LOCUS       NM_002749               2902 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 7 (MAPK7), transcript
            variant 3, mRNA.
ACCESSION   NM_002749
VERSION     NM_002749.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Filippelli,A., Ciccone,V., Del Gaudio,C., Simonis,V., Frosini,M.,
            Tusa,I., Menconi,A., Rovida,E. and Donnini,S.
  TITLE     ERK5 mediates pro-tumorigenic phenotype in non-small lung cancer
            cells induced by PGE2
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119810 (2024)
   PUBMED   39128596
  REMARK    GeneRIF: ERK5 mediates pro-tumorigenic phenotype in non-small lung
            cancer cells induced by PGE2.
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Song,C., Zhang,Z., Leng,D., He,Z., Wang,X., Liu,W., Zhang,W.,
            Wu,Q., Zhao,Q. and Chen,G.
  TITLE     ERK5 promotes autocrine expression to sustain mitogenic balance for
            cell fate specification in human pluripotent stem cells
  JOURNAL   Stem Cell Reports 19 (9), 1320-1335 (2024)
   PUBMED   39151429
  REMARK    GeneRIF: ERK5 promotes autocrine expression to sustain mitogenic
            balance for cell fate specification in human pluripotent stem
            cells.
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   You,H., Song,G., Xu,Z., Chen,S., Shen,W., Liu,H., Deng,B., Li,J.
            and Huang,G.
  TITLE     HuR promotes castration-resistant prostate cancer progression by
            altering ERK5 activation via posttranscriptional regulation of
            BCAT1
  JOURNAL   J Transl Med 22 (1), 178 (2024)
   PUBMED   38369471
  REMARK    GeneRIF: HuR promotes castration-resistant prostate cancer
            progression by altering ERK5 activation via posttranscriptional
            regulation of BCAT1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Casillo,S.M., Gatesman,T.A., Chilukuri,A., Varadharajan,S.,
            Johnson,B.J., David Premkumar,D.R., Jane,E.P., Plute,T.J.,
            Koncar,R.F., Stanton,A.J., Biagi-Junior,C.A.O., Barber,C.S.,
            Halbert,M.E., Golbourn,B.J., Halligan,K., Cruz,A.F., Mansi,N.M.,
            Cheney,A., Mullett,S.J., Land,C.V., Perez,J.L., Myers,M.I.,
            Agrawal,N., Michel,J.J., Chang,Y.F., Vaske,O.M., MichaelRaj,A.,
            Lieberman,F.S., Felker,J., Shiva,S., Bertrand,K.C., Amankulor,N.,
            Hadjipanayis,C.G., Abdullah,K.G., Zinn,P.O., Friedlander,R.M.,
            Abel,T.J., Nazarian,J., Venneti,S., Filbin,M.G., Gelhaus,S.L.,
            Mack,S.C., Pollack,I.F. and Agnihotri,S.
  TITLE     An ERK5-PFKFB3 axis regulates glycolysis and represents a
            therapeutic vulnerability in pediatric diffuse midline glioma
  JOURNAL   Cell Rep 43 (1), 113557 (2024)
   PUBMED   38113141
  REMARK    GeneRIF: An ERK5-PFKFB3 axis regulates glycolysis and represents a
            therapeutic vulnerability in pediatric diffuse midline glioma.
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   de Mattos,K., Dumas,F.O., Campolina-Silva,G.H., Belleannee,C.,
            Viger,R.S. and Tremblay,J.J.
  TITLE     ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10
            and MLTC-1 Leydig Cells
  JOURNAL   Endocrinology 164 (9) (2023)
   PUBMED   37539861
  REMARK    GeneRIF: ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription
            in MA-10 and MLTC-1 Leydig Cells.
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Kato,Y., Tapping,R.I., Huang,S., Watson,M.H., Ulevitch,R.J. and
            Lee,J.D.
  TITLE     Bmk1/Erk5 is required for cell proliferation induced by epidermal
            growth factor
  JOURNAL   Nature 395 (6703), 713-716 (1998)
   PUBMED   9790194
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   English,J.M., Pearson,G., Baer,R. and Cobb,M.H.
  TITLE     Identification of substrates and regulators of the
            mitogen-activated protein kinase ERK5 using chimeric protein
            kinases
  JOURNAL   J Biol Chem 273 (7), 3854-3860 (1998)
   PUBMED   9461566
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Purandare,S.M., Lee,J.D. and Patel,P.I.
  TITLE     Assignment of big MAP kinase (PRKM7) to human chromosome 17 band
            p11.2 with somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 258-259 (1998)
   PUBMED   10072598
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Lee,J.D., Ulevitch,R.J. and Han,J.
  TITLE     Primary structure of BMK1: a new mammalian map kinase
  JOURNAL   Biochem Biophys Res Commun 213 (2), 715-724 (1995)
   PUBMED   7646528
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Zhou,G., Bao,Z.Q. and Dixon,J.E.
  TITLE     Components of a new human protein kinase signal transduction
            pathway
  JOURNAL   J Biol Chem 270 (21), 12665-12669 (1995)
   PUBMED   7759517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA452383.1, BC009963.2 and
            BC030134.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002749.3.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase is specifically activated
            by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is
            involved in the downstream signaling processes of various receptor
            molecules including receptor type kinases, and G protein-coupled
            receptors. In response to extracelluar signals, this kinase
            translocates to cell nucleus, where it regulates gene expression by
            phosphorylating, and activating different transcription factors.
            Four alternatively spliced transcript variants of this gene
            encoding two distinct isoforms have been reported. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) is also known as BMK1 gamma.
            It differs in the 5' UTR, as compared to variant 1. Variants 1, 3
            and 4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009963.2, U25278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395604.8/ ENSP00000378968.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA452383.1         38-68
            32-2897             BC009963.2         1-2866
            2898-2902           BC030134.1         2782-2786
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..2902
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /note="mitogen-activated protein kinase 7"
                     /db_xref="GeneID:5598"
                     /db_xref="HGNC:HGNC:6880"
                     /db_xref="MIM:602521"
     exon            1..133
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            134..370
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2589
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 3;
                     extracellular-signal-regulated kinase 5; BMK1 kinase; big
                     MAP kinase 1; BMK-1; ERK-5; MAPK 7; MAP kinase 7"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 7 isoform 1"
                     /protein_id="NP_002740.2"
                     /db_xref="CCDS:CCDS11206.1"
                     /db_xref="GeneID:5598"
                     /db_xref="HGNC:HGNC:6880"
                     /db_xref="MIM:602521"
                     /translation="MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARS
                     FDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRE
                     LKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVR
                     YFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFM
                     TEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM
                     VLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSA
                     RISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR
                     EGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTID
                     LTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPV
                     TAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDR
                     SLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGST
                     SGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPG
                     VLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAG
                     YGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQRE
                     IQMDSPMLLADLPDLQDP"
     exon            371..536
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            537..1615
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2301
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2435
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2902
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /note="hexamer: ATTACA"
     polyA_site      2864
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /note="hexamer: AATACA"
     polyA_site      2902
                     /gene="MAPK7"
                     /gene_synonym="BMK1; ERK4; ERK5; PRKM7"
                     /note="major polyA site"
ORIGIN      
        1 agggcagctc aagacgctga ggtggtggct gcggcctttg aacaagtaag tgagccaccc
       61 tcggagaccc ccgcgctggg gacgggaggc cggcgagcct cgggacctct gaaagccttg
      121 aggaggcgcg gggacaccat ggccgagcct ctgaaggagg aagacggcga ggacggctct
      181 gcggagcccc ccgggcccgt gaaggccgaa cccgcccaca ccgctgcctc tgtagcggcc
      241 aagaacctgg ccctgcttaa agcccgctcc ttcgatgtga cctttgacgt gggcgacgag
      301 tacgagatca tcgagaccat aggcaacggg gcctatggag tggtgtcctc cgcccgccgc
      361 cgcctcaccg gccagcaggt ggccatcaag aagatcccta atgctttcga tgtggtgacc
      421 aatgccaagc ggaccctcag ggagctgaag atcctcaagc actttaaaca cgacaacatc
      481 atcgccatca aggacatcct gaggcccacc gtgccctatg gcgaattcaa atctgtctac
      541 gtggtcctgg acctgatgga aagcgacctg caccagatca tccactcctc acagcccctc
      601 acactggaac acgtgcgcta cttcctgtac caactgctgc ggggcctgaa gtacatgcac
      661 tcggctcagg tcatccaccg tgacctgaag ccctccaacc tattggtgaa tgagaactgt
      721 gagctcaaga ttggtgactt tggtatggct cgtggcctgt gcacctcgcc cgctgaacat
      781 cagtacttca tgactgagta tgtggccacg cgctggtacc gtgcgcccga gctcatgctc
      841 tctttgcatg agtatacaca ggctattgac ctctggtctg tgggctgcat ctttggtgag
      901 atgctggccc ggcgccagct cttcccaggc aaaaactatg tacaccagct acagctcatc
      961 atgatggtgc tgggtacccc atcaccagcc gtgattcagg ctgtgggggc tgagagggtg
     1021 cgggcctata tccagagctt gccaccacgc cagcctgtgc cctgggagac agtgtaccca
     1081 ggtgccgacc gccaggccct atcactgctg ggtcgcatgc tgcgttttga gcccagcgct
     1141 cgcatctcag cagctgctgc ccttcgccac cctttcctgg ccaagtacca tgatcctgat
     1201 gatgagcctg actgtgcccc gccctttgac tttgcctttg accgcgaagc cctcactcgg
     1261 gagcgcatta aggaggccat tgtggctgaa attgaggact tccatgcaag gcgtgagggc
     1321 atccgccaac agatccgctt ccagccttct ctacagcctg tggctagtga gcctggctgt
     1381 ccagatgttg aaatgcccag tccctgggct cccagtgggg actgtgccat ggagtctcca
     1441 ccaccagccc cgccaccatg ccccggccct gcacctgaca ccattgatct gaccctgcag
     1501 ccacctccac cagtcagtga gcctgcccca ccaaagaaag atggtgccat ctcagacaat
     1561 actaaggctg cccttaaagc tgccctgctc aagtctttga ggagccggct cagagatggc
     1621 cccagcgcac ccctggaggc tcctgagcct cggaagccgg tgacagccca ggagcgccag
     1681 cgggagcggg aggagaagcg gcggaggcgg caagaacgag ccaaggagcg ggagaaacgg
     1741 cggcaggagc gggagcgaaa ggaacggggg gctggggcct ctgggggccc ctccactgac
     1801 cccttggctg gactagtgct cagtgacaat gacagaagcc tgttggaacg ctggactcga
     1861 atggcccggc ccgcagcccc agccctcacc tctgtgccgg cccctgcccc agcgccaacg
     1921 ccaaccccaa ccccagtcca acctaccagt cctcctcctg gccctgtagc ccagcccact
     1981 ggcccgcaac cacaatctgc gggctctacc tctggccctg taccccagcc tgcctgccca
     2041 ccccctggcc ctgcacccca ccccactggc cctcctgggc ccatccctgt ccccgcgcca
     2101 ccccagattg ccacctccac cagcctcctg gctgcccagt cacttgtgcc accccctggg
     2161 ctgcctggct ccagcacccc aggagttttg ccttacttcc cacctggcct gccgccccca
     2221 gacgccgggg gagcccctca gtcttccatg tcagagtcac ctgatgtcaa ccttgtgacc
     2281 cagcagctat ctaagtcaca ggtggaggac cccctgcccc ctgtgttctc aggcacacca
     2341 aagggcagtg gggctggcta cggtgttggc tttgacctgg aggaattctt aaaccagtct
     2401 ttcgacatgg gcgtggctga tgggccacag gatggccagg cagattcagc ctctctctca
     2461 gcctccctgc ttgctgactg gctcgaaggc catggcatga accctgccga tattgagtcc
     2521 ctgcagcgtg agatccagat ggactcccca atgctgctgg ctgacctgcc tgacctccag
     2581 gacccctgag gcccccagcc tgtgccttgc tgccacagta gacctagttc caggatccat
     2641 gggagcattc tcaaaggctt tagccctgga cccagcaggt gaggctcggc ttggattatt
     2701 ctgcaggttc atctcagacc cacctttcag ccttaagcag ccacctgagc caccaccgag
     2761 ccatggcagg atcgggagac cccaactccc cctgaacaat ccttttcagt attatatttt
     2821 tattattatt atgttattat tacactgtct ttttgccatc aaaatgaggc ctgtgaaata
     2881 caaggttccc ttctgcacct ga
//
