LOCUS       NM_002752               4799 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript
            variant JNK2-a2, mRNA.
ACCESSION   NM_002752
VERSION     NM_002752.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4799)
  AUTHORS   Ishibashi,R., Itani,M., Kawashima,A., Arakawa,Y. and Aoki,T.
  TITLE     JNK2-MMP-9 axis facilitates the progression of intracranial
            aneurysms
  JOURNAL   Sci Rep 14 (1), 19458 (2024)
   PUBMED   39169203
  REMARK    GeneRIF: JNK2-MMP-9 axis facilitates the progression of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4799)
  AUTHORS   Yang,F., Zhuang,Z., Liu,C., Li,F. and Zhou,J.
  TITLE     Overexpression of circZNF720 Inhibits Hepatocellular Carcinoma
            Progression by Regulating miR-421/MAPK9
  JOURNAL   Mol Biotechnol 66 (5), 1165-1173 (2024)
   PUBMED   38159171
  REMARK    GeneRIF: Overexpression of circZNF720 Inhibits Hepatocellular
            Carcinoma Progression by Regulating miR-421/MAPK9.
REFERENCE   3  (bases 1 to 4799)
  AUTHORS   Wang,K., Lu,Q., Luo,Y., Yu,G., Wang,Z., Lin,J., Tan,Z., Lao,Y.,
            Liu,S. and Yang,H.
  TITLE     Circ_MAPK9 promotes STAT3 and LDHA expression by silencing
            miR-642b-3p and affects the progression of hepatocellular carcinoma
  JOURNAL   Biol Direct 19 (1), 4 (2024)
   PUBMED   38163874
  REMARK    GeneRIF: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing
            miR-642b-3p and affects the progression of hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4799)
  AUTHORS   Wang,L., Guo,M., Gao,L., Liu,K., Bai,J. and Liu,Z.
  TITLE     JNK2 Promotes Progression of Esophageal Squamous Cell Carcinoma via
            Inhibiting Axin2
  JOURNAL   Curr Pharm Des 29 (37), 2977-2987 (2023)
   PUBMED   37957865
  REMARK    GeneRIF: JNK2 Promotes Progression of Esophageal Squamous Cell
            Carcinoma via Inhibiting Axin2.
REFERENCE   5  (bases 1 to 4799)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4799)
  AUTHORS   Livingstone,C., Patel,G. and Jones,N.
  TITLE     ATF-2 contains a phosphorylation-dependent transcriptional
            activation domain
  JOURNAL   EMBO J 14 (8), 1785-1797 (1995)
   PUBMED   7737129
REFERENCE   7  (bases 1 to 4799)
  AUTHORS   Kallunki,T., Su,B., Tsigelny,I., Sluss,H.K., Derijard,B., Moore,G.,
            Davis,R. and Karin,M.
  TITLE     JNK2 contains a specificity-determining region responsible for
            efficient c-Jun binding and phosphorylation
  JOURNAL   Genes Dev 8 (24), 2996-3007 (1994)
   PUBMED   8001819
REFERENCE   8  (bases 1 to 4799)
  AUTHORS   Sluss,H.K., Barrett,T., Derijard,B. and Davis,R.J.
  TITLE     Signal transduction by tumor necrosis factor mediated by JNK
            protein kinases
  JOURNAL   Mol Cell Biol 14 (12), 8376-8384 (1994)
   PUBMED   7969172
REFERENCE   9  (bases 1 to 4799)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   10 (bases 1 to 4799)
  AUTHORS   Denys,H., Desmet,R., Stragier,M., Vergison,R. and Lemahieu,S.F.
  TITLE     Cystitis emphysematosa
  JOURNAL   Acta Urol Belg 45 (4), 327-331 (1977)
   PUBMED   602896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008610.7, DB451562.1,
            BC032539.1 and AC104115.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002752.4.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase targets specific
            transcription factors, and thus mediates immediate-early gene
            expression in response to various cell stimuli. It is most closely
            related to MAPK8, both of which are involved in UV radiation
            induced apoptosis, thought to be related to the cytochrome
            c-mediated cell death pathway. This gene and MAPK8 are also known
            as c-Jun N-terminal kinases. This kinase blocks the ubiquitination
            of tumor suppressor p53, and thus it increases the stability of p53
            in nonstressed cells. Studies of this gene's mouse counterpart
            suggest a key role in T-cell differentiation. Several alternatively
            spliced transcript variants encoding distinct isoforms have been
            reported. [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (JNK2-a2) encodes the longer of
            the two JNK2 alpha isoforms (JNK2 alpha2). The JNK2-a2 variant
            differs from the JNK2-b2 variant in the use of an alternate
            internal coding exon of the same length. Thus, JNK2 alpha2 isoform
            is the same length as JNK2 beta2 isoform, with a few aa differences
            in an internal protein segment. Variants JNK2-a2 and 8 both encode
            the same isoform (alpha2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.251946.1,
                                           SRR18074969.2967292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452135.7/ ENSP00000394560.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC008610.7         40559-40570         c
            13-110              DB451562.1         30-127
            111-113             AC008610.7         40458-40460         c
            114-236             DB451562.1         128-250
            237-2160            BC032539.1         15-1938
            2161-4348           AC104115.3         81606-83793         c
            4349-4799           AC104115.3         81155-81605         c
FEATURES             Location/Qualifiers
     source          1..4799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..4799
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="mitogen-activated protein kinase 9"
                     /db_xref="GeneID:5601"
                     /db_xref="HGNC:HGNC:6886"
                     /db_xref="MIM:602896"
     exon            1..236
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            237..405
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1558
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /EC_number="2.7.11.24"
                     /note="isoform alpha2 is encoded by transcript variant
                     JNK2-a2; c-Jun N-terminal kinase 2; stress-activated
                     protein kinase JNK2; MAP kinase 9; c-Jun kinase 2; MAPK 9;
                     stress-activated protein kinase 1a"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 9 isoform
                     alpha2"
                     /protein_id="NP_002743.3"
                     /db_xref="CCDS:CCDS4453.1"
                     /db_xref="GeneID:5601"
                     /db_xref="HGNC:HGNC:6886"
                     /db_xref="MIM:602896"
                     /translation="MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAF
                     DTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQ
                     DVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
                     SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEL
                     VKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFP
                     DWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPP
                     PQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSS
                     INDISSMSTEQTLASDTDSSLDASTGPLEGCR"
     exon            406..535
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            536..594
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            595..733
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            734..899
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            900..971
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1154
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1279
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1343
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1415
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..4799
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="major polyA site"
     regulatory      4290..4295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="hexamer: AATATA"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="hexamer: AATACA"
     polyA_site      4323
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="major polyA site"
     regulatory      4343..4348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="hexamer: GATAAA"
     polyA_site      4348
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
                     /note="major polyA site"
     polyA_site      4364
                     /gene="MAPK9"
                     /gene_synonym="JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B;
                     JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a"
ORIGIN      
        1 agaccgggcg ccgcggcggc ggcagcggcg gagaagggag cgggaccgga agggtcgcag
       61 cgccccggcg cccctcacac ccactgcggc ggcggcggcg gcggcggcgg cggggcggag
      121 cggagcgggg cgggccggcg gcggagccgg ggccgcggag ccaggagtga ctagcacgca
      181 gcgccgccag tccgcccgcc cgccctctcc ccgtggcgcg gcggcgggga ggcgagggat
      241 ctgaaacttg cccacccttc gggatattgc aggacgctgc atcatgagcg acagtaaatg
      301 tgacagtcag ttttatagtg tgcaagtggc agactcaacc ttcactgtcc taaaacgtta
      361 ccagcagctg aaaccaattg gctctggggc ccaagggatt gtttgtgctg catttgatac
      421 agttcttggg ataaatgttg cagtcaagaa actaagccgt ccttttcaga accaaactca
      481 tgcaaagaga gcttatcgtg aacttgtcct cttaaaatgt gtcaatcata aaaatataat
      541 tagtttgtta aatgtgttta caccacaaaa aactctagaa gaatttcaag atgtgtattt
      601 ggttatggaa ttaatggatg ctaacttatg tcaggttatt cacatggagc tggatcatga
      661 aagaatgtcc taccttcttt accagatgct ttgtggtatt aaacatctgc attcagctgg
      721 tataattcat agagatttga agcctagcaa cattgttgtg aaatcagact gcaccctgaa
      781 gatccttgac tttggcctgg cccggacagc gtgcactaac ttcatgatga ccccttacgt
      841 ggtgacacgg tactaccggg cgcccgaagt catcctgggt atgggctaca aagagaacgt
      901 tgatatctgg tcagtgggtt gcatcatggg agagctggtg aaaggttgtg tgatattcca
      961 aggcactgac catattgatc agtggaataa agttattgag cagctgggaa caccatcagc
     1021 agagttcatg aagaaacttc agccaactgt gaggaattat gtcgaaaaca gaccaaagta
     1081 tcctggaatc aaatttgaag aactctttcc agattggata ttcccatcag aatctgagcg
     1141 agacaaaata aaaacaagtc aagccagaga tctgttatca aaaatgttag tgattgatcc
     1201 tgacaagcgg atctctgtag acgaagctct gcgtcaccca tacatcactg tttggtatga
     1261 ccccgccgaa gcagaagccc caccacctca aatttatgat gcccagttgg aagaaagaga
     1321 acatgcaatt gaagaatgga aagagctaat ttacaaagaa gtcatggatt gggaagaaag
     1381 aagcaagaat ggtgttgtaa aagatcagcc ttcagatgca gcagtaagta gcaacgccac
     1441 tccttctcag tcttcatcga tcaatgacat ttcatccatg tccactgagc agacgctggc
     1501 ctcagacaca gacagcagtc ttgatgcctc gacgggaccc cttgaaggct gtcgatgata
     1561 ggttagaaat agcaaacctg tcagcattga aggaactctc acctccgtgg gcctgaaatg
     1621 cttgggagtt gatggaacca aatagaaaaa ctccatgttc tgcatgtaag aaacacaatg
     1681 ccttgcccta ctcagacctg ataggattgc ctgcttagat gataaaatga ggcagaatat
     1741 gtctgaagaa aaaaattgca agccacactt ctagagattt tgttcaagat catttcaggt
     1801 gagcagttag agtaggtgaa tttgtttcaa attgtactag tgacagtttc tcatcatctg
     1861 taactgttga gatgtatgtg catgtgacca caaatgcttg cttggacttg cccatctagc
     1921 actttggaaa tcagtattta aatgccaaat aatcttccag gtagtgctgc ttctgaagtt
     1981 atctcttaat cctcttaagt aatttggtgt ctgtccagaa aaagtcgatt tatgtgtatt
     2041 aattggccat catgatgtta tcatatctta ttccctttta tgctatgatt tattctatct
     2101 tttgtatttc agaagacata taattaaatc tatttaataa ataaaaatat atagcttttc
     2161 ttagatttgt gatgtttggg gctgagaatt atcacggcta aaaccaagac acttatgtgg
     2221 acatcttgtt ttctttaaac tgtcttgtct gggatgattg tacattcagc tttactgcac
     2281 gatacaattt taagttttgc ttagtgctgc ttgaaatcct agctacctta tctcttttct
     2341 tcttggtctt ctagacttct tatgaattta aaatgctacc tagaacttca ccttctttat
     2401 taggtgcgta acactccatc ttaattaaat atgatggcag ataggttcct gcatccatgg
     2461 cctaacgttg gagtggaatt ttacaaaatg ctcactagag atcactgcag tcatttccta
     2521 agtgcttcct ttgccacaga ctggcctggg tcctttattt accttccctc attcactttc
     2581 cctcggccaa taccacgttc ttgattttct ttcttcactg gaagaaagca gataaactcc
     2641 tctttggtct gttttcagag gccaggctga ttcagatgcc tgttgctatt gttgctctcc
     2701 attgttggga ggcattcctt ttcacaagaa tgttctggga aactcttcag aggacgtgaa
     2761 ggaaataccc tgaagagtca tgattaacta ttgactattt tctgatttaa aactgctcac
     2821 ctgaaattga tacttttaga ctttacgatc agtaaattat tcagaattca tgaagatgct
     2881 gagtatgtta agtgtcactg caggaacgga gctgtggtga tcacgttttg cctgcctgtg
     2941 cccatgtctc ttcccttgag cttattctgt tgctgattca tatcttgtgt tcaattattt
     3001 tggaagcttt tcagtcgaca ttctgtagag tgtgttctga ggaggaactg tgataagaaa
     3061 gtttattata aatattatgt aaaatatatg gctctctctg caccagttat atcttattgg
     3121 ttggtcatat cactggaaac tggaaccttt gattagcaaa attaatattg aaataagaaa
     3181 tagttctttt atattgtgtc atttggacac tttcaagtac aaaatggtaa taataacttg
     3241 gattgaggcg gaaacaccta ttttatggct atctatctaa acatcttaaa atggccttct
     3301 ctgtaataca ctttctttta aaagacttca ctaaatctat ctttaaaagg aaaaacaaaa
     3361 gggagaggtt gaaaatgcgc gagctgccct gcactgtgtg atgctccctc cccgggagac
     3421 gtggacgggg gacgaggcac ccgcagacgc ccttctgctc actcgctcct ctgtgcattc
     3481 agcgagccac ttgccacaga tggagcccgt gacggtgtgg agggtttcct ggaaaggcca
     3541 tcttccacca ggtagaggcg agcgtgccta ggacaggcca cagggctcca cagaaatacc
     3601 tcaccccagc ttcagggttc tctctcctga gcctagattt gccagggtct tggtgccacg
     3661 caaatggttt caaactgatc tctatggata aatgctgatg ttggttaaag aactgaaaaa
     3721 tgtgctcaac tgtttcatct tttctatttt atttttgtaa tttatattgt acacaaccca
     3781 ggaagtaact attttggaca tgtattttta taaaccaggt aatttactat tatcctggaa
     3841 tttagactag gtttgtttca tttgttgact tagtttccag ccaagaagga aacgactgtc
     3901 tcccccatgt ccaggtctca gtttcaaggg cagagtccag agagcagaca gagttctgtg
     3961 agagcaggag agcagtctgg aaaccctggc tgtgcatacc gtgtcagccg tgggcctgga
     4021 gatgggagca ggtgagacgc agagccccag tactgagagg aggaagccct cttacagggc
     4081 cccttgccca ccccaagtcc gtgtctgaaa cacggagcgg gtgctgcttc aacccgcatt
     4141 taatgctgtg taagtagcga taaccacgta cgagtctgtc tggttgattt ctaatgtgac
     4201 tcctctggta tttcctcctg gtaataaata caagtgtgac ctttcagatt gcatatctca
     4261 aaagtaacat tgctaatgtt ttataataaa atatattatg tgtgttttgg ttggtgaaaa
     4321 taatacagac tacattttaa aagataaatg tatagcatgt ccaatttttg tgtgttttta
     4381 catggcaatt agatatttct ccatcaccat ctctgatgac agatttaaca tgaacacaga
     4441 tagatgataa agtgtcatgc ttttgatcaa tattagcaag aggtttcaca ctgagaggca
     4501 gaaacattgc tgtttgttct cttattgaaa atattctgca aattcctaaa tctgtgtttt
     4561 caaaactaat ggcagtaagt tttgacttca ccaatatgca ggtccaattc agagtattgg
     4621 tgtaattgtt ttctcatgag gcgtggccag gagaattcac cagtcagcct tagtcatgtt
     4681 acttaacgtc attcatggtg cttgtggctt tgtgcctggg atgagccaag ttcatctgac
     4741 gtctgtgttt gaagcacttc aggctgttta gtacttaata ccacaggagt ggaaggaca
//
