LOCUS       NM_002969               1778 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 12 (MAPK12),
            transcript variant 1, mRNA.
ACCESSION   NM_002969 XM_003403746
VERSION     NM_002969.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Zang,Y., Li,J., Wan,B., Tai,Y., Liu,H., Li,Q., Ji,Y. and Wang,G.
  TITLE     LOC730101 transmitted by exosomes facilitates laryngeal squamous
            cell carcinoma tumorigenesis via regulation of p38 MAPK gamma
  JOURNAL   Cell Signal 122, 111336 (2024)
   PUBMED   39121975
  REMARK    GeneRIF: LOC730101 transmitted by exosomes facilitates laryngeal
            squamous cell carcinoma tumorigenesis via regulation of p38 MAPK
            gamma.
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Sengupta,P., Dutta,A., Suseela,Y.V., Roychowdhury,T., Banerjee,N.,
            Dutta,A., Halder,S., Jana,K., Mukherjee,G., Chattopadhyay,S.,
            Govindaraju,T. and Chatterjee,S.
  TITLE     G-quadruplex structural dynamics at MAPK12 promoter dictates
            transcriptional switch to determine stemness in breast cancer
  JOURNAL   Cell Mol Life Sci 81 (1), 33 (2024)
   PUBMED   38214819
  REMARK    GeneRIF: G-quadruplex structural dynamics at MAPK12 promoter
            dictates transcriptional switch to determine stemness in breast
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Yin,D.P., Zheng,Y.F., Sun,P., Yao,M.Y., Xie,L.X., Dou,X.W., Tian,Y.
            and Liu,J.S.
  TITLE     The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 13 (3), 210 (2022)
   PUBMED   35246508
  REMARK    GeneRIF: The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Vallabhaneni,S., Liu,J., Morel,M., Wang,J., DeMayo,F.J. and Long,W.
  TITLE     Conditional ERK3 overexpression cooperates with PTEN deletion to
            promote lung adenocarcinoma formation in mice
  JOURNAL   Mol Oncol 16 (5), 1184-1199 (2022)
   PUBMED   34719109
  REMARK    GeneRIF: Conditional ERK3 overexpression cooperates with PTEN
            deletion to promote lung adenocarcinoma formation in mice.
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Goedert,M., Hasegawa,M., Jakes,R., Lawler,S., Cuenda,A. and
            Cohen,P.
  TITLE     Phosphorylation of microtubule-associated protein tau by
            stress-activated protein kinases
  JOURNAL   FEBS Lett 409 (1), 57-62 (1997)
   PUBMED   9199504
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Goedert,M., Hasegawa,J., Craxton,M., Leversha,M.A. and Clegg,S.
  TITLE     Assignment of the human stress-activated protein kinase-3 gene
            (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization
  JOURNAL   Genomics 41 (3), 501-502 (1997)
   PUBMED   9169156
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Li,Z., Jiang,Y., Ulevitch,R.J. and Han,J.
  TITLE     The primary structure of p38 gamma: a new member of p38 group of
            MAP kinases
  JOURNAL   Biochem Biophys Res Commun 228 (2), 334-340 (1996)
   PUBMED   8920915
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Lechner,C., Zahalka,M.A., Giot,J.F., Moller,N.P. and Ullrich,A.
  TITLE     ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4355-4359 (1996)
   PUBMED   8633070
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Saleem,A., Datta,R., Yuan,Z.M., Kharbanda,S. and Kufe,D.
  TITLE     Involvement of stress-activated protein kinase in the cellular
            response to 1-beta-D-arabinofuranosylcytosine and other
            DNA-damaging agents
  JOURNAL   Cell Growth Differ 6 (12), 1651-1658 (1995)
   PUBMED   9019171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U66243.2, CB123561.1, Y10487.1,
            BC015741.1 and N94360.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002969.5.
            
            Summary: Activation of members of the mitogen-activated protein
            kinase family is a major mechanism for transduction of
            extracellular signals. Stress-activated protein kinases are one
            subclass of MAP kinases. The protein encoded by this gene functions
            as a signal transducer during differentiation of myoblasts to
            myotubes. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10487.1, SRR1163655.92310.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215659.13/ ENSP00000215659.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               U66243.2           128-483
            357-806             CB123561.1         6-455
            807-1776            Y10487.1           839-1808
            1777-1777           BC015741.1         1754-1754
            1778-1778           N94360.1           12-12               c
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..1778
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /note="mitogen-activated protein kinase 12"
                     /db_xref="GeneID:6300"
                     /db_xref="HGNC:HGNC:6874"
                     /db_xref="MIM:602399"
     exon            1..299
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1278
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitogen-activated protein kinase 3; stress-activated
                     protein kinase 3; MAP kinase 12; MAP kinase p38 gamma;
                     extracellular signal-regulated kinase 6; mitogen-activated
                     protein kinase p38 gamma"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 12 isoform 1"
                     /protein_id="NP_002960.2"
                     /db_xref="CCDS:CCDS14089.1"
                     /db_xref="GeneID:6300"
                     /db_xref="HGNC:HGNC:6874"
                     /db_xref="MIM:602399"
                     /translation="MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSA
                     VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDF
                     TDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA
                     VNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE
                     MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI
                     LTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVD
                     RTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL"
     exon            300..429
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            430..488
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..600
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..630
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..678
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            679..793
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..865
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..945
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1024
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1198
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1778
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /note="hexamer: AATAGA"
     polyA_site      1778
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /note="major polyA site"
ORIGIN      
        1 gggacatccc tgagggaagg gccgggagcg ggagcgcccc agcggccggc gggcgggcgg
       61 gcgagcggac gagcggcgcg gagccggccc gaggcgcgcg ccgagggagc cccgtccccg
      121 gtcgtggggg caccgcccgc aggctctgcg gggtgggcag ctcccgggcc tgccatgagc
      181 tctccgccgc ccgcccgcag tggcttttac cgccaggagg tgaccaagac ggcctgggag
      241 gtgcgcgccg tgtaccggga cctgcagccc gtgggctcgg gcgcctacgg cgcggtgtgc
      301 tcggccgtgg acggccgcac cggcgctaag gtggccatca agaagctgta tcggcctttc
      361 cagtccgagc tgttcgccaa gcgcgcctac cgcgagctgc gcctgctcaa gcacatgcgc
      421 cacgagaacg tgatcgggct gctggacgta ttcactcctg atgagaccct ggatgacttc
      481 acggactttt acctggtgat gccgttcatg ggcaccgacc tgggcaagct catgaaacat
      541 gagaagctag gcgaggaccg gatccagttc ctcgtgtacc agatgctgaa ggggctgagg
      601 tatatccacg ctgccggcat catccacaga gacctgaagc ccggcaacct ggctgtgaac
      661 gaagactgtg agctgaagat cctggacttc ggcctggcca ggcaggcaga cagtgagatg
      721 actgggtacg tggtgacccg gtggtaccgg gctcccgagg tcatcttgaa ttggatgcgc
      781 tacacgcaga cggtggacat ctggtctgtg ggctgcatca tggcggagat gatcacaggc
      841 aagacgctgt tcaagggcag cgaccacctg gaccagctga aggagatcat gaaggtgacg
      901 gggacgcctc cggctgagtt tgtgcagcgg ctgcagagcg atgaggccaa gaactacatg
      961 aagggcctcc ccgaattgga gaagaaggat tttgcctcta tcctgaccaa tgcaagccct
     1021 ctggctgtga acctcctgga gaagatgctg gtgctggacg cggagcagcg ggtgacggca
     1081 ggcgaggcgc tggcccatcc ctacttcgag tccctgcacg acacggaaga tgagccccag
     1141 gtccagaagt atgatgactc ctttgacgac gttgaccgca cactggatga atggaagcgt
     1201 gttacttaca aagaggtgct cagcttcaag cctccccggc agctgggggc cagggtctcc
     1261 aaggagacgc ctctgtgaag atctctgggc tccggggtgg cagtgaggac caccttcacc
     1321 ttccacctga gaggggactc tcgttgccac cttgaccttg gctggggctt gcatcccaag
     1381 gcatccatca gagcagacgc ccgggttcca tggaccctcc tccccacggc catgcctctg
     1441 ctcttgggcg cccatcatgg aggagcacct gaactttctg gacaagacct ctggccgacc
     1501 tggggatggc ctctgatccc tggagcagtg gcccacttgc ccggtgctct cagaaacctc
     1561 agagctggtg gggctccaga tcaggccttg gcctctgagc cctgcctgct ctgggccatg
     1621 cagaggaagg acagagggtg ggcgcagggc accaactcag ggacatcccc tctcctgggc
     1681 gacgtcagtg gaccttcctg cacccccagc ctggaatgta aatcagctgt gtggtgcccg
     1741 cgtggctgga aggaaataga cccttttgta gctccctg
//
