LOCUS       NM_152598               3071 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 10 (MARCHF10),
            transcript variant 1, mRNA.
ACCESSION   NM_152598
VERSION     NM_152598.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3071)
  AUTHORS   Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
            Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
  TITLE     GWAS for discovery and replication of genetic loci associated with
            sudden cardiac arrest in patients with coronary artery disease
  JOURNAL   BMC Cardiovasc Disord 11, 29 (2011)
   PUBMED   21658281
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3071)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3071)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3071)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3071)
  AUTHORS   Morokuma,Y., Nakamura,N., Kato,A., Notoya,M., Yamamoto,Y.,
            Sakai,Y., Fukuda,H., Yamashina,S., Hirata,Y. and Hirose,S.
  TITLE     MARCH-XI, a novel transmembrane ubiquitin ligase implicated in
            ubiquitin-dependent protein sorting in developing spermatids
  JOURNAL   J Biol Chem 282 (34), 24806-24815 (2007)
   PUBMED   17604280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093076.1, AK122947.1, AW473122.1 and BC035021.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152598.3.
            
            Summary: MARCH10 is a member of the MARCH family of membrane-bound
            E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin
            (see MIM 191339) to target lysines in substrate proteins, thereby
            signaling their vesicular transport between membrane compartments
            (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr
            2010].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 3. Variants 1 and
            2 encode the same isoform (1), which is shorter than isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311269.10/ ENSP00000311496.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1210              AK093076.1         21-1230
            1211-2626           AK122947.1         1332-2747
            2627-2813           AK093076.1         2647-2833
            2814-3070           AW473122.1         1-257               c
            3071-3071           BC035021.1         3061-3061
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..3071
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /note="membrane associated ring-CH-type finger 10"
                     /db_xref="GeneID:162333"
                     /db_xref="HGNC:HGNC:26655"
                     /db_xref="MIM:613337"
     exon            1..238
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            239..345
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2682
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 190; probable E3 ubiquitin-protein ligase
                     MARCH10; membrane-associated RING-CH protein X;
                     membrane-associated RING finger protein 10;
                     membrane-associated ring finger (C3HC4) 10, E3 ubiquitin
                     protein ligase; membrane associated ring finger 10; testis
                     secretory sperm-binding protein Li 228n; RING-type E3
                     ubiquitin transferase MARCH10; RING-type E3 ubiquitin
                     transferase MARCHF10; probable E3 ubiquitin-protein ligase
                     MARCHF10"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase MARCHF10
                     isoform 1"
                     /protein_id="NP_689811.2"
                     /db_xref="CCDS:CCDS11635.1"
                     /db_xref="GeneID:162333"
                     /db_xref="HGNC:HGNC:26655"
                     /db_xref="MIM:613337"
                     /translation="MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNE
                     KKRDQFWGQETSFERSRFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQT
                     SVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGD
                     RSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRA
                     KKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDF
                     YSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEE
                     NAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGG
                     SENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNS
                     LDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFH
                     VCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNP
                     QGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGF
                     TDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGS
                     LQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQ
                     NELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRNYPQPRTEENENSELGDGN
                     EGSISQSQVV"
     exon            346..465
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            466..637
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            638..790
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            791..2192
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2359
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2469
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2583
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2626
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..3071
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /note="hexamer: AGTAAA"
     polyA_site      3071
                     /gene="MARCHF10"
                     /gene_synonym="MARCH-X; MARCH10; RNF190"
                     /note="major polyA site"
ORIGIN      
        1 agccgccccc accgcctccg ccccaggcaa ggccggccgg cgccgcggaa agcagcctcg
       61 gggaaggagg aggaagaggg gcaggtgtag ggagtgaaga agcaaaaaga ggaggaggaa
      121 gaggagctca gggccgtccc cgcgcaatta atgggcggct cctgcgccct ggaccggccc
      181 gcccgcccag cccctcgacc cctgtagccc cggcagggga ggaagggcag acccacaggt
      241 cagggattag gaatcatgtt gcatgacgca agggacaggc agaagttctt cagcgatgtt
      301 cagtatctgc gggacatgca gcataaggtg gactctgagt atcaggcttg tctgagacga
      361 caggaatata gaagagaccc aaatgagaag aaacgcgatc agttttgggg gcaagagaca
      421 agttttgaga gatcccggtt ttctagcagg tcatcttcca aacagagttc tagtgaggag
      481 gatgctctaa ctgaaccaag gtcatctatc aagatatctg catttaagtg tgactccaaa
      541 cttccagcaa ttgaccaaac atcagtcaag cagaaacata aaagtaccat gactgtaagg
      601 aaagcagaga aagtggaccc cagcgaaccc tctccagcag accaagcacc aatggtttta
      661 ttaagaaaga ggaagccaaa cctgaggaga tttacagtca gcccagaatc gcacagcccg
      721 agagcatctg gggacagaag cagacagaaa cagcagtggc ctgcaaaggt gccggttccc
      781 aggggagcag atcaagtagt tcaacaagaa ggcctgatgt gtaacactaa gctgaagagg
      841 ccaaatcaag agagaagaaa cttggtccca tcgtcacagc caatgactga gaacgcccct
      901 gatagagcca aaaaaggaga cccgagtgct ccttcccaga gtgagctgca tccagccctg
      961 tcccaggcct tccaaggaaa aaatagtcct caagtattga gtgagttctc ggggccacca
     1021 ctcacaccca ccactgtagg agggccaaga aaggcatcat ttaggttccg agatgaagac
     1081 ttttattcca ttttgtcatt gaacagcaga agagaaagcg atgacactga agaggaaacc
     1141 cagtctgaag aatgtctgtg ggttggtgtg cgctcaccct gttctccttc ccatcacaaa
     1201 agaagtagat ttggggggac atcgacccct caggccaaaa ataaaaattt tgaagaaaat
     1261 gctgaaaatt gcagaggtca ttcttcaaga agaagtgagc ccagtcatgg ctcattgaga
     1321 ataagcaatg caatggagcc agcaacagag cggccttctg ctgggcaaag gttgtcccaa
     1381 gaccccgggc tgcctgatag ggaatctgct acagagaagg acagaggtgg cagtgaaaat
     1441 gcgaaaaaga gccctctttc gtgggacacc aaatccgagc ccagacaaga ggttggtgtc
     1501 aatgctgaaa atgtatggag tgattgtatt tctgtggaac ataggcctgg cacccatgat
     1561 tctgaaggat actggaaaga ctatttaaac agttctcaaa attctcttga ctactttatt
     1621 tctggcagac caatatctcc aagatcatca gtgaattcat cctataaccc tcctgcatca
     1681 ttcatgcatt ctgctctgag agatgatatt ccagtagact tgtcaatgtc atcgacttca
     1741 gttcacagct cagactcaga gggaaactca gggtttcatg tttgccaacc actgtctccc
     1801 attagaaata ggactccatt tgccagtgcc gaaaaccata attatttccc agtaaacagt
     1861 gcacacgaat ttgctgtcag ggaagcagaa gatactactt taacaagcca gcctcagggg
     1921 gctccactat atacagatct cttactaaat ccacagggca atttgtcctt agtggattct
     1981 tccagctcct ctccatcaag aatgaactca gaaggccatt tgcatgtgtc tgggtctctg
     2041 caagaaaata caccatttac tttctttgca gtgtctcatt tcccaaatca aaatgataat
     2101 gggagcagga tggcagcctc tggtttcaca gatgaaaagg aaaccagtaa gataaaggca
     2161 gaccctgaga aactcaagaa attgcaagaa agtctcctgg aggaggactc cgaggaggag
     2221 ggagacttgt gtcgcatctg tcagatagcc gggggttccc caagcaaccc cctcctggag
     2281 ccttgcggct gtgtgggaag cctgcagttt gttcatcaag agtgcctgaa aaagtggctg
     2341 aaagtgaaaa taacatcagg agcagatctt ggtgccgtga agacctgtga gatgtgtaag
     2401 caaggcctgc tggttgacct gggtgacttt aacatgattg agttctacca gaagcaccag
     2461 caatctcagg cacaaaacga gctgatgaat tcaggcttgt acctggtgct gctgcttcac
     2521 ctctatgagc agaggtttgc agaactcatg aggctcaacc acaaccaggt ggaaagagag
     2581 aggttgtcaa gaaattaccc acaacccaga acagaggaaa atgaaaattc ggagttggga
     2641 gatggaaatg aaggcagcat ttctcaaagc caggtcgtct agcaaggaag ccaactgtgg
     2701 agctcggcgg agacctctcc cgccagccct tctttctacg tccccaagtg cctccctccc
     2761 tcctcctctt tactgaaact gaaaccaaag cgttcacagt tagattttca cctcgtgcca
     2821 ctctcttttg gggtctggct tgagcatcta tgggcagcca cagcgaccag tctagtccca
     2881 gacagcacag gtcaagcagc gtgggactgt ggagcccctg gcaggctggc ctggtgctgc
     2941 ccccttagcc cagaagccct gccaggtcca gtggcctggg gtcccactgc tgagggcacc
     3001 tgccaggcct cactccaccc tgaatggact cgagccatgt attcattcag taaactgaca
     3061 ttattctccc a
//
