LOCUS       NM_138957               1514 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript
            variant 2, mRNA.
ACCESSION   NM_138957
VERSION     NM_138957.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Vangipurapu,R., Oliva,J., Fox,A. and Sverdrup,F.M.
  TITLE     Temporal variation in p38-mediated regulation of DUX4 in
            facioscapulohumeral muscular dystrophy
  JOURNAL   Sci Rep 14 (1), 26437 (2024)
   PUBMED   39488616
  REMARK    GeneRIF: Temporal variation in p38-mediated regulation of DUX4 in
            facioscapulohumeral muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Zeng,J., Zhang,L., Huang,L., Yu,X., Han,L., Zheng,Y., Wang,T.,
            Zhang,N. and Yang,M.
  TITLE     MAZ promotes thyroid cancer progression by driving transcriptional
            reprogram and enhancing ERK1/2 activation
  JOURNAL   Cancer Lett 602, 217201 (2024)
   PUBMED   39197582
  REMARK    GeneRIF: MAZ promotes thyroid cancer progression by driving
            transcriptional reprogram and enhancing ERK1/2 activation.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Cho,Y. and Kim,Y.K.
  TITLE     CARM1 phosphorylation at S595 by p38gamma MAPK drives ROS-mediated
            cellular senescence
  JOURNAL   Redox Biol 76, 103344 (2024)
   PUBMED   39265499
  REMARK    GeneRIF: CARM1 phosphorylation at S595 by p38gamma MAPK drives
            ROS-mediated cellular senescence.
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Song,C., Wang,G., Liu,M., Han,S., Dong,M., Peng,M., Wang,W.,
            Wang,Y., Xu,Y. and Liu,L.
  TITLE     Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic
            insight into IQGAP1 phosphorylation and pancreatic Cancer
            progression
  JOURNAL   J Transl Med 22 (1), 602 (2024)
   PUBMED   38943117
  REMARK    GeneRIF: Deciphering the SOX4/MAPK1 regulatory axis: a
            phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic
            Cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P.,
            Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H.
  TITLE     Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance
            via the PAK1-ERK1/2 axis in hepatocellular carcinoma
  JOURNAL   Int J Biol Sci 20 (9), 3269-3284 (2024)
   PUBMED   38993552
  REMARK    GeneRIF: Deubiquitination of CIB1 by USP14 promotes lenvatinib
            resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Hu,S., Xie,Z., Onishi,A., Yu,X., Jiang,L., Lin,J., Rho,H.S.,
            Woodard,C., Wang,H., Jeong,J.S., Long,S., He,X., Wade,H.,
            Blackshaw,S., Qian,J. and Zhu,H.
  TITLE     Profiling the human protein-DNA interactome reveals ERK2 as a
            transcriptional repressor of interferon signaling
  JOURNAL   Cell 139 (3), 610-622 (2009)
   PUBMED   19879846
  REMARK    GeneRIF: ERK2 acts as a transcriptional repressor for interferon
            gamma-induced genes.
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Rossomando,A.J., Wu,J., Michel,H., Shabanowitz,J., Hunt,D.F.,
            Weber,M.J. and Sturgill,T.W.
  TITLE     Identification of Tyr-185 as the site of tyrosine
            autophosphorylation of recombinant mitogen-activated protein kinase
            p42mapk
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5779-5783 (1992)
   PUBMED   1378617
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
  TITLE     Heterogeneous expression of four MAP kinase isoforms in human
            tissues
  JOURNAL   FEBS Lett 304 (2-3), 170-178 (1992)
   PUBMED   1319925
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
  TITLE     Extracellular signal-regulated kinases in T cells: characterization
            of human ERK1 and ERK2 cDNAs
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1416-1422 (1992)
   PUBMED   1540184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017832.1 and BQ774391.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 29, 2014 this sequence version replaced NM_138957.2.
            
            Summary: This gene encodes a member of the MAP kinase family. MAP
            kinases, also known as extracellular signal-regulated kinases
            (ERKs), act as an integration point for multiple biochemical
            signals, and are involved in a wide variety of cellular processes
            such as proliferation, differentiation, transcription regulation
            and development. The activation of this kinase requires its
            phosphorylation by upstream kinases. Upon activation, this kinase
            translocates to the nucleus of the stimulated cells, where it
            phosphorylates nuclear targets. One study also suggests that this
            protein acts as a transcriptional repressor independent of its
            kinase activity. The encoded protein has been identified as a
            moonlighting protein based on its ability to perform
            mechanistically distinct functions. Two alternatively spliced
            transcript variants encoding the same protein, but differing in the
            UTRs, have been reported for this gene. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (2) contains a different 3' UTR
            region, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017832.1, SRR1163658.9884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 19879846
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1487              BC017832.1         1-1487
            1488-1514           BQ774391.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..1514
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="mitogen-activated protein kinase 1"
                     /db_xref="GeneID:5594"
                     /db_xref="HGNC:HGNC:6871"
                     /db_xref="MIM:176948"
     exon            1..359
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1323
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /EC_number="2.7.11.24"
                     /note="protein tyrosine kinase ERK2; extracellular
                     signal-regulated kinase 2; mitogen-activated protein
                     kinase 2; MAPK 2; MAP kinase 1; MAP kinase 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 1"
                     /protein_id="NP_620407.1"
                     /db_xref="CCDS:CCDS13795.1"
                     /db_xref="GeneID:5594"
                     /db_xref="HGNC:HGNC:6871"
                     /db_xref="MIM:176948"
                     /translation="MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYD
                     NVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVY
                     IVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT
                     CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
                     AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWN
                     RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDME
                     LDDLPKEKLKELIFEETARFQPGYRS"
     exon            360..542
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..732
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..849
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..964
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1096
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1206
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1497
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="hexamer: ATTAAA"
     polyA_site      1491
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="major polyA site"
ORIGIN      
        1 gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg
       61 gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt
      121 cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga
      181 gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac
      241 atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac
      301 gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc
      361 tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag
      421 caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat
      481 gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat
      541 gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac
      601 ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc
      661 cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc
      721 tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac
      781 acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg
      841 aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa
      901 atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt
      961 ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct
     1021 aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca
     1081 aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag
     1141 aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt
     1201 gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag
     1261 gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct
     1321 taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt
     1381 ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct
     1441 tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa
     1501 aaaaaaaaaa aaaa
//
