LOCUS       NM_002747               4763 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 4 (MAPK4), transcript
            variant 1, mRNA.
ACCESSION   NM_002747
VERSION     NM_002747.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Fan,Z., Huang,Q., Zhang,Z., Han,L., Fang,X., Yang,K., Huang,G.,
            Zheng,Z., Yawalkar,N., Lin,Y., Wang,Z. and Yan,K.
  TITLE     Genetic Polymorphisms of rs9949644 in MAPK4 Are Associated with
            Clinical Response to Methotrexate in Patients with Psoriasis
  JOURNAL   Dermatology 240 (1), 111-118 (2024)
   PUBMED   37494889
  REMARK    GeneRIF: Genetic Polymorphisms of rs9949644 in MAPK4 Are Associated
            with Clinical Response to Methotrexate in Patients with Psoriasis.
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Zhang,Z., Lan,H. and Zhao,S.
  TITLE     LINC00467 enhanced the proliferative, migratory and invasive
            ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 88-93 (2023)
   PUBMED   38279470
  REMARK    GeneRIF: LINC00467 enhanced the proliferative, migratory and
            invasive ability of breast cancer cells by targeting
            miR-18a/b-5p/MAPK4 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Han,D., Wang,W., Jeon,J.H., Shen,T., Huang,X., Yi,P., Dong,B. and
            Yang,F.
  TITLE     Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer
            growth and resistance to therapy
  JOURNAL   PLoS Biol 21 (8), e3002227 (2023)
   PUBMED   37531320
  REMARK    GeneRIF: Cooperative activation of PDK1 and AKT by MAPK4 enhances
            cancer growth and resistance to therapy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Guan,W., Li,S., Zhang,Z., Xiao,H., He,J., Li,J., He,X., Luo,J.,
            Liu,Y., Lei,L., Ma,J., Chen,L. and Chen,C.
  TITLE     Promotor methylation status of MAPK4 is a novel epigenetic
            biomarker for prognosis of recurrence in patients with thymic
            epithelial tumors
  JOURNAL   Thorac Cancer 13 (20), 2844-2853 (2022)
   PUBMED   36073321
  REMARK    GeneRIF: Promotor methylation status of MAPK4 is a novel epigenetic
            biomarker for prognosis of recurrence in patients with thymic
            epithelial tumors.
REFERENCE   6  (bases 1 to 4763)
  AUTHORS   Davis,R.J.
  TITLE     Transcriptional regulation by MAP kinases
  JOURNAL   Mol Reprod Dev 42 (4), 459-467 (1995)
   PUBMED   8607977
  REMARK    Review article
REFERENCE   7  (bases 1 to 4763)
  AUTHORS   Seger,R. and Krebs,E.G.
  TITLE     The MAPK signaling cascade
  JOURNAL   FASEB J 9 (9), 726-735 (1995)
   PUBMED   7601337
  REMARK    Review article
REFERENCE   8  (bases 1 to 4763)
  AUTHORS   Zhu,A.X., Zhao,Y., Moller,D.E. and Flier,J.S.
  TITLE     Cloning and characterization of p97MAPK, a novel human homolog of
            rat ERK-3
  JOURNAL   Mol Cell Biol 14 (12), 8202-8211 (1994)
   PUBMED   7969157
REFERENCE   9  (bases 1 to 4763)
  AUTHORS   Li,L., Wysk,M., Gonzalez,F.A. and Davis,R.J.
  TITLE     Genomic loci of human mitogen-activated protein kinases
  JOURNAL   Oncogene 9 (2), 647-649 (1994)
   PUBMED   8290275
REFERENCE   10 (bases 1 to 4763)
  AUTHORS   Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
  TITLE     Heterogeneous expression of four MAP kinase isoforms in human
            tissues
  JOURNAL   FEBS Lett 304 (2-3), 170-178 (1992)
   PUBMED   1319925
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090638.11, BC050299.1,
            X59727.1, BC040493.1 and AI088913.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002747.3.
            
            Summary: Mitogen-activated protein kinase 4 is a member of the
            mitogen-activated protein kinase family. Tyrosine kinase growth
            factor receptors activate mitogen-activated protein kinases which
            then translocate into the nucleus and phosphorylate nuclear
            targets. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050299.1, AK295058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400384.7/ ENSP00000383234.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC090638.11        165724-165750
            28-969              BC050299.1         1-942
            970-2094            X59727.1           480-1604
            2095-4545           BC040493.1         1664-4114
            4546-4763           AI088913.1         1-218               c
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1-q21.2"
     gene            1..4763
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /note="mitogen-activated protein kinase 4"
                     /db_xref="GeneID:5596"
                     /db_xref="HGNC:HGNC:6878"
                     /db_xref="MIM:176949"
     exon            1..157
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     exon            158..1573
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1028..2791
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Erk3-related; extracellular signal-regulated kinase 4;
                     MAPK 4"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 4 isoform 1"
                     /protein_id="NP_002738.2"
                     /db_xref="CCDS:CCDS42437.1"
                     /db_xref="GeneID:5596"
                     /db_xref="HGNC:HGNC:6878"
                     /db_xref="MIM:176949"
                     /translation="MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACR
                     KVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAY
                     IVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTE
                     DLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCI
                     LAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRK
                     LLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEI
                     DDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAED
                     VQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHH
                     YSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHAS
                     PPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNG
                     ACIPEHPGDLVQTEAFSKERW"
     exon            1574..1718
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1880
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2094
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..4763
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4740..4745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /note="hexamer: AATAAA"
     polyA_site      4763
                     /gene="MAPK4"
                     /gene_synonym="ERK-4; ERK4; p63-MAPK; p63MAPK; PRKM4"
                     /note="major polyA site"
ORIGIN      
        1 ggagcccgag ctggagcagc gagccgggct gtcggggcga ccgcgggagc tcgccgtgcg
       61 ccgtggctgg gaccggcctg gccgagcgcg ccggcgccgc ggccgcagac aaagggcggc
      121 tcgcgcccgg gccgccacgc tctcgggctc tgcctcggga aggagacttg gtctgaaaga
      181 tgccacattc ctgcagcctc tcttggtgca gtggaataca gtcttgggcg aggtggcgtg
      241 gatgagctgg tgaaagagga tgctgcccac atccaaaggc tccagaggat cctggcctgg
      301 cagctgagct cccctgcatt tggaacctca ggcgtaactt ggtgtagagc tcatgaaagg
      361 tgcttgtgtt tctccagctt ttttcaccag tgcttaccag actggctcag gttttggaat
      421 ctaaggtgag ctggtagaaa caggagaggt agaaagaagc ccctggatgc ctccagaatt
      481 cattgatggg atccctgcat actgcttgga acacagaaag aggctgtgac acagctgagc
      541 tttggagcat cttaaggagc tcagctcagc aaacaactct tgcatttcag ccagaaagag
      601 cctcttgtaa caaagtattc aaaggggaga gtttctgcat cttttacttt gcagtccact
      661 atggtagaaa acttgacatt ccatagataa tgatactggg ttttctttcc aagatgccag
      721 ctttaaaaga aatatgagcc attctaagct ttaagaaggg ttcaggaaac acaggaatta
      781 gtagacagcc ctcccaatgc aggttaagac gacagcctgc gcccccaact agcacagctc
      841 agcgagcatg accatatgcc attctcgtct ccagagagct ggtggcagtg acctcactag
      901 gagaaaacac atccctcagc cgtgggactt gacagaatga ggtgcgcgag ggaggccgct
      961 agccgagact tggcctttcc tgactgcccc tgtgttacct gggcagctcc agatcactga
     1021 gcccacaatg gctgagaagg gtgactgcat cgccagtgtc tatgggtatg acctcggtgg
     1081 gcgctttgtt gacttccaac ccctgggctt cggtgtcaat ggtttggtgc tgtcggccgt
     1141 ggacagccgg gcctgccgga aggtcgctgt gaagaagatt gccctgagcg atgcccgcag
     1201 catgaagcac gcgctccgag agatcaagat cattcggcgc ctggaccacg acaacatcgt
     1261 caaagtgtac gaggtgctcg gtcccaaggg cactgacctg cagggtgagc tgttcaagtt
     1321 cagcgtggcg tacatcgtcc aggagtacat ggagaccgac ctggcacgcc tgctggagca
     1381 gggcacgctg gcagaagagc atgccaagct gttcatgtac cagctgctcc gcgggctcaa
     1441 gtacatccac tccgccaacg tgctgcacag ggacctgaag cccgccaaca tcttcatcag
     1501 cacagaggac ctcgtgctca agattgggga tttcgggttg gcaaggatcg ttgatcagca
     1561 ttactcccac aagggttatc tgtcagaagg gttggtaaca aagtggtacc gttccccacg
     1621 actgctcctt tcccccaata actacaccaa agccatcgac atgtgggccg ccggctgcat
     1681 cctggctgag atgcttacgg ggagaatgct ctttgctggg gcccatgagc tggagcagat
     1741 gcaactcatc ctggagacca tccctgtaat ccgggaggaa gacaaggacg agctgctcag
     1801 ggtgatgcct tcctttgtca gcagcacctg ggaggtgaag aggcctctgc gcaagctgct
     1861 ccctgaagtg aacagtgaag ccatcgactt tctggagaag atcctgacct ttaaccccat
     1921 ggatcgccta acagctgaga tggggctgca acacccctac atgagcccat actcgtgccc
     1981 tgaggacgag cccacctcac aacacccctt ccgcattgag gatgagatcg acgacatcgt
     2041 gctgatggcc gctaaccaga gccagctgtc caactgggac acgtgcagtt ccaggtaccc
     2101 tgtgagcctg tcgtcggacc tggagtggcg gcctgaccgg tgccaggacg ccagcgaggt
     2161 acagcgcgac ccgcgcgcgg gttcggcgcc actggctgag gacgtgcagg tggacccgcg
     2221 caaggactcg cacagcagct ccgagcgctt cctagagcag tcgcactcgt ccatggagcg
     2281 cgccttcgag gccgactacg ggcgctcctg cgactacaag gtggggtcgc cgtcctacct
     2341 ggacaagctg ctgtggcgcg acaacaagcc gcaccactac tcggagccca agctcatcct
     2401 ggacctgtcg cactggaagc aggcggccgg cgcgcccccc acggccacgg ggctggcgga
     2461 cacgggggcg cgcgaggacg agccggccag cctcttcctg gagatcgcgc agtgggtcaa
     2521 gagcacgcag ggcggcccag agcacgccag cccgcccgcc gacgaccccg agcgccgctt
     2581 gtctgcctcg ccccccggcc gcccggcccc ggtggacggc ggcgccagcc cccagttcga
     2641 cctggacgtg ttcatctccc gcgccctgaa gctctgcacc aagcccgagg acctgccgga
     2701 caataaactg ggcgacctca atggtgcgtg catccccgag caccctggcg acctcgtgca
     2761 gaccgaggcc ttctccaaag aaaggtggtg agggcggagg ggccgctcca ggccccacag
     2821 agcaggagac ccccagagaa agccggggct ggcaggaggc ggccgccctt cccgcccctc
     2881 tctgctgcct tggggttggc agaacacgtg aaggatccga ggagcgagag gaatgtccat
     2941 ttcttaaact gccttaataa ctagccttta acctgtggga gcgggtttga acaggaccct
     3001 ggcttagggg ttgatcactt tcctagcaaa ggggagacca catgtggtgc acagggaaga
     3061 aacggcttta gacagcagtc tgcgggcccc acctgggtgg caggatgccg agaaatcttg
     3121 cagaggtagc tccgaaacca tctggcccaa ctagcctcaa ctgacagctg aggaaaggca
     3181 attaggccca gagaggcaga gacactcgct taagatcaca ggcttagtgt gaggacgagc
     3241 ttgaaatccc agtctcctgg cccccaggcc agggtctgtc caccatagaa tgtcttcctc
     3301 tactggggtc gttctggctt tttgttagaa acttggtctg agatgtttct tccctgtcca
     3361 ttaccattcg atgttctttt attcagagca atgtttcttg tattctgaaa ctggaaactg
     3421 aaccagtttg tttctcctag tcaccaagca tactttcctg gctccccaag tacttaaatg
     3481 ttctcatctg tcgcacccct gtatttgcct cacccctgca tggtcggaaa tcttcgtttc
     3541 aggtcagaac agcctggggt ctgtgggtaa aatcagccct tctcccaggc ctgtgcacac
     3601 accccctcag cactccctat gcactttcct gacacgcaaa gacacagccc tctttcccca
     3661 ctgggcgtcc taccccagtg aggttgaagg caccaattcc aagaatccct ccaacctccc
     3721 tgccagcact cccccttcac cccacacccg gcccccccac ctaaccacag cgcctctcca
     3781 gacctacctc gggacctaat gttctctaca tgaactgctc atttggagga cagcagtgag
     3841 gtcctgccat agagcaaatg tgttaggaga gaaggtttca catgggaccc aacatccttc
     3901 atcaatactt tcctgagttt gatcatccat ttagccttga caaacagcag accctacaga
     3961 gatgtgttgg agagcacgtc gtgaccttgg gggcaaggaa tccagaaagg taggaagata
     4021 tgaaaagaga ggtgtcaaca gcaagggctc ttaggggtca ggcaccagca tggagacctc
     4081 atgacaaagg aagggactca aagcagcaat gcccctcata gtgtaggcta aggtgagttt
     4141 ggtgcatgca aacctgtgtg ctcacccaca gagcatgggg taatggtgtg tagacacagg
     4201 ccctctgcag aagcgtgggg tggggacact gacagcccct atctggtccc caggaacatt
     4261 ctaccatttc tgccactggt gttcagctcc ttctcttccc ccaacactcc caaagatacc
     4321 cacaggaagt ccagccagtt tccaggtaga ggattccacc agttggtctt gggctgcgtt
     4381 caccctcaca tcacagcacc ttaaatctaa tcagcaaact ataatttgta cgttgaaacc
     4441 tgcaacacat tagaaactta tatttaaaaa cagaattaat cacactgacc aacttttaaa
     4501 tggaaaatat gtaaatagga agtgtttggg ttttgttttt tctttaagaa aaagaaatgt
     4561 acaccactcc tcatgtgcca ttttgtcctc agagggcggc tttacttttt tggtaaagga
     4621 acaagctgct ggccttgacc aggagttcat atataactgt tattacagag gaattgttat
     4681 aactactaat gtttttaaaa aatttattaa acattattaa acttgatcag gtcaggccaa
     4741 ataaagtttt attggaacac aga
//
