LOCUS       NM_139012               4222 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase 14 (MAPK14),
            transcript variant 2, mRNA.
ACCESSION   NM_139012
VERSION     NM_139012.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4222)
  AUTHORS   Siyang,W., Xia,H. and Pinhu,L.
  TITLE     Potential diagnostic biomarkers and Mapk14 protein expression:
            Autophagy-related genes linking immune infiltration in acute
            respiratory distress syndrome
  JOURNAL   Int J Biol Macromol 279 (Pt 1), 135077 (2024)
   PUBMED   39191344
  REMARK    GeneRIF: Potential diagnostic biomarkers and Mapk14 protein
            expression: Autophagy-related genes linking immune infiltration in
            acute respiratory distress syndrome.
REFERENCE   2  (bases 1 to 4222)
  AUTHORS   Detka,J., Plachtij,N., Strzelec,M., Manik,A. and Salat,K.
  TITLE     p38alpha Mitogen-Activated Protein Kinase-An Emerging Drug Target
            for the Treatment of Alzheimer's Disease
  JOURNAL   Molecules 29 (18), 4354 (2024)
   PUBMED   39339348
  REMARK    GeneRIF: p38alpha Mitogen-Activated Protein Kinase-An Emerging Drug
            Target for the Treatment of Alzheimer's Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4222)
  AUTHORS   Maia,C.M.A., Vasconcelos,P.G.S., Pasetto,S., Godwin,W.C.,
            Silva,J.P.R.E., Tavares,J.F., Pardi,V., Costa,E.M.M.B. and
            Murata,R.M.
  TITLE     Anadenanthera colubrina regulated LPS-induced inflammation by
            suppressing NF-kappaB and p38-MAPK signaling pathways
  JOURNAL   Sci Rep 14 (1), 16028 (2024)
   PUBMED   38992070
  REMARK    GeneRIF: Anadenanthera colubrina regulated LPS-induced inflammation
            by suppressing NF-kappaB and p38-MAPK signaling pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4222)
  AUTHORS   Binlateh,T., Leethanakul,C. and Thammanichanon,P.
  TITLE     Involvement of RAMP1/p38MAPK signaling pathway in osteoblast
            differentiation in response to mechanical stimulation: a
            preliminary study
  JOURNAL   J Orthop Surg Res 19 (1), 330 (2024)
   PUBMED   38825686
  REMARK    GeneRIF: Involvement of RAMP1/p38MAPK signaling pathway in
            osteoblast differentiation in response to mechanical stimulation: a
            preliminary study.
            Erratum:[J Orthop Surg Res. 2024 Jul 9;19(1):399. doi:
            10.1186/s13018-024-04872-z.. PMID: 38982512]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4222)
  AUTHORS   Nikolic,I., Ruiz-Garrido,I., Crespo,M., Romero-Becerra,R.,
            Leiva-Vega,L., Mora,A., Leon,M., Rodriguez,E., Leiva,M.,
            Plata-Gomez,A.B., Alvarez Flores,M.B., Torres,J.L.,
            Hernandez-Cosido,L., Lopez,J.A., Vazquez,J., Efeyan,A., Martin,P.,
            Marcos,M. and Sabio,G.
  TITLE     Lack of p38 activation in T cells increases IL-35 and protects
            against obesity by promoting thermogenesis
  JOURNAL   EMBO Rep 25 (6), 2635-2661 (2024)
   PUBMED   38730210
  REMARK    GeneRIF: Lack of p38 activation in T cells increases IL-35 and
            protects against obesity by promoting thermogenesis.
REFERENCE   6  (bases 1 to 4222)
  AUTHORS   Engel,K., Schultz,H., Martin,F., Kotlyarov,A., Plath,K., Hahn,M.,
            Heinemann,U. and Gaestel,M.
  TITLE     Constitutive activation of mitogen-activated protein
            kinase-activated protein kinase 2 by mutation of phosphorylation
            sites and an A-helix motif
  JOURNAL   J Biol Chem 270 (45), 27213-27221 (1995)
   PUBMED   7592979
REFERENCE   7  (bases 1 to 4222)
  AUTHORS   Zervos,A.S., Faccio,L., Gatto,J.P., Kyriakis,J.M. and Brent,R.
  TITLE     Mxi2, a mitogen-activated protein kinase that recognizes and
            phosphorylates Max protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10531-10534 (1995)
   PUBMED   7479834
REFERENCE   8  (bases 1 to 4222)
  AUTHORS   Raingeaud,J., Gupta,S., Rogers,J.S., Dickens,M., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Pro-inflammatory cytokines and environmental stress cause p38
            mitogen-activated protein kinase activation by dual phosphorylation
            on tyrosine and threonine
  JOURNAL   J Biol Chem 270 (13), 7420-7426 (1995)
   PUBMED   7535770
REFERENCE   9  (bases 1 to 4222)
  AUTHORS   Han,J., Richter,B., Li,Z., Kravchenko,V. and Ulevitch,R.J.
  TITLE     Molecular cloning of human p38 MAP kinase
  JOURNAL   Biochim Biophys Acta 1265 (2-3), 224-227 (1995)
   PUBMED   7696354
REFERENCE   10 (bases 1 to 4222)
  AUTHORS   Zhukov-Verezhnikov,N.N., Anisimov,P.I., Goncharova,N.S.,
            Bochko,G.M. and Karaseva,Z.N.
  TITLE     [Study of the heterogenetic antigens in vaccinal preparations of V.
            cholerae]
  JOURNAL   Biull Eksp Biol Med 82 (8), 961-962 (1976)
   PUBMED   1088347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA438432.1, AF100544.1 and
            Z95152.1.
            
            On Feb 27, 2020 this sequence version replaced NM_139012.2.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as an integration point for multiple
            biochemical signals, and are involved in a wide variety of cellular
            processes such as proliferation, differentiation, transcription
            regulation and development. This kinase is activated by various
            environmental stresses and proinflammatory cytokines. The
            activation requires its phosphorylation by MAP kinase kinases
            (MKKs), or its autophosphorylation triggered by the interaction of
            MAP3K7IP1/TAB1 protein with this kinase. The substrates of this
            kinase include transcription regulator ATF2, MEF2C, and MAX, cell
            cycle regulator CDC25B, and tumor suppressor p53, which suggest the
            roles of this kinase in stress related transcription and cell cycle
            regulation, as well as in genotoxic stress response. Four
            alternatively spliced transcript variants of this gene encoding
            distinct isoforms have been reported. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) contains a different segment
            within the coding region when compared to variant 1. The
            translation frame remains the same, and the resulting isoform 2 has
            an internal segment different from that of isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031574.1, SRR11853564.23333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229794.9/ ENSP00000229794.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               DA438432.1         132-466
            336-1470            AF100544.1         1-1135
            1471-4222           Z95152.1           54990-57741         c
FEATURES             Location/Qualifiers
     source          1..4222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..4222
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /note="mitogen-activated protein kinase 14"
                     /db_xref="GeneID:1432"
                     /db_xref="HGNC:HGNC:6876"
                     /db_xref="MIM:600289"
     exon            1..466
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1433
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /EC_number="2.7.11.24"
                     /note="isoform 2 is encoded by transcript variant 2; MAP
                     kinase Mxi2; p38 mitogen activated protein kinase; p38 MAP
                     kinase; p38alpha Exip; stress-activated protein kinase 2A;
                     MAX-interacting protein 2; cytokine suppressive
                     anti-inflammatory drug binding protein; MAP kinase 14; MAP
                     kinase p38 alpha; CSAID-binding protein; mitogen-activated
                     protein kinase p38 alpha"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 14 isoform 2"
                     /protein_id="NP_620581.1"
                     /db_xref="CCDS:CCDS4816.1"
                     /db_xref="GeneID:1432"
                     /db_xref="HGNC:HGNC:6876"
                     /db_xref="MIM:600289"
                     /translation="MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDT
                     KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDV
                     YLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE
                     DCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT
                     GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIG
                     ANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLI
                     DEWKSLTYDEVISFVPPPLDQEEMES"
     exon            467..596
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            597..655
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            656..767
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            768..797
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            798..845
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            846..960
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1032
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1112
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1191
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1365
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..4222
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /note="hexamer: AATAAA"
     polyA_site      3745
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /note="major polyA site"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
                     /note="hexamer: AATAAA"
     polyA_site      4222
                     /gene="MAPK14"
                     /gene_synonym="CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38;
                     p38ALPHA; PRKM14; PRKM15; RK; SAPK2A"
ORIGIN      
        1 actggagcct tagcgggcgc agcagctgga acgggagtac tgcgacgcag cccggagtcg
       61 gccttgtagg ggcgaaggtg cagggagatc gcggcgggcg cagtcttgag cgccggagcg
      121 cgtccctgcc cttagcgggg cttgccccag tcgcaggggc acatccagcc gctgcggctg
      181 acagcagccg cgcgcgcggg agtctgcggg gtcgcggcag ccgcacctgc gcgggcgacc
      241 agcgcaaggt ccccgcccgg ctgggcgggc agcaagggcc ggggagaggg tgcgggtgca
      301 ggcgggggcc ccacagggcc accttcttgc ccggcggctg ccgctggaaa atgtctcagg
      361 agaggcccac gttctaccgg caggagctga acaagacaat ctgggaggtg cccgagcgtt
      421 accagaacct gtctccagtg ggctctggcg cctatggctc tgtgtgtgct gcttttgaca
      481 caaaaacggg gttacgtgtg gcagtgaaga agctctccag accatttcag tccatcattc
      541 atgcgaaaag aacctacaga gaactgcggt tacttaaaca tatgaaacat gaaaatgtga
      601 ttggtctgtt ggacgttttt acacctgcaa ggtctctgga ggaattcaat gatgtgtatc
      661 tggtgaccca tctcatgggg gcagatctga acaacattgt gaaatgtcag aagcttacag
      721 atgaccatgt tcagttcctt atctaccaaa ttctccgagg tctaaagtat atacattcag
      781 ctgacataat tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa gactgtgagc
      841 tgaagattct ggattttgga ctggctcggc acacagatga tgaaatgaca ggctacgtgg
      901 ccactaggtg gtacagggct cctgagatca tgctgaactg gatgcattac aaccagacag
      961 ttgatatttg gtcagtggga tgcataatgg ccgagctgtt gactggaaga acattgtttc
     1021 ctggtacaga ccatattgat cagttgaagc tcattttaag actcgttgga accccagggg
     1081 ctgagctttt gaagaaaatc tcctcagagt ctgcaagaaa ctatattcag tctttgactc
     1141 agatgccgaa gatgaacttt gcgaatgtat ttattggtgc caatcccctg gctgtcgact
     1201 tgctggagaa gatgcttgta ttggactcag ataagagaat tacagcggcc caagcccttg
     1261 cacatgccta ctttgctcag taccacgatc ctgatgatga accagtggcc gatccttatg
     1321 atcagtcctt tgaaagcagg gacctcctta tagatgagtg gaaaagcctg acctatgatg
     1381 aagtcatcag ctttgtgcca ccaccccttg accaagaaga gatggagtcc tgagcacctg
     1441 gtttctgttc tgttgatccc acttcactgt gaggggaagg ccttttcacg ggaactctcc
     1501 aaatattatt caagtgcctc ttgttgcaga gatttcctcc atggtggaag ggggtgtgcg
     1561 tgcgtgtgcg tgcgtgttag tgtgtgtgca tgtgtgtgtc tgtctttgtg ggagggtaag
     1621 acaatatgaa caaactatga tcacagtgac tttacaggag gttgtggatg ctccagggca
     1681 gcctccacct tgctcttctt tctgagagtt ggctcaggca gacaagagct gctgtccttt
     1741 taggaatatg ttcaatgcaa agtaaaaaaa tatgaattgt ccccaatccc ggtcatgctt
     1801 ttgccacttt ggcttctcct gtgaccccac cttgacggtg gggcgtagac ttgacaacat
     1861 cccacagtgg cacggagaga aggcccatac cttctggttg cttcagacct gacaccgtcc
     1921 ctcagtgata cgtacagcca aaaaggacca actggcttct gtgcactagc ctgtgattaa
     1981 cttgcttagt atggttctca gatcttgaca gtatatttga aactgtaaat atgtttgtgc
     2041 cttaaaagga gagaagaaag tgtagatagt taaaagactg cagctgctga agttctgagc
     2101 cgggcaagtc gagagggctg ttggacagct gcttgtgggc ccggagtaat caggcagcct
     2161 tcataggcgg tcatgtgtgc atgtgagcac atgcgtatat gtgcgtctct ctttctccct
     2221 cacccccagg tgttgccatt tctctgctta cccttcacct ttggtgcaga ggtttcttga
     2281 atatctgccc cagtagtcag aagcaggttc ttgatgtcat gtacttcctg tgtactcttt
     2341 atttctagca gagtgaggat gtgttttgca cgtcttgcta tttgagcatg cacagctgct
     2401 tgtcctgctc tcttcaggag gccctggtgt caggcaggtt tgccagtgaa gacttcttgg
     2461 gtagtttaga tcccatgtca cctcagctga tattatggca agtgatatca cctctcttca
     2521 gcccctagtg ctattctgtg ttgaacacaa ttgatacttc aggtgctttt gatgtgaaaa
     2581 tcatgaaaag aggaacaggt ggatgtatag catttttatt catgccatct gttttcaacc
     2641 aactattttt gaggaattat catgggaaaa gaccagggct tttcccagga atatcccaaa
     2701 cttcggaaac aagttattct cttcactccc aataactaat gctaagaaat gctgaaaatc
     2761 aaagtaaaaa attaaagccc ataaggccag aaactccttt tgctgtcttt ctctaaatat
     2821 gattacttta aaataaaaaa gtaacaaggt gtcttttcca ctcctatgga aaagggtctt
     2881 cttggcagct taacattgac ttcttggttt ggggagaaat aaattttgtt tcagaatttt
     2941 gtatattgta ggaatccttt gagaatgtga ttccttttga tggggagaaa gggcaaatta
     3001 ttttaatatt ttgtattttc aactttataa agataaaata tcctcagggg tggagaagtg
     3061 tcgttttcat aacttgctga atttcaggca ttttgttcta catgaggact catatattta
     3121 agccttttgt gtaataagaa agtataaagt cacttccagt gttggctgtg tgacagaatc
     3181 ttgtatttgg gccaaggtgt ttccatttct caatcagtgc agtgatacat gtactccaga
     3241 gggacagggt ggaccccctg agtcaactgg agcaagaagg aaggaggcag actgatggcg
     3301 attccctctc acccgggact ctcccccttt caaggaaagt gaacctttaa agtaaaggcc
     3361 tcatctcctt tattgcagtt caaatcctca ccatccacag caagatgaat tttatcagcc
     3421 atgtttggtt gtaaatgctc gtgtgatttc ctacagaaat actgctctga atattttgta
     3481 ataaaggtct ttgcacatgt gaccacatac gtgttaggag gctgcatgct ctggaagcct
     3541 ggactctaag ctggagctct tggaagagct cttcggtttc tgagcataat gctcccatct
     3601 cctgatttct ctgaacagaa aacaaaagag agaatgaggg aaattgctat tttatttgta
     3661 ttcatgaact tggctgtaat cagttatgcc gtataggatg tcagacaata ccactggtta
     3721 aaataaagcc tatttttcaa atttagtgag tttctcaagt ttattatatt tttctcttgt
     3781 ttttatttaa tgcacaatat ggcattatat caatatcctt taaactgtga cctggcatac
     3841 ttgtctgaca gatcttaata ctactcctaa catttagaaa atgttgataa agcttcttag
     3901 ttgtacattt tttggtgaag agtatccagg tctttgctgt ggatgggtaa agcaaagagc
     3961 aaatgaacga agtattaagc attggggcct gtcttatcta cactcgagtg taagagtggc
     4021 cgaaatgaca gggctcagca gactgtggcc tgagggccaa atctggccca ccacctgttt
     4081 ggtgtagcct gctaagaatg gcttttacat ttttaaatgg ttgggaaaga aaaaaaaaga
     4141 agtagtagat tttgtagcat gtgatgtaag taatgtaaaa cttaaattcc agtatccata
     4201 aataaagttt tatgagaaca ga
//
