LOCUS       NM_002751               2418 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 11 (MAPK11),
            transcript variant 1, mRNA.
ACCESSION   NM_002751 XM_003960822
VERSION     NM_002751.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Higgins,C.A., Nilsson-Payant,B.E., Bonaventure,B., Kurland,A.P.,
            Ye,C., Yaron,T.M., Johnson,J.L., Adhikary,P., Golynker,I.,
            Panis,M., Danziger,O., Rosenberg,B.R., Cantley,L.C.,
            Martinez-Sobrido,L., tenOever,B. and Johnson,J.R.
  TITLE     SARS-CoV-2 hijacks p38beta/MAPK11 to promote virus replication
  JOURNAL   mBio 14 (4), e0100723 (2023)
   PUBMED   37345956
  REMARK    GeneRIF: SARS-CoV-2 hijacks p38beta/MAPK11 to promote virus
            replication.
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Robinson,K.S., Toh,G.A., Rozario,P., Chua,R., Bauernfried,S.,
            Sun,Z., Firdaus,M.J., Bayat,S., Nadkarni,R., Poh,Z.S., Tham,K.C.,
            Harapas,C.R., Lim,C.K., Chu,W., Tay,C.W.S., Tan,K.Y., Zhao,T.,
            Bonnard,C., Sobota,R., Connolly,J.E., Common,J., Masters,S.L.,
            Chen,K.W., Ho,L., Wu,B., Hornung,V. and Zhong,F.L.
  TITLE     ZAKalpha-driven ribotoxic stress response activates the human NLRP1
            inflammasome
  JOURNAL   Science 377 (6603), 328-335 (2022)
   PUBMED   35857590
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Enslen,H., Raingeaud,J. and Davis,R.J.
  TITLE     Selective activation of p38 mitogen-activated protein (MAP) kinase
            isoforms by the MAP kinase kinases MKK3 and MKK6
  JOURNAL   J Biol Chem 273 (3), 1741-1748 (1998)
   PUBMED   9430721
REFERENCE   6  (bases 1 to 2418)
  AUTHORS   Stein,B., Yang,M.X., Young,D.B., Janknecht,R., Hunter,T.,
            Murray,B.W. and Barbosa,M.S.
  TITLE     p38-2, a novel mitogen-activated protein kinase with distinct
            properties
  JOURNAL   J Biol Chem 272 (31), 19509-19517 (1997)
   PUBMED   9235954
REFERENCE   7  (bases 1 to 2418)
  AUTHORS   Kumar,S., McDonnell,P.C., Gum,R.J., Hand,A.T., Lee,J.C. and
            Young,P.R.
  TITLE     Novel homologues of CSBP/p38 MAP kinase: activation, substrate
            specificity and sensitivity to inhibition by pyridinyl imidazoles
  JOURNAL   Biochem Biophys Res Commun 235 (3), 533-538 (1997)
   PUBMED   9207191
REFERENCE   8  (bases 1 to 2418)
  AUTHORS   Goedert,M., Cuenda,A., Craxton,M., Jakes,R. and Cohen,P.
  TITLE     Activation of the novel stress-activated protein kinase SAPK4 by
            cytokines and cellular stresses is mediated by SKK3 (MKK6);
            comparison of its substrate specificity with that of other SAP
            kinases
  JOURNAL   EMBO J 16 (12), 3563-3571 (1997)
   PUBMED   9218798
REFERENCE   9  (bases 1 to 2418)
  AUTHORS   Cuenda,A., Cohen,P., Buee-Scherrer,V. and Goedert,M.
  TITLE     Activation of stress-activated protein kinase-3 (SAPK3) by
            cytokines and cellular stresses is mediated via SAPKK3 (MKK6);
            comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
  JOURNAL   EMBO J 16 (2), 295-305 (1997)
   PUBMED   9029150
REFERENCE   10 (bases 1 to 2418)
  AUTHORS   Jiang,Y., Chen,C., Li,Z., Guo,W., Gegner,J.A., Lin,S. and Han,J.
  TITLE     Characterization of the structure and function of a new
            mitogen-activated protein kinase (p38beta)
  JOURNAL   J Biol Chem 271 (30), 17920-17926 (1996)
   PUBMED   8663524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022328.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002751.6.
            
            Summary: This gene encodes a member of a family of protein kinases
            that are involved in the integration of biochemical signals for a
            wide variety of cellular processes, including cell proliferation,
            differentiation, transcriptional regulation, and development. The
            encoded protein can be activated by proinflammatory cytokines and
            environmental stresses through phosphorylation by mitogen activated
            protein kinase kinases (MKKs). Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027933.1, SRR14038196.2088099.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330651.11/ ENSP00000333685.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL022328.21        170332-170535       c
            205-334             AL022328.21        167975-168104       c
            335-393             AL022328.21        167724-167782       c
            394-505             AL022328.21        167526-167637       c
            506-535             AL022328.21        167412-167441       c
            536-583             AL022328.21        167282-167329       c
            584-698             AL022328.21        167089-167203       c
            699-770             AL022328.21        166695-166766       c
            771-850             AL022328.21        166381-166460       c
            851-929             AL022328.21        165737-165815       c
            930-1103            AL022328.21        165476-165649       c
            1104-2418           AL022328.21        163868-165182       c
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2418
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /note="mitogen-activated protein kinase 11"
                     /db_xref="GeneID:5600"
                     /db_xref="HGNC:HGNC:6873"
                     /db_xref="MIM:602898"
     exon            1..204
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1183
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /EC_number="2.7.11.24"
                     /note="mitogen-activated protein kinase p38-2;
                     stress-activated protein kinase-2b; mitogen-activated
                     protein kinase p38 beta; MAP kinase 11; MAP kinase p38
                     beta"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 11"
                     /protein_id="NP_002742.3"
                     /db_xref="CCDS:CCDS14090.1"
                     /db_xref="GeneID:5600"
                     /db_xref="HGNC:HGNC:6873"
                     /db_xref="MIM:602898"
                     /translation="MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDA
                     RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEV
                     YLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE
                     DCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
                     GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRG
                     ANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTL
                     EEWKELTYQEVLSFKPPEPPKPPGSLEIEQ"
     exon            205..334
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            335..393
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            394..505
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            506..535
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            536..583
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            584..698
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            699..770
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            771..850
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..929
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1103
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..2418
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /note="hexamer: AATAAA"
     polyA_site      2418
                     /gene="MAPK11"
                     /gene_synonym="p38-2; P38B; p38Beta; P38BETA2; PRKM11;
                     SAPK2; SAPK2B"
                     /note="major polyA site"
ORIGIN      
        1 gccctccgct ccgctcggct cgggctcggc tcgggcgcgg gcgcggggcg cggggctggg
       61 cccgggcgga gcggcggctg ctccggacat gtcgggccct cgcgccggct tctaccggca
      121 ggagctgaac aagaccgtgt gggaggtgcc gcagcggctg caggggctgc gcccggtggg
      181 ctccggcgcc tacggctccg tctgttcggc ctacgacgcc cggctgcgcc agaaggtggc
      241 ggtgaagaag ctgtcgcgcc ccttccagtc gctgatccac gcgcgcagaa cgtaccggga
      301 gctgcggctg ctcaagcacc tgaagcacga gaacgtcatc gggcttctgg acgtcttcac
      361 gccggccacg tccatcgagg acttcagcga agtgtacttg gtgaccaccc tgatgggcgc
      421 cgacctgaac aacatcgtca agtgccaggc gctgagcgac gagcacgttc aattcctggt
      481 ttaccagctg ctgcgcgggc tgaagtacat ccactcggcc gggatcatcc accgggacct
      541 gaagcccagc aacgtggctg tgaacgagga ctgtgagctc aggatcctgg attttgggct
      601 ggcgcgccag gcggacgagg agatgaccgg ctatgtggcc acgcgctggt accgggcacc
      661 tgagatcatg ctcaactgga tgcattacaa ccaaacagtg gatatctggt ccgtgggctg
      721 catcatggct gagctgctcc agggcaaggc cctcttcccg ggaagcgact acattgacca
      781 gctgaagcgc atcatggaag tggtgggcac acccagccct gaggttctgg caaaaatctc
      841 ctcagaacac gcccggacat atatccagtc cctgcccccc atgccccaga aggacctgag
      901 cagcatcttc cgtggagcca accccctggc catagacctc cttggaagga tgctggtgct
      961 ggacagtgac cagagggtca gtgcagctga ggcactggcc cacgcctact tcagccagta
     1021 ccacgacccc gaggatgagc cagaggccga gccatatgat gagagcgttg aggccaagga
     1081 gcgcacgctg gaggagtgga aggagctcac ttaccaggaa gtcctcagct tcaagccccc
     1141 agagccaccg aagccacctg gcagcctgga gattgagcag tgaggtgctg cccagcagcc
     1201 cctgagagcc tgtggagggg cttgggcctg cacccttcca cagctggcct ggtttcctcg
     1261 agaggcacct cccacactcc tatggtcaca gacttctggc ctaggacccc tcgccttcag
     1321 gagaatctac acgcatgtat gcatgcacaa acatgtgtgt acatgtgctt gccatgtgta
     1381 ggagtctggg cacaagtgtc cctgggccta ccttggtcct cctgtcctct tctggctact
     1441 gcactctcca ctgggacctg actgtggggt cctagatgcc aaaggggttc ccctgcggag
     1501 ttcccctgtc tgtcccaggc cgacccaagg gagtgtcagc cttgggctct cttctgtccc
     1561 agggctttct ggaggacgcg ctggggccgg gaccccggga gactcaaagg gagaggtctc
     1621 agtggttaga gctgctcagc ctggaggtag ggggctgtct tggtcactgc tgagacccac
     1681 aggtctaaga ggagaggcag agccagtgtg ccaccaggct gggcagggac aaccaccagg
     1741 tgtcaaatga gaaaagctgc ctggagtctt gtgttcaccc gtgggtgtgt gtgggcacgt
     1801 gtggatgagc gtgcactccc cgtgttcata tgtcagggca catgtgatgt ggtgcgtgtg
     1861 aatctgtggg cgcccaaggc cagcagccat atctggcaag aagctggagc cggggtgggt
     1921 gtgctgttgc cttccctctc ctcggttcct gatgccttga ggggtgtttc agactggcgg
     1981 ctccagtggg ccaaagggca accacatgag catgggcagg ggctttctcc ttggatgtgg
     2041 gacccacagc agcttcctga ggctgggggt gggtgggtgg gtggtttggc cttgaggacg
     2101 ctagggcagg cagcacacct ggatgtggac ttggactcgg acacttctgc cctgcaccct
     2161 ggcccgctct ctacctctgc ccaccgttgt ggccctgcag ccggagatct gaggtgctct
     2221 ggtctgtggg tcagtcctct ttccttgtcc caggatggag ctgatccagt aacctcggag
     2281 acgggaccct gcccagagct gagttggggg tgtggctctg ccctggaaag ggggtgacct
     2341 cttgcctcga ggggcccagg gaagcctggg tgtcaagtgc ctgcaccagg ggtgcacaat
     2401 aaagggggtt ctctctca
//
