LOCUS       NM_002746               1787 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript
            variant 1, mRNA.
ACCESSION   NM_002746 XM_055766
VERSION     NM_002746.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1787)
  AUTHORS   Zeng,J., Zhang,L., Huang,L., Yu,X., Han,L., Zheng,Y., Wang,T.,
            Zhang,N. and Yang,M.
  TITLE     MAZ promotes thyroid cancer progression by driving transcriptional
            reprogram and enhancing ERK1/2 activation
  JOURNAL   Cancer Lett 602, 217201 (2024)
   PUBMED   39197582
  REMARK    GeneRIF: MAZ promotes thyroid cancer progression by driving
            transcriptional reprogram and enhancing ERK1/2 activation.
REFERENCE   2  (bases 1 to 1787)
  AUTHORS   Daneshmandi,S., Yan,Q., Choi,J.E., Katsuta,E., MacDonald,C.R.,
            Goruganthu,M., Roberts,N., Repasky,E.A., Singh,P.K., Attwood,K.,
            Wang,J., Landesman,Y., McCarthy,P.L. and Mohammadpour,H.
  TITLE     Exportin 1 governs the immunosuppressive functions of
            myeloid-derived suppressor cells in tumors through ERK1/2 nuclear
            export
  JOURNAL   Cell Mol Immunol 21 (8), 873-891 (2024)
   PUBMED   38902348
  REMARK    GeneRIF: Exportin 1 governs the immunosuppressive functions of
            myeloid-derived suppressor cells in tumors through ERK1/2 nuclear
            export.
REFERENCE   3  (bases 1 to 1787)
  AUTHORS   Hou,H.X., Pang,L., Zhao,L. and Xing,J.
  TITLE     Ferroptosis-related gene MAPK3 is associated with the neurological
            outcome after cardiac arrest
  JOURNAL   PLoS One 19 (6), e0301647 (2024)
   PUBMED   38885209
  REMARK    GeneRIF: Ferroptosis-related gene MAPK3 is associated with the
            neurological outcome after cardiac arrest.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1787)
  AUTHORS   Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P.,
            Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H.
  TITLE     Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance
            via the PAK1-ERK1/2 axis in hepatocellular carcinoma
  JOURNAL   Int J Biol Sci 20 (9), 3269-3284 (2024)
   PUBMED   38993552
  REMARK    GeneRIF: Deubiquitination of CIB1 by USP14 promotes lenvatinib
            resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1787)
  AUTHORS   He,Y., Zhang,X., Pan,W., Zhang,J., Zhu,W., Zhang,J. and Shi,J.
  TITLE     Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell
            Proliferation and Chemoresistance via Phosphorylating ERK1
  JOURNAL   Int J Biol Sci 20 (7), 2403-2421 (2024)
   PUBMED   38725848
  REMARK    GeneRIF: Ciliogenesis-associated Kinase 1 Promotes Breast Cancer
            Cell Proliferation and Chemoresistance via Phosphorylating ERK1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1787)
  AUTHORS   Guan,K.L. and Butch,E.
  TITLE     Isolation and characterization of a novel dual specific
            phosphatase, HVH2, which selectively dephosphorylates the
            mitogen-activated protein kinase
  JOURNAL   J Biol Chem 270 (13), 7197-7203 (1995)
   PUBMED   7535768
REFERENCE   7  (bases 1 to 1787)
  AUTHORS   Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
  TITLE     Heterogeneous expression of four MAP kinase isoforms in human
            tissues
  JOURNAL   FEBS Lett 304 (2-3), 170-178 (1992)
   PUBMED   1319925
REFERENCE   8  (bases 1 to 1787)
  AUTHORS   Haycock,J.W., Ahn,N.G., Cobb,M.H. and Krebs,E.G.
  TITLE     ERK1 and ERK2, two microtubule-associated protein 2 kinases,
            mediate the phosphorylation of tyrosine hydroxylase at serine-31 in
            situ
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2365-2369 (1992)
   PUBMED   1347949
REFERENCE   9  (bases 1 to 1787)
  AUTHORS   Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
  TITLE     Extracellular signal-regulated kinases in T cells: characterization
            of human ERK1 and ERK2 cDNAs
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1416-1422 (1992)
   PUBMED   1540184
REFERENCE   10 (bases 1 to 1787)
  AUTHORS   Pulverer,B.J., Kyriakis,J.M., Avruch,J., Nikolakaki,E. and
            Woodgett,J.R.
  TITLE     Phosphorylation of c-jun mediated by MAP kinases
  JOURNAL   Nature 353 (6345), 670-674 (1991)
   PUBMED   1922387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC013992.1 and AC012645.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002746.2.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases, also known as extracellular
            signal-regulated kinases (ERKs), act in a signaling cascade that
            regulates various cellular processes such as proliferation,
            differentiation, and cell cycle progression in response to a
            variety of extracellular signals. This kinase is activated by
            upstream kinases, resulting in its translocation to the nucleus
            where it phosphorylates nuclear targets. Alternatively spliced
            transcript variants encoding different protein isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the most common
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013992.1, M84490.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263025.9/ ENSP00000263025.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1372              BC013992.1         1-1372
            1373-1744           AC012645.7         51515-51886         c
            1745-1787           BC013992.1         1745-1787
FEATURES             Location/Qualifiers
     source          1..1787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1787
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /note="mitogen-activated protein kinase 3"
                     /db_xref="GeneID:5595"
                     /db_xref="HGNC:HGNC:6877"
                     /db_xref="MIM:601795"
     exon            1..181
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1151
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     extracellular signal-regulated kinase 1; extracellular
                     signal-related kinase 1; MAPK 1; insulin-stimulated MAP2
                     kinase; microtubule-associated protein 2 kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 3 isoform 1"
                     /protein_id="NP_002737.2"
                     /db_xref="CCDS:CCDS10672.1"
                     /db_xref="GeneID:5595"
                     /db_xref="HGNC:HGNC:6877"
                     /db_xref="MIM:601795"
                     /translation="MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQ
                     LQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIG
                     IRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA
                     NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLN
                     SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK
                     ARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY
                     DPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP"
     exon            182..364
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..554
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..671
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..786
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..918
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1028
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1183
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1787
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /note="hexamer: AATATA"
     polyA_site      1787
                     /gene="MAPK3"
                     /gene_synonym="ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A;
                     p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3"
                     /note="major polyA site"
ORIGIN      
        1 gaggagtgga gatggcggcg gcggcggctc aggggggcgg gggcggggag ccccgtagaa
       61 ccgagggggt cggcccgggg gtcccggggg aggtggagat ggtgaagggg cagccgttcg
      121 acgtgggccc gcgctacacg cagttgcagt acatcggcga gggcgcgtac ggcatggtca
      181 gctcggccta tgaccacgtg cgcaagactc gcgtggccat caagaagatc agccccttcg
      241 aacatcagac ctactgccag cgcacgctcc gggagatcca gatcctgctg cgcttccgcc
      301 atgagaatgt catcggcatc cgagacattc tgcgggcgtc caccctggaa gccatgagag
      361 atgtctacat tgtgcaggac ctgatggaga ctgacctgta caagttgctg aaaagccagc
      421 agctgagcaa tgaccatatc tgctacttcc tctaccagat cctgcggggc ctcaagtaca
      481 tccactccgc caacgtgctc caccgagatc taaagccctc caacctgctc atcaacacca
      541 cctgcgacct taagatttgt gatttcggcc tggcccggat tgccgatcct gagcatgacc
      601 acaccggctt cctgacggag tatgtggcta cgcgctggta ccgggcccca gagatcatgc
      661 tgaactccaa gggctatacc aagtccatcg acatctggtc tgtgggctgc attctggctg
      721 agatgctctc taaccggccc atcttccctg gcaagcacta cctggatcag ctcaaccaca
      781 ttctgggcat cctgggctcc ccatcccagg aggacctgaa ttgtatcatc aacatgaagg
      841 cccgaaacta cctacagtct ctgccctcca agaccaaggt ggcttgggcc aagcttttcc
      901 ccaagtcaga ctccaaagcc cttgacctgc tggaccggat gttaaccttt aaccccaata
      961 aacggatcac agtggaggaa gcgctggctc acccctacct ggagcagtac tatgacccga
     1021 cggatgagcc agtggccgag gagcccttca ccttcgccat ggagctggat gacctaccta
     1081 aggagcggct gaaggagctc atcttccagg agacagcacg cttccagccc ggagtgctgg
     1141 aggcccccta gcccagacag acatctctgc accctggggc ctggacctgc ctcctgcctg
     1201 cccctctccc gccagactgt tagaaaatgg acactgtgcc cagcccggac cttggcagcc
     1261 caggccgggg tggagcatgg gcctggccac ctctctcctt tgctgaggcc tccagcttca
     1321 ggcaggccaa ggccttctcc tccccacccg ccctccccac ggggcctcgg gacctcaggt
     1381 ggccccagtt caatctcccg ctgctgctgc tgcgccctta ccttccccag cgtcccagtc
     1441 tctggcagtt ctggaatgga agggttctgg ctgccccaac ctgctgaagg gcagaggtgg
     1501 agggtggggg gcgctgagta gggactcagg gccatgcctg cccccctcat ctcattcaaa
     1561 ccccacccta gtttccctga aggaacattc cttagtctca agggctagca tccctgagga
     1621 gccaggccgg gccgaatccc ctccctgtca aagctgtcac ttcgcgtgcc ctcgctgctt
     1681 ctgtgtgtgg tgagcagaag tggagctggg gggcgtggag agcccggcgc ccctgccacc
     1741 tccctgaccc gtctaatata taaatataga gatgtgtcta tggctga
//
