LOCUS       NM_014268               4212 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens microtubule associated protein RP/EB family member 2
            (MAPRE2), transcript variant 1, mRNA.
ACCESSION   NM_014268
VERSION     NM_014268.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4212)
  AUTHORS   Chiang,D.Y., Verkerk,A.O., Victorio,R., Shneyer,B.I., van der
            Vaart,B., Jouni,M., Narendran,N., Kc,A., Sampognaro,J.R.,
            Vetrano-Olsen,F., Oh,J.S., Buys,E., de Jonge,B., Shah,D.A.,
            Kiviniemi,T., Burridge,P.W., Bezzina,C.R., Akhmanova,A. and
            MacRae,C.A.
  TITLE     The Role of MAPRE2 and Microtubules in Maintaining Normal
            Ventricular Conduction
  JOURNAL   Circ Res 134 (1), 46-59 (2024)
   PUBMED   38095085
  REMARK    GeneRIF: The Role of MAPRE2 and Microtubules in Maintaining Normal
            Ventricular Conduction.
REFERENCE   2  (bases 1 to 4212)
  AUTHORS   Zhang,D., Pan,G., Cheng,N., Sun,L., Zhou,X., Li,C. and Zhao,J.
  TITLE     JUND facilitates proliferation and angiogenesis of esophageal
            squamous cell carcinoma cell via MAPRE2 up-regulation
  JOURNAL   Tissue Cell 81, 102010 (2023)
   PUBMED   36608637
  REMARK    GeneRIF: JUND facilitates proliferation and angiogenesis of
            esophageal squamous cell carcinoma cell via MAPRE2 up-regulation.
REFERENCE   3  (bases 1 to 4212)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4212)
  AUTHORS   Zhang,D., Li,C., Cheng,N., Sun,L., Zhou,X., Pan,G. and Zhao,J.
  TITLE     CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal
            cancer progression by modulating MAPRE2 expression
  JOURNAL   Acta Histochem 123 (7), 151776 (2021)
   PUBMED   34461454
  REMARK    GeneRIF: CircAGFG1 acts as a sponge of miR-4306 to stimulate
            esophageal cancer progression by modulating MAPRE2 expression.
REFERENCE   5  (bases 1 to 4212)
  AUTHORS   Wadle,A., Thiel,G., Mischo,A., Jung,V., Pfreundschuh,M. and
            Renner,C.
  TITLE     Chromosomal localization and promoter analysis of the adenomatous
            polyposis coli binding protein RP1
  JOURNAL   Oncogene 20 (41), 5920-5929 (2001)
   PUBMED   11593399
REFERENCE   6  (bases 1 to 4212)
  AUTHORS   Su,L.K. and Qi,Y.
  TITLE     Characterization of human MAPRE genes and their proteins
  JOURNAL   Genomics 71 (2), 142-149 (2001)
   PUBMED   11161807
REFERENCE   7  (bases 1 to 4212)
  AUTHORS   Juwana,J.P., Henderikx,P., Mischo,A., Wadle,A., Fadle,N.,
            Gerlach,K., Arends,J.W., Hoogenboom,H., Pfreundschuh,M. and
            Renner,C.
  TITLE     EB/RP gene family encodes tubulin binding proteins
  JOURNAL   Int J Cancer 81 (2), 275-284 (1999)
   PUBMED   10188731
REFERENCE   8  (bases 1 to 4212)
  AUTHORS   Morrison,E.E., Wardleworth,B.N., Askham,J.M., Markham,A.F. and
            Meredith,D.M.
  TITLE     EB1, a protein which interacts with the APC tumour suppressor, is
            associated with the microtubule cytoskeleton throughout the cell
            cycle
  JOURNAL   Oncogene 17 (26), 3471-3477 (1998)
   PUBMED   10030671
REFERENCE   9  (bases 1 to 4212)
  AUTHORS   Berrueta,L., Kraeft,S.K., Tirnauer,J.S., Schuyler,S.C., Chen,L.B.,
            Hill,D.E., Pellman,D. and Bierer,B.E.
  TITLE     The adenomatous polyposis coli-binding protein EB1 is associated
            with cytoplasmic and spindle microtubules
  JOURNAL   Proc Natl Acad Sci U S A 95 (18), 10596-10601 (1998)
   PUBMED   9724749
REFERENCE   10 (bases 1 to 4212)
  AUTHORS   Renner,C., Pfitzenmeier,J.P., Gerlach,K., Held,G., Ohnesorge,S.,
            Sahin,U., Bauer,S. and Pfreundschuh,M.
  TITLE     RP1, a new member of the adenomatous polyposis coli-binding
            EB1-like gene family, is differentially expressed in activated T
            cells
  JOURNAL   J Immunol 159 (3), 1276-1283 (1997)
   PUBMED   9233623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC354326.1, BC007318.2,
            AC015967.8 and BM673789.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014268.3.
            
            Summary: The protein encoded by this gene shares significant
            homology to the adenomatous polyposis coli (APC) protein-binding
            EB1 gene family. This protein is a microtubule-associated protein
            that is necessary for spindle symmetry during mitosis. It is
            thought to play a role in the tumorigenesis of colorectal cancers
            and the proliferative control of normal cells. Alternative splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.123849.1,
                                           SRR1803611.245781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300249.10/ ENSP00000300249.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DC354326.1         54-57
            5-2602              BC007318.2         1-2598
            2603-3836           AC015967.8         54442-55675         c
            3837-4212           BM673789.1         15-390              c
FEATURES             Location/Qualifiers
     source          1..4212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1-q12.2"
     gene            1..4212
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /note="microtubule associated protein RP/EB family member
                     2"
                     /db_xref="GeneID:10982"
                     /db_xref="HGNC:HGNC:6891"
                     /db_xref="MIM:605789"
     exon            1..249
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1111
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell activation protein, EB1 family; APC-binding protein
                     EB1; end-binding protein 2; APC-binding protein EB2"
                     /codon_start=1
                     /product="microtubule-associated protein RP/EB family
                     member 2 isoform 1"
                     /protein_id="NP_055083.1"
                     /db_xref="CCDS:CCDS11910.1"
                     /db_xref="GeneID:10982"
                     /db_xref="HGNC:HGNC:6891"
                     /db_xref="MIM:605789"
                     /translation="MPGPTQTLSPNGENNNDIIQDNNGTIIPFRKHTVRGERSYSWGM
                     AVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLK
                     KVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDA
                     NYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTP
                     SRPSSAKRASSSGSASKSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIE
                     LLCQEHGQENDDLVQRLMDILYASEEHEGHTEEPEAEEQAHEQQPPQQEEY"
     exon            250..377
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..523
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..737
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..877
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1036
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..4212
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2575..2580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /note="hexamer: AATAAA"
     polyA_site      2602
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /note="major polyA site"
     regulatory      4187..4192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
                     /note="hexamer: AATAAA"
     polyA_site      4212
                     /gene="MAPRE2"
                     /gene_synonym="CSCSC2; EB1; EB2; RP1"
ORIGIN      
        1 gagaaggcag tgagcgagca ggcggcaggc acggtccgtg cggagcaggc gagcgagcgg
       61 gaagacgcag ccaccttcct caccagccag cccacagcgg tttgttcccc ttctcgggag
      121 tgcgccaatg cctgggccga cccaaaccct gtccccaaat ggcgagaaca acaacgacat
      181 catccaggat aataacggga ccatcattcc tttccggaag cacacagtgc gcggggagcg
      241 ttcctacagt tggggaatgg cggtcaatgt gtattctacc tcgataaccc aagagactat
      301 gagcagacat gacatcattg catgggttaa tgacatagta tctttaaact acacaaaagt
      361 ggaacagctt tgttcaggag cggcctattg ccaattcatg gacatgctct tccctggctg
      421 cattagtttg aagaaagtaa aatttcaagc aaagctggaa catgaatata ttcacaattt
      481 taaacttctg caagcatcat ttaagcgaat gaacgttgat aaggtaattc cagtggagaa
      541 gctagtgaaa ggacgtttcc aggacaacct ggattttatt caatggttta agaaattcta
      601 tgatgctaac tacgatggga aggagtatga tcctgtagag gcacgacaag ggcaagatgc
      661 aattcctcct cctgaccctg gtgaacagat cttcaacctg ccaaaaaagt ctcaccatgc
      721 aaactccccc acagcaggtg cagctaaatc aagtccagca gctaaaccag gatccacacc
      781 ttctcgaccc tcatcagcca aaagggcttc ttccagtggc tcagcatcca aatccgataa
      841 agatttagaa acgcaggtca tacagcttaa tgaacaggta cattcattaa aacttgccct
      901 tgaaggcgtg gaaaaggaaa gggatttcta ctttgggaag ttgagagaga tcgagctact
      961 ctgccaagaa cacgggcagg aaaatgatga cctcgtgcag agactaatgg acatcctgta
     1021 tgcttcagaa gaacacgagg gccacacaga agagccggaa gcagaggagc aagcccacga
     1081 acagcagccc ccgcagcagg aagagtactg acccaccccg gctgctcttg acacttccat
     1141 tgtgtgtggg aacgtttctt ctggagaatt ggaacatgtg tggccccaag ctcaacagaa
     1201 accagttgtt cccaatctgc cgttaccatc aacgcactgt tgcatatgcc agccactgcg
     1261 cttggttccc attttctttg ccaaggtgta ttagcggacg gccctctggc cacctacccg
     1321 agagatcgta gggtcacata catccaactt caccacttgg ctgcttgaga ttggttctgc
     1381 tcttttcttc atttctttcc agaacaactc tttcccaccc caacaccact gccaccaccc
     1441 ctctttttat cctggtgtga aacaatggta atttgatata tggtatttat attggcattt
     1501 ttcaacccag tgtcactaga tgtcacacac atttgtggtg ctttgatgtt tgcaagtcta
     1561 acctctgaac ataaatttgg tcaaataatt ggaacaaagg gaaacagata cttgatatga
     1621 aagccataat gacggtgact tgtgtcgtgg gggaaaacat aaggtcattt tctccctcta
     1681 ctcacaatac taaagggaaa aaatggattc aaagctagga tttcagggcc cagcagtgtt
     1741 cctccatcag catgttagac aactacacag tatgttgtta gttttgaaag acattcactc
     1801 aaggaaaaca ccatctcaac tttgcccgct caccatgtcc cttgccccca tgtagcccat
     1861 ttcccaggtt atgctctttt ctttctcagg gtcctctttg gtgggcagcc actccccgag
     1921 atgttgccat cagttttctg cagtccaaag agggtatggt taggtacggg tcttcctgcc
     1981 tcattcctct tcctctttgt gtaggtttca gccacaaaac tgtcattcac tctaggggac
     2041 ccctactaaa gggtaacttc aggtgtgcag ccctgagctc caaggctctg caccatgcca
     2101 cacacttgct gtaaggctag aagtgaagac cttattaata ggagcataat tgcgagggag
     2161 aatcatggtt ctgcagtctg gtgtagacac tggaataaca gcacagaaaa atctatgact
     2221 cccaatatct tctagaataa agaattttcc ctctttaaca caagggccct ccttgtcatt
     2281 gaccttagct aaaccatggc aattcataaa tagaggaaac attaatgaat taaaagcatt
     2341 ccttattttt taactaatat ttgtacattt tcttagtctc tttccaagtc tttgcctctt
     2401 ttttttcttt atttttattt tttcctttga cagatggtat cccttcctgg atcattcatt
     2461 tcaccttggt ttctaacttt aggtttactt tcacttgtta tttgacttag caggtgcaac
     2521 aaaaacaaga aacaaatgtg cccaccccac tttccgctta actgaaaagc ttaaaataaa
     2581 tttctgaatt atgtatcctg aagctttgaa atttctttat taatcgatga aatatgaatt
     2641 ctaaattcta gcattgaagc ttttcaccaa aagaagtctc tccaaaataa atcttttgca
     2701 gcaaagtgat atttattgag ttatgtggaa aagatggctt gtatttttca gattattaca
     2761 acacactgtg cagaattaga cagatgttcc gtggtgtttg gtttcccttt cttctctctc
     2821 ctgctcactc tgcattatag cagcagctta tttctctaag gctggacagc ctggctctcg
     2881 gcagtgacgt cctcccacac ctggtcacaa gtagtagtgg ctgtgctata cccagcatca
     2941 tgcttaacag cgtgttgccc ttctgagcct gttgtactca ctgatctctt taaaaacaaa
     3001 aaatagctct tgtaaaaggt cacaataact ctatgcacct gatactgcag tggttcctag
     3061 gccattcttc atctgctctg gacatctcag tcatacccaa tgctcagtgg atcatgacca
     3121 aactcctgtc atgtggatgc acgtgagtgg gtagcaggga gtcaggatcc tgccttctcc
     3181 agcaacccct tactgctgta taacttgcat aagcctccct ggtgactctt gcaggaacca
     3241 ctccattgcc ctccagctcc ccagccttct cagttataaa catgctggcc agatctctta
     3301 gcctgcaaag agaactttcc ccagtcacca tagaccattc tccttcctga aggcttgggg
     3361 cagaccattc gtttatttag agaagagcta tacattcttc tttctggtcc catcttaaac
     3421 gtcttctgtt gtgctgcacc ccagatggtg tctcagatgc tttggggaat ctttaacagc
     3481 tgaatttgag tcagtcctct taggctgcac ctccagcctc tgcagatccc ccctcatttc
     3541 ccatggatgg tgggacccca ttattctctc atctcggcat tcagggaaca gtttccttag
     3601 cggcccctgg tcacatgtca tcgggctggg caggaagcgt ccctgattgc gtgctccact
     3661 tctccctctc aggaagccca gtttcatcct tagtaccccc cctcgtgccc gctgtcggct
     3721 ggttatagca cttccactgc tactgtcaga taggaagtga tcgaagcagg gggcaaagag
     3781 aaagcccata tttgttctaa gcagaaaagc aggaaaaaaa aaaaaaaaaa agaaagaaaa
     3841 acacctgttg acctgagaga agtaaattcc agaagggaac caagaactct tcccttccct
     3901 ggtgagtatt tccattattc cgttaaggtt taatatgcat tcagattact tttactaaat
     3961 aggacaccat aaagcttttg ttatatatta aatgtaaact gaaaggaatg taaacatatg
     4021 tattgttaat tataaatata gataagtaat gacataatag atgaaaaagt cttattcaga
     4081 tgtatcacat tcattttaca ttacccacct attgtcgcat ggtagaatag ttttttgtct
     4141 ctgaatatgt gaataacttg acttgcattg atctttttac atatttaata aaaaaaaaag
     4201 tatatgttaa aa
//
