LOCUS       NM_002754               6316 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 13 (MAPK13),
            transcript variant 1, mRNA.
ACCESSION   NM_002754
VERSION     NM_002754.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6316)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6316)
  AUTHORS   Basu,A., Das,A.S., Borah,P.K., Duary,R.K. and Mukhopadhyay,R.
  TITLE     Biochanin A impedes STAT3 activation by upregulating p38delta MAPK
            phosphorylation in IL-6-stimulated macrophages
  JOURNAL   Inflamm Res 69 (11), 1143-1156 (2020)
   PUBMED   32852592
REFERENCE   3  (bases 1 to 6316)
  AUTHORS   Stramucci,L., Pranteda,A., Stravato,A., Amoreo,C.A., Pennetti,A.,
            Diodoro,M.G., Bartolazzi,A., Milella,M. and Bossi,G.
  TITLE     MKK3 sustains cell proliferation and survival through p38DELTA MAPK
            activation in colorectal cancer
  JOURNAL   Cell Death Dis 10 (11), 842 (2019)
   PUBMED   31695024
  REMARK    GeneRIF: MKK3 sustains cell proliferation and survival through
            p38DELTA MAPK activation in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6316)
  AUTHORS   Matesanz,N., Nikolic,I., Leiva,M., Pulgarin-Alfaro,M.,
            Santamans,A.M., Bernardo,E., Mora,A., Herrera-Melle,L.,
            Rodriguez,E., Beiroa,D., Caballero,A., Martin-Garcia,E.,
            Acin-Perez,R., Hernandez-Cosido,L., Leiva-Vega,L., Torres,J.L.,
            Centeno,F., Nebreda,A.R., Enriquez,J.A., Nogueiras,R., Marcos,M.
            and Sabio,G.
  TITLE     p38alpha blocks brown adipose tissue thermogenesis through p38delta
            inhibition
  JOURNAL   PLoS Biol 16 (7), e2004455 (2018)
   PUBMED   29979672
  REMARK    GeneRIF: These observations indicate that p38alpha probably blocks
            brown adipose tissue thermogenesis through p38delta inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6316)
  AUTHORS   New,L., Jiang,Y., Zhao,M., Liu,K., Zhu,W., Flood,L.J., Kato,Y.,
            Parry,G.C. and Han,J.
  TITLE     PRAK, a novel protein kinase regulated by the p38 MAP kinase
  JOURNAL   EMBO J 17 (12), 3372-3384 (1998)
   PUBMED   9628874
REFERENCE   6  (bases 1 to 6316)
  AUTHORS   Jiang,Y., Gram,H., Zhao,M., New,L., Gu,J., Feng,L., Di Padova,F.,
            Ulevitch,R.J. and Han,J.
  TITLE     Characterization of the structure and function of the fourth member
            of p38 group mitogen-activated protein kinases, p38delta
  JOURNAL   J Biol Chem 272 (48), 30122-30128 (1997)
   PUBMED   9374491
REFERENCE   7  (bases 1 to 6316)
  AUTHORS   Wang,X.S., Diener,K., Manthey,C.L., Wang,S., Rosenzweig,B.,
            Bray,J., Delaney,J., Cole,C.N., Chan-Hui,P.Y., Mantlo,N.,
            Lichenstein,H.S., Zukowski,M. and Yao,Z.
  TITLE     Molecular cloning and characterization of a novel p38
            mitogen-activated protein kinase
  JOURNAL   J Biol Chem 272 (38), 23668-23674 (1997)
   PUBMED   9295308
REFERENCE   8  (bases 1 to 6316)
  AUTHORS   Joneson,T. and Bar-Sagi,D.
  TITLE     Ras effectors and their role in mitogenesis and oncogenesis
  JOURNAL   J Mol Med (Berl) 75 (8), 587-593 (1997)
   PUBMED   9297626
  REMARK    Review article
REFERENCE   9  (bases 1 to 6316)
  AUTHORS   Kumar,S., McDonnell,P.C., Gum,R.J., Hand,A.T., Lee,J.C. and
            Young,P.R.
  TITLE     Novel homologues of CSBP/p38 MAP kinase: activation, substrate
            specificity and sensitivity to inhibition by pyridinyl imidazoles
  JOURNAL   Biochem Biophys Res Commun 235 (3), 533-538 (1997)
   PUBMED   9207191
REFERENCE   10 (bases 1 to 6316)
  AUTHORS   Goedert,M., Cuenda,A., Craxton,M., Jakes,R. and Cohen,P.
  TITLE     Activation of the novel stress-activated protein kinase SAPK4 by
            cytokines and cellular stresses is mediated by SKK3 (MKK6);
            comparison of its substrate specificity with that of other SAP
            kinases
  JOURNAL   EMBO J 16 (12), 3563-3571 (1997)
   PUBMED   9218798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR006449.1, DB473379.1,
            U93232.1, AF092535.1, Z95152.1 and DB335275.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002754.4.
            
            Summary: This gene encodes a member of the mitogen-activated
            protein (MAP) kinase family. MAP kinases act as an integration
            point for multiple biochemical signals, and are involved in a wide
            variety of cellular processes such as proliferation,
            differentiation, transcription regulation and development. The
            encoded protein is a p38 MAP kinase and is activated by
            proinflammatory cytokines and cellular stress. Substrates of the
            encoded protein include the transcription factor ATF2 and the
            microtubule dynamics regulator stathmin. Alternatively spliced
            transcript variants have been observed for this gene. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF004709.1, SRR1163655.151777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000211287.9/ ENSP00000211287.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DR006449.1         35-41
            8-63                DB473379.1         1-56
            64-990              U93232.1           1-927
            991-1830            AF092535.1         942-1781
            1831-6176           Z95152.1           21845-26190         c
            6177-6316           DB335275.1         4-143               c
FEATURES             Location/Qualifiers
     source          1..6316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..6316
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /note="mitogen-activated protein kinase 13"
                     /db_xref="GeneID:5603"
                     /db_xref="HGNC:HGNC:6875"
                     /db_xref="MIM:602899"
     exon            1..189
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1168
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /EC_number="2.7.11.24"
                     /note="stress-activated protein kinase 4;
                     mitogen-activated protein kinase p38 delta; MAP kinase 13;
                     MAP kinase p38 delta"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 13"
                     /protein_id="NP_002745.1"
                     /db_xref="CCDS:CCDS4818.1"
                     /db_xref="GeneID:5603"
                     /db_xref="HGNC:HGNC:6875"
                     /db_xref="MIM:602899"
                     /translation="MSLIRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAID
                     KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYD
                     FYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE
                     DCELKILDFGLARHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT
                     GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR
                     ASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDSLEHEKLT
                     VDEWKQHIYKEIVNFSPIARKDSRRRSGMKL"
     exon            190..319
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            320..378
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            379..487
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..517
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            518..565
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            566..680
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..752
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..832
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            833..911
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1088
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..6316
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /note="hexamer: AATAAA"
     polyA_site      1845
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /note="major polyA site"
     regulatory      6294..6299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /note="hexamer: AATAAA"
     polyA_site      6316
                     /gene="MAPK13"
                     /gene_synonym="MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgctgg gagcccgttg ggccgcgaac gcagccgcca cgctggggcc gccgagatcg
       61 ggtgcccggg atgagcctca tccggaaaaa gggcttctac aagcaggacg tcaacaagac
      121 agcctgggag ctgcccaaga cctacgtgtc cccgacgcac gtcggcagcg gggcctatgg
      181 ctccgtgtgc tcggccatcg acaagcggtc aggggagaag gtggccatca agaagctgag
      241 ccgacccttt cagtccgaga tcttcgccaa gcgcgcctac cgggagctgc tgctgctgaa
      301 gcacatgcag catgagaacg tcattgggct cctggatgtc ttcaccccag cctcctccct
      361 gcgcaacttc tatgacttct acctggtgat gcccttcatg cagacggatc tgcagaagat
      421 catggggatg gagttcagtg aggagaagat ccagtacctg gtgtatcaga tgctcaaagg
      481 ccttaagtac atccactctg ctggggtcgt gcacagggac ctgaagccag gcaacctggc
      541 tgtgaatgag gactgtgaac tgaagattct ggattttggg ctggcgcgac atgcagacgc
      601 cgagatgact ggctacgtgg tgacccgctg gtaccgagcc cccgaggtga tcctcagctg
      661 gatgcactac aaccagacag tggacatctg gtctgtgggc tgtatcatgg cagagatgct
      721 gacagggaaa actctgttca aggggaaaga ttacctggac cagctgaccc agatcctgaa
      781 agtgaccggg gtgcctggca cggagtttgt gcagaagctg aacgacaaag cggccaaatc
      841 ctacatccag tccctgccac agacccccag gaaggatttc actcagctgt tcccacgggc
      901 cagcccccag gctgcggacc tgctggagaa gatgctggag ctagacgtgg acaagcgcct
      961 gacggccgcg caggccctca cccatccctt ctttgaaccc ttccgggacc ctgaggaaga
     1021 gacggaggcc cagcagccgt ttgatgattc cttagaacac gagaaactca cagtggatga
     1081 atggaagcag cacatctaca aggagattgt gaacttcagc cccattgccc ggaaggactc
     1141 acggcgccgg agtggcatga agctgtaggg actcatcttg catggcaccg ccggccagac
     1201 actgcccaag gaccagtatt tgtcactacc aaactcagcc cttcttggaa tacagccttt
     1261 caagcagagg acagaagggt ccttctcctt atgtgggaaa tgggcctagt agatgcagaa
     1321 ttcaaagatg tcggttggga gaaactagct ctgatcctaa caggccacgt taaactgccc
     1381 atctggagaa tcgcctgcag gtggggccct ttccttcccg ccagagtggg gctgagtggg
     1441 cgctgagcca ggccgggggc ctatggcagt gatgctgtgt tggtttccta gggatgctct
     1501 aacgaattac cacaaacctg gtggattgaa acagcagaac ttgattccct tacagttctg
     1561 gaggctggaa atctgggatg gaggtgttgg cagggctgtg gtccctttga aggctctggg
     1621 gaagaatcct tccttggctc tttttagctt gtggcggcag tgggcagtcc gtggcattcc
     1681 ccagcttatt gctgcatcac tccagtctct gtctcttctg ttctctcctc ttttaacaac
     1741 agtcattgga tttagggccc accctaatcc tgtgtgatct tatcttgatc cttattaatt
     1801 aaacctgcaa atactctagt tccaaataaa gtcacattct caggttccag gtggacatga
     1861 attccagggg gaaatgattc aactcactac agacagctgg gagggagggg ccccttcctg
     1921 ggccccgtgc tgaggccttg tgctctgtga aggaacccaa tgtgtttggc tgctaaatta
     1981 agggagttgc agagagagct gcagctggtg cgattgcatt caggttattt tgggtgagtg
     2041 ataagcaatc aagatatgaa acaacagcag gctcggagac tgcgagctgc acaggcagaa
     2101 atgggctctt gcctggcttg atggcaaacc gttctgctcc ctttgggaga tggcacagct
     2161 ctccagagct ttgacctgac agtggctaga acctctctgt ttttatctga gaaactttgg
     2221 cagaacaaat ttccatgtgc acaagctgtc gggcacagtg ggtctcaaat ttccttgtgc
     2281 accaggggac ttgttaaaat gcagattcct gggccccacc ccagggcttg tgactcagca
     2341 ggtctgcagt tgagacctta gaatgtgcat ttgaatgagg acctctcgcc ctgacccaag
     2401 cctagtgatt ctgatggata tcagaccata gttcgagaca tttagtggat ttcagtcata
     2461 cttgatttgt tgggaggcct aaatcaaaaa cctataggag gagactgggg ggcttcagat
     2521 ggagtttcac actcatctta caggtgttaa aactgaggct cagaaagctt ttttttgttt
     2581 gtttgtttga gacagggtct ggctctgtca cccgggctgg agttcagtgg cacaattaca
     2641 tcttactgca acctcagcct cctgggctca agccatcctc ccacctcagc ctcctaagta
     2701 gctgggacta caggtctgtg ccacccaggt gcaccaggac tgcaggtggc taattaaaac
     2761 attttttttc ttttttgtat aggcggggtt tctctatgtt gcccaggctg atcttgaact
     2821 tctggactca agtgatcctc ccactttggc ctcccaaagt gctgggatta taggcatgag
     2881 ccaccctgca ggcccagaca gcatttttaa ggccttgaaa ctcttctgta taatactgta
     2941 atggtggata cctattgtgc atttgttacc atctgtagga ctggataaca cagagtgaac
     3001 cctcaagtaa actatggact tcagttaata ataatgtatc agtattggtt cataaattgt
     3061 aacaattgtg ccacactaat gcaagatgtt actcatcaag aaaactgagg agagagaagg
     3121 ggaggaagta ggtgggaacc tctatacttt ctaccaacct aaaactgctc taaaaaataa
     3181 accacaggcc ggtcgcagta gctcacgcct gtaatcccag caccttggga ggctgaggtg
     3241 ggcggatcac ttgaggtcag gagttcaaga ccagcctggc caacatggtg aaaccccatc
     3301 tctaccaaaa atacaaaaat tagctgggct tggtggtgca tgcctgtaat cccaaactac
     3361 tcgggaggct gaggcagaat tgcttgaacc tgggaggtgg aggttgcagt gagctgagat
     3421 cacaccactg cactccagcc tgggtgacag agtgagactc catctcaaaa aaacaaaaaa
     3481 aacaaatacc ctgaggacac agagacattg ggtcagacac ccacagctag gaagtggtgg
     3541 agtcagattg gaacccaagt aggcttgagc actgtaccca gcttggattc aagggttgcc
     3601 cagccttccc tcttcacgcc agtctgagac ccttactgct gactgtgtcc atggtctctg
     3661 ttttctctcc cacagaatgg ccctgctgtc aaggagctgg ggagtccttg actgggactg
     3721 gctagtcttg ccacagccct ggcctcgctg gttactaaaa ctgccccagg ttccctgagt
     3781 ctacatccct ctaagcctcc tgagaattct cactgcccca aggaaaaagt ctagccttcc
     3841 ttcttggcct ggcattcaaa accccttgtg ttctctctaa tctcatcagc tcccactgcc
     3901 tcccctagct agtccttatg tcagtgtggg acaccagtcc tgggatccac cgtaaggttc
     3961 attctgcatt cacaggttaa aggtcttgac aagtcctgca gtaaagagat ccgttcctca
     4021 tttaatccag aacttcccag atgtacttaa ccgcaggacc cattttctcc caacagcatg
     4081 acacacatag ccttttttgc ccagtgcagc ccagtgcaca ggtcccgata ttgcctctcc
     4141 ccaagtaggc ttggccttct tttagtgccc gtgcgtggaa ggccctccat tctcctctcc
     4201 attctccttg gccttcaagg ctctacctta ggcctccctc caggcagctg ttctccatca
     4261 tcccccctgg gctgcaggcc ctctgtgggc agcatttagt gtgtggtttg gcctcccctt
     4321 cccattgccc actgtgagca aatacctgtg cgtgaatgaa taatgagtga aagatgtccc
     4381 aggggcctgt cggtcacttc tttgccccga ccaggccaat gtcatatgga aggtggcaga
     4441 gagcccagca ggaagcagaa gtgggcggcc ctgggctgta cctttgagct gctctcctga
     4501 aaatctctat tatttcagac tcccagaccc caccccccgc ttcatcctct ggtgtcctcc
     4561 taggccatcc ccactccgga attaaacctc agcccctccc acagagtttt ctcaaatctg
     4621 tgaagtttct tcaaaaggcg gtggaggtgc tcagcagtgc aaggtggggg gtggaggggg
     4681 tggggagtag agggagtggg ggttccacgg gtttgggtct tgcccagtgg gcacatggcc
     4741 tgtgtaatag gaaacaagtc cattctcctg ctgtgggggg cagaggagct ggcggggcga
     4801 gggaggggga gatgtgggct caggtattct tggtggatgc gcttcgttct gtggctgatg
     4861 gggtggctta aaagatctta acagagagag atcaggaagc cagactgcaa ggtgggggac
     4921 atttcctaag agcaagtgta ccctccattc cctcttttga ggaacaaaga gtatctttgc
     4981 tggggcctga gtcatccatg aaaacagaca gcagcggtgt cccagggcag ggcttgcctg
     5041 gcgtggattg gggtggtgct gcccccagtg aggggcagca caaggggaga cagaaatgga
     5101 ggaatagccc ccgtaagggc aagcccagtg tgcaccagtg cccagagctg cctgatggag
     5161 gaacagctcc gtaagggtga acccagtgtg cacgggtgcc cggagctgcc tgcgtgaggc
     5221 tgggggctag tttggatgag ggcatggctc aactttcact tggcacattg aaatagcttt
     5281 tgctgtctgc tagggtgtgg aaaactgttt ttccatggcc ccaagcaatg ctatagctac
     5341 agctgaggag ggaggaatct ctccctgcct ctcctcccaa ctcttggctt ttgcttcctt
     5401 aaatttgaac aattccctaa gatctaatgc tgggaggctc cccttccttc attacacagt
     5461 gaactcatgt gctctatctg cattccccct aaatcctcct gagcttttag gtaagaggcc
     5521 gatgatttca caatcggcag cagaggccta aggccattcc atcaaactga agatggcagc
     5581 aagttgtcct cacttcttca ttgagcaccc atgggtgtgt actggagcaa gggtggtgcc
     5641 agggattctc ctgctctggt tcctcctgcg gggtccctgc tcagctgggc agctgccctc
     5701 actctgggcg ggtggcatgt gagtgtcaac agggcccctc tcagtcaggg gctcttggcc
     5761 attttttgtg ccatggatcg cttctcaaaa tcatattttc ttttcttttc ttttgagatg
     5821 gggtctcact ccattaccca ggctggagtg cagtggtgca atcacagctc actgtagcct
     5881 cgacctccct gggttcaggt gatcctccca cctcagcctc ccaagtagct gggactatag
     5941 gcatgcacca ccatgcctgg ctaatttcag aataatattt tcatacacat aaaatatgta
     6001 ggattacaaa gtaagctagt tatatttata tacagttgtc aaaatatttt taaaatgtat
     6061 aacgtgatac tatgtgtata ggtttcttta ttaacatatt gaataaaaag atcgagggta
     6121 ggcctattaa acaatggtaa actgaagaga gatgagtgta aacaatattt taagatagat
     6181 acctgtggca aactgtaaag ggatatgaaa aactctgtaa tttctattgg cactgctgat
     6241 acaactgcac tttgctacct ttgttcataa ccaaggaaat agaaatgact gaaaataaag
     6301 ttgtattcta ttccaa
//
