LOCUS       NM_138982               8735 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 10 (MAPK10),
            transcript variant 1, mRNA.
ACCESSION   NM_138982
VERSION     NM_138982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8735)
  AUTHORS   Chen,J., Ye,C., Wan,C., Li,G., Peng,L., Peng,Y. and Fang,R.
  TITLE     The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
  JOURNAL   Int J Mol Sci 22 (17), 9640 (2021)
   PUBMED   34502556
  REMARK    GeneRIF: The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8735)
  AUTHORS   Tsai,Y.C., Huang,C.Y., Hsueh,Y.M., Fan,Y.C., Fong,Y.C., Huang,S.P.,
            Geng,J.H., Chen,L.C., Lu,T.L. and Bao,B.Y.
  TITLE     Genetic variants in MAPK10 modify renal cell carcinoma
            susceptibility and clinical outcomes
  JOURNAL   Life Sci 275, 119396 (2021)
   PUBMED   33774030
  REMARK    GeneRIF: Genetic variants in MAPK10 modify renal cell carcinoma
            susceptibility and clinical outcomes.
REFERENCE   3  (bases 1 to 8735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8735)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   5  (bases 1 to 8735)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   6  (bases 1 to 8735)
  AUTHORS   Yoshida,S., Fukino,K., Harada,H., Nagai,H., Imoto,I., Inazawa,J.,
            Takahashi,H., Teramoto,A. and Emi,M.
  TITLE     The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure,
            chromosomal assignment, and loss of expression in brain tumors
  JOURNAL   J Hum Genet 46 (4), 182-187 (2001)
   PUBMED   11322657
REFERENCE   7  (bases 1 to 8735)
  AUTHORS   Yang,D.D., Kuan,C.Y., Whitmarsh,A.J., Rincon,M., Zheng,T.S.,
            Davis,R.J., Rakic,P. and Flavell,R.A.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (bases 1 to 8735)
  AUTHORS   Gupta,S., Barrett,T., Whitmarsh,A.J., Cavanagh,J., Sluss,H.K.,
            Derijard,B. and Davis,R.J.
  TITLE     Selective interaction of JNK protein kinase isoforms with
            transcription factors
  JOURNAL   EMBO J 15 (11), 2760-2770 (1996)
   PUBMED   8654373
REFERENCE   9  (bases 1 to 8735)
  AUTHORS   Mohit,A.A., Martin,J.H. and Miller,C.A.
  TITLE     p493F12 kinase: a novel MAP kinase expressed in a subset of neurons
            in the human nervous system
  JOURNAL   Neuron 14 (1), 67-78 (1995)
   PUBMED   7826642
REFERENCE   10 (bases 1 to 8735)
  AUTHORS   Pulverer,B.J., Kyriakis,J.M., Avruch,J., Nikolakaki,E. and
            Woodgett,J.R.
  TITLE     Phosphorylation of c-jun mediated by MAP kinases
  JOURNAL   Nature 353 (6345), 670-674 (1991)
   PUBMED   1922387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC035057.1, BC022492.1,
            AK057723.1, AC104059.5 and AF052141.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_138982.3.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous
            system, and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1, also known as JNK3 alpha2) results from translation
            termination at the upstream UGA stop codon, while the longer
            isoform (1x) results from UGA stop codon readthrough to the
            downstream UGA termination codon. This RefSeq represents the
            shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.191033.1, BC035057.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641462.2/ ENSP00000493435.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1635              BC035057.1         15-1649
            1636-2239           BC022492.1         1638-2241
            2240-2660           AK057723.1         1736-2156
            2661-5767           AC104059.5         17645-20751         c
            5768-6844           AF052141.1         503-1579
            6845-8735           AC104059.5         14677-16567         c
FEATURES             Location/Qualifiers
     source          1..8735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.3"
     gene            1..8735
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="mitogen-activated protein kinase 10"
                     /db_xref="GeneID:5602"
                     /db_xref="HGNC:HGNC:6872"
                     /db_xref="MIM:602897"
     exon            1..396
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            397..511
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            512..583
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..1912
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /EC_number="2.7.11.24"
                     /note="isoform 1 is encoded by transcript variant 1; c-Jun
                     N-terminal kinase 3; JNK3 alpha protein kinase; stress
                     activated protein kinase beta; MAP kinase 10; MAP kinase
                     p49 3F12; stress-activated protein kinase JNK3;
                     stress-activated protein kinase 1b"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /protein_id="NP_620448.1"
                     /db_xref="CCDS:CCDS34026.1"
                     /db_xref="GeneID:5602"
                     /db_xref="HGNC:HGNC:6872"
                     /db_xref="MIM:602897"
                     /translation="MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKV
                     DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ
                     THAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME
                     LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
                     MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI
                     EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD
                     LLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE
                     LIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTD
                     SSLEASAGPLGCCR"
     exon            584..753
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            754..883
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            884..942
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1081
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1247
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1319
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1502
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1627
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1691
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1769
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..8735
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2640..2645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: ATTAAA"
     polyA_site      2662
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="major polyA site"
     regulatory      3994..3999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: AATAAA"
     polyA_site      4017
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
     regulatory      6652..6657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: CATAAA"
     polyA_site      6673
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
     regulatory      6822..6827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: AATAAA"
     regulatory      6833..6838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: AATAAG"
     polyA_site      6844
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
     polyA_site      6856
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
     regulatory      8714..8719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
                     /note="hexamer: AATAAA"
     polyA_site      8735
                     /gene="MAPK10"
                     /gene_synonym="JNK3; JNK3A; p493F12; p54bSAPK; PRKM10;
                     SAPK1b"
ORIGIN      
        1 acaatggtac aggcagcatc acgctgcaca atggtttcca ggcagtgaaa gagggtgatt
       61 cagcaagcca ctcttcttct attttcttta acctcccctt cactttttat ttttatgggg
      121 gtgggtggtg cttgctatat gcttaccttt ttcttttctt ttttcatttt tacaaatttc
      181 cttttttgtc ctcacccctc aattcctagg ggcttgagtg agtttaagat tgggttttct
      241 tggaaatcac ctgtccatcg ttaattttaa acaatctcca tatctccaaa gaatctcttc
      301 catgttagtc tggaatgtgg ttaatgaaaa acaagtaggg aggatttctg gggcaaacac
      361 tgccggatca ggatcgtagt tctcaggcac ggaatggcta gtgtgagaaa caccaacagc
      421 aggcccatct cagatcttca ctatggcaac ttatgcaaga aactgttgaa ttagacccgt
      481 ttcctataga tgagaaacca tacaagctgt ggtatttatg agcctccatt tcttatacta
      541 ctgcagtgaa ccaacattgg atgtgaaaat tgccttttgt cagggattcg ataaacaagt
      601 ggatgtgtca tatattgcca aacattacaa catgagcaaa agcaaagttg acaaccagtt
      661 ctacagtgtg gaagtgggag actcaacctt cacagttctc aagcgctacc agaatctaaa
      721 gcctattggc tctggggctc agggcatagt ttgtgccgcg tatgatgctg tccttgacag
      781 aaatgtggcc attaagaagc tcagcagacc ctttcagaac caaacacatg ccaagagagc
      841 gtaccgggag ctggtcctca tgaagtgtgt gaaccataaa aacattatta gtttattaaa
      901 tgtcttcaca ccccagaaaa cgctggagga gttccaagat gtttacttag taatggaact
      961 gatggatgcc aacttatgtc aagtgattca gatggaatta gaccatgagc gaatgtctta
     1021 cctgctgtac caaatgttgt gtggcattaa gcacctccat tctgctggaa ttattcacag
     1081 ggatttaaaa ccaagtaaca ttgtagtcaa gtctgattgc acattgaaaa tcctggactt
     1141 tggactggcc aggacagcag gcacaagctt catgatgact ccatatgtgg tgacacgtta
     1201 ttacagagcc cctgaggtca tcctggggat gggctacaag gagaacgtgg atatatggtc
     1261 tgtgggatgc attatgggag aaatggttcg ccacaaaatc ctctttccag gaagggacta
     1321 tattgaccag tggaataagg taattgaaca actaggaaca ccatgtccag aattcatgaa
     1381 gaaattgcaa cccacagtaa gaaactatgt ggagaatcgg cccaagtatg cgggactcac
     1441 cttccccaaa ctcttcccag attccctctt cccagcggac tccgagcaca ataaactcaa
     1501 agccagccaa gccagggact tgttgtcaaa gatgctagtg attgacccag caaaaagaat
     1561 atcagtggac gacgccttac agcatcccta catcaacgtc tggtatgacc cagccgaagt
     1621 ggaggcgcct ccacctcaga tatatgacaa gcagttggat gaaagagaac acacaattga
     1681 agaatggaaa gaacttatct acaaggaagt aatgaattca gaagaaaaga ctaaaaatgg
     1741 tgtagtaaaa ggacagcctt ctccttcagg tgcagcagtg aacagcagtg agagtctccc
     1801 tccatcctcg tctgtcaatg acatctcctc catgtccacc gaccagaccc tggcatctga
     1861 cactgacagc agcctggaag cctcggcagg acccctgggt tgttgcaggt gactagccgc
     1921 ctgcctgcga aacccagcgt tcttcaggag atgatgtgat ggaacacaca cacacgcaga
     1981 cacacacaca cacacaaatg cagacacaca acatcaagaa aacagcaagg gagagaatcc
     2041 aagcctaaaa ttaaataaat ctttcagcct gcttcttccc cagggttctg tattgcagct
     2101 aagctcaaat gtatatttaa cttctagttg ctcttgcttt ggtcttcttc caatgatgct
     2161 tactacagaa agcaaatcag acacaattag agaagccttt tccataaagt gtaattttaa
     2221 tggctgcaaa accggcaacc tgtaactgcc cttttaaatg gcatgacaag gtgtgcagtg
     2281 gccccatcca gcatgtgtgt gtctctatct tgcatctacc tgctccttgg cctagtcaga
     2341 tggatgtaga tacagatccg catgtgtctg tattcataca gcactactta cttagagatg
     2401 ctactgtcag tgtcctcagg gctctaccaa gacataatgc actggggtac cacatggtcc
     2461 atttcatgtg atctattact ctgacataaa cccatctgta atatattgcc agtatataag
     2521 ctgtttagtt tgttaattga ttaaactgta tgtcttataa gaaaacatgt aaagggggaa
     2581 tatatggggg gagtgagctc tctcagaccc ttgaagatgt agcttccaaa tttgaatgga
     2641 ttaaatggca cctgtatacc aatttgtaga aagaacatat gtgatactta tgtaaagtgt
     2701 ggggcgagtg ggtaacagtt ttcaggcaca aaatggtttg gccttctgaa ggcaggtgtg
     2761 aataaaagct gagagtcttt tctgtgacag taaagagtag gagagactgg agggtagtgt
     2821 gtggtgtgga ctaagactga aaggaggtta ttacccagat actaggagac actggtgtcc
     2881 ctgttttaga gatttggctc tatacccatt tgtcatttct caattactgg tcacaacaag
     2941 aggccactgg agaaagtggc aggtggtgaa gcaaggttat tgtgtgtgct tttgatgata
     3001 agaatctctc tctggaactg agcagaattg cctccatgtg aattccttca acaaaaaaat
     3061 gagcctgcct agactacttt cagattgtgg attgtgtttt ccatgtgtgg gctgcttccc
     3121 tgattcatac tctgccaaag ttttattttg agaaataata ttactttcct cttctgaaat
     3181 aaaataataa taataataat gaaaccccca aaccacagtg tgagtctcag gttagcattt
     3241 gaaaacatct ccagagacat tgttattcct caggagtttc cctgactcct taatgtggct
     3301 gatgtttcat gtttatttat ttattttaat aagtatgagc aatcgaaggg ctgatcatct
     3361 gagttttgta ctgcagtaga tgtaagagca ataactctgc ccataaattt actgctgcca
     3421 aatagtttta gcaatatgag tttgtcttaa aagccatgaa gcattaatgt caatgtttag
     3481 caaaatctcc agaatttagc ttaaattaaa ttaaatgaaa gtgctttcct gagcacttaa
     3541 ggaggcactg tgaaacatct tggttatgta caaggcaata ccaaggtgat ctcagcaata
     3601 atcaggcttc ccttcttatt cacttcgaag tatccatcac agttatttgc actctgacca
     3661 tgttggtgct cactagagtg gtgatatttc acctgaagaa gtgaaagaca ggaagtggat
     3721 ggttgatgag tgtgaactga ttggcaaata gaatatcccc aaaacagagc aaacaagaat
     3781 gccagtgctc tgaaaactgc cttaaatata ataataggga actttctttc tctcttcaag
     3841 caatagagac cacagggaac tgcacccacc tgcaccatcg ccatgccagt ggtgctgcca
     3901 ttctgagatt atttcacaca gtcagattca gtacacgcag tcatttgttt aaaataaata
     3961 gaagaacatt cctttgtgca gcttgtcccc tggaataaaa atggcccatt ttctctattt
     4021 tgctaccatt ttttttctgg ttaatattgc agataacctg attgttaaaa atgcctcctc
     4081 agtcacttga gctccctctc tttcatattc ctgttttttt tttttttttt taaaaacttc
     4141 tcctctctgt atctctaatt ctttactgat tttctttctc ggtacttttc tcttgatata
     4201 tctgtggctt ctcccctccc ttactttata ccacatggga ttaagtgcgg agagcaggaa
     4261 gctgctttaa agagagtctc aaggggaatt tcatcagccg caagatgaca tcacaagaca
     4321 gaaggaagtc tccagccagc atcttcaaag tgcttgacag gctatctctc gtacctgcat
     4381 aagtggtgaa tttccccctc agagtaaacc aggcaagaac tagacagggc ccctcccccg
     4441 ctgttagtac cttcccaaag ctcaattagt cttacatctt ctgtgcatgg ctcttgggag
     4501 ctggttagct ttagccagat ttcccttatg gacaagagaa aaatggaaca aattccttga
     4561 atataagtat catttacaaa tagaggtaag gatttggccc ccagaatttt tgcaggatca
     4621 gttttattag gtgattaaag caaggcagat gatggaacaa caaagagaat caccactgta
     4681 aaagcccccc agtcctttgc ccactaggtc tgctttccta taatatgtct aggaggtgat
     4741 gatattatca aattcacaga atataatatg ttctgcattc acttgtctgt cttaacacac
     4801 acacacacac acacacacac acacacacac acacacccca aatatttctt aaatagtcac
     4861 ctgttatttc ccaagaacat cccaactttt ccggtaggca agtgtcaagt cacctggaca
     4921 atattcctga aaaaaagtga aggttctacc tggggttggg gctcattttg gaacatgaag
     4981 ttggcactct gaggagccta accttctgtt aggcttcctt tggggcagtt ggtttgcagt
     5041 gatccttaat aaaatagttt gcagtatttt gtaggaagga tggctgtgta ctcatgtgca
     5101 gggaaaatta aactgctgca agagtttggc aaaaccgcca ccactttact attaatatgt
     5161 ctttactatt tttatatgtg ttttgtgggt cagcgtgttc aattttaaat aggaatacac
     5221 tagccttaca acggaatttc ttcttgtgga ataaaaactg ataataacct ttcatcttca
     5281 agaatctgat gactgagttt tgtaggaatg tacccaacag ttggaccaga gcctggccag
     5341 ttcccaccaa ttggagtaag ctatttaatt gagggttaag aagctcgata gttttttcaa
     5401 tctgttatca gaaaaatatt atctaaagac actgatagca gctgactggt aaaactgaaa
     5461 gttggcctta gtaaatggaa ctagtaaaaa atagataaaa atatgtaaaa ccttttatgt
     5521 cctgtcaagg aaaaaaaaat aagcaaactt gatttgtttt aaaattgtaa atattcattg
     5581 caaaacctaa attatacaaa atctatttcg atttgaatct cttaacatat gaaaagccac
     5641 atcttaagtg cattatgctc tgtaaggcat gttattagcc agctttgctg aaaaatgtat
     5701 tcttctacag ctcagaaaga ggagtaaaat tgctctagaa atttttgatc tcagccactt
     5761 tgcatccaaa gaggaaccca actccccact cacaatcccc cacacacatt ttaattataa
     5821 gagttcaaca ttttccacag atatcattaa gccaagcaag gaaactcctc tctgtaaaaa
     5881 caacaaaaaa gttgcaatgt aaatagttat tttagctatt ttctttgtga ttagaggata
     5941 agattttgtt atttcttttg gtacttagtc ctttaactat ctgaaaatgg ctcactttga
     6001 cctgtttctt tggtcagcca aactgaagtg aggggcctct gtttatatat agaatcttgt
     6061 atatgtaact ttacttatgt gggaccaatg gccagtatat tctaatggac acaaatctcc
     6121 caatccttat gtaggattat ctgttcacct tgccatgtcc atcttgcaat gagacctaac
     6181 ttgcacctgc ctgtttttct gcatgattgg actccaaaga ctattaccaa tgatgagaat
     6241 tgtcttgtgt cagtgtttat aaaatggact taaagcacac acacatgcat acccacattc
     6301 acatgcaccc ttacagttct agatcaaccc tggaaggcaa aaccatgtac gtccagtttc
     6361 tttgcaaggt ctgagcagtg agaactaaat tcagtcagtc taatgggtaa aatgcaacct
     6421 cagtgatgct taataaggat ttgaaatcgt tcaagtcatt tctgtgttct ttctcacacc
     6481 ctttcctttc tattttgtct tcttttattt tcaaaatgtc tgtggaacaa gaggatgaat
     6541 cgggggagaa cttctgcttc ttttgactct ttttaggtaa tatggagtca atatattatg
     6601 atttctgttt cttatggatt attaaaatca gaggaaatct gcttctctca acataaaacc
     6661 aaatccaaac ccagacattg ttggagtttg cctgttgaca atggttatga tgctgctcgt
     6721 tgtcttgagt tgcatgtaac gacagtagct ctgaagggtg tcatgatttc attttggcaa
     6781 ctggtaaaag aaacttgtag tgtggtctga ttgtgccagg gaataaataa gaaataagga
     6841 atgacctact ttctcacctt gggtcaagag tgtgtgatat gaatgtgacc atgtagaaat
     6901 ctgtgttttc atttgacact ggtttcttct aaaactgacc ttcatttctg tctgtagata
     6961 ctagttgtat atctgcaatt cagtaatttc tttttaaggt ataaaatcaa tgaagaaaaa
     7021 aaagatcatc ttttgggggg gcattaggta agtagagcag ggttaaattt cccagattaa
     7081 ttatcagatt tctattcatt ttaactattt tccaagagaa aaggtaaaag cctttgttta
     7141 gctacatgat atccaacttt actatctcaa actccttgga gaattaaaaa tatatatgat
     7201 tttgtggctg gatgaagagg tcactgcact tgcattagtt tactttgcag tgtttgaaca
     7261 gttgaggagt ggctcttcta tttctgtaaa taatgtttta tttaaccaat taactattag
     7321 aaagcctgga agataaacat acacattatt ttgagttatc acatttatcg ttttacctag
     7381 ttcctgttgg aatatagaaa gcaacagctt tttgttatct ctggaacagc ttctatccta
     7441 gtttaaatca cagatcctta ctctctttaa aaaaggtcaa gcataggtac ctaaaaatac
     7501 ccacaataat aagaagggaa attgcattcc acaagatgat tgctcttaaa gagtcagaag
     7561 gagttattgg tgcattcctg ataccataaa tggttaccaa acatttggta attttgacca
     7621 agttcacagt aaggagaaaa aagggtgttg gacttgcttt tcttgaagat tacttatgga
     7681 gcaaccaacc tagaaggatg aatctacttg ccaataacaa cactggatca cagccaaggc
     7741 agaggttttt gacattccca attcatcatg gtggtgtttt gtatttgtaa catgtctttt
     7801 ctccacagat gttgaaaggc atgcttggat gacacatgct aatagtgaaa cacgctgaaa
     7861 gtcctgccat cacagatcac tttatgttgg gagccactct atgtggcaag tcatctgtcc
     7921 cagttccaga ctaaatttca actgttcaac catttacatc attgtagtct gtttaaggca
     7981 ctaaaaatgt gctgtagaaa tttatatttc tcagacacat gaaatgtggt gacacatcca
     8041 gcaacaagtc aaacactcct ttgaaatttt ctaccttatg tcaaatattt cttactttta
     8101 aagacattcc tatcctggtg taaaatccaa cataaaataa tttgagggaa tttaaggaat
     8161 tcaaatttca ctccgtgggg tacgtggctt tatttcttaa tcactgaact tctagtaatg
     8221 ttcttcacct gatcttgtct gcgatgttta accaacagtc cagatcattt gcaactcaaa
     8281 agcaggtaca aaatgttatc catcttaaaa acccctcaca tattccctag aagactgtcc
     8341 cacacataat tcgccttcca ttaacacttg tgaacccatc ctggtgaaaa tattgcctat
     8401 gaacaattat accaaaaaat caatttttat aatgcaaata atattttaca cagaccaaga
     8461 gaattcataa tattaaagta tttcttttat aaaaggaagg ttttcagaaa gcaatggcct
     8521 attccttcat gttaatacat tgcgaacttg gatttggtgt aaatcaagcc ctgagaatat
     8581 tgctctgaat ttctagctta atttctgagc aacattctaa agcagttcat taatttactc
     8641 caaaaacatt tcttggacac ttcggtgtag gagatatata ttgcatggtc cttaacctaa
     8701 aaaattcaga gttaataaat ctttgtttaa aaaaa
//
