LOCUS       NM_014994               7182 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase binding protein 1
            (MAPKBP1), transcript variant 1, mRNA.
ACCESSION   NM_014994 XM_031706
VERSION     NM_014994.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7182)
  AUTHORS   Schonauer,R., Jin,W., Ertel,A., Nemitz-Kliemchen,M., Panitz,N.,
            Hantmann,E., Seidel,A., Braun,D.A., Shril,S., Hansen,M.,
            Shahzad,K., Sandford,R., Saunier,S., Benmerah,A., Bergmann,C.,
            Hildebrandt,F. and Halbritter,J.
  TITLE     Novel nephronophthisis-associated variants reveal functional
            importance of MAPKBP1 dimerization for centriolar recruitment
  JOURNAL   Kidney Int 98 (4), 958-969 (2020)
   PUBMED   32505465
  REMARK    GeneRIF: Novel nephronophthisis-associated variants reveal
            functional importance of MAPKBP1 dimerization for centriolar
            recruitment.
REFERENCE   2  (bases 1 to 7182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7182)
  AUTHORS   Macia,M.S., Halbritter,J., Delous,M., Bredrup,C., Gutter,A.,
            Filhol,E., Mellgren,A.E.C., Leh,S., Bizet,A., Braun,D.A., Gee,H.Y.,
            Silbermann,F., Henry,C., Krug,P., Bole-Feysot,C., Nitschke,P.,
            Joly,D., Nicoud,P., Paget,A., Haugland,H., Brackmann,D., Ahmet,N.,
            Sandford,R., Cengiz,N., Knappskog,P.M., Boman,H., Linghu,B.,
            Yang,F., Oakeley,E.J., Saint Mezard,P., Sailer,A.W., Johansson,S.,
            Rodahl,E., Saunier,S., Hildebrandt,F. and Benmerah,A.
  TITLE     Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent
            Nephronophthisis
  JOURNAL   Am J Hum Genet 100 (2), 323-333 (2017)
   PUBMED   28089251
  REMARK    GeneRIF: We identified mutations in MAPKBP1 as a genetic cause of
            juvenile or late-onset and cilia-independent nephronophthisis.
            Erratum:[Am J Hum Genet. 2017 Feb 2;100(2):372. doi:
            10.1016/j.ajhg.2017.01.025.. PMID: 28157543]
REFERENCE   4  (bases 1 to 7182)
  AUTHORS   Fu,L., Shi,J., Hu,K., Wang,J., Wang,W. and Ke,X.
  TITLE     Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an
            unfavorable prognostic biomarker in cytogenetically normal acute
            myeloid leukemia
  JOURNAL   Oncotarget 6 (10), 8144-8154 (2015)
   PUBMED   25924238
REFERENCE   5  (bases 1 to 7182)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 7182)
  AUTHORS   Cohen-Katsenelson,K., Wasserman,T., Darlyuk-Saadon,I., Rabner,A.,
            Glaser,F. and Aronheim,A.
  TITLE     Identification and analysis of a novel dimerization domain shared
            by various members of c-Jun N-terminal kinase (JNK) scaffold
            proteins
  JOURNAL   J Biol Chem 288 (10), 7294-7304 (2013)
   PUBMED   23341463
REFERENCE   7  (bases 1 to 7182)
  AUTHORS   Lecat,A., Di Valentin,E., Somja,J., Jourdan,S., Fillet,M.,
            Kufer,T.A., Habraken,Y., Sadzot,C., Louis,E., Delvenne,P.,
            Piette,J. and Legrand-Poels,S.
  TITLE     The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as
            a negative regulator of NOD2 protein signaling by inhibiting its
            oligomerization process
  JOURNAL   J Biol Chem 287 (35), 29213-29226 (2012)
   PUBMED   22700971
  REMARK    GeneRIF: JNKBP1 and NOD2 are co-expressed in the human intestinal
            epithelium and in immune cells recruited in the lamina propria,
            which suggests that JNKBP1 contributes to maintain NOD2-mediated
            intestinal immune homeostasis.
REFERENCE   8  (bases 1 to 7182)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 7182)
  AUTHORS   Homma,K., Kikuno,R.F., Nagase,T., Ohara,O. and Nishikawa,K.
  TITLE     Alternative splice variants encoding unstable protein domains exist
            in the human brain
  JOURNAL   J Mol Biol 343 (5), 1207-1220 (2004)
   PUBMED   15491607
REFERENCE   10 (bases 1 to 7182)
  AUTHORS   Koyano,S., Ito,M., Takamatsu,N., Shiba,T., Yamamoto,K. and
            Yoshioka,K.
  TITLE     A novel Jun N-terminal kinase (JNK)-binding protein that enhances
            the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase
            1
  JOURNAL   FEBS Lett 457 (3), 385-388 (1999)
   PUBMED   10471813
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036660.1, AB011168.2,
            BC113983.1, BC114493.1, AC020659.5 and AL833267.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014994.2.
            
            Summary: This gene encodes a scaffold protein that regulates the
            JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding
            oligomerization domain-containing protein 2) signaling pathways.
            The encoded protein interacts with another related JNK pathway
            scaffold protein, WDR62, via a conserved dimerization domain, and
            enhances JNK signaling. This protein may play a role in bacterial
            immunity by binding to the NOD2 receptor and negatively regulating
            downstream antibacterial and pro-inflammatory signaling. Mutations
            in this gene that impair cellular localization of the encoded
            protein cause a form of nephronophthisis, an autosomal-recessive
            kidney disorder, in human patients. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833267.1, BX648786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457542.7/ ENSP00000397570.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BC036660.1         56-95
            41-1055             AB011168.2         1-1015
            1056-1936           AB011168.2         1034-1914
            1937-3618           BC113983.1         1879-3560
            3619-3936           AB011168.2         3597-3914
            3937-5779           BC114493.1         3897-5739
            5780-7029           AC020659.5         67335-68584
            7030-7182           AL833267.1         7007-7159
FEATURES             Location/Qualifiers
     source          1..7182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..7182
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /note="mitogen-activated protein kinase binding protein 1"
                     /db_xref="GeneID:23005"
                     /db_xref="HGNC:HGNC:29536"
                     /db_xref="MIM:616786"
     exon            1..127
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            128..350
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..4763
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /note="isoform a is encoded by transcript variant 1;
                     JNK-binding protein 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase-binding protein
                     1 isoform a"
                     /protein_id="NP_055809.2"
                     /db_xref="CCDS:CCDS32201.1"
                     /db_xref="GeneID:23005"
                     /db_xref="HGNC:HGNC:29536"
                     /db_xref="MIM:616786"
                     /translation="MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKV
                     LGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDG
                     KYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIV
                     NVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVP
                     LLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRTTV
                     AHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVA
                     NARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVY
                     PEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGN
                     TQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEM
                     LKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITA
                     VKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKY
                     TAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIF
                     DFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAE
                     LRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALP
                     VLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRGRWVQPGV
                     ELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQ
                     ASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARG
                     TLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEP
                     AEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSES
                     RSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVE
                     PSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEA
                     SLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISVGENL
                     GLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAE
                     KPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPEN
                     LQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAG
                     CKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSE
                     LLLRAVERRMERKL"
     exon            351..442
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            443..505
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            506..563
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            564..734
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            735..872
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1055
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1216
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1406
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1553
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1729
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1821
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1947
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2018
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2140
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2216
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2328
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2392
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2527
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2661
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2717
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2954
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3121
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3267
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3465
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3550
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3834
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..4449
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..4535
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     exon            4536..7182
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7161..7166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /note="hexamer: AATAAA"
     polyA_site      7182
                     /gene="MAPKBP1"
                     /gene_synonym="JNKBP-1; JNKBP1; NPHP20"
                     /note="major polyA site"
ORIGIN      
        1 gagccgatcg tgccaccata gctcctgctg ctgcctctac cgctgcggct accgcggcgg
       61 agctgaaatt gccgaacgcg atgcccgagg gcgctgtgag cggggtggcc ttagctcgcc
      121 gaggctggtc agtgagaggg catactggga agccctctgg agtgggaaga cagtgccgct
      181 gttgagacaa gacccaggac tgggccgggg actgtcccaa agggtttctc gtcataatgg
      241 ctgtggaagg gtcaaccatt accagccgga tcaagaatct gttgagatct ccatccatca
      301 aactgcgcag gagtaaggca ggaaaccgac gagaggacct cagctccaag gtgaccttgg
      361 agaaggtgct gggaattaca gtgtctggag gcagaggact tgcctgtgac ccccgatcag
      421 gtttagttgc ttacccagca gggtgtgtgg ttgtgttgtt caatccccgg aaacacaaac
      481 agcaccacat cctcaacagt tccaggaaaa ccatcactgc ccttgccttc tcccctgatg
      541 gcaagtactt ggtcactgga gagagtgggc acatgcctgc cgtgcgggtt tgggacgtgg
      601 cagagcacag ccaggtggcc gagctgcagg agcacaagta tggtgtggct tgtgtggcct
      661 tctctcctag cgccaagtac attgtctctg tgggctacca gcatgacatg atcgtcaacg
      721 tgtgggcctg gaagaaaaac attgtggtgg cctccaacaa ggtgtccagt cgggtgacag
      781 cagtgtcctt ctctgaggat tgcagctact ttgtcactgc aggcaaccga cacatcaaat
      841 tctggtatct cgatgacagc aagacctcaa aggtgaatgc cactgtgccc ttgctgggcc
      901 gctcagggct gctgggagag ctacggaaca acctattcac tgatgtggcc tgtggcagag
      961 gaaaaaaggc ggacagtacc ttctgcatca cgtcctcagg gctgctgtgc gagttcagtg
     1021 atcgaaggct tttggacaag tgggtggagc tgaggaccac agtggcccac tgcatctctg
     1081 tgagccaaga ctacatcttc tgtggctgtg ctgatggcac cgtgcgcctt ttcaacccct
     1141 ctaacctgca cttccttagc accttgcccc gaccccatgc tctggggaca gacattgcta
     1201 gcgtcaccga ggccagtcgc ctcttctctg gagtggcgaa tgccaggtat ccagacacca
     1261 ttgccttgac ctttgatcct actaatcagt ggctgtcttg tgtgtacaac gatcatagca
     1321 tttatgtttg ggatgtgagg gaccccaaga aagtgggcaa ggtgtactcg gctctgtatc
     1381 attcttcctg cgtctggagt gtggaggtct accccgaggt gaaggatagt aaccaggcct
     1441 gcctgccccc cagttccttt attacctgct cctcagacaa caccatccgc ctgtggaaca
     1501 cagagagctc cggggtgcat ggctccaccc tccaccgaaa catcctcagc agtgacctca
     1561 ttaaaatcat ctatgtggat gggaacaccc aggccctgct ggacacagag ctgcctggag
     1621 gagacaaagc tgatgcatcc ctgttggatc cccgcgtggg catccgctcg gtgtgtgtca
     1681 gccccaatgg acagcatcta gcatcagggg accgtatggg cacacttagg gtgcacgaac
     1741 ttcagtccct gagtgagatg ctgaaggtgg aggcccatga ctctgagatt ctgtgcctgg
     1801 agtattctaa gccagacaca ggtctgaaac tgctagcatc ggcgagccgg gaccggctga
     1861 tccatgtgct ggatgccggg cgggagtaca gcctacagca gacgctggac gaacactcat
     1921 cctccatcac tgctgttaag tttgcagcca gtgatgggca agtccgcatg atcagctgtg
     1981 gagcagacaa gagcatctac ttccgcactg cgcagaagtc tggagatgga gtgcagttca
     2041 cacggacaca ccacgtggtg cggaagacga ccctctatga catggatgtg gagcccagct
     2101 ggaagtacac ggctatcggc tgccaggacc gaaatattcg gatatttaac atcagcagtg
     2161 gaaagcagaa gaagctgttt aaagggtcac agggtgagga cggcacactc attaaggtgc
     2221 agacagaccc ctcagggatc tacattgcca ccagctgttc tgacaagaat ctctccattt
     2281 ttgacttctc ctcaggcgag tgcgtggcca ccatgtttgg ccactcagag attgtcactg
     2341 gcatgaaatt tagtaatgat tgtaaacatc tcatctctgt gtctggggac agctgcatat
     2401 ttgtgtggcg cctgagctct gagatgacca tcagcatgag gcagcgtctg gccgagttgc
     2461 gccagcgtca gcggggcggc aagcagcaag gaccatcctc tccccaaagg gcttctggac
     2521 ccaaccggca ccaggcccca tcaatgctgt ctcctggacc ggctctctca tcagacagtg
     2581 acaaggaggg agaagatgag gggactgaag aagaacttcc agcactgccc gtccttgcca
     2641 agagtaccaa gaaggcactg gcctcggtcc ccagcccagc tttgccccga agcctgtccc
     2701 actgggagat gagtcgggca caggagtccg tggggttcct ggacccagct cctgcagcca
     2761 acccaggacc cagaagaaga gggcgctggg ttcagccagg tgtggaactg agcgttagat
     2821 ccatgctgga tctgcggcag ctggaaacac tggccccaag cctgcaggac cctagccagg
     2881 actcgctggc catcatccca tctggtccca ggaagcatgg gcaggaggcc cttgagactt
     2941 cactcactag ccagaatgaa aagccccctc ggcctcaggc ttcccaacct tgttcctatc
     3001 cccatattat ccgattattg tcacaagagg aaggggtctt tgcccaagat ctggaacctg
     3061 cacccattga agatggtatt gtctacccgg agccgagtga caaccccacc atggatacca
     3121 gtgagttcca agtgcaggct ccagcccggg gaactctggg aagagtgtac ccaggcagca
     3181 ggagctcaga aaagcacagc cctgacagtg cctgctctgt ggattacagc agcagctgcc
     3241 tttccagccc ggagcacccc actgaagact ctgagagcac ggagcccctc agtgtggatg
     3301 gcatctcctc agaccttgaa gagccagctg agggtgatga agaagaggaa gaagaggagg
     3361 gaggcatggg cccctatggg ctacaggagg gcagccccca gactccagac caggagcagt
     3421 ttctaaaaca gcactttgag actctggcca gtggagctgc tccaggggcc ccagtgcagg
     3481 tcccagagag gtcagagtct cggagtatct cttcacgatt cctgttgcaa gtacagaccc
     3541 gcccactcag ggaaccatcc ccatcctcct caagcctggc actgatgtcg agaccagccc
     3601 aggtgccaca ggcatctggt gagcagccga gaggcaatgg tgccaatccc cctggagcac
     3661 ccccggaggt ggaaccgtcc tctggcaacc ccagccccca gcaggcagcc tctgtgctgt
     3721 tgccacgatg ccgtctcaac cctgacagca gctgggctcc caagagagtg gccacagcca
     3781 gccccttttc tggactccag aaggcccagt ctgtgcacag tctggtgcca caggaaagac
     3841 atgaggccag tctgcaggcc ccttcaccag gcgcactgct gtctcgggag atcgaagctc
     3901 aggatggtct gggctccctg cccccagctg atggccgtcc gtctcggcct cactcctatc
     3961 agaaccccac caccagttcc atggccaaga tatcccgcag tatctctgtt ggggagaacc
     4021 tgggcctggt ggctgaacct caagctcatg cccccatccg agtctcacca ctcagcaagc
     4081 tggccctgcc cagccgggct cacctggtcc tggacatccc caaaccactg cctgaccgtc
     4141 ctaccctggc tgcattctct cctgtcacca aaggccgggc ccctggcgag gcagaaaagc
     4201 ctggcttccc ggtgggccta ggaaaagctc acagtacaac tgagagatgg gcctgtttgg
     4261 gggagggcac cactcccaag cctaggacag agtgccaggc tcatcctggg cccagcagcc
     4321 cctgtgccca gcaactgcca gtcagcagcc tcttccaagg ccctgaaaac ttgcagcccc
     4381 caccccctga gaagactccc aaccccatgg aatgcaccaa gccaggggca gccctgagcc
     4441 aggactcaga gccagcggtg agcctggagc agtgtgagca gctggtggca gagctccgcg
     4501 gcagcgtgcg ccaggcagtg cggctctacc actcggtggc tggctgcaag atgccctcag
     4561 cagagcaaag tcggattgcc cagctcctca gagacacctt ctcttcagtg cgacaggagc
     4621 tggaagctgt ggctggggca gtgctgtcca gcccaggcag cagccctggg gctgtgggag
     4681 ccgagcagac acaggccctg ctggagcaat actcagaact gttgcttcga gccgtggaac
     4741 ggcgtatgga acgcaaactc tgagttctgg aagcctgtcc caagtgaatg aatgctccag
     4801 cgattccaaa ctgcagcccc tctgcccctc accaaaacct gcggggctgc ttggagtgga
     4861 aagcagggag cagtgttcag aggcaaagca gccttcccag ccgctcctcg tggggggcct
     4921 gtatttatta atttatttcc ctgactgttg cctcacttcc ttggaactcc tgcctccaca
     4981 gcccctccag tggcagggac aggtcttggg tctttgtcat cttggtgctg tgagaggtag
     5041 gagggcagcc tgccccatct aggaatctgg gaagggctgg ccctctctta gaagccattt
     5101 gaaattactg cagggattag ctccctgtgg tggagcatac acagggtact ctggggtcga
     5161 ggtgagaggt gatgtggtat tcagtgcccg tcagccaact gtgggccttc acctctacct
     5221 gcacttcccc tctcacacca gctgcactcc cgtggctgcc agagcagggt ggttttcccc
     5281 aatacctgga gctcagaaag gcagagccat ctggccctcc agggtgtccc cagccatcag
     5341 gagacttgag ttggtatttg gacctgagcc cgcacattcc actcccattc tccctccaag
     5401 aggggcccag cattgtattt ccctgtgacc ccttactctc ctggccagaa cttgagccag
     5461 ctgtgggatg ttgctgcagg acagtaagcc ctcacctggg caaacatgaa gctctggcct
     5521 cctttcctca gccccttgtt cttccctgtc ctccaccctg gaccccagcc ggctgctgga
     5581 gcccagaggc caccttctcc ctgcatcctg aatgatgctt agtcagaagc ctgtgttgga
     5641 acatccctcg tttacggggc gctggcctac ctcctgagga cctcagccac agatgagatc
     5701 acacgcatgc acgtgcacac atgtacacac acacacctac ctgcacagca cgctgttgag
     5761 tgttggttgc tagagtatct ggctggctgc tgtgtgcctg gtttcctcac atcctgcctc
     5821 agcttcacca ccctggctta tgtggaacac ctatcaggga gcagaaaagg ggtgcagtac
     5881 actaagtgaa cccagattct ggattcttgg tgtccacagc ctagctgata cgagatagcc
     5941 cataggacac ctggtttagg tagaaggagc ctcctcaaag gcagtgctgg gcacccacgg
     6001 gtgtgctgga tactggagtt tgagaggagg gaggtgctgg ggccaaagga gacactagaa
     6061 aagtggtaga tgggacaggt aagtggcaga ggtgagggga taagttagaa tgtaaaaggg
     6121 cagtaattag gggtgaggga aaggagatag gggaccctag gaggtagagt gggaccatgt
     6181 cgtgaggcag ttgaagagtt gaggaaaggt ttttctgggc cctactgctc ccctctgctg
     6241 caggtaagtc agagcagctt taccacagct tcaggccacg agagcccctt cacccgccct
     6301 gctgcgccat aggcagaggc ttataaagaa atgggttctg ggccaggtgt ggtggctcaa
     6361 gcctgtaatc ccagcacttt gggaggccga ggcgggtgga tcacctgagg ttaggagttc
     6421 gagatcagcc tggccaacat ggtgaaaccc tgtctactaa aaataaaaaa attagctggg
     6481 cgtggtggtg ggcgcctgta atcccagcta ctcgggaggt ttaggcagga gaatcgcttg
     6541 aaccctggag gtggaggtgg aggttgcagt gagccgagat cgcgccattg cactccaacc
     6601 taggtgacaa agctacacgc catctcaaaa aaaaaaaaga aaaagggtta caaaaggttc
     6661 ccagctccgg ggcatcagcc tgagtgcgct tgagctgctc caaacctggc ccttccccac
     6721 tcctctagca tcgccacccg catggccctg gaactcccgc ggcggcgggg gcgggcccgt
     6781 gcctgctgtg ccccgacttc ccacaccagc cgcgcccacc gcaggtggga ctcaggttcg
     6841 ccctctgggc caggtccttc acgaggaggg agctaccctt cgccagaagt ttgtgagaat
     6901 gtggccgccc ttttcctgcc ctctgcccca tgtgggtggg gggcctcgtg gcccggccgg
     6961 cgccccgtcc ccttctgcat gtctgaggcc accggcaacc gccgccccac tccagatttg
     7021 cccccgcctt gttttgaaag ccccttattt ataactttta tactttgtgc aggtcgcggc
     7081 gcttcctgcc tcatcctcgg ctgcatgggg cgggggcgct gtttttaacg tgcccgtttg
     7141 tactgatgta tgaacttgtc aataaacaca attgtttgtt aa
//
