LOCUS       NM_002748               5330 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 6 (MAPK6), mRNA.
ACCESSION   NM_002748
VERSION     NM_002748.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Bao,Z., Yu,X. and Zhang,L.
  TITLE     The circ_0003928/miR-31-5p/MAPK6 cascade affects high
            glucose-induced inflammatory response, fibrosis and oxidative
            stress in HK-2 cells
  JOURNAL   Transpl Immunol 86, 102078 (2024)
   PUBMED   38964515
  REMARK    GeneRIF: The circ_0003928/miR-31-5p/MAPK6 cascade affects high
            glucose-induced inflammatory response, fibrosis and oxidative
            stress in HK-2 cells.
REFERENCE   2  (bases 1 to 5330)
  AUTHORS   Zhang,W., Liu,T., Li,X., Li,T., Ma,X., Zhao,D. and Zhao,X.
  TITLE     Increased methylation of ZNF671 suppresses tumor progression by
            promoting MAPK6 transcription in laryngeal carcinoma
  JOURNAL   Int J Biol Sci 19 (8), 2443-2457 (2023)
   PUBMED   37215982
  REMARK    GeneRIF: Increased methylation of ZNF671 suppresses tumor
            progression by promoting MAPK6 transcription in laryngeal
            carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5330)
  AUTHORS   Bogucka-Janczi,K., Harms,G., Coissieux,M.M., Bentires-Alj,M.,
            Thiede,B. and Rajalingam,K.
  TITLE     ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin
            polymerization
  JOURNAL   Elife 12, e85167 (2023)
   PUBMED   37057894
  REMARK    GeneRIF: ERK3/MAPK6 dictates CDC42/RAC1 activity and
            ARP2/3-dependent actin polymerization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5330)
  AUTHORS   Pang,Y., Luo,D. and Wang,S.
  TITLE     miR-128-3p inhibits the inflammation by targeting MAPK6 in
            penicillin-induced astrocytes
  JOURNAL   Neuroreport 33 (17), 742-749 (2022)
   PUBMED   36250437
  REMARK    GeneRIF: miR-128-3p inhibits the inflammation by targeting MAPK6 in
            penicillin-induced astrocytes.
REFERENCE   5  (bases 1 to 5330)
  AUTHORS   Zhu,H., Liu,Q., Yang,X., Ding,C., Wang,Q. and Xiong,Y.
  TITLE     LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to
            promote the development of lung squamous cell carcinoma via
            activating MAPK signaling pathway
  JOURNAL   Cancer Gene Ther 29 (8-9), 1285-1295 (2022)
   PUBMED   35228660
  REMARK    GeneRIF: LncRNA LINC00649 recruits TAF15 and enhances MAPK6
            expression to promote the development of lung squamous cell
            carcinoma via activating MAPK signaling pathway.
REFERENCE   6  (bases 1 to 5330)
  AUTHORS   Meloche,S., Beatty,B.G. and Pellerin,J.
  TITLE     Primary structure, expression and chromosomal locus of a human
            homolog of rat ERK3
  JOURNAL   Oncogene 13 (7), 1575-1579 (1996)
   PUBMED   8875998
REFERENCE   7  (bases 1 to 5330)
  AUTHORS   Sauma,S. and Friedman,E.
  TITLE     Increased expression of protein kinase C beta activates ERK3
  JOURNAL   J Biol Chem 271 (19), 11422-11426 (1996)
   PUBMED   8626698
REFERENCE   8  (bases 1 to 5330)
  AUTHORS   Cheng,M., Boulton,T.G. and Cobb,M.H.
  TITLE     ERK3 is a constitutively nuclear protein kinase
  JOURNAL   J Biol Chem 271 (15), 8951-8958 (1996)
   PUBMED   8621539
REFERENCE   9  (bases 1 to 5330)
  AUTHORS   Zhu,A.X., Zhao,Y., Moller,D.E. and Flier,J.S.
  TITLE     Cloning and characterization of p97MAPK, a novel human homolog of
            rat ERK-3
  JOURNAL   Mol Cell Biol 14 (12), 8202-8211 (1994)
   PUBMED   7969157
REFERENCE   10 (bases 1 to 5330)
  AUTHORS   Boulton,T.G., Nye,S.H., Robbins,D.J., Ip,N.Y., Radziejewska,E.,
            Morgenbesser,S.D., DePinho,R.A., Panayotatos,N., Cobb,M.H. and
            Yancopoulos,G.D.
  TITLE     ERKs: a family of protein-serine/threonine kinases that are
            activated and tyrosine phosphorylated in response to insulin and
            NGF
  JOURNAL   Cell 65 (4), 663-675 (1991)
   PUBMED   2032290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA109756.1, BC035492.2,
            L77964.1 and AC023906.7.
            
            On Nov 22, 2018 this sequence version replaced NM_002748.3.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family, and is most closely related to
            mitogen-activated protein kinases (MAP kinases). MAP kinases also
            known as extracellular signal-regulated kinases (ERKs), are
            activated through protein phosphorylation cascades and act as
            integration points for multiple biochemical signals. This kinase is
            localized in the nucleus, and has been reported to be activated in
            fibroblasts upon treatment with serum or phorbol esters. [provided
            by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.178394.1,
                                           SRR1803616.168540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261845.7/ ENSP00000261845.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DA109756.1         6-40
            36-1656             BC035492.2         1-1621
            1657-3288           L77964.1           1693-3324
            3289-4220           AC023906.7         17550-18481
            4221-5330           AC023906.7         18482-19591
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..5330
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="mitogen-activated protein kinase 6"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
     exon            1..158
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     exon            159..1344
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             790..2955
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /EC_number="2.7.11.24"
                     /note="extracellular signal-regulated kinase, p97;
                     extracellular signal-regulated kinase 3; protein kinase,
                     mitogen-activated 6; protein kinase, mitogen-activated 5;
                     ERK-3; MAPK 6; p97-MAPK; MAP kinase 6"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 6"
                     /protein_id="NP_002739.1"
                     /db_xref="CCDS:CCDS10147.1"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
                     /translation="MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDK
                     RVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELN
                     SVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI
                     NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAA
                     GCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHK
                     PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHI
                     EDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEE
                     EVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRS
                     SSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALE
                     EASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLI
                     SKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENT
                     YTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQF
                     HSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN"
     exon            1345..1489
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1654
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1856
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..5330
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4079..4084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="hexamer: AATAAA"
     polyA_site      4099
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="major polyA site"
     regulatory      4197..4202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="hexamer: AATAAA"
     polyA_site      4220
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="major polyA site"
     regulatory      4369..4374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="hexamer: AATAAA"
     polyA_site      4393
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
     regulatory      5307..5312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /note="hexamer: AATAAA"
     polyA_site      5330
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
ORIGIN      
        1 cttcctcgcc ctctctcgcg ggtcggggtt acatggcggc gactgcggca aagcgagagc
       61 ctcggagacg ccgctgccgc cagcacagcc ggagacctga gccgacactg ggggcagtcc
      121 gcgagccccg cactctctcg atgagtcgga gaagtcccgt tgtatcagag taagatggac
      181 ggtagctttg attgtgattg tggtgagctg gagccacctg atcactaaca aaagacatct
      241 tctgttaacc aacagccgcc agggcttcct gttgaaataa atatatagca acaaaggaaa
      301 aaaagaagca aaacggaaat agtgcttacc agcaccttag aatgatgctg ctcaggacca
      361 gtccaacact gaatgtatct gcactgtgag gagaatgttc atagaagcct gttgtgtgca
      421 tatttattca catttttgtt aaatgttaaa tcgtttagca cggtaatctg agtgcacagt
      481 atgtcatttc attccgtttg agtttcttgt tttcgttaaa tgtctgcaga gttgctgccc
      541 ctttcttgaa ctatgagtac tgcaatcttt ttaattctca atatgaatag agctttttga
      601 gctttaaatc taaggggaac tcgacaggcc tgtttggcat atgcaatgaa catcaagaaa
      661 ccatcttgct gtggaagcat aattattttt cttctccctt tttgaaagat ctttcctttt
      721 gatgccagtt ttcttccttg tttacacaag ttcaatttga aaggaaaagg caatagtaag
      781 ggtttcaaaa tggcagagaa atttgaaagt ctcatgaaca ttcatggttt tgatctgggt
      841 tctaggtata tggacttaaa accattgggt tgtggaggca atggcttggt tttttctgct
      901 gtagacaatg actgtgacaa aagagtagcc atcaagaaaa ttgtccttac tgatccccag
      961 agtgtcaaac atgctctacg tgaaatcaaa attattagaa gacttgacca tgataacatt
     1021 gtgaaagtgt ttgagattct tggtcccagt ggaagccaat taacagacga tgtgggctct
     1081 cttacggaac tgaacagtgt ttacattgtt caggagtaca tggagacaga cttggctaat
     1141 gtgctggagc agggcccttt actggaagag catgccaggc ttttcatgta tcagctgcta
     1201 cgggggctca agtatattca ctctgcaaat gtactgcaca gagatctcaa accagctaat
     1261 cttttcatta atacggaaga cttggtgctg aagataggtg actttggtct tgcacggatc
     1321 atggatcctc attattccca taagggtcat ctttctgaag gattggttac taaatggtac
     1381 agatctccac gtcttttact ttctcctaat aattatacta aagccattga catgtgggct
     1441 gcaggctgca tctttgctga aatgctgact ggtaaaaccc tttttgcagg tgcacatgaa
     1501 cttgaacaga tgcagctgat tttagaatct attcctgttg tacatgagga agatcgtcag
     1561 gagcttctca gcgtaattcc agtttacatt agaaatgaca tgactgagcc acacaaacct
     1621 ttaactcagc tgcttccagg aattagtcga gaagcactgg atttcctgga acaaattttg
     1681 acatttagcc ccatggatcg gttaacagca gaagaagcac tctcccatcc ttacatgagc
     1741 atatattctt ttccaatgga tgagccaatt tcaagccatc cttttcatat tgaagatgaa
     1801 gttgatgata ttttgcttat ggatgaaact cacagtcaca tttataactg ggaaaggtat
     1861 catgattgtc agttttcaga gcatgattgg cctgtacata acaactttga tattgatgaa
     1921 gttcagcttg atccaagagc tctgtccgat gtcactgatg aagaagaagt acaagttgat
     1981 ccccgaaaat atttggatgg agatcgggaa aagtatctgg aggatcctgc ttttgatacc
     2041 aattactcta ctgagccttg ttggcaatac tcagatcatc atgaaaacaa atattgtgat
     2101 ctggagtgta gccatacttg taactacaaa acgaggtcat catcatattt agataactta
     2161 gtttggagag agagtgaagt taaccattac tatgaaccca agcttattat agatctttcc
     2221 aattggaaag aacaaagcaa agaaaaatct gataagaaag gcaaatcaaa atgtgaaagg
     2281 aatggattgg ttaaagccca gatagcgcta gaggaagcat cacagcaact ggctggaaaa
     2341 gaaagggaaa agaatcaggg atttgatttt gattccttta ttgcaggaac tattcagctt
     2401 agttcccagc atgagcctac tgatgttgtt gataaattaa atgacttgaa tagctcagtg
     2461 tcccaactag aattgaaaag tttgatatca aagtcagtaa gccaagaaaa acaggaaaaa
     2521 ggaatggcaa atctggctca attagaagcc ttgtaccagt cttcttggga cagccagttt
     2581 gtgagtggtg gggaggactg ttttttcata aatcagtttt gtgaggtaag gaaggatgaa
     2641 caagttgaga aggaaaacac ttacactagt tacttggaca agttctttag caggaaagaa
     2701 gatactgaaa tgctagaaac tgagccagta gaggatggga agcttgggga gagaggacat
     2761 gaggaaggat ttctgaacaa cagtggggag ttcctcttta acaagcagct cgagtccata
     2821 ggcatcccac agtttcacag tccagttggg tcaccactta agtcaataca ggccacatta
     2881 acaccttctg ctatgaaatc ttcccctcaa attcctcatc aaacatacag cagcattctg
     2941 aaacatctga actaaaacac tcagcagaca tttatctttg tattcttcat gaaatgtgtt
     3001 ttgtcttttt ttattactag tgtttaagtc attttttact tgaatcagat ggtgtcattt
     3061 agtaaggatt ttatgagttc ttgtttttta aaatccagac tttctttttc tacatgtgag
     3121 atagttttca ttttaactgg catgtcattt gcacacaaaa ataaagacta gagcaaaata
     3181 atgcaacgca ggaggagaaa agaaatgcac taagacaaga acattctctc atagaacatt
     3241 gatctgtttt acaggaaaca aaccttgcct tgaaatttac acagtgagac tgtacataat
     3301 tgcatgaaaa tagctatttt tttcctaaga catttttcat tcatgaatat tttcaagttt
     3361 ttcatactgt acacatttct taaaacacat gataccagca gcaactgaaa atgaatgccg
     3421 aatttggtac acatgtgtta tctacctcaa ggtaacaaga gtatgtggca aaacatatac
     3481 cacccatagt gcttcacaaa atgcacttct atttagccag cgtttattgt agtaaactat
     3541 tcttaataaa actcactcac tgtttataaa tgttctggta tgcattcttt atagtgaagt
     3601 gttaatacat cacatcttat ttattttagc aaatcagtat attttctgta tttaattata
     3661 aaaaattaac ttagttttta aaatttattt gcaaatatac tttacttttt ccatttggca
     3721 ctatggtttg ttgcctacct agctgcatct ataatgtcag cttatcctaa ggctgtccac
     3781 gtacttaatt tacttaagtg ttcattttaa gtaacgtgct cactgtgtat aggaatttgt
     3841 attttggagg tgcttgatct atctacaaag aaaaattaat taggaattac tttattataa
     3901 aatgctccta gaagtcttaa ttgtgtttat tttttaaaaa aacaaatgtt agacttgtgt
     3961 gcatggaagt aattaaggta catcattatt gtagtttgaa agttgtacat gataagacat
     4021 tttgttttta ctgtatgttt ttactgaatg atctattccc catcccaagg caagcatgaa
     4081 taaaattagg ttaaacgtag catgtggcat cgcagtctct tagaatttgt ttcatctatt
     4141 ttattttatt gaatactgtc tgtatctttg gttatcctgt ttgaagaaaa aggacaaata
     4201 aaacatggcc agcaaataca gctcctgttt cactcttggg ttaatgaaaa ttttctgcta
     4261 gaatgaaaat tactaccaga atcactttga attatggcca taaattgcta gtctgaaagg
     4321 ctgagaaggt tcaagtcttt tgacttaaac catcacatat tagaatggaa taaagcttta
     4381 taatatttca aaactgttag gtaaaatgtg tagttgaaac tttgaactgt gcagtcagaa
     4441 aacttgagat ttgctctgta atacatcttt gcgtaagaac ttaccctttt acctatccag
     4501 ctacaaaacc atcctcttca cctcactttt ctttcatcct tgttttgtac aacaccaatt
     4561 ctattaatat ctgcccacct accttctcaa caactccatc ctcttcacct cacttttctt
     4621 tcatccttgt tttgtacaac accaattcta ttaatatctg cccacctacc ttctcaacaa
     4681 ctgacttcat ctggattcac aaagccatat atatacacgt gtgtgtgtgt gtgtgtgtgt
     4741 gtgtgtgtat atatattcat ttatttattt tctggttgaa tactgtcacg ttattaattt
     4801 aaacatactc aaattacctt aagaggacaa gctctgaagt gcagtcatga gaattgattt
     4861 gtggggaaaa aaaaaatggg acacttttag ttggagctgg gtggggtgac aagtgcagag
     4921 gctttgagtg tcatgagagc atcagacagg atgtaaagga agcaacgggc agcagacatt
     4981 ggtccctgat cctccattat aaccaatttt ttgcaaacgt atgttgattt tgagaataat
     5041 tagctttgac tctaaaatgc tgtcttccct gaaggagacc taggattttt cttactggga
     5101 aacttggctc ctggacttaa tccacattcg ttaaactgtc accttggcag tttagtggcc
     5161 atctacacaa tgatctgact tgttggcatt aaaaagtcca aacatagtca tcaaaggaag
     5221 aagaaagtaa aactgaaacc ccttatataa aatatgcttg ctttagggtg acccaggctg
     5281 agtactaagt tgtaaagtca atttccaata aaaattttat gtgccaatta
//
