LOCUS       NM_144578               6466 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase 1 interacting protein
            1 like (MAPK1IP1L), mRNA.
ACCESSION   NM_144578
VERSION     NM_144578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6466)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 6466)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6466)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6466)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 6466)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6466)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 6466)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   8  (bases 1 to 6466)
  AUTHORS   Lefebvre,C., Terret,M.E., Djiane,A., Rassinier,P., Maro,B. and
            Verlhac,M.H.
  TITLE     Meiotic spindle stability depends on MAPK-interacting and
            spindle-stabilizing protein (MISS), a new MAPK substrate
  JOURNAL   J Cell Biol 157 (4), 603-613 (2002)
   PUBMED   12011110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139316.5.
            
            On Nov 22, 2018 this sequence version replaced NM_144578.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.250266.1,
                                           SRR1803613.25651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395468.9/ ENSP00000378851.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL139316.5         174563-174719       c
            158-179             AL139316.5         164665-164686       c
            180-887             AL139316.5         163041-163748       c
            888-6466            AL139316.5         156172-161750       c
FEATURES             Location/Qualifiers
     source          1..6466
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..6466
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="mitogen-activated protein kinase 1 interacting
                     protein 1 like"
                     /db_xref="GeneID:93487"
                     /db_xref="HGNC:HGNC:19840"
                     /db_xref="MIM:617226"
     exon            1..157
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /inference="alignment:Splign:2.1.0"
     exon            158..179
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..899
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="MAPK-interacting and spindle-stabilizing protein"
                     /codon_start=1
                     /product="MAPK-interacting and spindle-stabilizing
                     protein-like"
                     /protein_id="NP_653179.1"
                     /db_xref="CCDS:CCDS32085.1"
                     /db_xref="GeneID:93487"
                     /db_xref="HGNC:HGNC:19840"
                     /db_xref="MIM:617226"
                     /translation="MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSNPWNNPS
                     APSSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPY
                     PAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQ
                     YPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLY
                     PTPSNPFQVPSGPSGAPPMPGGPHSYH"
     exon            180..887
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /inference="alignment:Splign:2.1.0"
     exon            888..6466
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: AATAAA"
     polyA_site      2198
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="major polyA site"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: ATTAAA"
     polyA_site      2488
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="major polyA site"
     regulatory      5749..5754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: GATAAA"
     regulatory      5772..5777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: ATTATA"
     polyA_site      5775
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
     polyA_site      5821
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
     regulatory      6203..6208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: ATTAAA"
     polyA_site      6230
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
     regulatory      6445..6450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /note="hexamer: AATAAG"
     polyA_site      6466
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
ORIGIN      
        1 gcttcctgtt ccggcgccag gaggagccgc gcgctgctgg tgctgttgcc gccgctgctc
       61 tagctgccgt cagtcaggct gcgcccgcgt cttcagggcc cagtccctcg gacccatcgc
      121 cgcttctaga ccctactgcg gtctcggata ttgccgggaa aatgtctgat gaattttcgt
      181 tggcagatgc actacctgaa cactcccctg ccaaaacctc tgctgtgagc aatacaaaac
      241 ctggccaacc tcctcaaggc tggccaggct ccaacccttg gaataatccg agtgctccat
      301 cttcagtgcc atctggactc ccaccaagtg caacaccctc cactgtgcct tttggaccag
      361 caccaacagg aatgtatccc tccgtgcctc ccaccggacc acctccagga cccccagcac
      421 cctttcctcc ttccggacca tcatgtcccc cacctggtgg tccttatcca gccccaactg
      481 tgccgggccc tggccccaca gggccatatc ctacaccaaa tatgcccttt ccagagctac
      541 ccagaccata tggtgcaccc acagatccag ctgcagctgg tcctttaggt ccatggggat
      601 ccatgtcttc tggaccttgg gcgccaggaa tgggagggca gtatcctacc cctaatatgc
      661 catatccatc tccaggccca tatcccgctc ctcctcctcc ccaagcccct ggggcagcac
      721 cacctgttcc atggggcacc gttccaccag gagcctgggg accaccagca ccatatcctg
      781 cccctacagg atcgtatccc acaccaggac tctatcctac tcccagtaat cctttccaag
      841 tgccttcagg accttctggt gctccaccaa tgcctggtgg cccccattct taccattaag
      901 ttaacaatgg acgaagagat gacgctttgc tttttgaagt acatgtatat gcacatgaat
      961 gcatatataa aaattgctgg tttcactatt agagggcatt catgaaagaa caactcttgc
     1021 acctctcaga gaagataact gcctcttgta cttggatgcg tagtacatca tatgtataca
     1081 atcagataaa agcatagaag taaatcattc ggatgtgatt tttatttggt tttcatggaa
     1141 agttaaagtg ataaagtata ttgaatagtt ctttgacaga atttgtttaa actatgaaac
     1201 tacacactta aaaatctaag atgtggatta ttgttagaat ctgcaacttc attggcaaat
     1261 tatttcaagt atttttctat aatcactttc cccttctaaa taaataaact tcgagaataa
     1321 cccatcataa tccaaacaaa tgatgcctca acattttgag ctgctctgtc ggacaaataa
     1381 acctggtcct cttgaggtta tattttggat atacattttt aaactgtcag taattattgt
     1441 cagatgtgga gttcaatagc cagccagtgt tcatttttat ccttgagctt ttagtaaaaa
     1501 cttcctggtt ttatttttag tcattgggtc atacagcact aaagtctgct atttatggaa
     1561 actaactttt ttgtttttaa tccaggccaa catgtatgta aattaaattt ttagataatt
     1621 gattatctct ttgtactact tgagatttga ttatgagatg tgcatattgc tttgggaaga
     1681 gctcgaggaa ggaaataatt ctctcctttg ttttgaacct caaactagat aaaccctagg
     1741 aattgcttaa ctgcaacaag taattttcat tcccacaaaa acctgaggca gctcttttgc
     1801 ccagagcgtt ccctgtagcc acccccaccc cacttgccct tggttcttta gaaggagcac
     1861 acacatccct tgattcctcc ctgatgtggt aaactggcac actccagggg tctaaaacat
     1921 aaaacagttg tgtttaggga accttaagtc atgcagacat gactgttctc tttgtacaag
     1981 tgtgaatcaa aatatgtatc tctttttcag agtctggtta agctatgtca ttgtctactg
     2041 catagtttcc tgagtctgtt tgtaaagtgc ttatggctaa cagttcagtt ctgtatttgt
     2101 tgacaggtaa ataagtggag ttgagtgcca tctttgaaaa aattaccctc tagctctaac
     2161 actgaaaata ataataaatt gtagatctct gcaactaagt ttaaagcagt gtgactgtgt
     2221 tgcttaaata tcaagtattg tttataacca ccaaaaaaaa aaagccctgg tagttttttg
     2281 gcaccttatg tttaaatcag attcttagat ttggagtaga cctgaccttg ttatttatta
     2341 gataacattt tgaatgtatc cattggattt ctaaaatgta ttgtgaattt ctcagacaaa
     2401 caggatttat gctggagctc tgttttgctt agaaataaaa tatttagtag tttatttctg
     2461 ctctaattaa aatgtcaaga atgccaaatg ctgccagttt tttggtttga tagctacctc
     2521 cttctaagaa agcaaaatgg ttacctttga gaggaacatt cagtgtttaa tcatccctta
     2581 tgttaactag atgatagatt caagctttta gaaatgagaa agtagaaact aatttgttaa
     2641 gatattttca gactgcggaa tgttgttagc tttttctttc acttctcttc aaggacaggt
     2701 gttagctgtc tacaatactg ttgaactctg ttgtcaaagt agccccctta gtctacaagg
     2761 caggtagcct tggcttgaat tatcaatatc aaaatgtcag ttaaccatgg agggataaag
     2821 taatgtgaaa agtgagatgg ctgcaaagat agctctcctt acagttattt tggctgtcct
     2881 acattgggat aagctgacaa attagcagta tttagtttaa cactggagca aatataattt
     2941 gagtaggaag aagagatagc aggtttggga atctataatt atgaagtcca ttgattttgg
     3001 gagaaaatct gttgctaaag gatttgaagg gccatgaaca caatttggga ttattactcc
     3061 ctataagtat aataattttg ctagtgaccc atactgtcca gtgtgcccta aatcatactg
     3121 ctattgtact ccctttgttt tcaaggactt tgcaactggt atttggggga gatttttttt
     3181 tttttttgag acggagtctc gctctgtcgc ccatgctgga gtgcagtggt gctatcttgg
     3241 ttcactgcaa gctccatctc ccaggttcac accattctcc tgcctcagcc tcccaagcag
     3301 ctgggactac aggtgcccgc caccatgccc ggctaatttt tttttttttt tttttttagt
     3361 agagatgggg tttcactgtg ttagccagga tggtctcgat ctcctgacct cgtgatctgc
     3421 ccgccttggc ttcccaaagt gctgggatta caggcgtgag ccaccacgtc cggccgattt
     3481 tttttttttt ttttaatgta agaatggaga taaaagggat aatataattt gcttttatat
     3541 tgttattttt gtaaagcatc ttttcttcaa ttcttgttgg cattctgggc caaaatattt
     3601 caggttggtt cggtgtggag ttaagaaaag caggcgtttt agtggagaaa tggggaacag
     3661 catcaagaaa ggcttttttc cttttttctt ttttttttgg agacagagtc ttgccctgtc
     3721 acccaggctg gagtgcaatg gcgtgatctt ggctcgctgc aacctctgcc tccaggttca
     3781 aacgattctt ctgcctcagc ctcccaagta gctgggatta caggtgcccg ccaccacacc
     3841 catttttgta tttttagtag agacgggggt ttcaccatgt tggccagggt ggtctgaaac
     3901 tcctgacctc gtgatccgcc tgcctcagcc tcccaaagtg ctgagattac aggcgtgagc
     3961 caccatgcgt gacctttttt tctttttaaa agggaacaat gttgctttca aaacaagaca
     4021 tgctaggctg aaactgattt atggaaaaga ctgcttgtta gcaagtatat ttggtcttga
     4081 gggggataca gattatagaa tatgctgaca tttgggcttc agaggaagaa ttttcaaatc
     4141 taatggaaat agttgaggtg ttcaggaatg ctgtttcttg gagttggaag cttaggtttt
     4201 gaaatgttga aaccaaaaag acaaaaatta aaacatagac cttaggtcgt cattcacacc
     4261 cggttctcaa gaatcaagtg gagcacttca aagaccttgg cttgtctgtc ccatcctgcc
     4321 actttctcat cttttcatgc ttttgaagac accatttaca gctctgactc agccctattt
     4381 tgtgtaaagt aatatattga ttattcagaa atagacaata cattttttaa ttacccaagg
     4441 actgactgtt ttgtgcattt tactgttggt tgtcttcagt agagaatagt aatagggcag
     4501 agaaaagtat atattttgcc tcagtcagtc ccaccaccac aatggactat tgggatattt
     4561 tctaaaaaac caatcaattt gcccatgatt acctcacaaa taattagtgc tacctggggt
     4621 actctcaaat atacagcttt tgaaactgta gatgaaaaaa gctctactca gagtttttgt
     4681 caagactgtg cctgggttga atatcagtca attgcctaca cttctaaaca ataagtgcca
     4741 atgtctcaat tttctcaccc tgaatgatag aagctagctt tatcaaatgc caaggttaga
     4801 aagcctggaa ataaaactta agcacagaca ttcaagtttt tgaaaagcat aagcctaaat
     4861 tcagataaat cacactgata tattgtacta tgcatagaaa gttgtaggtg gcgttcaggg
     4921 aagactttga ttttaataaa gcaatattta gtattgaaga caaacacttt ttattttcag
     4981 atttctgcca agtaaaacag aaattgccaa taaaataatc agtattttgt aaatggcagg
     5041 caagcttctg gctgtcgaaa acatctgagt catttattca gtagacaata tgtccttgat
     5101 ccaggttctt tgccagctat aagggaatcc ctgtccttga gaggctcata gtctataagt
     5161 aacattacag aatttgttag catacccatt cattattagt tttacctaaa cgtgttagga
     5221 tcactactgg tggaaattgt aaccagcctt tgggcatctt aaagggtgac atgtggcatg
     5281 cctttttttt tttttaagaa tttaatgttt ttcaagattg tagtgttgat cagcgcaaca
     5341 attcaagtgt gcaaagtaac aggatagttt gcctcttcac tttacccctg gataaaggca
     5401 ctttcactgc ctgtcactga tcagcagata ctgacttgtt gccattaagt gaacttgact
     5461 tcttatgtgt gctctatgag tttgttgtaa ttttcttctt gaaattgtga tttttcactg
     5521 acagtaatga caaatttaat gtatgtaatt gtctatgcat tttaagttaa actgcctaaa
     5581 atgtgatttg agacatatac atatgtttgt attataaatt gtaagcaatc agtttgagat
     5641 actaggtttt atcacctgct gctgtatttg taaacaaaga caaatgttgc tttaagaagt
     5701 aattataatt aggaataggc tatggatgtg atacttggta ttttttaaga taaacttgtt
     5761 tgcttttgtg tattatacct ggaaactttt tttaaaaaat gtattttcat ggtttcacag
     5821 atttttcatg ttattttatt ctttaggccc aattctgggc ttctctgagc aagtccagag
     5881 cctaattaac tgtaaatttg ttgtcaaaaa ggaagaaaaa agggcctgag atacctcttt
     5941 gcatgtgacc tgcattcact aaggatatct ggaaaccacc cttcctccgc aaaccctctc
     6001 agcaacatgg tgtccattgt ggtgattttc tcttctttta aggctaggct actcttggta
     6061 accagattat ccgtatatat gataatatga agtcagggaa ctttctctgt ctgtccctac
     6121 tcccctcact cccccacttt ctgttatgaa agatagttct acttttatca ttaactgcta
     6181 cgcatttagt gagggtcaca ttattaaact tggagtttac cattttccca caggagattt
     6241 cgctggcatt ccttggaact cccaatttca gtagggcaat gaatgaatga atactttgca
     6301 gtgctacttt tggaaggaat ttctgctttt tgccttatga ttggacaaaa tgcagctgta
     6361 aaattttaaa ttgtttttga tatgttattc aatatcccat gaaagtattc acctaaagtg
     6421 gagttatgaa atggatggtg aaataataag accattctgg agcagg
//
