane ubiquitin ligase implicated in
            ubiquitin-dependent protein sorting in developing spermatids
  JOURNAL   J Biol Chem 282 (34), 24806-24815 (2007)
   PUBMED   17604280
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092335.2, DB455291.1, AC016650.6 and BG209034.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001102562.2.
            
            Summary: MARCH11 is a member of the MARCH family of membrane-bound
            E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin
            (see MIM 191339) to target lysines in substrate proteins, thereby
            signaling their intracellular transport. March11 appears to have a
            role in ubiquitin-mediated protein sorting in the trans-Golgi
            network (TGN)-multivesicular body (MVB) transport pathway (Morokuma
            et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.441748.1,
                                           SRR5189667.305018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332432.9/ ENSP00000333181.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC092335.2         39264-39266         c
            4-333               DB455291.1         4-333
            334-753             AC092335.2         38514-38933         c
            754-909             AC092335.2         37201-37356         c
            910-1102            AC016650.6         125535-125727
            1103-1531           AC016650.6         148823-149251
            1532-1590           BG209034.1         435-493
            1591-1757           AC016650.6         149311-149477
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..1757
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /note="membrane associated ring-CH-type finger 11"
                     /db_xref="GeneID:441061"
                     /db_xref="HGNC:HGNC:33609"
                     /db_xref="MIM:613338"
     exon            1..753
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1425
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase MARCH11;
                     membrane-associated RING-CH protein XI;
                     membrane-associated RING finger protein 11;
                     membrane-associated ring finger (C3HC4) 11; membrane
                     associated ring finger 11; RING-type E3 ubiquitin
                     transferase MARCH11; RING-type E3 ubiquitin transferase
                     MARCHF11; ring finger protein 226"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF11"
                     /protein_id="NP_001096032.1"
                     /db_xref="CCDS:CCDS47192.1"
                     /db_xref="GeneID:441061"
                     /db_xref="HGNC:HGNC:33609"
                     /db_xref="MIM:613338"
                     /translation="MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPA
                     APRYLPPLPASPETPERAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDS
                     GEGPRRLPEAAAAKGGPGESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAG
                     HQHQHHQPICKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYR
                     YHVIAIKMKQPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRK
                     DILFQICYGMYGFMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESS
                     RGESSTSRTLWLPLTALRNRNLVHPTQLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSS
                     GEVVMRVTSV"
     exon            754..909
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1102
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1757
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /note="hexamer: AATACA"
     polyA_site      1590
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /note="major polyA site"
     regulatory      1736..1741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
                     /note="hexamer: AATATA"
     polyA_site      1757
                     /gene="MARCHF11"
                     /gene_synonym="MARCH-XI; MARCH11; RNF226"
ORIGIN      
        1 agagccgagc cggcggctcc accgaacggc cgcgcctgcc gccgccgcag ctgcagaacc
       61 ttccgcatcc cctccccgtc ccgcccccta gccccaggcg tccgggcccc ctccctcctt
      121 ttcccctctc cctcccgccc cctccgcgct ctctttccct gcagccagag cccggcccgc
      181 cagccgggcc ggcaggaggg cggcggcggc acaaccatga gctttgaggg cggccacggc
      241 ggcagtcggt gtcgcggggc ggagagcggg gacgccgagc ctcccccgca acctcccccg
      301 ccgccgccgc cgacgccgcc gccgggagag ccggccccgg tccccgcggc cccgcgctac
      361 ctgccgccgc tgcccgcgtc ccccgagacc cccgagcgcg ccgcggggcc aagcgagccg
      421 ctaggggagg tggccccgcg gtgcagggga gcggacgagc tgccgcctcc gcccctgccc
      481 ctgcagcccg ccggccagga agtggcggcg gccggcgact ccggggaagg tccgaggcgc
      541 ctcccggagg cggcagcagc gaaaggcggc cccggggagt ctgaggccgg cgcgggcggc
      601 gagcgcgagc ggcggggcgc cggagaccag cccgagacgc gctcggtgtg cagcagccgc
      661 agcagcagca gtggcggcgg cgaccagcgc gctgggcacc agcaccagca ccaccagccc
      721 atctgcaaga tctgcttcca gggcgcggag cagggtgagt tgttgaaccc ctgccgatgt
      781 gatgggtcag ttcggtatac acatcagctg tgcctgctaa aatggatcag tgagagaggt
      841 tcctggacct gtgaactttg ctgttataga taccatgtta tagccattaa aatgaaacaa
      901 ccttgccagt ggcagagcat ttctataaca ctggttgaga aagttcagat gattgctgta
      961 atcctaggat ccctgttctt aatagccagt gtgacttggc tcctctggtc agccttcagc
     1021 ccctatgcag tgtggcagag gaaggacatc ctttttcaga tctgctatgg aatgtatggt
     1081 tttatggatc tagtgtgcat aggtctcatt gttcatgaag gagctgcagt ttacagagtg
     1141 tttaagcgct ggcgagctgt gaatttgcac tgggatgtgt taaattatga caaagccaca
     1201 gacatcgaag aaagcagccg gggagagtct tccacaagta ggactttgtg gttgccattg
     1261 acagctctgc ggaacagaaa cttggtccac ccaactcagt taacctcacc aaggtttcag
     1321 tgtggctatg tgttattgca cctgttcaat cggatgaggc cccatgaaga cttatcagaa
     1381 gataacagct cgggggaggt tgtgatgaga gtgacttcag tgtgacaaaa gcataagatg
     1441 atgcagtgtg gaccaccctg cacattttgc aatgtaattg cagtgaatgg caaaaccata
     1501 gcacttctaa aaacacatct atgaactttt taaaatttat gctttttata tgaacatttg
     1561 aattgcaaat acatttttct gagaaaaaga gtcctcttgt tcttcgttgt ctggtttgtc
     1621 acatctttta taagttggta cttgaaatca ttatacatat aatttaacta tacttggtta
     1681 aaagaataat gaaagttatc cttaaggcca aaactatttt ttcttgcttg ttttaaatat
     1741 atttttatga aagcttt
//
