LOCUS       XM_011526074            5033 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens mitogen-activated protein kinase 4 (MAPK4),
            transcript variant X1, mRNA.
ACCESSION   XM_011526074
VERSION     XM_011526074.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000018.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011526074.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
     gene            1..5033
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /note="mitogen-activated protein kinase 4; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 34 ESTs, 288 long SRA reads, 8 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5596"
                     /db_xref="HGNC:HGNC:6878"
                     /db_xref="MIM:176949"
     CDS             1298..3061
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 4 isoform X1"
                     /protein_id="XP_011524376.1"
                     /db_xref="GeneID:5596"
                     /db_xref="HGNC:HGNC:6878"
                     /db_xref="MIM:176949"
                     /translation="MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACR
                     KVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAY
                     IVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTE
                     DLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
                     LAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRK
                     LLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEI
                     DDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAED
                     VQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHH
                     YSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHAS
                     PPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNG
                     ACIPEHPGDLVQTEAFSKERW"
ORIGIN      
        1 agttcctgtc ctggactccc agtgcctgga agaactgtag agatcttggc tactggcagg
       61 attgcatttg tcaagctaat gtgctgctgc tgttgtcaag gttgcagtat tttctgcatt
      121 gaggactata tcaagtgtat gtccaaggct cccaggcagt gagaatactc cgtctctgtg
      181 tcctgagtgc taatcacggc aaagcaactc aaaaagaagg caggcagctg cctctggggc
      241 tggaggggag tgctacgcac agcaggaggg tggctgggca gtgcaaagcc ccggaatccc
      301 ctgagcaagc agtgtttcag ctggctggac agatcaaata acacttgggc tggttaacaa
      361 aagacgcaag tgggaaggtg ttggaagccg gagtgtggaa atttacccaa cgttatttct
      421 ttgacaggga aggagacttg gtctgaaaga tgccacattc ctgcagcctc tcttggtgca
      481 gtggaataca gtcttgggcg aggtggcgtg gatgagctgg tgaaagagga tgctgcccac
      541 atccaaaggc tccagaggat cctggcctgg cagctgagct cccctgcatt tggaacctca
      601 ggcgtaactt ggtgtagagc tcatgaaagg tgcttgtgtt tctccagctt ttttcaccag
      661 tgcttaccag actggctcag gttttggaat ctaaggtgag ctggtagaaa caggagaggt
      721 agaaagaagc ccctggatgc ctccagaatt cattgatggg atccctgcat actgcttgga
      781 acacagaaag aggctgtgac acagctgagc tttggagcat cttaaggagc tcagctcagc
      841 aaacaactct tgcatttcag ccagaaagag cctcttgtaa caaagtattc aaaggggaga
      901 gtttctgcat cttttacttt gcagtccact atggtagaaa acttgacatt ccatagataa
      961 tgatactggg ttttctttcc aagatgccag ctttaaaaga aatatgagcc attctaagct
     1021 ttaagaaggg ttcaggaaac acaggaatta gtagacagcc ctcccaatgc aggttaagac
     1081 gacagcctgc gcccccaact agcacagctc agcgagcatg accatatgcc attctcgtct
     1141 ccagagagct ggtggcagtg acctcactag gagaaaacac atccctcagc cgtgggactt
     1201 gacagaatga ggtgcgcgag ggaggccgct agccgagact tggcctttcc tgactgcccc
     1261 tgtgttacct gggcagctcc agatcactga gcccacaatg gctgagaagg gtgactgcat
     1321 cgccagtgtc tatgggtatg acctcggtgg gcgctttgtt gacttccaac ccctgggctt
     1381 cggtgtcaat ggtttggtgc tgtcggccgt ggacagccgg gcctgccgga aggtcgctgt
     1441 gaagaagatt gccctgagcg atgcccgcag catgaagcac gcgctccgag agatcaagat
     1501 cattcggcgc ctggaccacg acaacatcgt caaagtgtac gaggtgctcg gtcccaaggg
     1561 cactgacctg cagggtgagc tgttcaagtt cagcgtggcg tacatcgtcc aggagtacat
     1621 ggagaccgac ctggcacgcc tgctggagca gggcacgctg gcagaagagc atgccaagct
     1681 gttcatgtac cagctgctcc gcgggctcaa gtacatccac tccgccaacg tgctgcacag
     1741 ggacctgaag cccgccaaca tcttcatcag cacagaggac ctcgtgctca agattgggga
     1801 tttcgggttg gcaaggatcg ttgatcagca ttactcccac aagggttatc tgtcagaagg
     1861 gttggtaaca aagtggtacc gttccccacg actgctcctt tcccccaata actacaccaa
     1921 agccatcgac atgtgggccg ccggctgcat cctggctgag atgcttacgg ggagaatgct
     1981 ctttgctggg gcccatgagc tggagcagat gcaactcatc ctggagacca tccctgtaat
     2041 ccgggaggaa gacaaggacg agctgctcag ggtgatgcct tcctttgtca gcagcacctg
     2101 ggaggtgaag aggcctctgc gcaagctgct ccctgaagtg aacagtgaag ccatcgactt
     2161 tctggagaag atcctgacct ttaaccccat ggatcgccta acagctgaga tggggctgca
     2221 acacccctac atgagcccat actcgtgccc tgaggacgag cccacctcac aacacccctt
     2281 ccgcattgag gatgagatcg acgacatcgt gctgatggcc gctaaccaga gccagctgtc
     2341 caactgggac acgtgcagtt ccaggtaccc tgtgagcctg tcgtcggacc tggagtggcg
     2401 gcctgaccgg tgccaggacg ccagcgaggt acagcgcgac ccgcgcgcgg gttcggcgcc
     2461 actggctgag gacgtgcagg tggacccgcg caaggactcg cacagcagct ccgagcgctt
     2521 cctagagcag tcgcactcgt ccatggagcg cgccttcgag gccgactacg ggcgctcctg
     2581 cgactacaag gtggggtcgc cgtcctacct ggacaagctg ctgtggcgcg acaacaagcc
     2641 gcaccactac tcggagccca agctcatcct ggacctgtcg cactggaagc aggcggccgg
     2701 cgcgcccccc acggccacgg ggctggcgga cacgggggcg cgcgaggacg agccggccag
     2761 cctcttcctg gagatcgcgc agtgggtcaa gagcacgcag ggcggcccag agcacgccag
     2821 cccgcccgcc gacgaccccg agcgccgctt gtctgcctcg ccccccggcc gcccggcccc
     2881 ggtggacggc ggcgccagcc cccagttcga cctggacgtg ttcatctccc gcgccctgaa
     2941 gctctgcacc aagcccgagg acctgccgga caataaactg ggcgacctca atggtgcgtg
     3001 catccccgag caccctggcg acctcgtgca gaccgaggcc ttctccaaag aaaggtggtg
     3061 agggcggagg ggccgctcca ggccccacag agcaggagac ccccagagaa agccggggct
     3121 ggcaggaggc ggccgccctt cccgcccctc tctgctgcct tggggttggc agaacacgtg
     3181 aaggatccga ggagcgagag gaatgtccat ttcttaaact gccttaataa ctagccttta
     3241 acctgtggga gcgggtttga acaggaccct ggcttagggg ttgatcactt tcctagcaaa
     3301 ggggagacca catgtggtgc acagggaaga aacggcttta gacagcagtc tgcgggcccc
     3361 acctgggtgg caggatgccg agaaatcttg cagaggtagc tccgaaacca tctggcccaa
     3421 ctagcctcaa ctgacagctg aggaaaggca attaggccca gagaggcaga gacactcgct
     3481 taagatcaca ggcttagtgt gaggacgagc ttgaaatccc agtctcctgg cccccaggcc
     3541 agggtctgtc caccatagaa tgtcttcctc tactggggtc gttctggctt tttgttagaa
     3601 acttggtctg agatgtttct tccctgtcca ttaccattcg atgttctttt attcagagca
     3661 atgtttcttg tattctgaaa ctggaaactg aaccagtttg tttctcctag tcaccaagca
     3721 tactttcctg gctccccaag tacttaaatg ttctcatctg tcgcacccct gtatttgcct
     3781 cacccctgca tggtcggaaa tcttcgtttc aggtcagaac agcctggggt ctgtgggtaa
     3841 aatcagccct tctcccaggc ctgtgcacac accccctcag cactccctat gcactttcct
     3901 gacacgcaaa gacacagccc tctttcccca ctgggcgtcc taccccagtg aggttgaagg
     3961 caccaattcc aagaatccct ccaacctccc tgccagcact cccccttcac cccacacccg
     4021 gcccccccac ctaaccacag cgcctctcca gacctacctc gggacctaat gttctctaca
     4081 tgaactgctc atttggagga cagcagtgag gtcctgccat agagcaaatg tgttaggaga
     4141 gaaggtttca catgggaccc aacatccttc atcaatactt tcctgagttt gatcatccat
     4201 ttagccttga caaacagcag accctacaga gatgtgttgg agagcacgtc gtgaccttgg
     4261 gggcaaggaa tccagaaagg taggaagata tgaaaagaga ggtgtcaaca gcaagggctc
     4321 ttaggggtca ggcaccagca tggagacctc atgacaaagg aagggactca aagcagcaat
     4381 gcccctcata gtgtaggcta aggtgagttt ggtgcatgca aacctgtgtg ctcacccaca
     4441 gagcatgggg taatggtgtg tagacacagg ccctctgcag aagcgtgggg tggggacact
     4501 gacagcccct atctggtccc caggaacatt ctaccatttc tgccactggt gttcagctcc
     4561 ttctcttccc ccaacactcc caaagatacc cacaggaagt ccagccagtt tccaggtaga
     4621 ggattccacc agttggtctt gggctgcgtt caccctcaca tcacagcacc ttaaatctaa
     4681 tcagcaaact ataatttgta cgttgaaacc tgcaacacat tagaaactta tatttaaaaa
     4741 cagaattaat cacactgacc aacttttaaa tggaaaatat gtaaatagga agtgtttggg
     4801 ttttgttttt tctttaagaa aaagaaatgt acaccactcc tcatgtgcca ttttgtcctc
     4861 agagggcggc tttacttttt tggtaaagga acaagctgct ggccttgacc aggagttcat
     4921 atataactgt tattacagag gaattgttat aactactaat gtttttaaaa aatttattaa
     4981 acattattaa acttgatcag gtcaggccaa ataaagtttt attggaacac aga
//
