LOCUS       NM_001377265            6815 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens microtubule associated protein tau (MAPT), transcript
            variant 9, mRNA.
ACCESSION   NM_001377265 XM_005257364
VERSION     NM_001377265.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6815)
  AUTHORS   Sattarov,R., Havers,M., Orbjorn,C., Stomrud,E., Janelidze,S.,
            Laurell,T. and Mattsson-Carlgren,N.
  TITLE     Phosphorylated tau in cerebrospinal fluid-derived extracellular
            vesicles in Alzheimer's disease: a pilot study
  JOURNAL   Sci Rep 14 (1), 25419 (2024)
   PUBMED   39455624
  REMARK    GeneRIF: Phosphorylated tau in cerebrospinal fluid-derived
            extracellular vesicles in Alzheimer's disease: a pilot study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6815)
  AUTHORS   Toral-Rios,D., Pichardo-Rojas,P., Ruiz-Sanchez,E.,
            Rosas-Carrasco,O., Carvajal-Garcia,R., Galvez-Coutino,D.C.,
            Martinez-Rodriguez,N.L., Rubio-Chavez,A.D., Alcantara-Flores,M.,
            Lopez-Ramirez,A., Martinez-Rosas,A.R., Ruiz-Chow,A.A.,
            Alonso-Vanegas,M. and Campos-Pena,V.
  TITLE     Synergistic Effect between the APOE epsilon4 Allele with Genetic
            Variants of GSK3B and MAPT: Differential Profile between Refractory
            Epilepsy and Alzheimer Disease
  JOURNAL   Int J Mol Sci 25 (18), 10228 (2024)
   PUBMED   39337715
  REMARK    GeneRIF: Synergistic Effect between the APOE epsilon4 Allele with
            Genetic Variants of GSK3B and MAPT: Differential Profile between
            Refractory Epilepsy and Alzheimer Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6815)
  AUTHORS   Nho,K., Risacher,S.L., Apostolova,L.G., Bice,P.J., Brosch,J.R.,
            Deardorff,R., Faber,K., Farlow,M.R., Foroud,T., Gao,S.,
            Rosewood,T., Kim,J.P., Nudelman,K., Yu,M., Aisen,P., Sperling,R.,
            Hooli,B., Shcherbinin,S., Svaldi,D., Jack,C.R. Jr., Jagust,W.J.,
            Landau,S., Vasanthakumar,A., Waring,J.F., Dore,V., Laws,S.M.,
            Masters,C.L., Porter,T., Rowe,C.C., Villemagne,V.L., Dumitrescu,L.,
            Hohman,T.J., Libby,J.B., Mormino,E., Buckley,R.F., Johnson,K.,
            Yang,H.S., Petersen,R.C., Ramanan,V.K., Ertekin-Taner,N.,
            Vemuri,P., Cohen,A.D., Fan,K.H., Kamboh,M.I., Lopez,O.L.,
            Bennett,D.A., Ali,M., Benzinger,T., Cruchaga,C., Hobbs,D., De
            Jager,P.L., Fujita,M., Jadhav,V., Lamb,B.T., Tsai,A.P.,
            Castanho,I., Mill,J., Weiner,M.W. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative (ADNI); Department of
            Defense Alzheimer's Disease Neuroimaging Initiative (DoD-ADNI);
            Anti-Amyloid Treatment in Asymptomatic Alzheimer's Study (A4 Study)
            and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration
            (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL)
  TITLE     CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for
            cerebral tau PET
  JOURNAL   Nat Commun 15 (1), 8251 (2024)
   PUBMED   39304655
  REMARK    GeneRIF: CYP1B1-RMDN2 Alzheimer's disease endophenotype locus
            identified for cerebral tau PET.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6815)
  AUTHORS   Ressler,H.W., Humphrey,J., Vialle,R.A., Babrowicz,B., Kandoi,S.,
            Raj,T., Dickson,D.W., Ertekin-Taner,N., Crary,J.F. and Farrell,K.
  TITLE     MAPT haplotype-associated transcriptomic changes in progressive
            supranuclear palsy
  JOURNAL   Acta Neuropathol Commun 12 (1), 135 (2024)
   PUBMED   39154163
  REMARK    GeneRIF: MAPT haplotype-associated transcriptomic changes in
            progressive supranuclear palsy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6815)
  AUTHORS   Dando,O., McGeachan,R., McQueen,J., Baxter,P., Rockley,N.,
            McAlister,H., Prasad,A., He,X., King,D., Rose,J., Jones,P.B.,
            Tulloch,J., Chandran,S., Smith,C., Hardingham,G. and
            Spires-Jones,T.L.
  TITLE     Synaptic gene expression changes in frontotemporal dementia due to
            the MAPT 10 + 16 mutation
  JOURNAL   Neuropathol Appl Neurobiol 50 (4), e13006 (2024)
   PUBMED   39164997
  REMARK    GeneRIF: Synaptic gene expression changes in frontotemporal
            dementia due to the MAPT 10 + 16 mutation.
REFERENCE   6  (bases 1 to 6815)
  AUTHORS   Rohrer,J., Ryan,B. and Ahmed,R.
  TITLE     MAPT-Related Frontotemporal Dementia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301678
REFERENCE   7  (bases 1 to 6815)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 6815)
  AUTHORS   Caceres,A., Mautino,J. and Kosik,K.S.
  TITLE     Suppression of MAP2 in cultured cerebellar macroneurons inhibits
            minor neurite formation
  JOURNAL   Neuron 9 (4), 607-618 (1992)
   PUBMED   1389180
REFERENCE   9  (bases 1 to 6815)
  AUTHORS   Weingarten,M.D., Lockwood,A.H., Hwo,S.Y. and Kirschner,M.W.
  TITLE     A protein factor essential for microtubule assembly
  JOURNAL   Proc Natl Acad Sci U S A 72 (5), 1858-1862 (1975)
   PUBMED   1057175
REFERENCE   10 (bases 1 to 6815)
  AUTHORS   Ameli,N.O., Teymoorian,G.A., Saleh,H. and Slamdoost,A.
  TITLE     Proceedings: Aneurysmal bone cysts of the spine
  JOURNAL   Acta Neurochir (Wien) 31 (3-4), 273 (1975)
   PUBMED   1181841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC217771.1 and CR936218.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2019 this sequence version replaced XM_005257364.4.
            
            Summary: This gene encodes the microtubule-associated protein tau
            (MAPT) whose transcript undergoes complex, regulated alternative
            splicing, giving rise to several mRNA species. MAPT transcripts are
            differentially expressed in the nervous system, depending on stage
            of neuronal maturation and neuron type. MAPT gene mutations have
            been associated with several neurodegenerative disorders such as
            Alzheimer's disease, Pick's disease, frontotemporal dementia,
            cortico-basal degeneration and progressive supranuclear palsy.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142680,
                              SAMEA2147975 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262410.10/ ENSP00000262410.6
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC217771.1         11162-11294         c
            134-283             CR936218.6         132608-132757       c
            284-370             CR936218.6         123133-123219       c
            371-436             CR936218.6         116638-116703       c
            437-1501            CR936218.6         111148-112212       c
            1502-1557           CR936218.6         107983-108038       c
            1558-1755           CR936218.6         105003-105200       c
            1756-1882           CR936218.6         103492-103618       c
            1883-2148           CR936218.6         98414-98679         c
            2149-2241           CR936218.6         84676-84768         c
            2242-2323           CR936218.6         80754-80835         c
            2324-2436           CR936218.6         76348-76460         c
            2437-6815           CR936218.6         66744-71122         c
FEATURES             Location/Qualifiers
     source          1..6815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..6815
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="microtubule associated protein tau"
                     /db_xref="GeneID:4137"
                     /db_xref="HGNC:HGNC:6893"
                     /db_xref="MIM:157140"
     exon            1..133
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            134..283
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2652
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="isoform 9 is encoded by transcript variant 9; G
                     protein beta1/gamma2 subunit-interacting factor 1;
                     PHF-tau; paired helical filament-tau; neurofibrillary
                     tangle protein; protein phosphatase 1, regulatory subunit
                     103; Tau-derived paired helical filament hexapeptide"
                     /codon_start=1
                     /product="microtubule-associated protein tau isoform 9"
                     /protein_id="NP_001364194.1"
                     /db_xref="CCDS:CCDS92345.1"
                     /db_xref="GeneID:4137"
                     /db_xref="HGNC:HGNC:6893"
                     /db_xref="MIM:157140"
                     /translation="MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK
                     ESPLQTPTEDGSEEPGSETSDAKSTPTAEAEEAGIGDTPSLEDEAAGHVTQEELRVPG
                     RQRKAPERPLANEISAHVQPGPCGEASGVSGPCLGEKEPEAPVPLTASLPQHRPVCPA
                     PPPTGGPQEPSLEWGQKGGDWAEKGPAFPKPATTAYLHTEPESGKVVQEGFLREPGPP
                     GLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGP
                     PLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGF
                     PAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAH
                     SEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLK
                     ARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCP
                     EPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAK
                     TPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTP
                     PKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSK
                     CGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKD
                     RVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPR
                     HLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL"
     exon            284..370
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..436
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            437..1501
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1557
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1755
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1882
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2148
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2241
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2323
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2436
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..6815
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6792..6797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="hexamer: AATAAA"
     polyA_site      6815
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcaccg ccacccacca gctccggcac caacagcagc gccgctgcca ccgcccacct
       61 tctgccgccg ccaccacagc caccttctcc tcctccgctg tcctctcccg tcctcgcctc
      121 tgtcgactat caggtgaact ttgaaccagg atggctgagc cccgccagga gttcgaagtg
      181 atggaagatc acgctgggac gtacgggttg ggggacagga aagatcaggg gggctacacc
      241 atgcaccaag accaagaggg tgacacggac gctggcctga aagaatctcc cctgcagacc
      301 cccactgagg acggatctga ggaaccgggc tctgaaacct ctgatgctaa gagcactcca
      361 acagcggaag ctgaagaagc aggcattgga gacaccccca gcctggaaga cgaagctgct
      421 ggtcacgtga cccaagagga gttgagagtt ccgggccggc agaggaaggc gcctgaaagg
      481 cccctggcca atgagattag cgcccacgtc cagcctggac cctgcggaga ggcctctggg
      541 gtctctgggc cgtgcctcgg ggagaaagag ccagaagctc ccgtcccgct gaccgcgagc
      601 cttcctcagc accgtcccgt ttgcccagcg cctcctccaa caggaggccc tcaggagccc
      661 tccctggagt ggggacaaaa aggcggggac tgggccgaga agggtccggc ctttccgaag
      721 cccgccacca ctgcgtatct ccacacagag cctgaaagtg gtaaggtggt ccaggaaggc
      781 ttcctccgag agccaggccc cccaggtctg agccaccagc tcatgtccgg catgcctggg
      841 gctcccctcc tgcctgaggg ccccagagag gccacacgcc aaccttcggg gacaggacct
      901 gaggacacag agggcggccg ccacgcccct gagctgctca agcaccagct tctaggagac
      961 ctgcaccagg aggggccgcc gctgaagggg gcagggggca aagagaggcc ggggagcaag
     1021 gaggaggtgg atgaagaccg cgacgtcgat gagtcctccc cccaagactc ccctccctcc
     1081 aaggcctccc cagcccaaga tgggcggcct ccccagacag ccgccagaga agccaccagc
     1141 atcccaggct tcccagcgga gggtgccatc cccctccctg tggatttcct ctccaaagtt
     1201 tccacagaga tcccagcctc agagcccgac gggcccagtg tagggcgggc caaagggcag
     1261 gatgcccccc tggagttcac gtttcacgtg gaaatcacac ccaacgtgca gaaggagcag
     1321 gcgcactcgg aggagcattt gggaagggct gcatttccag gggcccctgg agaggggcca
     1381 gaggcccggg gcccctcttt gggagaggac acaaaagagg ctgaccttcc agagccctct
     1441 gaaaagcagc ctgctgctgc tccgcggggg aagcccgtca gccgggtccc tcaactcaaa
     1501 gctcgcatgg tcagtaaaag caaagacggg actggaagcg atgacaaaaa agccaagaca
     1561 tccacacgtt cctctgctaa aaccttgaaa aataggcctt gccttagccc caaacacccc
     1621 actcctggta gctcagaccc tctgatccaa ccctccagcc ctgctgtgtg cccagagcca
     1681 ccttcctctc ctaaatacgt ctcttctgtc acttcccgaa ctggcagttc tggagcaaag
     1741 gagatgaaac tcaagggggc tgatggtaaa acgaagatcg ccacaccgcg gggagcagcc
     1801 cctccaggcc agaagggcca ggccaacgcc accaggattc cagcaaaaac cccgcccgct
     1861 ccaaagacac cacccagctc tggtgaacct ccaaaatcag gggatcgcag cggctacagc
     1921 agccccggct ccccaggcac tcccggcagc cgctcccgca ccccgtccct tccaacccca
     1981 cccacccggg agcccaagaa ggtggcagtg gtccgtactc cacccaagtc gccgtcttcc
     2041 gccaagagcc gcctgcagac agcccccgtg cccatgccag acctgaagaa tgtcaagtcc
     2101 aagatcggct ccactgagaa cctgaagcac cagccgggag gcgggaaggt gcagataatt
     2161 aataagaagc tggatcttag caacgtccag tccaagtgtg gctcaaagga taatatcaaa
     2221 cacgtcccgg gaggcggcag tgtgcaaata gtctacaaac cagttgacct gagcaaggtg
     2281 acctccaagt gtggctcatt aggcaacatc catcataaac caggaggtgg ccaggtggaa
     2341 gtaaaatctg agaagcttga cttcaaggac agagtccagt cgaagattgg gtccctggac
     2401 aatatcaccc acgtccctgg cggaggaaat aaaaagattg aaacccacaa gctgaccttc
     2461 cgcgagaacg ccaaagccaa gacagaccac ggggcggaga tcgtgtacaa gtcgccagtg
     2521 gtgtctgggg acacgtctcc acggcatctc agcaatgtct cctccaccgg cagcatcgac
     2581 atggtagact cgccccagct cgccacgcta gctgacgagg tgtctgcctc cctggccaag
     2641 cagggtttgt gatcaggccc ctggggcggt caataattgt ggagaggaga gaatgagaga
     2701 gtgtggaaaa aaaaagaata atgacccggc ccccgccctc tgcccccagc tgctcctcgc
     2761 agttcggtta attggttaat cacttaacct gcttttgtca ctcggctttg gctcgggact
     2821 tcaaaatcag tgatgggagt aagagcaaat ttcatctttc caaattgatg ggtgggctag
     2881 taataaaata tttaaaaaaa aacattcaaa aacatggcca catccaacat ttcctcaggc
     2941 aattcctttt gattcttttt tcttccccct ccatgtagaa gagggagaag gagaggctct
     3001 gaaagctgct tctgggggat ttcaagggac tgggggtgcc aaccacctct ggccctgttg
     3061 tgggggtgtc acagaggcag tggcagcaac aaaggatttg aaacttggtg tgttcgtgga
     3121 gccacaggca gacgatgtca accttgtgtg agtgtgacgg gggttggggt ggggcgggag
     3181 gccacggggg aggccgaggc aggggctggg cagaggggag aggaagcaca agaagtggga
     3241 gtgggagagg aagccacgtg ctggagagta gacatccccc tccttgccgc tgggagagcc
     3301 aaggcctatg ccacctgcag cgtctgagcg gccgcctgtc cttggtggcc gggggtgggg
     3361 gcctgctgtg ggtcagtgtg ccaccctctg cagggcagcc tgtgggagaa gggacagcgg
     3421 gtaaaaagag aaggcaagct ggcaggaggg tggcacttcg tggatgacct ccttagaaaa
     3481 gactgacctt gatgtcttga gagcgctggc ctcttcctcc ctccctgcag ggtagggggc
     3541 ctgagttgag gggcttccct ctgctccaca gaaaccctgt tttattgagt tctgaaggtt
     3601 ggaactgctg ccatgatttt ggccactttg cagacctggg actttagggc taaccagttc
     3661 tctttgtaag gacttgtgcc tcttgggaga cgtccacccg tttccaagcc tgggccactg
     3721 gcatctctgg agtgtgtggg ggtctgggag gcaggtcccg agccccctgt ccttcccacg
     3781 gccactgcag tcaccccgtc tgcgccgctg tgctgttgtc tgccgtgaga gcccaatcac
     3841 tgcctatacc cctcatcaca cgtcacaatg tcccgaattc ccagcctcac caccccttct
     3901 cagtaatgac cctggttggt tgcaggaggt acctactcca tactgagggt gaaattaagg
     3961 gaaggcaaag tccaggcaca agagtgggac cccagcctct cactctcagt tccactcatc
     4021 caactgggac cctcaccacg aatctcatga tctgattcgg ttccctgtct cctcctcccg
     4081 tcacagatgt gagccagggc actgctcagc tgtgacccta ggtgtttctg ccttgttgac
     4141 atggagagag ccctttcccc tgagaaggcc tggccccttc ctgtgctgag cccacagcag
     4201 caggctgggt gtcttggttg tcagtggtgg caccaggatg gaagggcaag gcacccaggg
     4261 caggcccaca gtcccgctgt cccccacttg caccctagct tgtagctgcc aacctcccag
     4321 acagcccagc ccgctgctca gctccacatg catagtatca gccctccaca cccgacaaag
     4381 gggaacacac ccccttggaa atggttcttt tcccccagtc ccagctggaa gccatgctgt
     4441 ctgttctgct ggagcagctg aacatataca tagatgttgc cctgccctcc ccatctgcac
     4501 cctgttgagt tgtagttgga tttgtctgtt tatgcttgga ttcaccagag tgactatgat
     4561 agtgaaaaga aaaaaaaaaa aaaaaaagga cgcatgtatc ttgaaatgct tgtaaagagg
     4621 tttctaaccc accctcacga ggtgtctctc acccccacac tgggactcgt gtggcctgtg
     4681 tggtgccacc ctgctggggc ctcccaagtt ttgaaaggct ttcctcagca cctgggaccc
     4741 aacagagacc agcttctagc agctaaggag gccgttcagc tgtgacgaag gcctgaagca
     4801 caggattagg actgaagcga tgatgtcccc ttccctactt ccccttgggg ctccctgtgt
     4861 cagggcacag actaggtctt gtggctggtc tggcttgcgg cgcgaggatg gttctctctg
     4921 gtcatagccc gaagtctcat ggcagtccca aaggaggctt acaactcctg catcacaaga
     4981 aaaaggaagc cactgccagc tggggggatc tgcagctccc agaagctccg tgagcctcag
     5041 ccacccctca gactgggttc ctctccaagc tcgccctctg gaggggcagc gcagcctccc
     5101 accaagggcc ctgcgaccac agcagggatt gggatgaatt gcctgtcctg gatctgctct
     5161 agaggcccaa gctgcctgcc tgaggaagga tgacttgaca agtcaggaga cactgttccc
     5221 aaagccttga ccagagcacc tcagcccgct gaccttgcac aaactccatc tgctgccatg
     5281 agaaaaggga agccgccttt gcaaaacatt gctgcctaaa gaaactcagc agcctcaggc
     5341 ccaattctgc cacttctggt ttgggtacag ttaaaggcaa ccctgaggga cttggcagta
     5401 gaaatccagg gcctcccctg gggctggcag cttcgtgtgc agctagagct ttacctgaaa
     5461 ggaagtctct gggcccagaa ctctccacca agagcctccc tgccgttcgc tgagtcccag
     5521 caattctcct aagttgaagg gatctgagaa ggagaaggaa atgtggggta gatttggtgg
     5581 tggttagaga tatgcccccc tcattactgc caacagtttc ggctgcattt cttcacgcac
     5641 ctcggttcct cttcctgaag ttcttgtgcc ctgctcttca gcaccatggg ccttcttata
     5701 cggaaggctc tgggatctcc cccttgtggg gcaggctctt ggggccagcc taagatcatg
     5761 gtttagggtg atcagtgctg gcagataaat tgaaaaggca cgctggcttg tgatcttaaa
     5821 tgaggacaat ccccccaggg ctgggcactc ctcccctccc ctcacttctc ccacctgcag
     5881 agccagtgtc cttgggtggg ctagatagga tatactgtat gccggctcct tcaagctgct
     5941 gactcacttt atcaatagtt ccatttaaat tgacttcagt ggtgagactg tatcctgttt
     6001 gctattgctt gttgtgctat ggggggaggg gggaggaatg tgtaagatag ttaacatggg
     6061 caaagggaga tcttggggtg cagcacttaa actgcctcgt aacccttttc atgatttcaa
     6121 ccacatttgc tagagggagg gagcagccac ggagttagag gcccttgggg tttctctttt
     6181 ccactgacag gctttcccag gcagctggct agttcattcc ctccccagcc aggtgcaggc
     6241 gtaggaatat ggacatctgg ttgctttggc ctgctgccct ctttcagggg tcctaagccc
     6301 acaatcatgc ctccctaaga ccttggcatc cttccctcta agccgttggc acctctgtgc
     6361 cacctctcac actggctcca gacacacagc ctgtgctttt ggagctgaga tcactcgctt
     6421 caccctcctc atctttgttc tccaagtaaa gccacgaggt cggggcgagg gcagaggtga
     6481 tcacctgcgt gtcccatcta cagacctgca gcttcataaa acttctgatt tctcttcagc
     6541 tttgaaaagg gttaccctgg gcactggcct agagcctcac ctcctaatag acttagcccc
     6601 atgagtttgc catgttgagc aggactattt ctggcacttg caagtcccat gatttcttcg
     6661 gtaattctga gggtgggggg agggacatga aatcatctta gcttagcttt ctgtctgtga
     6721 atgtctatat agtgtattgt gtgttttaac aaatgattta cactgactgt tgctgtaaaa
     6781 gtgaatttgg aaataaagtt attactctga ttaaa
//
