LOCUS       NM_012324               5700 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 8 interacting protein
            2 (MAPK8IP2), mRNA.
ACCESSION   NM_012324
VERSION     NM_012324.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5700)
  AUTHORS   Marino Perez,L., Ielasi,F.S., Lee,A., Delaforge,E., Juyoux,P.,
            Tengo,M., Davis,R.J., Palencia,A. and Jensen,M.R.
  TITLE     Structural basis of homodimerization of the JNK scaffold protein
            JIP2 and its heterodimerization with JIP1
  JOURNAL   Structure 32 (9), 1394-1403 (2024)
   PUBMED   39013462
  REMARK    GeneRIF: Structural basis of homodimerization of the JNK scaffold
            protein JIP2 and its heterodimerization with JIP1.
REFERENCE   2  (bases 1 to 5700)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5700)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5700)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5700)
  AUTHORS   Petschnigg,J., Groisman,B., Kotlyar,M., Taipale,M., Zheng,Y.,
            Kurat,C.F., Sayad,A., Sierra,J.R., Mattiazzi Usaj,M., Snider,J.,
            Nachman,A., Krykbaeva,I., Tsao,M.S., Moffat,J., Pawson,T.,
            Lindquist,S., Jurisica,I. and Stagljar,I.
  TITLE     The mammalian-membrane two-hybrid assay (MaMTH) for probing
            membrane-protein interactions in human cells
  JOURNAL   Nat Methods 11 (5), 585-592 (2014)
   PUBMED   24658140
REFERENCE   6  (bases 1 to 5700)
  AUTHORS   Schoorlemmer,J. and Goldfarb,M.
  TITLE     Fibroblast growth factor homologous factors are intracellular
            signaling proteins
  JOURNAL   Curr Biol 11 (10), 793-797 (2001)
   PUBMED   11378392
REFERENCE   7  (bases 1 to 5700)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   8  (bases 1 to 5700)
  AUTHORS   Negri,S., Oberson,A., Steinmann,M., Sauser,C., Nicod,P., Waeber,G.,
            Schorderet,D.F. and Bonny,C.
  TITLE     cDNA cloning and mapping of a novel islet-brain/JNK-interacting
            protein
  JOURNAL   Genomics 64 (3), 324-330 (2000)
   PUBMED   10756100
REFERENCE   9  (bases 1 to 5700)
  AUTHORS   Kelkar,N., Gupta,S., Dickens,M. and Davis,R.J.
  TITLE     Interaction of a mitogen-activated protein kinase signaling module
            with the neuronal protein JIP3
  JOURNAL   Mol Cell Biol 20 (3), 1030-1043 (2000)
   PUBMED   10629060
REFERENCE   10 (bases 1 to 5700)
  AUTHORS   Yasuda,J., Whitmarsh,A.J., Cavanagh,J., Sharma,M. and Davis,R.J.
  TITLE     The JIP group of mitogen-activated protein kinase scaffold proteins
  JOURNAL   Mol Cell Biol 19 (10), 7245-7254 (1999)
   PUBMED   10490659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF136382.1, U62317.2,
            AK094442.1 and AI066766.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012324.5.
            
            Summary: This gene encodes a scaffold protein that is thought to be
            involved in the regulation of the c-Jun amino-terminal kinase
            signaling pathway. This protein has been shown to interact with and
            regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases.
            [provided by RefSeq, Jun 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047527.1, AF136382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329492.6/ ENSP00000330572.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3264              AF136382.1         92-3355
            3265-3283           U62317.2           28894-28912         c
            3284-5672           AK094442.1         1-2389
            5673-5700           AI066766.1         4-31                c
FEATURES             Location/Qualifiers
     source          1..5700
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..5700
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 2"
                     /db_xref="GeneID:23542"
                     /db_xref="HGNC:HGNC:6883"
                     /db_xref="MIM:607755"
     exon            1..91
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2501
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /note="JNK-interacting protein 2; JNK MAP kinase scaffold
                     protein JIP2; homologous to mouse JIP-1; islet-brain 2;
                     JNK MAP kinase scaffold protein 2"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     2"
                     /protein_id="NP_036456.1"
                     /db_xref="CCDS:CCDS74886.1"
                     /db_xref="GeneID:23542"
                     /db_xref="HGNC:HGNC:6883"
                     /db_xref="MIM:607755"
                     /translation="MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDC
                     GLGLSYDSDHCEKDSLSLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEE
                     EGDGEGQEGGDPGSEAPAPGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDL
                     VRPASWQETALCSPAPEALRELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPG
                     GTSPSSDPGIEADLRSRSSGGRGGRRSSQELSSPGSDSEDAGGARLGRMISSISETEL
                     ELSSDGGSSSSGRSSHLTNSIEEASSPASEPEPPREPPRRPAFLPVGPDDTNSEYESG
                     SESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQ
                     DSQDPEAAAGPGGVELVDMETLCAPPPPAPAAPRPGPAQPGPCLFLSNPTRDTITPLW
                     AAPGRAARPGRACSAACSEEEDEEDDEEEEDAEDSAGSPGGRGTGPSAPRDASLVYDA
                     VKYTLVVDEHTQLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALLGGGQVSGDTSPD
                     SPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHRAVFRFIPRHPDELE
                     LDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDLLGSKRSPCWVER
                     FDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEISLRGVKLSLSG
                     GGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVFVSQESMRPVAQ
                     SVGRAFLEYYQEHLAYACPTEDIYLE"
     exon            92..197
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            198..473
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            474..567
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1791
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1867
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2040
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2150
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2258
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2329
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2428
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..5700
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /note="hexamer: AATAAA"
     polyA_site      3271
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /note="major polyA site"
     regulatory      5678..5683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
                     /note="hexamer: AATAAA"
     polyA_site      5700
                     /gene="MAPK8IP2"
                     /gene_synonym="IB-2; IB2; JIP2; PRKM8IPL"
ORIGIN      
        1 gcagtcgcgg gcctctcccg gagaagatgg cggatcgcgc ggagatgttt tctctctcca
       61 ccttccactc gctgtcgccg ccgggctgca ggcctcccca ggacataagc ctggaagaat
      121 ttgacgacga agatctgtct gagatcactg atgactgtgg cctgggcctc agctacgact
      181 cagaccactg tgagaaggac agcctctccc tggggcgctc ggagcagccg caccccatct
      241 gctccttcca ggatgacttc caggagtttg agatgatcga tgacaatgaa gaggaggacg
      301 atgaggacga ggaagaggag gaggaggagg aggagggaga tggggaaggc caggagggag
      361 gagaccctgg ctcagaggca cctgcccccg ggccccttat cccctcccct tccgtggagg
      421 agccccacaa gcaccggccc accaccctcc gtctgaccac actgggggcc caggactccc
      481 taaacaacaa cggaggcttt gacctggtgc gtccggcctc ctggcaggag acagcgctat
      541 gctcacccgc cccggaggcc ctcagagagc tcccgggccc cctccctgcc acggacaccg
      601 ggcccggcgg ggcgcagtcg ccagtgcgcc cgggttgcga ctgcgaaggg aaccggcctg
      661 cggaaccccc tgcgccaggg gggacttcgc cctcctcaga tcccggcatc gaggctgacc
      721 tgagaagccg ctcgagcggc ggccgcgggg gacgtcgcag cagccaggag ctgtcctcgc
      781 ccggctccga ctcggaggac gcgggcggcg cgcgcctggg gcgcatgatc tcgtccatct
      841 cggagacgga gctggagctg agcagcgatg gcggaagcag cagcagcggc cgctcctcgc
      901 acctcaccaa ctccatcgag gaggcctcgt cgcccgcctc ggagccggag cccccgcgcg
      961 aacccccgcg ccgccccgcc ttcctgcccg tgggccccga cgacaccaac agcgagtacg
     1021 agtcggggtc ggagtcggag ccggacctca gcgaggacgc ggactcgccc tggctgctca
     1081 gcaacctggt gagccgcatg atctccgagg gctcctcgcc catccgctgc cccggccagt
     1141 gcctgtctcc tgcgccgcgc ccgcccgggg agcccgtgtc gccggccggc ggggccgccc
     1201 aggactccca ggaccccgag gcggccgcgg ggcccggcgg cgtggagctg gtggacatgg
     1261 agacgctgtg cgcgccgccg ccgcccgcgc ccgccgcgcc tcgacccggc cccgcgcagc
     1321 ccgggccctg cctattcctc agcaacccca cgcgtgacac catcacgccg ctgtgggccg
     1381 cgcccggccg cgccgcccgc ccgggacgag cctgctccgc cgcctgctcc gaggaggagg
     1441 acgaagagga cgacgaggaa gaggaggatg ccgaggacag tgcggggtcc cccgggggca
     1501 ggggcacggg cccctcggcg ccgcgggacg cgtcgctggt gtacgacgcg gtcaagtaca
     1561 cgctggtggt ggatgagcac acgcagctgg agctggtgag cctgcggcgc tgtgctgggc
     1621 tgggccacga cagcgaagag gacagcggcg gggaggccag cgaggaggag gcgggcgcgg
     1681 cgctgctagg cggcggtcag gtctcggggg acacctcgcc ggacagccct gacctcactt
     1741 tctccaagaa gttcctcaat gtcttcgtca acagcacatc tcggtcctcc agcaccgagt
     1801 cctttggcct tttctcctgt ctggtcaacg gcgaggagcg agagcagact caccgggctg
     1861 tgttcaggtt catcccgcgg catccagacg agctggagct ggatgtggat gaccctgtgt
     1921 tggtggaggc cgaggaggac gacttctggt tccgtggctt caacatgcgc acgggggagc
     1981 gcggtgtgtt tcctgccttc tacgcccatg cggtgcccgg ccctgccaag gacctgctgg
     2041 ggagtaagcg gagcccctgc tgggtggagc gctttgacgt gcagttcctg ggctccgtgg
     2101 aggtgccctg ccaccagggc aacggcatcc tgtgtgcagc catgcagaag attgccactg
     2161 cccggaaact gaccgtccac ctgcgccctc ctgcctcctg tgacctcgag atctctcttc
     2221 ggggggtcaa gctgagtctg agcggaggag ggcccgagtt ccagcgctgc agccatttct
     2281 tccagatgaa gaacatctcc ttctgcggct gccatccccg caacagctgc tatttcggct
     2341 tcatcaccaa acaccccctg ctgagccgct tcgcctgcca cgtctttgtc tcccaggagt
     2401 ccatgaggcc ggtggcgcag agtgtgggcc gcgccttcct ggagtactac caagagcacc
     2461 tggcgtacgc ctgccccacg gaggacatct acctggagta gcctgcccac cgctctgtct
     2521 cctggccgtc tgctccaggc gcagctgggg ctgaggatgt ctcaagaggc caccatggct
     2581 ttggcaagga ctggattggg gggacatggg accttacgct tgtgggggtc tgcgggctgg
     2641 gaactctcgt cctcggtccc cagggcgcag ctgttggggc tgcgggggag tggagccccc
     2701 gtgcccctgc ttttcctcag atccgttctt tctctgtgtt gtcctcctcc ttcccttccc
     2761 agtctccctt ttctctctcc tggtgtctct gcccctctct gtgcctgcaa accttatcct
     2821 ctattcttca ctttggggtc agaacttcgg gggtgtggag gaggtgcggc tctagggaca
     2881 ggtaatgtcg gcttccaagt gatgccctcc tgccactccc ctgcgattta taagggaatt
     2941 ttaattttta tagtgaatct caagggatca tcccatcctt gaccacaggg acaagagggg
     3001 ccccctcgcc ccagccccac cccacatgga gctcaggggg aagcagggag gggttcccaa
     3061 aagagccctg cggaggctag gagtggttct tgatgctcac ctgaagcccc tagacgctgc
     3121 taggaggggg ggccctcctg ggcccccaat acccctccgc ttgccgctgc tagcgcaccc
     3181 ctgcagtcca gcgtgcatcc accccacgca cgccccgtgc tgtgttcctg ggccctgccc
     3241 atggcctcaa taaactctct gcttggtgtg acattggctg tttctagagg gtgctaagac
     3301 atggggccag gtgcccaggg gctgcccatt gtggtaggga cagagtcccc agtggcggga
     3361 gtgttgtggc aatctcaccc ttttagctct ttccgaaatt gtgccggggg tccctgcggt
     3421 gctgctctgg ggccttatct gaggtgccgt atctagaagc acccttggga attctcccta
     3481 gatacactcg attggccaca gaggaatccg aggctgtgca atggggtgtc ctttccacgt
     3541 gcacggactg ggggccagca cggctcaggt cagtgtgtag tgggggcatg aactccttga
     3601 agaacaatct ggccgggcac ggtggctcac gcttgtaatc ccaacacttt gggaggccga
     3661 gccggggcgt atcacctgag gtcaggagtt tgagaccagc ttggccaaca tggtgaaacc
     3721 ccatctccac aaaaaataca aaaattagct aggtgtcctg gcgcacacct gtaatcccag
     3781 ctactcagga ggctaaggca tgagaatcgc ttgaacctgg gaggcggagg ttgcagtgag
     3841 ccaagattgc accactgcac tccagcctgg gcgacagagg gagactccgt ctcagaaaaa
     3901 ggaaaagaaa aacaatctac ttagatctta aaatggatat ttaaaaaatt ctccagagaa
     3961 agccagaaga aaataggtga ctttttcact atgtgcttag gtgactgcag atgcccggca
     4021 atgttccctc ccaggccctc ctgggtgagc ccgcctccca ggcaggggtc agcatggccg
     4081 gggtccctct gtctgagccc aggattcgtg caacaccagg aagacaacag ttgaaggttc
     4141 cttagtgagc taagggaagt atacacaaac ttactacata aacattagaa agtgctgtcc
     4201 gtaaaaaaca cgtcttcaca gagccaacaa gcagagaaat agctgcccag tgttaggaag
     4261 tgcatcatga tccagaggtt cagcccgtgt gcagcgcaca gacctgaggc cccagagaga
     4321 ccgaggacgc agaccagtgg cacgacggaa acgcagaacg tttatgagaa aactttccta
     4381 ctaattgaga taaagctgta aagaggcaga tagccccact gggtgtgtac gtttgaaact
     4441 tgtgccccct gggctagggc attcggggtg tggccctcag tcccctgtag ctgctgcctg
     4501 gaaaccgctg ccacccaccc acctcctccc tctgctcttc cactcaggtg agaattctcc
     4561 aagccctgcc ctccggcgcc cccgtcccgc ccctgcccgg cctggccccg cccctgcccg
     4621 gccccgcccc ccaacgtgtc ttcaggtctc tttccctcca gccggccctt aggacggctg
     4681 ttggacgtgc tcgtgagtcc ttcgcctgtc tgccttccac ctctctgcag ctccttctcc
     4741 aatctcatgg tcttcttgag cttggccgcc ctccacgccc catgctgggc ttggtcggtt
     4801 ctggggtcta cctctctggc ttcatccctc ccacagtttc gagggtttcc ctgtgctcag
     4861 gcccctggca gccgccccct gtgcagacca ctgggcagat ccagctgacc tccaggggca
     4921 cttcctcggc tcatcactgg gccggtgctc tgcagaatga gctgtgagag ccactgtggc
     4981 tggccagagg gtgccactca cagtcacttc agactcacag gagccttcgt cccgacccct
     5041 gcattcatct gtgttctgtt ttatgttttt tcccagtcac ctgagctgca ggccttggtc
     5101 accccagact cctccctcct gtcaccctta tcctcacccc agcaccttta cgtctgcccc
     5161 aggctccatt tccccctctt ctgcctggat caaaccaccc tgactttcct gggtcttcgt
     5221 gcaacagcct gctccggccg ctgcctcact gcacctgcaa atccacttgc acccacaccc
     5281 aggccagggt ttttaaacag aagcctcagc agatccctct ctctggccag ctccctgttg
     5341 aaccaggaag caggtccctg ttgaacctca gcatgacccg cccccacccc tgcatcccac
     5401 ttctgctctg ggagcctctg ggttcctggg cgcacctgct gcccttccct gtttgtcact
     5461 gggtgacctc ccgtccttgt gggcgctccc gggccctggt ctcgggcctt ctgaggactt
     5521 gctctcctgg tagcggctgc tgactgtgag cccagagagc aggcgtggct gttgacctta
     5581 ggtcctccca gaacctggcg gatcgcctgg ctcccaggca ggaggcgctg catgacgcct
     5641 ccaacttccg ccaatctagc ccaaggatgg cgttctaaat aaaacgcgtt ctacagaaaa
//
