LOCUS       NM_001394959            6140 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens membrane associated ring-CH-type finger 1 (MARCHF1),
            transcript variant 3, mRNA.
ACCESSION   NM_001394959
VERSION     NM_001394959.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6140)
  AUTHORS   Li,X., Cheng,K., Shang,M.D., Yang,Y., Hu,B., Wang,X., Wei,X.D.,
            Han,Y.C., Zhang,X.G., Dong,M.H., Yang,Z.L. and Wang,J.Q.
  TITLE     MARCH1 negatively regulates TBK1-mTOR signaling pathway by
            ubiquitinating TBK1
  JOURNAL   BMC Cancer 24 (1), 902 (2024)
   PUBMED   39061024
  REMARK    GeneRIF: MARCH1 negatively regulates TBK1-mTOR signaling pathway by
            ubiquitinating TBK1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6140)
  AUTHORS   Valizadeh,M., Raoofian,R., Homayoonfar,A., Hajati,E. and
            Pourfathollah,A.A.
  TITLE     MARCH-I: A negative regulator of dendritic cell maturation
  JOURNAL   Exp Cell Res 436 (1), 113946 (2024)
   PUBMED   38331309
  REMARK    GeneRIF: MARCH-I: A negative regulator of dendritic cell
            maturation.
REFERENCE   3  (bases 1 to 6140)
  AUTHORS   Yu,C., Bai,Y., Tan,W., Bai,Y., Li,X., Zhou,Y., Zhai,J., Xue,M.,
            Tang,Y.D., Zheng,C. and Liu,Q.
  TITLE     Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein
            cleavage via targeting furin P domain
  JOURNAL   J Med Virol 96 (2), e29445 (2024)
   PUBMED   38299743
  REMARK    GeneRIF: Human MARCH1, 2, and 8 block Ebola virus envelope
            glycoprotein cleavage via targeting furin P domain.
REFERENCE   4  (bases 1 to 6140)
  AUTHORS   Liu,L., Guo,B., Han,Y., Xu,S. and Liu,S.
  TITLE     MARCH1 silencing suppresses growth of oral squamous cell carcinoma
            through regulation of PHLPP2
  JOURNAL   Clin Transl Oncol 24 (7), 1311-1321 (2022)
   PUBMED   35122633
  REMARK    GeneRIF: MARCH1 silencing suppresses growth of oral squamous cell
            carcinoma through regulation of PHLPP2.
REFERENCE   5  (bases 1 to 6140)
  AUTHORS   Martin,M., Sandhu,P., Kumar,R. and Buchkovich,N.J.
  TITLE     The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is Upregulated
            during Human Cytomegalovirus Infection to Regulate Iron Levels
  JOURNAL   J Virol 96 (6), e0180621 (2022)
   PUBMED   35045264
  REMARK    GeneRIF: The Immune-Specific E3 Ubiquitin Ligase MARCH1 Is
            Upregulated during Human Cytomegalovirus Infection to Regulate Iron
            Levels.
REFERENCE   6  (bases 1 to 6140)
  AUTHORS   Sim,X., Ong,R.T., Suo,C., Tay,W.T., Liu,J., Ng,D.P., Boehnke,M.,
            Chia,K.S., Wong,T.Y., Seielstad,M., Teo,Y.Y. and Tai,E.S.
  TITLE     Transferability of type 2 diabetes implicated loci in multi-ethnic
            cohorts from Southeast Asia
  JOURNAL   PLoS Genet 7 (4), e1001363 (2011)
   PUBMED   21490949
REFERENCE   7  (bases 1 to 6140)
  AUTHORS   Lapaque,N., Jahnke,M., Trowsdale,J. and Kelly,A.P.
  TITLE     The HLA-DRalpha chain is modified by polyubiquitination
  JOURNAL   J Biol Chem 284 (11), 7007-7016 (2009)
   PUBMED   19117940
REFERENCE   8  (bases 1 to 6140)
  AUTHORS   Thibodeau,J., Bourgeois-Daigneault,M.C., Huppe,G., Tremblay,J.,
            Aumont,A., Houde,M., Bartee,E., Brunet,A., Gauvreau,M.E., de
            Gassart,A., Gatti,E., Baril,M., Cloutier,M., Bontron,S., Fruh,K.,
            Lamarre,D. and Steimle,V.
  TITLE     Interleukin-10-induced MARCH1 mediates intracellular sequestration
            of MHC class II in monocytes
  JOURNAL   Eur J Immunol 38 (5), 1225-1230 (2008)
   PUBMED   18389477
  REMARK    GeneRIF: The immunosuppressive effect of IL-10 on antigen
            presentation is mediated through induced expression of MARCH1.
REFERENCE   9  (bases 1 to 6140)
  AUTHORS   De Gassart,A., Camosseto,V., Thibodeau,J., Ceppi,M., Catalan,N.,
            Pierre,P. and Gatti,E.
  TITLE     MHC class II stabilization at the surface of human dendritic cells
            is the result of maturation-dependent MARCH I down-regulation
  JOURNAL   Proc Natl Acad Sci U S A 105 (9), 3491-3496 (2008)
   PUBMED   18305173
  REMARK    GeneRIF: MARCH I is a major regulator of HLA-DR traffic, and its
            loss contributes to the acquisition of the potent immunostimulatory
            properties of mature human DCs.
REFERENCE   10 (bases 1 to 6140)
  AUTHORS   Bartee,E., Mansouri,M., Hovey Nerenberg,B.T., Gouveia,K. and
            Fruh,K.
  TITLE     Downregulation of major histocompatibility complex class I by human
            ubiquitin ligases related to viral immune evasion proteins
  JOURNAL   J Virol 78 (3), 1109-1120 (2004)
   PUBMED   14722266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079240.6, AC079232.7, AC092631.1, AC098867.3, AC108154.4 and
            AC093788.3.
            
            Summary: MARCH1 is a member of the MARCH family of membrane-bound
            E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin
            (see MIM 191339) to target lysines in substrate proteins, thereby
            signaling their vesicular transport between membrane compartments.
            MARCH1 downregulates the surface expression of major
            histocompatibility complex (MHC) class II molecules (see MIM
            142880) and other glycoproteins by directing them to the late
            endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed
            14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et
            al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000514618.6/ ENSP00000421322.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC079240.6         186297-186446       c
            151-225             AC079232.7         149745-149819       c
            226-434             AC079232.7         26658-26866         c
            435-583             AC092631.1         166222-166370       c
            584-634             AC092631.1         13014-13064         c
            635-714             AC098867.3         65829-65908         c
            715-1482            AC098867.3         64786-65553         c
            1483-1663           AC098867.3         38264-38444         c
            1664-1811           AC108154.4         105-252             c
            1812-6140           AC093788.3         138080-142408       c
FEATURES             Location/Qualifiers
     source          1..6140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2-q32.3"
     gene            1..6140
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /note="membrane associated ring-CH-type finger 1"
                     /db_xref="GeneID:55016"
                     /db_xref="HGNC:HGNC:26077"
                     /db_xref="MIM:613331"
     exon            1..150
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            151..225
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            226..434
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            435..583
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..2110
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3;
                     membrane-associated RING-CH protein I; E3
                     ubiquitin-protein ligase MARCH1; RING finger protein 171;
                     membrane-associated RING finger protein 1;
                     membrane-associated ring finger (C3HC4) 1, E3 ubiquitin
                     protein ligase; membrane associated ring finger 1;
                     RING-type E3 ubiquitin transferase MARCH1; RING-type E3
                     ubiquitin transferase MARCHF1; E3 ubiquitin-protein ligase
                     MARCHF1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MARCHF1 isoform 3"
                     /protein_id="NP_001381888.1"
                     /db_xref="CCDS:CCDS93664.1"
                     /db_xref="GeneID:55016"
                     /db_xref="HGNC:HGNC:26077"
                     /db_xref="MIM:613331"
                     /translation="MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGR
                     SASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRSAILHDMSEESFEYCTPVMVL
                     SPARKESGKKSVIQRPRRRRKASERYEHAAEEQIRGRKNDFHLQISSPRWRELYTDSS
                     DSSSTDESHWIQAKRRAQVKFRLSRRRRRNNNKPCENLAGSSTPNGIELVDLGSKGKE
                     QQELIECESCSLNLHRGKHTRYQECNPSLTQGSSEIKRSSRNHEKSKGRYHHRDPQLL
                     QSLRKNEIMKKTFSETDSSTEILGVPEGSKDMNDAGLQVNNPVQKPPATYDDGSDNLE
                     VCRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKL
                     KPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLE
                     WPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNF
                     SCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV"
     exon            584..634
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            635..714
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1482
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1663
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1811
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..6140
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3984..3989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /note="hexamer: AACAAA"
     polyA_site      4005
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /note="hexamer: ATTAAA"
     polyA_site      6140
                     /gene="MARCHF1"
                     /gene_synonym="MARCH-I; MARCH1; RNF171"
                     /note="major polyA site"
ORIGIN      
        1 agagccgggc tgcctgccac ccggctgctc gtccgctagc tggggaggag cgctccaccc
       61 gcaactgaca aaggatggga gaatgcccgc gccccgggat gccggccgca cgcagcctgg
      121 cggccgcctg agctacttca ccctccgccg gaaatgtacc ccaaaagaac tctgagagaa
      181 tatactcaac tgtcctgctg tgattaaaca agactgctgt attttacctg agcttggcaa
      241 agcaaggata tgaacaattg tgcaggtggg ctactcaggg cgagtgaaga gataaggcat
      301 ccaatcaggg attggccacc tgcagccctg ccaatatgcc cctccaccag atttccgtaa
      361 tcccagcacg ggagactgcc agcaatggga gaaattcaat gggcagaaac aaagagaaga
      421 acaaggaagt cgagaatttc agaaattgaa aagggataag aggaaggaga aaatgctggg
      481 ctggtgtgaa gcgatagccc gtaaccctca cagaattcca aacaacacgc gaacacccga
      541 gatctcaggg gatttggctg acgcctcaca aacctccaca ttgaatgaaa aatccccagg
      601 gcgatctgca agtcgatcaa gtaacatttc aaaagcaagc agcccaacaa cagggacagc
      661 tcccaggagc cagtcaaggt tgtctgtctg tccatccact caggacatct gcagatctgc
      721 catcttgcat gacatgtcag aagagtcatt tgagtattgc acccctgtca tggtgctgag
      781 ccctgctagg aaggagtctg gtaagaaatc agtaatacaa agacctagga ggaggagaaa
      841 agcctctgag agatatgagc atgctgcaga agaacaaata agagggagaa aaaatgactt
      901 tcaccttcaa atctcaagcc ccaggtggag ggagctttac acagattctt cagattcatc
      961 ttccacagat gagagtcatt ggattcaggc aaaaagaaga gcccaggtta aattcagact
     1021 gtcaagaaga aggaggagaa ataataataa gccgtgtgaa aacttagctg ggtcttccac
     1081 tcctaacgga attgagctcg ttgatctggg atccaaaggt aaagagcaac aagagctgat
     1141 tgaatgtgag agttgctctt taaatctcca cagaggaaaa catacaaggt accaagaatg
     1201 caacccttct ctgactcaag ggtcctctga aattaagaga tcctcaagga atcatgagaa
     1261 gagcaaaggc agatatcacc acagagatcc tcagctcttg caaagtctta ggaaaaatga
     1321 aataatgaag aagacatttt cagaaacaga ttccagcact gaaatactgg gagttccaga
     1381 aggcagcaag gacatgaatg atgcagggct ccaggtgaat aaccctgttc agaagcctcc
     1441 tgccacctat gacgatgggt ctgataattt agaagtatgc agaatctgtc actgcgaagg
     1501 ggatgaagag agccccctca tcacaccctg tcgctgcact gggacactgc gctttgtcca
     1561 ccagtcctgc ctccaccagt ggataaagag ctcagataca cgctgctgtg agctctgcaa
     1621 gtatgacttc ataatggaga ccaagctcaa acccctccgg aagtgggaga aactacagat
     1681 gaccacaagt gaaaggagga aaatattctg ctctgtcaca ttccacgtaa tcgcgatcac
     1741 ctgtgtggtt tggtctttgt atgtattgat agaccggaca gcggaggaaa tcaagcaagg
     1801 caatgacaat ggtgtccttg aatggccatt ttggacaaaa ctggttgtgg tagccattgg
     1861 cttcacagga ggtcttgtct tcatgtacgt acagtgtaaa gtctatgttc agttgtggcg
     1921 caggctgaag gcctacaacc gtgtgatctt tgtacaaaat tgcccagaca ctgccaaaaa
     1981 actggagaag aacttctcat gtaatgtaaa cacagacatc aaagatgctg tggtagtgcc
     2041 tgtaccacaa acaggtgcaa attcactgcc atctgcagag ggtggccccc ctgaagttgt
     2101 atcagtctga tggaacctgt tgggagtttc ttcaccgaag aatatctttc tagccctcag
     2161 ccactacaaa tgacagaagt gatcttgaat tatttactcc cttcagctcc tcctttctcc
     2221 tactgacaca tttttcctga ctttgttcaa agaggaaagg agaaaaacaa acagaccaaa
     2281 tgcccaggag cccatgaagt aatagcgtaa agtaaagtat gatatggaaa tgtgaagttt
     2341 gcaagagaat gatttccaag acaattaaga actactgggg caatgaatgc ttttaggcag
     2401 taatcaaaga ttaaatggac ccatgatact cttcttcaca gtaacagggg aaaagttcaa
     2461 gaatacagac ttgaattgcg atgtgtatta cttctagggc cttgtaatgt taactgtctc
     2521 atctggaaat aactaacata tttggtttta agcctgaaat tgtctgcatt atccctaagt
     2581 cacattggaa gtgaacttgg aggatgcata ttttgatatg ctttgacagc taacagattt
     2641 gtatggttta gtggagtctg gttattttga cagatgcatg ttttttttaa atagatgcaa
     2701 tatacatttg aagacattga tatttggaat taattacgtt tgtttaagtc acgcaaaaga
     2761 ttttcagaaa atgttcggat ataattagct ctgttaaata cccacagaac tgttatcagg
     2821 tcttatattt attttcatct ggttcctcta atacagtgct gtccaataga aacacaacag
     2881 ccacaaatgc aggccacaga tgcaaatatt taacttccca gtagccctat tttaaaaagt
     2941 aaaaataaat gtttgtttgt taaaatgaat tttgattttt taaaaacact atatgttatt
     3001 tcaacatgtc atcaatataa aaaattgatt gattgattga tagtttacat ctgtttcttg
     3061 aaccaagttt tcaaaatcca gttggtaatt taaaagtaca cttcaacttg aattaactat
     3121 attggatagc acagccgtaa aattagagac taagcttctg ctttatttaa cagttgttga
     3181 gtatttcaaa acagtttaat tcattctttt atttcaaagt cacaaaagtt agttatgatt
     3241 tttaaaagca ttaaattaag tgtcctcatt ttaaagtcag atgaagttca catctctaaa
     3301 gggtaaaaat ccaaaagtat agaaagataa aacaatcaat ctgcctatag cagagttgtg
     3361 aaataaataa attgttacta tgaagtactt acaatagggg aataaaatta cctatttttg
     3421 ttattaaatc aaatgtgtaa ggcttatttc atccatatga ggtgtcaact tgacagatga
     3481 tgagtaatta tgactaagaa tctagccctt acttttaaaa gctgacagga tttcccttgc
     3541 tcagttagaa aacaaaaata ttcaacagat tctgtgataa gtaattaatc gtttaggttt
     3601 gacagttgat tattgtgttc tttgcatatt catgtaaaac tgatgtgtga atgacattgc
     3661 agtgagctag attaacggtg attatagata cagtagcctg tcaaagaaag atgtcctaca
     3721 ttaaaaaagg tgacttattt ttgttagctg tcattattta ttaacatgaa aaggcaatga
     3781 tggccataag aaccaaagca tgagtatcac actgcacaaa tctgggtatc acatggatgc
     3841 actttgtaat tatcagtgtg cttgttcttc acagatcata ggaaaaaggg aaaaaaaaaa
     3901 caaaccttta aatgaggaga aagatggtat aaatattagt agtggctgac actgagtcca
     3961 gatagtcttg attcctagaa ataaacaaaa ggtaaacaat gtcaattttg tgtgtgtgta
     4021 tggcgtgtgt gtagtcatgt atatatgcgg ggaaaatgtt aaggtattca gtcaggaaac
     4081 aaaaggttta aaactcatct ttcttaaaac ttgttataag cacagggaaa gcaaagttga
     4141 ggtaactaaa ctgaaccaaa aattctgtat aaataaggat ataagtaatt aacgttttaa
     4201 aaaacatgtg gaccttaaac aaactgtata ttaaattcct cttaaatgcc cattttaaat
     4261 atttaagata aatacattta tgaataacaa atctgtgggt gatttaacca tggcaccata
     4321 tccaagggat taaccttaat gcaattttcc tgttaattgt cctaagcttt ttactaatcc
     4381 attttccctg tgggttagta atggcaacat gctgcttaca gatattcccg gggaaaaaca
     4441 tccagacacc agcaaacaaa gaaatgttga tttctctttt gtttgctctg aaagtaaaat
     4501 aattatttac tttaattaac atggaaaata ttgtttaaat tctgtacgaa cctaaacaag
     4561 atacgttgca gggctgattt cacagtggag gatgatcggc taaaataaag cctcatttat
     4621 taagggctac acttttaaca ctaagaaaac atttctagaa taaaaagcaa aggtaagcat
     4681 tattctatta atagtaaaag aggacatggg attttaaaac tatacctaaa ttcttgcaat
     4741 taacttttat gggcttggac attgttgaaa tgagaaaata atataatata gcttcctggc
     4801 aggttaaaag tcaacacttg attttgctat tcttctgact ttttgaaacc ctgaagttct
     4861 gaatttcaag cttttaagaa gcttttcagc aatggttgtt tgtttatggt tcaaacatct
     4921 gaaataacta cctgcattta aaatctaatg ttgattattt tctttttaca ttctgtgtgg
     4981 caatggaaca tttgcccttt caaacaataa aacgatttag ctttgtggca gtgctttttt
     5041 gtagactgac tgactatacc cttcaaaaag aaaaactgct ctacggaatg caaattttga
     5101 ggcatgttta cctgctcgtg gaagaaataa aatggaattg aaaaaaaaag gactaaaatt
     5161 gaagaatgaa attacagttg tgttaaaaac cttggctctt tataatcatg aatcttcagt
     5221 attaaaccag acattgatgc tgttaatttt tttaaagaac tatcactctt atcgtacagg
     5281 agtaaagatt aaattgtaaa agaaagaaat tccaattttt taaaaagtaa agcccaaaag
     5341 gcaattaagc ttaagtacaa aaacaaaata aaaatgaaca aaatctaaac taaagtgagc
     5401 ccaacaacct gagatacagc aatgtgtaac ctgaaggaag ataggtgtag actgaaggag
     5461 tctttcaaaa caccccagca ttaaatctca ctctgcgctg cttctacacg tgattatagt
     5521 cccagacaga cgacctcatg gttttttatc ttgttttaca aaaggtcctt gggtactctt
     5581 taaaacatct attctttggc aggaaaatta gctcattaga acaatgacac cattaaggga
     5641 cattataagg gtcctggggc tgaggtggga agatttttct atctgcccca tatagtttac
     5701 ccttccttgc cttgaaaatg aatattatag aacagagtac agctcttaaa agttattagt
     5761 atcattatta ttatagttgt tatataatac tttaattaag aaagatgaaa accttttttc
     5821 tttcctaagt cagcccaatg gtgctatttt acatatcaac acagttgaaa ggaagtactg
     5881 ttattttggg ctgcagtgtt tcctccacat ctaaagaaag cccattttga aactggatac
     5941 tgcattaaaa caaagaagga aaaattattt taactgtgtg cagtttttga aattaggcat
     6001 ttgtactatt ttggttttac ataattctct tgcattaaca atttactgtt ttgtgaatca
     6061 tgtgtactaa agcaaattaa gaaaaagaaa ataattatct gtgaaagact ttgtatatta
     6121 aacaagtgac gcaaacctta
//
