LOCUS       NM_001203251            5459 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens microtubule associated protein tau (MAPT), transcript
            variant 7, mRNA.
ACCESSION   NM_001203251 XM_003403601 XM_003403602 XM_003403603 XM_003403604
            XM_003403605 XM_003403606 XM_003403607 XM_003403608 XM_003403609
VERSION     NM_001203251.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5459)
  AUTHORS   Sattarov,R., Havers,M., Orbjorn,C., Stomrud,E., Janelidze,S.,
            Laurell,T. and Mattsson-Carlgren,N.
  TITLE     Phosphorylated tau in cerebrospinal fluid-derived extracellular
            vesicles in Alzheimer's disease: a pilot study
  JOURNAL   Sci Rep 14 (1), 25419 (2024)
   PUBMED   39455624
  REMARK    GeneRIF: Phosphorylated tau in cerebrospinal fluid-derived
            extracellular vesicles in Alzheimer's disease: a pilot study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5459)
  AUTHORS   Toral-Rios,D., Pichardo-Rojas,P., Ruiz-Sanchez,E.,
            Rosas-Carrasco,O., Carvajal-Garcia,R., Galvez-Coutino,D.C.,
            Martinez-Rodriguez,N.L., Rubio-Chavez,A.D., Alcantara-Flores,M.,
            Lopez-Ramirez,A., Martinez-Rosas,A.R., Ruiz-Chow,A.A.,
            Alonso-Vanegas,M. and Campos-Pena,V.
  TITLE     Synergistic Effect between the APOE epsilon4 Allele with Genetic
            Variants of GSK3B and MAPT: Differential Profile between Refractory
            Epilepsy and Alzheimer Disease
  JOURNAL   Int J Mol Sci 25 (18), 10228 (2024)
   PUBMED   39337715
  REMARK    GeneRIF: Synergistic Effect between the APOE epsilon4 Allele with
            Genetic Variants of GSK3B and MAPT: Differential Profile between
            Refractory Epilepsy and Alzheimer Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5459)
  AUTHORS   Nho,K., Risacher,S.L., Apostolova,L.G., Bice,P.J., Brosch,J.R.,
            Deardorff,R., Faber,K., Farlow,M.R., Foroud,T., Gao,S.,
            Rosewood,T., Kim,J.P., Nudelman,K., Yu,M., Aisen,P., Sperling,R.,
            Hooli,B., Shcherbinin,S., Svaldi,D., Jack,C.R. Jr., Jagust,W.J.,
            Landau,S., Vasanthakumar,A., Waring,J.F., Dore,V., Laws,S.M.,
            Masters,C.L., Porter,T., Rowe,C.C., Villemagne,V.L., Dumitrescu,L.,
            Hohman,T.J., Libby,J.B., Mormino,E., Buckley,R.F., Johnson,K.,
            Yang,H.S., Petersen,R.C., Ramanan,V.K., Ertekin-Taner,N.,
            Vemuri,P., Cohen,A.D., Fan,K.H., Kamboh,M.I., Lopez,O.L.,
            Bennett,D.A., Ali,M., Benzinger,T., Cruchaga,C., Hobbs,D., De
            Jager,P.L., Fujita,M., Jadhav,V., Lamb,B.T., Tsai,A.P.,
            Castanho,I., Mill,J., Weiner,M.W. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative (ADNI); Department of
            Defense Alzheimer's Disease Neuroimaging Initiative (DoD-ADNI);
            Anti-Amyloid Treatment in Asymptomatic Alzheimer's Study (A4 Study)
            and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration
            (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL)
  TITLE     CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for
            cerebral tau PET
  JOURNAL   Nat Commun 15 (1), 8251 (2024)
   PUBMED   39304655
  REMARK    GeneRIF: CYP1B1-RMDN2 Alzheimer's disease endophenotype locus
            identified for cerebral tau PET.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5459)
  AUTHORS   Ressler,H.W., Humphrey,J., Vialle,R.A., Babrowicz,B., Kandoi,S.,
            Raj,T., Dickson,D.W., Ertekin-Taner,N., Crary,J.F. and Farrell,K.
  TITLE     MAPT haplotype-associated transcriptomic changes in progressive
            supranuclear palsy
  JOURNAL   Acta Neuropathol Commun 12 (1), 135 (2024)
   PUBMED   39154163
  REMARK    GeneRIF: MAPT haplotype-associated transcriptomic changes in
            progressive supranuclear palsy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5459)
  AUTHORS   Dando,O., McGeachan,R., McQueen,J., Baxter,P., Rockley,N.,
            McAlister,H., Prasad,A., He,X., King,D., Rose,J., Jones,P.B.,
            Tulloch,J., Chandran,S., Smith,C., Hardingham,G. and
            Spires-Jones,T.L.
  TITLE     Synaptic gene expression changes in frontotemporal dementia due to
            the MAPT 10 + 16 mutation
  JOURNAL   Neuropathol Appl Neurobiol 50 (4), e13006 (2024)
   PUBMED   39164997
  REMARK    GeneRIF: Synaptic gene expression changes in frontotemporal
            dementia due to the MAPT 10 + 16 mutation.
REFERENCE   6  (bases 1 to 5459)
  AUTHORS   Rohrer,J., Ryan,B. and Ahmed,R.
  TITLE     MAPT-Related Frontotemporal Dementia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301678
REFERENCE   7  (bases 1 to 5459)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 5459)
  AUTHORS   Caceres,A., Mautino,J. and Kosik,K.S.
  TITLE     Suppression of MAP2 in cultured cerebellar macroneurons inhibits
            minor neurite formation
  JOURNAL   Neuron 9 (4), 607-618 (1992)
   PUBMED   1389180
REFERENCE   9  (bases 1 to 5459)
  AUTHORS   Weingarten,M.D., Lockwood,A.H., Hwo,S.Y. and Kirschner,M.W.
  TITLE     A protein factor essential for microtubule assembly
  JOURNAL   Proc Natl Acad Sci U S A 72 (5), 1858-1862 (1975)
   PUBMED   1057175
REFERENCE   10 (bases 1 to 5459)
  AUTHORS   Ameli,N.O., Teymoorian,G.A., Saleh,H. and Slamdoost,A.
  TITLE     Proceedings: Aneurysmal bone cysts of the spine
  JOURNAL   Acta Neurochir (Wien) 31 (3-4), 273 (1975)
   PUBMED   1181841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN996935.1, AK095802.1 and
            CR936218.6.
            
            On Jun 2, 2019 this sequence version replaced NM_001203251.1.
            
            Summary: This gene encodes the microtubule-associated protein tau
            (MAPT) whose transcript undergoes complex, regulated alternative
            splicing, giving rise to several mRNA species. MAPT transcripts are
            differentially expressed in the nervous system, depending on stage
            of neuronal maturation and neuron type. MAPT gene mutations have
            been associated with several neurodegenerative disorders such as
            Alzheimer's disease, Pick's disease, frontotemporal dementia,
            cortico-basal degeneration and progressive supranuclear palsy.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) lacks four internal coding
            exons, as compared to variant 6. The reading frame is not affected,
            and the resulting isoform (7) has identical N- and C-termini but
            lacks four segments, as compared to isoform 6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.819893.1,
                                           SRR3476690.958322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               DN996935.1         181-676
            497-530             AK095802.1         433-466
            531-554             CR936218.6         103557-103580       c
            555-1546            AK095802.1         467-1458
            1547-5459           CR936218.6         66744-70656         c
FEATURES             Location/Qualifiers
     source          1..5459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..5459
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="microtubule associated protein tau"
                     /db_xref="GeneID:4137"
                     /db_xref="HGNC:HGNC:6893"
                     /db_xref="MIM:157140"
     exon            1..133
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            134..283
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1296
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="isoform 7 is encoded by transcript variant 7; G
                     protein beta1/gamma2 subunit-interacting factor 1;
                     PHF-tau; paired helical filament-tau; neurofibrillary
                     tangle protein; protein phosphatase 1, regulatory subunit
                     103; Tau-derived paired helical filament hexapeptide"
                     /codon_start=1
                     /product="microtubule-associated protein tau isoform 7"
                     /protein_id="NP_001190180.1"
                     /db_xref="CCDS:CCDS92347.1"
                     /db_xref="GeneID:4137"
                     /db_xref="HGNC:HGNC:6893"
                     /db_xref="MIM:157140"
                     /translation="MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK
                     ESPLQTPTEDGSEEPGSETSDAKSTPTAEAEEAGIGDTPSLEDEAAGHVTQARMVSKS
                     KDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPP
                     KSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAP
                     VPMPDLKNVKSKIGSTENLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQ
                     VEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVY
                     KSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL"
     exon            284..370
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            371..436
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            437..492
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            493..619
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            620..885
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..967
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1080
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..5459
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5436..5441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="hexamer: AATAAA"
     polyA_site      5459
                     /gene="MAPT"
                     /gene_synonym="DDPAC; FTD1; FTDP-17; MAPTL; MSTD; MTBT1;
                     MTBT2; PPND; PPP1R103; TAU; tau-40; Tau-PHF6"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcaccg ccacccacca gctccggcac caacagcagc gccgctgcca ccgcccacct
       61 tctgccgccg ccaccacagc caccttctcc tcctccgctg tcctctcccg tcctcgcctc
      121 tgtcgactat caggtgaact ttgaaccagg atggctgagc cccgccagga gttcgaagtg
      181 atggaagatc acgctgggac gtacgggttg ggggacagga aagatcaggg gggctacacc
      241 atgcaccaag accaagaggg tgacacggac gctggcctga aagaatctcc cctgcagacc
      301 cccactgagg acggatctga ggaaccgggc tctgaaacct ctgatgctaa gagcactcca
      361 acagcggaag ctgaagaagc aggcattgga gacaccccca gcctggaaga cgaagctgct
      421 ggtcacgtga cccaagctcg catggtcagt aaaagcaaag acgggactgg aagcgatgac
      481 aaaaaagcca agggggctga tggtaaaacg aagatcgcca caccgcgggg agcagcccct
      541 ccaggccaga agggccaggc caacgccacc aggattccag caaaaacccc gcccgctcca
      601 aagacaccac ccagctctgg tgaacctcca aaatcagggg atcgcagcgg ctacagcagc
      661 cccggctccc caggcactcc cggcagccgc tcccgcaccc cgtcccttcc aaccccaccc
      721 acccgggagc ccaagaaggt ggcagtggtc cgtactccac ccaagtcgcc gtcttccgcc
      781 aagagccgcc tgcagacagc ccccgtgccc atgccagacc tgaagaatgt caagtccaag
      841 atcggctcca ctgagaacct gaagcaccag ccgggaggcg ggaaggtgca aatagtctac
      901 aaaccagttg acctgagcaa ggtgacctcc aagtgtggct cattaggcaa catccatcat
      961 aaaccaggag gtggccaggt ggaagtaaaa tctgagaagc ttgacttcaa ggacagagtc
     1021 cagtcgaaga ttgggtccct ggacaatatc acccacgtcc ctggcggagg aaataaaaag
     1081 attgaaaccc acaagctgac cttccgcgag aacgccaaag ccaagacaga ccacggggcg
     1141 gagatcgtgt acaagtcgcc agtggtgtct ggggacacgt ctccacggca tctcagcaat
     1201 gtctcctcca ccggcagcat cgacatggta gactcgcccc agctcgccac gctagctgac
     1261 gaggtgtctg cctccctggc caagcagggt ttgtgatcag gcccctgggg cggtcaataa
     1321 ttgtggagag gagagaatga gagagtgtgg aaaaaaaaag aataatgacc cggcccccgc
     1381 cctctgcccc cagctgctcc tcgcagttcg gttaattggt taatcactta acctgctttt
     1441 gtcactcggc tttggctcgg gacttcaaaa tcagtgatgg gagtaagagc aaatttcatc
     1501 tttccaaatt gatgggtggg ctagtaataa aatatttaaa aaaaaacatt caaaaacatg
     1561 gccacatcca acatttcctc aggcaattcc ttttgattct tttttcttcc ccctccatgt
     1621 agaagaggga gaaggagagg ctctgaaagc tgcttctggg ggatttcaag ggactggggg
     1681 tgccaaccac ctctggccct gttgtggggg tgtcacagag gcagtggcag caacaaagga
     1741 tttgaaactt ggtgtgttcg tggagccaca ggcagacgat gtcaaccttg tgtgagtgtg
     1801 acgggggttg gggtggggcg ggaggccacg ggggaggccg aggcaggggc tgggcagagg
     1861 ggagaggaag cacaagaagt gggagtggga gaggaagcca cgtgctggag agtagacatc
     1921 cccctccttg ccgctgggag agccaaggcc tatgccacct gcagcgtctg agcggccgcc
     1981 tgtccttggt ggccgggggt gggggcctgc tgtgggtcag tgtgccaccc tctgcagggc
     2041 agcctgtggg agaagggaca gcgggtaaaa agagaaggca agctggcagg agggtggcac
     2101 ttcgtggatg acctccttag aaaagactga ccttgatgtc ttgagagcgc tggcctcttc
     2161 ctccctccct gcagggtagg gggcctgagt tgaggggctt ccctctgctc cacagaaacc
     2221 ctgttttatt gagttctgaa ggttggaact gctgccatga ttttggccac tttgcagacc
     2281 tgggacttta gggctaacca gttctctttg taaggacttg tgcctcttgg gagacgtcca
     2341 cccgtttcca agcctgggcc actggcatct ctggagtgtg tgggggtctg ggaggcaggt
     2401 cccgagcccc ctgtccttcc cacggccact gcagtcaccc cgtctgcgcc gctgtgctgt
     2461 tgtctgccgt gagagcccaa tcactgccta tacccctcat cacacgtcac aatgtcccga
     2521 attcccagcc tcaccacccc ttctcagtaa tgaccctggt tggttgcagg aggtacctac
     2581 tccatactga gggtgaaatt aagggaaggc aaagtccagg cacaagagtg ggaccccagc
     2641 ctctcactct cagttccact catccaactg ggaccctcac cacgaatctc atgatctgat
     2701 tcggttccct gtctcctcct cccgtcacag atgtgagcca gggcactgct cagctgtgac
     2761 cctaggtgtt tctgccttgt tgacatggag agagcccttt cccctgagaa ggcctggccc
     2821 cttcctgtgc tgagcccaca gcagcaggct gggtgtcttg gttgtcagtg gtggcaccag
     2881 gatggaaggg caaggcaccc agggcaggcc cacagtcccg ctgtccccca cttgcaccct
     2941 agcttgtagc tgccaacctc ccagacagcc cagcccgctg ctcagctcca catgcatagt
     3001 atcagccctc cacacccgac aaaggggaac acaccccctt ggaaatggtt cttttccccc
     3061 agtcccagct ggaagccatg ctgtctgttc tgctggagca gctgaacata tacatagatg
     3121 ttgccctgcc ctccccatct gcaccctgtt gagttgtagt tggatttgtc tgtttatgct
     3181 tggattcacc agagtgacta tgatagtgaa aagaaaaaaa aaaaaaaaaa aggacgcatg
     3241 tatcttgaaa tgcttgtaaa gaggtttcta acccaccctc acgaggtgtc tctcaccccc
     3301 acactgggac tcgtgtggcc tgtgtggtgc caccctgctg gggcctccca agttttgaaa
     3361 ggctttcctc agcacctggg acccaacaga gaccagcttc tagcagctaa ggaggccgtt
     3421 cagctgtgac gaaggcctga agcacaggat taggactgaa gcgatgatgt ccccttccct
     3481 acttcccctt ggggctccct gtgtcagggc acagactagg tcttgtggct ggtctggctt
     3541 gcggcgcgag gatggttctc tctggtcata gcccgaagtc tcatggcagt cccaaaggag
     3601 gcttacaact cctgcatcac aagaaaaagg aagccactgc cagctggggg gatctgcagc
     3661 tcccagaagc tccgtgagcc tcagccaccc ctcagactgg gttcctctcc aagctcgccc
     3721 tctggagggg cagcgcagcc tcccaccaag ggccctgcga ccacagcagg gattgggatg
     3781 aattgcctgt cctggatctg ctctagaggc ccaagctgcc tgcctgagga aggatgactt
     3841 gacaagtcag gagacactgt tcccaaagcc ttgaccagag cacctcagcc cgctgacctt
     3901 gcacaaactc catctgctgc catgagaaaa gggaagccgc ctttgcaaaa cattgctgcc
     3961 taaagaaact cagcagcctc aggcccaatt ctgccacttc tggtttgggt acagttaaag
     4021 gcaaccctga gggacttggc agtagaaatc cagggcctcc cctggggctg gcagcttcgt
     4081 gtgcagctag agctttacct gaaaggaagt ctctgggccc agaactctcc accaagagcc
     4141 tccctgccgt tcgctgagtc ccagcaattc tcctaagttg aagggatctg agaaggagaa
     4201 ggaaatgtgg ggtagatttg gtggtggtta gagatatgcc cccctcatta ctgccaacag
     4261 tttcggctgc atttcttcac gcacctcggt tcctcttcct gaagttcttg tgccctgctc
     4321 ttcagcacca tgggccttct tatacggaag gctctgggat ctcccccttg tggggcaggc
     4381 tcttggggcc agcctaagat catggtttag ggtgatcagt gctggcagat aaattgaaaa
     4441 ggcacgctgg cttgtgatct taaatgagga caatcccccc agggctgggc actcctcccc
     4501 tcccctcact tctcccacct gcagagccag tgtccttggg tgggctagat aggatatact
     4561 gtatgccggc tccttcaagc tgctgactca ctttatcaat agttccattt aaattgactt
     4621 cagtggtgag actgtatcct gtttgctatt gcttgttgtg ctatgggggg aggggggagg
     4681 aatgtgtaag atagttaaca tgggcaaagg gagatcttgg ggtgcagcac ttaaactgcc
     4741 tcgtaaccct tttcatgatt tcaaccacat ttgctagagg gagggagcag ccacggagtt
     4801 agaggccctt ggggtttctc ttttccactg acaggctttc ccaggcagct ggctagttca
     4861 ttccctcccc agccaggtgc aggcgtagga atatggacat ctggttgctt tggcctgctg
     4921 ccctctttca ggggtcctaa gcccacaatc atgcctccct aagaccttgg catccttccc
     4981 tctaagccgt tggcacctct gtgccacctc tcacactggc tccagacaca cagcctgtgc
     5041 ttttggagct gagatcactc gcttcaccct cctcatcttt gttctccaag taaagccacg
     5101 aggtcggggc gagggcagag gtgatcacct gcgtgtccca tctacagacc tgcagcttca
     5161 taaaacttct gatttctctt cagctttgaa aagggttacc ctgggcactg gcctagagcc
     5221 tcacctccta atagacttag ccccatgagt ttgccatgtt gagcaggact atttctggca
     5281 cttgcaagtc ccatgatttc ttcggtaatt ctgagggtgg ggggagggac atgaaatcat
     5341 cttagcttag ctttctgtct gtgaatgtct atatagtgta ttgtgtgttt taacaaatga
     5401 tttacactga ctgttgctgt aaaagtgaat ttggaaataa agttattact ctgattaaa
//
