LOCUS       NM_139021               1871 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 15 (MAPK15), mRNA.
ACCESSION   NM_139021
VERSION     NM_139021.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Franci,L., Vallini,G., Bertolino,F.M., Cicaloni,V., Inzalaco,G.,
            Cicogni,M., Tinti,L., Calabrese,L., Barone,V., Salvini,L.,
            Rubegni,P., Galvagni,F. and Chiariello,M.
  TITLE     MAPK15 controls cellular responses to oxidative stress by
            regulating NRF2 activity and expression of its downstream target
            genes
  JOURNAL   Redox Biol 72, 103131 (2024)
   PUBMED   38555711
  REMARK    GeneRIF: MAPK15 controls cellular responses to oxidative stress by
            regulating NRF2 activity and expression of its downstream target
            genes.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Zhong,Q.H., Lau,A.T.Y. and Xu,Y.M.
  TITLE     Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker
            and Potential Therapeutic Target for Ovarian Cancer
  JOURNAL   Int J Mol Sci 25 (1), 109 (2023)
   PUBMED   38203280
  REMARK    GeneRIF: Mitogen-Activated Protein Kinase 15 Is a New Predictive
            Biomarker and Potential Therapeutic Target for Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Franci,L., Tubita,A., Bertolino,F.M., Palma,A., Cannino,G.,
            Settembre,C., Rasola,A., Rovida,E. and Chiariello,M.
  TITLE     MAPK15 protects from oxidative stress-dependent cellular senescence
            by inducing the mitophagic process
  JOURNAL   Aging Cell 21 (7), e13620 (2022)
   PUBMED   35642724
  REMARK    GeneRIF: MAPK15 protects from oxidative stress-dependent cellular
            senescence by inducing the mitophagic process.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Zhang,M., Fang,L., Zhou,L., Molino,A., Valentino,M.R., Yang,S.,
            Zhang,J., Li,Y. and Roth,M.
  TITLE     MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell
            in chronic obstructive pulmonary disease
  JOURNAL   Free Radic Biol Med 172, 541-549 (2021)
   PUBMED   34224814
  REMARK    GeneRIF: MAPK15-ULK1 signaling regulates mitophagy of airway
            epithelial cell in chronic obstructive pulmonary disease.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Klevernic,I.V., Martin,N.M. and Cohen,P.
  TITLE     Regulation of the activity and expression of ERK8 by DNA damage
  JOURNAL   FEBS Lett 583 (4), 680-684 (2009)
   PUBMED   19166846
  REMARK    GeneRIF: Regulation of the activity and expression of DERK8 by DNA
            damage are reported.
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Saelzler,M.P., Spackman,C.C., Liu,Y., Martinez,L.C., Harris,J.P.
            and Abe,M.K.
  TITLE     ERK8 down-regulates transactivation of the glucocorticoid receptor
            through Hic-5
  JOURNAL   J Biol Chem 281 (24), 16821-16832 (2006)
   PUBMED   16624805
  REMARK    GeneRIF: human ERK8 has a role as a negative regulator of human
            GRalpha, acting through Hic-5
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Iavarone,C., Acunzo,M., Carlomagno,F., Catania,A., Melillo,R.M.,
            Carlomagno,S.M., Santoro,M. and Chiariello,M.
  TITLE     Activation of the Erk8 mitogen-activated protein (MAP) kinase by
            RET/PTC3, a constitutively active form of the RET proto-oncogene
  JOURNAL   J Biol Chem 281 (15), 10567-10576 (2006)
   PUBMED   16484222
  REMARK    GeneRIF: Erk8 has a role as a novel effector of RET/PTC3 and,
            therefore, RET biological functions
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Klevernic,I.V., Stafford,M.J., Morrice,N., Peggie,M., Morton,S. and
            Cohen,P.
  TITLE     Characterization of the reversible phosphorylation and activation
            of ERK8
  JOURNAL   Biochem J 394 (Pt 1), 365-373 (2006)
   PUBMED   16336213
  REMARK    GeneRIF: The activity of ERK8 in transfected HEK-293 cells depends
            on the relative rates of ERK8 autophosphorylation and
            dephosphorylation by one or more members of the PPP family of
            protein serine/threonine phosphatases.
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Abe,M.K., Saelzler,M.P., Espinosa,R. 3rd, Kahle,K.T.,
            Hershenson,M.B., Le Beau,M.M. and Rosner,M.R.
  TITLE     ERK8, a new member of the mitogen-activated protein kinase family
  JOURNAL   J Biol Chem 277 (19), 16733-16743 (2002)
   PUBMED   11875070
  REMARK    GeneRIF: ERK8, a new member of the mitogen-activated protein kinase
            family.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP357805.1 and AY065978.1.
            
            On Nov 22, 2018 this sequence version replaced NM_139021.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY065978.1, DRR138523.526105.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338033.9/ ENSP00000337691.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               BP357805.1         13-582
            571-1871            AY065978.1         575-1875
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1871
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /note="mitogen-activated protein kinase 15"
                     /db_xref="GeneID:225689"
                     /db_xref="HGNC:HGNC:24667"
                     /db_xref="MIM:618616"
     exon            1..95
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1664
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /EC_number="2.7.11.24"
                     /note="extracellular regulated kinase 8 delta; ERK-7;
                     ERK-8; MAPK 15; MAP kinase 15; extracellular
                     signal-regulated kinase 7; extracellular signal-regulated
                     kinase 8"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 15"
                     /protein_id="NP_620590.2"
                     /db_xref="CCDS:CCDS6409.2"
                     /db_xref="GeneID:225689"
                     /db_xref="HGNC:HGNC:24667"
                     /db_xref="MIM:618616"
                     /translation="MCTVVDPRIVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKI
                     FDAFRDKTDAQRTFREITLLQEFGDHPNIISLLDVIRAENDRDIYLVFEFMDTDLNAV
                     IRKGGLLQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLAR
                     SLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLF
                     PGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRPRQTLDALLPPDTSPE
                     ALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAHEGVQLSVPE
                     YRSRVYQMILECGGSSGTSREKGPEGVSPSQAHLHKPRADPQLPSRTPVQGPRPRPQS
                     SPGHDPAEHESPRAAKNVPRQNSAPLLQTALLGNGERPPGAKEAPPLTLSLVKPSGRG
                     AAPSLTSQAAAQVANQALIRGDWNRGGGVRVASVQQVPPRLPPEARPGRRMFSTSALQ
                     GAQGGARALLGGYSQAYGTVCHSALGHLPLLEGHHV"
     exon            96..194
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            195..224
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            225..315
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            316..446
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            447..610
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            611..750
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            751..808
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            809..946
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1052
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1233
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1358
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1487
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1871
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1849..1854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /note="hexamer: AATAAA"
     polyA_site      1871
                     /gene="MAPK15"
                     /gene_synonym="ERK7; ERK8"
                     /note="major polyA site"
ORIGIN      
        1 agtaaggccc cgcgggcgtc ctggccgcca tgtgcaccgt agtggaccct cgcattgtcc
       61 ggagatacct actcaggcgg cagctcgggc agggggccta tggcattgtg tggaaggcag
      121 tggaccggag gactggtgag gtcgtggcca tcaagaaaat ctttgatgct tttagggata
      181 agacagatgc ccagagaaca ttccgggaaa tcacgctcct ccaggagttt ggggaccatc
      241 ccaacatcat cagcctcctt gacgtgatcc gggcagagaa cgacagggac atttacctgg
      301 tgtttgagtt tatggacact gacctgaacg cagtcatccg gaagggcggc ctgctgcagg
      361 acgtccacgt gcgctccatc ttctaccagc tcctgcgggc cacccggttc ctccactcgg
      421 ggcacgttgt gcaccgggac cagaagccgt ccaatgtgct cctggatgcc aactgcacag
      481 tgaagctgtg tgactttggc ctggcccgct ccctgggcga cctccccgag gggcctgagg
      541 accaggccgt gacagagtac gtggccacac gctggtaccg agcaccggag gtgctgctct
      601 cttcgcaccg atacaccctt ggggtggaca tgtggagtct gggctgtatc ctgggggaga
      661 tgctgcgggg gagacccctg ttccccggca cgtccaccct ccaccagctg gagctgatcc
      721 tggagaccat cccaccgcca tctgaggagg acctcctggc tctcggctca ggctgccgtg
      781 cctctgtgct gcaccagctg gggtcccggc cacgacagac gctggatgcc ctcctaccgc
      841 cagacacctc cccagaggcc ttggacctcc ttaggcgact cctggtgttc gccccggaca
      901 agcggttaag cgcgacccag gcactgcagc acccctacgt gcagaggttc cactgcccca
      961 gcgacgagtg ggcacgagag gcagatgtgc ggccccgggc acacgaaggg gtccagctct
     1021 ctgtgcctga gtaccgcagc cgcgtctatc agatgatcct ggagtgtgga ggcagcagcg
     1081 gcacctcgag agagaagggc ccggagggtg tctccccaag ccaggcacac ctgcacaaac
     1141 ccagagccga ccctcagctg ccttctagga cacctgtgca gggtcccaga cccaggcccc
     1201 agagcagccc aggccatgac cctgccgagc acgagtcccc ccgtgcagcc aagaacgttc
     1261 ccaggcagaa ctccgctccc ctgctccaaa ctgctctcct agggaatggg gaaaggcccc
     1321 ctggggcgaa ggaagcgccc cccttgacac tctcgctggt gaagccaagc gggaggggag
     1381 ctgcgccctc cctgacctcc caggctgcgg ctcaggtggc caaccaggcc ctgatccggg
     1441 gtgactggaa ccggggcggt ggggtgaggg tggccagcgt acaacaggtc cctccccggc
     1501 ttcctccgga ggcccggccc ggccggagga tgttcagcac ctctgccttg cagggtgccc
     1561 aggggggtgc cagggctttg cttggaggct actcccaagc ctacgggact gtctgccact
     1621 cggcactggg ccacctgccc ctgctggagg ggcaccatgt gtgagccgcc ctactccctt
     1681 cacctggccc tctgttcctg ccccagcccc ttccccagac ccctctccag tctcctgcac
     1741 cccttagccc tccctgcttt gcctggcccg ttgaagttcc agggagcttg cccgggtctc
     1801 ctcgggggag cagatgaggg ccctgccccc gccccactga cttcctccaa taaagtcatg
     1861 tctgccccca a
//
