LOCUS       NM_012326               1890 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein RP/EB family member 3
            (MAPRE3), transcript variant 1, mRNA.
ACCESSION   NM_012326
VERSION     NM_012326.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Zhang,Y., Liu,F., Zheng,J., Jiang,K., Ai,H., Liu,L. and Mao,D.
  TITLE     MAPRE3 as an epigenetic target of EZH2 restricts ovarian cancer
            proliferation in vitro and in vivo
  JOURNAL   Exp Cell Res 435 (1), 113913 (2024)
   PUBMED   38199479
  REMARK    GeneRIF: MAPRE3 as an epigenetic target of EZH2 restricts ovarian
            cancer proliferation in vitro and in vivo.
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Abdelkarim,H., Hitchinson,B., Qu,X., Banerjee,A., Komarova,Y.A. and
            Gaponenko,V.
  TITLE     NMR resonance assignment and structure prediction of the C-terminal
            domain of the microtubule end-binding protein 3
  JOURNAL   PLoS One 15 (5), e0232338 (2020)
   PUBMED   32421702
  REMARK    GeneRIF: structure prediction of the C-terminal domain of the
            microtubule end-binding protein 3
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Bu,W. and Su,L.K.
  TITLE     Characterization of functional domains of human EB1 family proteins
  JOURNAL   J Biol Chem 278 (50), 49721-49731 (2003)
   PUBMED   14514668
  REMARK    GeneRIF: neither APC nor p150glued binding domain is necessary for
            EB1 or EBF3 to induce microtubule bundling
REFERENCE   7  (bases 1 to 1890)
  AUTHORS   Su,L.K. and Qi,Y.
  TITLE     Characterization of human MAPRE genes and their proteins
  JOURNAL   Genomics 71 (2), 142-149 (2001)
   PUBMED   11161807
REFERENCE   8  (bases 1 to 1890)
  AUTHORS   Nakagawa,H., Koyama,K., Murata,Y., Morito,M., Akiyama,T. and
            Nakamura,Y.
  TITLE     EB3, a novel member of the EB1 family preferentially expressed in
            the central nervous system, binds to a CNS-specific APC homologue
  JOURNAL   Oncogene 19 (2), 210-216 (2000)
   PUBMED   10644998
REFERENCE   9  (bases 1 to 1890)
  AUTHORS   Juwana,J.P., Henderikx,P., Mischo,A., Wadle,A., Fadle,N.,
            Gerlach,K., Arends,J.W., Hoogenboom,H., Pfreundschuh,M. and
            Renner,C.
  TITLE     EB/RP gene family encodes tubulin binding proteins
  JOURNAL   Int J Cancer 81 (2), 275-284 (1999)
   PUBMED   10188731
REFERENCE   10 (bases 1 to 1890)
  AUTHORS   Renner,C., Pfitzenmeier,J.P., Gerlach,K., Held,G., Ohnesorge,S.,
            Sahin,U., Bauer,S. and Pfreundschuh,M.
  TITLE     RP1, a new member of the adenomatous polyposis coli-binding
            EB1-like gene family, is differentially expressed in activated T
            cells
  JOURNAL   J Immunol 159 (3), 1276-1283 (1997)
   PUBMED   9233623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC417465.1, BC011557.1,
            AC013472.8 and AB025186.1.
            
            On May 17, 2019 this sequence version replaced NM_012326.3.
            
            Summary:  The protein encoded by this gene is a member of the RP/EB
            family of genes.  The protein localizes to the cytoplasmic
            microtubule network and binds APCL, a homolog of the adenomatous
            polyposis coli tumor suppressor gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025186.1, SRR3476690.840810.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233121.7/ ENSP00000233121.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DC417465.1         269-303
            36-379              BC011557.1         1-344
            380-380             AC013472.8         111598-111598
            381-1867            BC011557.1         346-1832
            1868-1890           AB025186.1         1848-1870
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1890
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /note="microtubule associated protein RP/EB family member
                     3"
                     /db_xref="GeneID:22924"
                     /db_xref="HGNC:HGNC:6892"
                     /db_xref="MIM:605788"
     exon            1..166
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            167..294
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1019
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /note="isoform 1 is encoded by transcript variant 1; APC
                     binding protein; end-binding protein 3; EB1 protein family
                     member 3"
                     /codon_start=1
                     /product="microtubule-associated protein RP/EB family
                     member 3 isoform 1"
                     /protein_id="NP_036458.2"
                     /db_xref="CCDS:CCDS1731.1"
                     /db_xref="GeneID:22924"
                     /db_xref="HGNC:HGNC:6892"
                     /db_xref="MIM:605788"
                     /translation="MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAY
                     CQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQ
                     DNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQR
                     TSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLVDLKLTVDG
                     LEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQE
                     DQDEY"
     exon            295..440
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            441..642
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..797
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            798..950
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1890
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /note="hexamer: AATAAA"
     polyA_site      1867
                     /gene="MAPRE3"
                     /gene_synonym="EB3; EBF3; EBF3-S; RP3"
                     /note="major polyA site"
ORIGIN      
        1 agtgccctcg tcccccgcag tctctgtgcg ttgaagccgg agaccgcggc ggcctcagcg
       61 aggaccctcc gccccggagc cgccggccgg agccgcagcc tctgccgcag cgcccccgcc
      121 acctgtcccc tccccctccg cctccgccgg agccgcctcg tgcactctgg ggtatggccg
      181 tcaatgtgta ctccacatct gtgaccagtg aaaatctgag tcgccatgat atgcttgcat
      241 gggtcaacga ctccctgcac ctcaactata ccaagataga acagctttgt tcaggggcag
      301 cctactgcca gttcatggac atgctcttcc ccggctgtgt gcacttgagg aaagtgaagt
      361 tccaggccaa actagagcac gaatacatcc acaacttcaa ggtgctgcaa gcagctttca
      421 agaagatggg tgttgacaaa atcattcctg tagagaaatt agtgaaagga aaattccaag
      481 ataattttga gtttattcag tggtttaaga aattctttga cgcaaactat gatggaaagg
      541 attacaaccc tctgctggcg cggcagggcc aggacgtagc gccacctcct aacccaggtg
      601 atcagatctt caacaaatcc aagaaactca ttggcacagc agttccacag aggacgtccc
      661 ccacaggccc aaaaaacatg cagacctctg gccggctgag caatgtggcc cccccctgca
      721 ttctccggaa gaatcctcca tcagcccgaa atggcggcca tgagactgat gcccaaattc
      781 ttgaactcaa ccaacagctg gtggacttga agctgacagt ggatgggctg gagaaggaac
      841 gtgacttcta cttcagcaaa cttcgtgaca tcgagctcat ctgccaggag catgaaagtg
      901 aaaacagccc tgttatctca ggcatcattg gcatcctcta tgccacagag gaaggattcg
      961 caccccctga ggacgatgag attgaagagc atcaacaaga agaccaggac gagtactgag
     1021 ggcggccgca gccctggctg actgcacagc ttccccgtgc ctccctccct gctccactcc
     1081 cacattatag tcctttccta acacggtcgg ccgggtgctt tgtgtcagtg ctgcagcact
     1141 ggggagccag gcgagggggg cttgggggca tggggccgga aagcaggcag aagcccgtcc
     1201 tgggtggtgc tggcccagtt ggtgggaccc ctgtccacac ccaccctatt tatttccgtt
     1261 gtctctctgc tgtgtcgccc aacacttccc agggtgctgc tgccacccgc cccagccagc
     1321 cacctgctcc tgacagccag cagctgtgta tttgacaaag tcattggtat atttttactt
     1381 actggattct ccttgcactt tacctgttct tttccagagc tgacagcacg ggctccggcg
     1441 cagtgtgcct ggcttggctt cccttcccca tggctggggg ctggggtagg actcacccat
     1501 tctaatttat tttgtctttt ggcttctcag tagctaaggg gaaggctgat gtcaggagag
     1561 ggagaggggg ctgaggaggt agtgctgtag gcccaggggg tcagggaaag ggaggggggc
     1621 atgtgaggga tggaaatgac ctcctggcac caggctcacc cacccaaggc cccctgcccc
     1681 agcactgaat cccagcgctg ccctgaggcc cccagccact ccctccagca gcctggttca
     1741 ccacacaaac tctgcctgga ccccattgtc tgtctgcttc ccacctgccc tccccacccc
     1801 ctgcccctcg ggcaccagcc tgcatatgtg ttcactttta tttaaataaa cttgtgtggt
     1861 aaaagtacat gccatgtgtc cctcaactga
//
