LOCUS       NM_001318852            5686 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 8 interacting protein
            3 (MAPK8IP3), transcript variant 3, mRNA.
ACCESSION   NM_001318852 XM_005255187
VERSION     NM_001318852.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Singh,K., Lau,C.K., Manigrasso,G., Gama,J.B., Gassmann,R. and
            Carter,A.P.
  TITLE     Molecular mechanism of dynein-dynactin complex assembly by LIS1
  JOURNAL   Science 383 (6690), eadk8544 (2024)
   PUBMED   38547289
  REMARK    GeneRIF: Molecular mechanism of dynein-dynactin complex assembly by
            LIS1.
REFERENCE   2  (bases 1 to 5686)
  AUTHORS   Karteszi,J., Ziegler,A., Tihanyi,M., Elmont,B., Zhang,Y.,
            Patocs,B., Molnar,M.J., Mehes,G., Wells,K., Jakus,R., Bessenyei,B.,
            Ranatunga,W. and Morava,E.
  TITLE     Compound heterozygous variants in MAPK8IP3 were detected in severe
            congenital hypotonia mimicking lethal spinal muscular atrophy
  JOURNAL   Am J Med Genet A 191 (9), 2428-2432 (2023)
   PUBMED   37462082
  REMARK    GeneRIF: Compound heterozygous variants in MAPK8IP3 were detected
            in severe congenital hypotonia mimicking lethal spinal muscular
            atrophy.
REFERENCE   3  (bases 1 to 5686)
  AUTHORS   Celestino,R., Gama,J.B., Castro-Rodrigues,A.F., Barbosa,D.J.,
            Rocha,H., d'Amico,E.A., Musacchio,A., Carvalho,A.X.,
            Morais-Cabral,J.H. and Gassmann,R.
  TITLE     JIP3 interacts with dynein and kinesin-1 to regulate bidirectional
            organelle transport
  JOURNAL   J Cell Biol 221 (8) (2022)
   PUBMED   35829703
  REMARK    GeneRIF: JIP3 interacts with dynein and kinesin-1 to regulate
            bidirectional organelle transport.
REFERENCE   4  (bases 1 to 5686)
  AUTHORS   Rafiq,N.M., Lyons,L.L., Gowrishankar,S., De Camilli,P. and
            Ferguson,S.M.
  TITLE     JIP3 links lysosome transport to regulation of multiple components
            of the axonal cytoskeleton
  JOURNAL   Commun Biol 5 (1), 5 (2022)
   PUBMED   35013510
  REMARK    GeneRIF: JIP3 links lysosome transport to regulation of multiple
            components of the axonal cytoskeleton.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5686)
  AUTHORS   Cason,S.E., Carman,P.J., Van Duyne,C., Goldsmith,J., Dominguez,R.
            and Holzbaur,E.L.F.
  TITLE     Sequential dynein effectors regulate axonal autophagosome motility
            in a maturation-dependent pathway
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   34014261
  REMARK    GeneRIF: Sequential dynein effectors regulate axonal autophagosome
            motility in a maturation-dependent pathway.
REFERENCE   6  (bases 1 to 5686)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   7  (bases 1 to 5686)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   8  (bases 1 to 5686)
  AUTHORS   Kuboki,Y., Ito,M., Takamatsu,N., Yamamoto,K.I., Shiba,T. and
            Yoshioka,K.
  TITLE     A scaffold protein in the c-Jun NH2-terminal kinase signaling
            pathways suppresses the extracellular signal-regulated kinase
            signaling pathways
  JOURNAL   J Biol Chem 275 (51), 39815-39818 (2000)
   PUBMED   11044439
REFERENCE   9  (bases 1 to 5686)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   10 (bases 1 to 5686)
  AUTHORS   Ito,M., Yoshioka,K., Akechi,M., Yamashita,S., Takamatsu,N.,
            Sugiyama,K., Hibi,M., Nakabeppu,Y., Shiba,T. and Yamamoto,K.I.
  TITLE     JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein
            that functions as a Scaffold factor in the JNK signaling pathway
  JOURNAL   Mol Cell Biol 19 (11), 7539-7548 (1999)
   PUBMED   10523642
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031710.11, AL031717.11 and
            AC012180.6.
            
            On Feb 26, 2020 this sequence version replaced NM_001318852.1.
            
            Summary: The protein encoded by this gene shares similarity with
            the product of Drosophila syd gene, required for the functional
            interaction of kinesin I with axonal cargo. Studies of the similar
            gene in mouse suggested that this protein may interact with, and
            regulate the activity of numerous protein kinases of the JNK
            signaling pathway, and thus function as a scaffold protein in
            neuronal cells. The C. elegans counterpart of this gene is found to
            regulate synaptic vesicle transport possibly by integrating JNK
            signaling and kinesin-1 transport. Several alternatively spliced
            transcript variants of this gene have been described, but the
            full-length nature of some of these variants has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the  5' coding region, compared to variant 1. It
            encodes isoform 3, which is shorter than isoform 1 by a single
            amino acid.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144486.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610761.2/ ENSP00000481780.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AL031710.11        8345-8807
            464-584             AL031717.11        2054-2174
            585-655             AL031717.11        6635-6705
            656-747             AL031717.11        6984-7075
            748-892             AL031717.11        20829-20973
            893-1139            AL031717.11        24526-24772
            1140-1242           AL031717.11        25741-25843
            1243-1361           AL031717.11        26099-26217
            1362-1373           AL031717.11        35645-35656
            1374-1391           AL031717.11        36475-36492
            1392-1449           AL031717.11        37455-37512
            1450-1602           AL031717.11        37877-38029
            1603-1684           AL031717.11        38721-38802
            1685-1815           AL031717.11        39848-39978
            1816-1872           AL031717.11        40172-40228
            1873-2043           AL031717.11        40333-40503
            2044-2170           AL031717.11        41154-41280
            2171-2266           AL031717.11        41612-41707
            2267-2425           AL031717.11        41798-41956
            2426-2591           AL031717.11        42510-42675
            2592-2774           AC012180.6         2971-3153
            2775-2964           AC012180.6         3231-3420
            2965-3084           AC012180.6         3540-3659
            3085-3165           AC012180.6         3734-3814
            3166-3233           AC012180.6         3915-3982
            3234-3382           AC012180.6         4160-4308
            3383-3554           AC012180.6         4575-4746
            3555-3668           AC012180.6         4816-4929
            3669-3707           AC012180.6         5080-5118
            3708-3887           AC012180.6         5210-5389
            3888-4037           AC012180.6         5488-5637
            4038-5686           AC012180.6         5714-7362
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5686
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 3"
                     /db_xref="GeneID:23162"
                     /db_xref="HGNC:HGNC:6884"
                     /db_xref="MIM:605431"
     exon            1..463
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..4159
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     JNK-interacting protein 3; JNK/SAPK-associated protein-1;
                     JNK/stress-activated protein kinase-associated protein 1;
                     homolog of Drosophila Sunday driver 2;
                     C-jun-amino-terminal kinase interacting protein 3;
                     C-Jun-amino-terminal kinase-interacting protein 3; JNK MAP
                     kinase scaffold protein 3"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     3 isoform 3"
                     /protein_id="NP_001305781.1"
                     /db_xref="CCDS:CCDS81929.1"
                     /db_xref="GeneID:23162"
                     /db_xref="HGNC:HGNC:6884"
                     /db_xref="MIM:605431"
                     /translation="MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLI
                     HCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRR
                     QAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKE
                     YNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRSRKERPTSLNVFPLADGT
                     VRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNT
                     PTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMG
                     SSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGS
                     EVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD
                     QLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSY
                     LCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQ
                     EKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHAMCPISAGS
                     RPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRLQACGWSLPAKYKQLSPNGGQ
                     EDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAGNGVKPAPGRDPLT
                     CDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTLTTSKVVIIDANQPGTVV
                     DQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGADGVLAGITLVGCATRC
                     NVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGPSEPETAT
                     LRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSSAAPTM
                     WLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGED
                     GQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRR
                     ESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFV
                     RITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGI
                     IHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSP
                     AEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLS
                     KAERSHIIVWQVSYTPE"
     exon            464..584
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..655
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..747
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..892
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1139
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1242
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1361
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1373
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1391
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1449
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1602
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1684
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1815
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1872
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2043
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2170
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2266
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2425
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2591
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2774
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2964
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3084
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3165
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3233
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3382
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3383..3554
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3668
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3707
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3887
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4037
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..5686
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5632..5637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /note="hexamer: AATAAA"
     polyA_site      5652
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
                     /note="major polyA site"
     polyA_site      5686
                     /gene="MAPK8IP3"
                     /gene_synonym="JIP-3; JIP3; JSAP1; NEDBA; syd; SYD2"
ORIGIN      
        1 agcctcggca gcggcggcgg cggagccctg aggcgacagc agctgcggga ggcgacgggc
       61 tgcggcctgc ggaacctgag gcagctgggg agggccgggc gcgccggccg gatagcgagc
      121 cgcgctggcg gcggcggtgg ccgcgatgat ggagatccag atggacgagg gcggcggcgt
      181 ggtggtgtac caggacgact actgctccgg ctcggtgatg tcggagcggg tgtcgggcct
      241 ggcgggctcc atctaccgcg agttcgagcg cctcatccac tgctacgacg aggaggtggt
      301 caaggagctc atgccgctgg tggtgaacgt gctggagaac ctagactcgg tgctcagcga
      361 gaaccaggag cacgaggtgg agctggagct gctgcgcgag gacaacgagc agctgctcac
      421 ccagtacgag cgtgagaagg cgctgcgcag gcaggcggag gagaaattca ttgagtttga
      481 agatgctctg gaacaagaga agaaagagct gcaaatccag gtggagcact acgagttcca
      541 gacgcgccag ctggagctga aggccaagaa ctatgccgat cagatttccc ggttggagga
      601 gcgggagtcg gagatgaaga aggagtacaa tgccctgcac cagcggcaca cagagatgat
      661 acagacctac gtggagcaca ttgagaggtc caagatgcag caggtcggag gaaacagcca
      721 gaccgagagc agcctgccgg ggcggagcag gaaggagcgc cccacctccc tgaacgtgtt
      781 ccccctggct gacggcacgg tacgtgcaca gatcgggggc aagctcgtgc ctgcggggga
      841 ccactggcac ctgagtgacc tcggccagct gcagtccagc tccagctacc agtgtccaca
      901 ggatgaaatg tccgagtcag gccagtcctc ggcggccgcc acacccagca ccacaggcac
      961 caagtccaac acgcccacat cctccgtgcc ctcggccgcc gtcacacccc tcaacgagag
     1021 cctgcagccc ctgggggact atggcgtggg ctccaagaac agcaagcgtg cccgggagaa
     1081 gcgcgacagc cgcaacatgg aagtacaggt cacccaggag atgcgcaacg tcagtatagg
     1141 catgggcagc agtgacgagt ggtctgatgt tcaagacatt attgactcca cgccagagct
     1201 ggacatgtgt ccagagaccc gcctggaccg cacaggaagc agcccaaccc agggcatcgt
     1261 gaacaaagct ttcggcatca acaccgactc cctgtaccat gagctgtcga cggcagggtc
     1321 tgaggtcatc ggggatgtgg acgaaggggc cgacctccta ggggagttct cagtgcgcga
     1381 tgatttcttt ggaatgggca aagaagtggg gaatctgcta ctggaaaact cacagcttct
     1441 ggaaaccaaa aacgccttga atgtggtgaa gaatgacctg attgccaagg tcgaccagct
     1501 gtccggggag caggaggtgc tgaggggcga gttggaggct gctaagcagg ccaaagtcaa
     1561 gctggaaaac cgtatcaagg agctggaaga ggaactgaaa agagtgaagt ccgaggccat
     1621 catcgcccgc cgtgaaccca aagaagaggc ggaggatgta agcagctatc tctgtacaga
     1681 atcggacaaa atccccatgg cccagcgccg ccgcttcacg cgggtggaga tggcccgtgt
     1741 gctcatggag cggaaccagt acaaggagcg gctgatggag ctgcaggagg ctgtgcggtg
     1801 gactgagatg atcagagcgt cccgagagca cccatccgtc caggagaaga agaagtcgac
     1861 catctggcag ttcttcagcc gcctcttcag ctcttcctcc agcccccctc cggccaagcg
     1921 cccctatccc tcggtgaaca tccactacaa gtcacccacc actgccggct tcagccagcg
     1981 ccgcaaccat gccatgtgcc cgatctcggc aggcagccgg cccctggaat tcttccctga
     2041 cgacgactgc acgtcctccg cccgtcgaga gcagaagcgc gagcagtacc gccaggtgcg
     2101 tgagcacgtg cgtaacgacg acggccgtct gcaggcctgc ggctggagcc tgcccgccaa
     2161 gtacaagcag ctgagtccca acgggggcca ggaggacacg cggatgaaga acgtgccggt
     2221 gccggtgtac tgccgccctc tggtggagaa ggaccccacc atgaagctgt ggtgtgccgc
     2281 gggcgtcaac ctgagcgggt ggaggcccaa tgaggacgac gctgggaatg gagtcaagcc
     2341 agcgccaggc cgcgatcccc tgacctgcga ccgcgaagga gacggcgagc ccaagagcgc
     2401 ccacacgtct cccgagaaga agaaggccaa ggagctccct gaaatggacg ccacctccag
     2461 ccgggtgtgg atcctgacca gcaccctgac caccagcaag gtggtgatca tcgacgccaa
     2521 ccagccgggc acggtggtgg accagttcac cgtctgcaac gcgcacgtgc tgtgcatctc
     2581 cagcatcccc gcggccagcg acagcgacta ccctcccggg gagatgttcc tggacagcga
     2641 cgtgaaccca gaggacccgg gcgcagatgg cgtgctggcc ggtatcaccc tggtgggctg
     2701 tgccacccgc tgcaacgtgc cgcggagcaa ctgctcctcc cgaggggaca ccccagtgct
     2761 agacaagggg cagggggagg tggccaccat cgccaacggg aaggtcaacc cgtcccagtc
     2821 cacagaggag gccacagagg ccacggaggt gccagaccct gggcccagcg agccagagac
     2881 agccacattg cggcccgggc ctctcacaga gcacgtcttc actgacccag ccccgacccc
     2941 gtcctctggc ccccagcctg gcagcgagaa cgggccagag cctgacagca gcagcacacg
     3001 gccagagcca gagcccagcg gggaccccac gggagcaggc agcagtgctg cacccaccat
     3061 gtggctggga gcccagaacg gctggctcta tgtgcactcg gctgtggcca actggaagaa
     3121 gtgcctgcac tccatcaagc tgaaggattc tgtgctgagc ctggtgcatg tcaaaggccg
     3181 tgtgctggtg gctctggcgg acgggaccct ggccatcttc caccgtggtg aagatggcca
     3241 gtgggatctg agcaactatc acctaatgga cctgggccac ccgcaccact ccatccgctg
     3301 catggctgtt gtgtacgacc gcgtgtggtg tggctacaag aacaaggtgc acgtcatcca
     3361 gcccaagacc atgcagatag agaagtcatt tgacgcccac ccgcggcggg agagccaggt
     3421 gcggcagctg gcgtggatcg gcgatggcgt atgggtgtcc atccgcctgg actccaccct
     3481 gaggctctac catgcacaca cgcaccagca tctacaggac gtggacattg agccctacgt
     3541 cagcaagatg ctaggcactg gcaagctggg tttctccttc gtacgcatca cggccctgct
     3601 tgtcgcgggc agccggctct gggtgggcac cggcaacgga gtggtcatct ccatccccct
     3661 gacagagact gtggtcctgc accgaggcca gctcctgggg ctccgagcca ataagacatc
     3721 ccccacctct ggggagggcg cccgtcccgg gggcatcatc cacgtgtatg gcgatgacag
     3781 cagtgacagg gcggccagca gcttcatccc ctactgctcc atggcccagg cccagctatg
     3841 cttccatggg caccgcgatg ccgtgaagtt ctttgtctcg gtgccaggga acgtgctggc
     3901 caccctgaat gggagtgtgc tggacagccc agccgagggc cctgggccag ctgcccctgc
     3961 ctcggaggtc gagggccaga agctgcggaa cgtgctggtg ctgagcggcg gggagggcta
     4021 catcgacttc cgcattggag acggagagga cgacgagacg gaggagggcg caggggacat
     4081 gagccaggtg aagcccgtgc tgtccaaggc agagcgcagt cacatcatcg tgtggcaggt
     4141 gtcctacacc cccgagtgaa gctgctgccc tgcctggccc gacctgtaca taggaccccc
     4201 gaccacctga cccccgcccg gcccgcgggg tagccagcca ggcgccgccg cccctcttct
     4261 aacctctcaa cctgcagctt tcacctgagt ctggcccctc cagcgggcag ggagtgcggg
     4321 gatgcggatc agctgggagg aggaggggag gggaacttcc acccgagggg aagatgctct
     4381 cgggacagtt tcccgggcag ctcctggcca gcttccagcc cagagtcctc aagtccaggg
     4441 caccttgggc ccagcgcagg cagaatccga ggtggtcctg gctctaccct gggcctccta
     4501 ctccccagca cccctggagg aggcaggggc tccccgccgc cgaggctgcc tgccctgggc
     4561 ccacctctgc atgctgctca tggggccacc ctgcctcctg ggccctcact ctgcctaggg
     4621 gagctgggcc aggcactagc ctttgcccag ggaggtgggc ctcaggctgc ccaggtgcct
     4681 gcaccccagc cggccttctc tggggcctcc ccgtcgtcaa gcctctatcc tgtctgtccc
     4741 caccccagct gtcccctgcc cagggagctg gcataaaagc acgaggcccg gctccctggg
     4801 gcagctgctt gagaacagag actgctaccc catcctgccc atgcaggcag gctcttgcca
     4861 gccccgttct gacccgtgtc cccccaggct ctgcctgggc agaagactca ccttggagga
     4921 gtgggccctg gagtcctgtc cctcccagaa gcccccaggg tgggatttct caggctgcca
     4981 gggcaggccc aggcctcagg aagaagggga ggcccctggc ctctccggga tcagtcctag
     5041 gacacaggct cagcctcagg ttgatggggg atgatgtgct cccggggcct gcctcctgca
     5101 cggggctcca cggagcccag ctcccagaca cgctactaag tgcctagggt tgcccgctgt
     5161 ggcctgcttc cagggagcaa cagagaggcc accaagcaga ggcccgtggg gctgaggatg
     5221 gagccgcccc cagccgactc caagcccgca gagggcagac gccaccctgg actgctctcc
     5281 ctgcccagct gggcctctct ggcctattcc taccttccag gcccactgca ctcctgtctg
     5341 ggaggccctt atgagggcag cccagccccc gcacccaccc ccaaccagag aagcacagat
     5401 cttggggagc tgccccacaa gccccgctgg ccaccgaggg ctgcagccgc tgcgctgccg
     5461 gcttctcccc accaccctgc cacctccact gtgatgtatg tccgctccct cgtctgttcc
     5521 cccaggatct cgaagtgact ccgggctgag cagtggggcg gctgggggag gggtgacgat
     5581 tctcctcagg ctttggccct gcaagcaaac ccacatatct gctctgtatg taataaatgt
     5641 cttaacgtcg tagctgcctg ttcctgggcc caaatcgaaa cgaaaa
//
