LOCUS       NM_005456               3050 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 8 interacting protein
            1 (MAPK8IP1), mRNA.
ACCESSION   NM_005456
VERSION     NM_005456.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Marino Perez,L., Ielasi,F.S., Lee,A., Delaforge,E., Juyoux,P.,
            Tengo,M., Davis,R.J., Palencia,A. and Jensen,M.R.
  TITLE     Structural basis of homodimerization of the JNK scaffold protein
            JIP2 and its heterodimerization with JIP1
  JOURNAL   Structure 32 (9), 1394-1403 (2024)
   PUBMED   39013462
  REMARK    GeneRIF: Structural basis of homodimerization of the JNK scaffold
            protein JIP2 and its heterodimerization with JIP1.
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   Saeed,R., Mohammed,A.K., Saleh,S.E., Aboulwafa,M.M., Aboshanab,K.M.
            and Taneera,J.
  TITLE     Dual Role of Mitogen-Activated Protein Kinase 8 Interacting
            Protein-1 in Inflammasome and Pancreatic beta-Cell Function
  JOURNAL   Int J Mol Sci 24 (5), 4990 (2023)
   PUBMED   36902422
  REMARK    GeneRIF: Dual Role of Mitogen-Activated Protein Kinase 8
            Interacting Protein-1 in Inflammasome and Pancreatic beta-Cell
            Function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Shi,J., Lu,D., Gu,R., Xu,Y., Pan,R., Bo,F. and Zhang,Y.
  TITLE     Identification of Key Biomarkers and Immune Infiltration in
            Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling
  JOURNAL   World Neurosurg 160, e591-e600 (2022)
   PUBMED   35092815
  REMARK    GeneRIF: Identification of Key Biomarkers and Immune Infiltration
            in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide
            Profiling.
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Cason,S.E., Carman,P.J., Van Duyne,C., Goldsmith,J., Dominguez,R.
            and Holzbaur,E.L.F.
  TITLE     Sequential dynein effectors regulate axonal autophagosome motility
            in a maturation-dependent pathway
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   34014261
  REMARK    GeneRIF: Sequential dynein effectors regulate axonal autophagosome
            motility in a maturation-dependent pathway.
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Yasuda,J., Whitmarsh,A.J., Cavanagh,J., Sharma,M. and Davis,R.J.
  TITLE     The JIP group of mitogen-activated protein kinase scaffold proteins
  JOURNAL   Mol Cell Biol 19 (10), 7245-7254 (1999)
   PUBMED   10490659
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Mooser,V., Maillard,A., Bonny,C., Steinmann,M., Shaw,P.,
            Yarnall,D.P., Burns,D.K., Schorderet,D.F., Nicod,P. and Waeber,G.
  TITLE     Genomic organization, fine-mapping, and expression of the human
            islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting
            protein-1 (JIP-1) gene
  JOURNAL   Genomics 55 (2), 202-208 (1999)
   PUBMED   9933567
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Whitmarsh,A.J., Cavanagh,J., Tournier,C., Yasuda,J. and Davis,R.J.
  TITLE     A mammalian scaffold complex that selectively mediates MAP kinase
            activation
  JOURNAL   Science 281 (5383), 1671-1674 (1998)
   PUBMED   9733513
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Bonny,C., Nicod,P. and Waeber,G.
  TITLE     IB1, a JIP-1-related nuclear protein present in insulin-secreting
            cells
  JOURNAL   J Biol Chem 273 (4), 1843-1846 (1998)
   PUBMED   9442013
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Dickens,M., Rogers,J.S., Cavanagh,J., Raitano,A., Xia,Z.,
            Halpern,J.R., Greenberg,M.E., Sawyers,C.L. and Davis,R.J.
  TITLE     A cytoplasmic inhibitor of the JNK signal transduction pathway
  JOURNAL   Science 277 (5326), 693-696 (1997)
   PUBMED   9235893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC068470.1, AF074091.1 and
            AF007134.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005456.3.
            
            Summary: This gene encodes a regulator of the pancreatic beta-cell
            function. It is highly similar to JIP-1, a mouse protein known to
            be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein
            has been shown to prevent MAPK8 mediated activation of
            transcription factors, and to decrease IL-1 beta and MAP kinase
            kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This
            protein also functions as a DNA-binding transactivator of the
            glucose transporter GLUT2. RE1-silencing transcription factor
            (REST) is reported to repress the expression of this gene in
            insulin-secreting beta cells. This gene is found to be mutated in a
            type 2 diabetes family, and thus is thought to be a susceptibility
            gene for type 2 diabetes. [provided by RefSeq, May 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068470.1, AF074091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241014.6/ ENSP00000241014.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               BC068470.1         1-692
            693-2306            AF074091.1         523-2136
            2307-3050           AF007134.1         738-1481
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..3050
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /note="mitogen-activated protein kinase 8 interacting
                     protein 1"
                     /db_xref="GeneID:9479"
                     /db_xref="HGNC:HGNC:6882"
                     /db_xref="MIM:604641"
     exon            1..271
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2306
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /note="islet-brain 1; JNK-interacting protein 1; PRKM8
                     interacting protein; IB-1; JNK MAP kinase scaffold protein
                     1"
                     /codon_start=1
                     /product="C-Jun-amino-terminal kinase-interacting protein
                     1"
                     /protein_id="NP_005447.1"
                     /db_xref="CCDS:CCDS7916.1"
                     /db_xref="GeneID:9479"
                     /db_xref="HGNC:HGNC:6882"
                     /db_xref="MIM:604641"
                     /translation="MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEF
                     EDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGD
                     TPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKR
                     PTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELP
                     PQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLE
                     ATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEE
                     GFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLE
                     LVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPD
                     EPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELE
                     LEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQ
                     FRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKA
                     DDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKA
                     LAESVGRAFQQFYKQFVEYTCPTEDIYLE"
     exon            272..377
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            378..692
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            693..774
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1587
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1663
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1836
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1946
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2063
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2134
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2233
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..3050
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /note="hexamer: ATTAAA"
     polyA_site      3050
                     /gene="MAPK8IP1"
                     /gene_synonym="IB1; JIP-1; JIP1; PRKM8IP"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcgg gccgtgcgcg gtgctgtgcc gcgccctgcc agacacaggt gcgcccgcct
       61 agcccgaact ccgcggcggc ggctgccctc tcgccgcgcc tccgcctcct tcgcagccgc
      121 cgcctcctcc gcgccgcgct ccgcccggat ggccagggct gtgcccgaga atggcggagc
      181 gagaaagcgg cggcctggga gggggggccg cgtccccgcc cgccgcctcc ccgttcctgg
      241 ggctgcacat cgcttcgcct cccaatttca ggctcaccca tgacatcagc ctggaggagt
      301 ttgaggatga agacctctcg gagatcactg atgagtgtgg catcagctta cagtgcaaag
      361 acaccctgtc cttacggccc ccgcgcgccg ggctgctctc tgcgggcggc ggcggcgcgg
      421 ggagccggtt gcaggccgag atgctgcaga tggacctgat cgacgcgacg ggggacactc
      481 ccggggccga ggacgacgag gaggacgacg acgaggagcg cgcggcccgg cggccgggag
      541 cggggccgcc caaggccgag tccggccagg agccggcgtc ccgcggccag ggccagagcc
      601 aaggccagag ccagggcccg ggcagcgggg acacgtaccg gcccaagcgg cccaccacgc
      661 tcaacctctt tccgcaggtg ccgcggtctc aggacacact gaataataat tctctgggca
      721 aaaagcacag ttggcaggat cgggtgtctc gatcatcctc acccctgaag acaggggagc
      781 agacaccacc gcatgaacac atctgcctga gcgatgagct gcccccccag agcggccccg
      841 cccccaccac agatcgaggc acctccaccg acagcccttg ccgccgcagc acagccaccc
      901 agatggcacc tccgggtggt ccccctgctg ccccgcctgg gggtcggggc cactcgcatc
      961 gagaccgaat ccactaccag gccgatgtgc gactagaggc cactgaggag atctacctga
     1021 ccccagtgca gaggccccca gacgctgcag agcccacctc cgccttcctg ccgcccactg
     1081 agagccggat gtcagtcagc tccgatccag accctgccgc ctacccctcc acggcagggc
     1141 ggccgcaccc ctccatcagt gaagaggaag agggcttcga ctgcctgtcg tccccagagc
     1201 gggctgagcc cccaggcgga gggtggcggg ggagcctggg ggagccgccg ccacctccac
     1261 gggcctctct gagctcggac accagcgccc tgtcctatga ctctgtcaag tacacgctgg
     1321 tggtagatga gcatgcacag ctggagctgg tgagcctgcg gccgtgcttc ggagactaca
     1381 gtgacgagag tgactctgcc accgtctatg acaactgtgc ctccgtctcc tcgccctatg
     1441 agtcggccat cggagaggaa tatgaggagg ccccgcggcc ccagccccct gcctgcctct
     1501 ccgaggactc cacgcctgat gaacccgacg tccatttctc caagaaattc ctgaacgtct
     1561 tcatgagtgg ccgctcccgc tcctccagtg ctgagtcctt cgggctgttc tcctgcatca
     1621 tcaacgggga ggagcaggag cagacccacc gggccatatt caggtttgtg cctcgacacg
     1681 aagacgaact tgagctggaa gtggatgacc ctctgctagt ggagctccag gctgaagact
     1741 actggtacga ggcctacaac atgcgcactg gtgcccgggg tgtctttcct gcctattacg
     1801 ccatcgaggt caccaaggag cccgagcaca tggcagccct ggccaaaaac agtgactggg
     1861 tggaccagtt ccgggtgaag ttcctgggct cagtccaggt tccctatcac aagggcaatg
     1921 acgtcctctg tgctgctatg caaaagattg ccaccacccg ccggctcacc gtgcacttta
     1981 acccgccctc cagctgtgtc ctggagatca gcgtgcgggg tgtgaagata ggcgtcaagg
     2041 ccgatgactc ccaggaggcc aaggggaata aatgtagcca ctttttccag ttaaaaaaca
     2101 tctctttctg cggatatcat ccaaagaaca acaagtactt tgggttcatc accaagcacc
     2161 ccgccgacca ccggtttgcc tgccacgtct ttgtgtctga agactccacc aaagccctgg
     2221 cagagtccgt ggggagagca ttccagcagt tctacaagca gtttgtggag tacacctgcc
     2281 ccacagaaga tatctacctg gagtagctgt gcagccccgc cctctgcgtc ccccagccct
     2341 caggccagtg ccaggacagc tggctgctga caggatgtgg cactgcttga ggaggggcac
     2401 ctgccaccgc cagaggacaa ggaagtgggg gccgctggcc cagggtaggg gagggtgggg
     2461 caatggggag aggcaaatgc agtttattgt aatatatggg attagattca tctatggagg
     2521 gcagagtggg ctgcctgggg attgggaggg acagggcttg gggagcaggt ctctggcaga
     2581 gaaggatgtc cgttccagga gcacacggcc ctgccccatc ctgggcctta cctcccctgc
     2641 cagggctcgg gcgctgtggc tcctgccttg atgaagcccg tgtcctgcct tgatgaagcc
     2701 tgtgccacct gcaagtgccc gccctgcccc tgccccaacc cccaccgaag agccctgagc
     2761 tcaggctgag cccagccacc tcccaaggac tttccagtga ggaaatggca acacgtggag
     2821 gtgaagtccc tgttctcagc tccgtcatct gcggggcttc tgggtggctc ctgccactga
     2881 cctcaccggc atgctggcct gtggcaggcc taggacctca ggcggggagg aggagctgcc
     2941 gcaaggccct gtcccagcag aagagggagg cttcctgact gacacaggcc agccccatct
     3001 tggtcctgtc accctggccc caactattaa agtgccattt cctgtctgga
//
