LOCUS       NM_002745               5881 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript
            variant 1, mRNA.
ACCESSION   NM_002745
VERSION     NM_002745.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5881)
  AUTHORS   Vangipurapu,R., Oliva,J., Fox,A. and Sverdrup,F.M.
  TITLE     Temporal variation in p38-mediated regulation of DUX4 in
            facioscapulohumeral muscular dystrophy
  JOURNAL   Sci Rep 14 (1), 26437 (2024)
   PUBMED   39488616
  REMARK    GeneRIF: Temporal variation in p38-mediated regulation of DUX4 in
            facioscapulohumeral muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5881)
  AUTHORS   Zeng,J., Zhang,L., Huang,L., Yu,X., Han,L., Zheng,Y., Wang,T.,
            Zhang,N. and Yang,M.
  TITLE     MAZ promotes thyroid cancer progression by driving transcriptional
            reprogram and enhancing ERK1/2 activation
  JOURNAL   Cancer Lett 602, 217201 (2024)
   PUBMED   39197582
  REMARK    GeneRIF: MAZ promotes thyroid cancer progression by driving
            transcriptional reprogram and enhancing ERK1/2 activation.
REFERENCE   3  (bases 1 to 5881)
  AUTHORS   Cho,Y. and Kim,Y.K.
  TITLE     CARM1 phosphorylation at S595 by p38gamma MAPK drives ROS-mediated
            cellular senescence
  JOURNAL   Redox Biol 76, 103344 (2024)
   PUBMED   39265499
  REMARK    GeneRIF: CARM1 phosphorylation at S595 by p38gamma MAPK drives
            ROS-mediated cellular senescence.
REFERENCE   4  (bases 1 to 5881)
  AUTHORS   Song,C., Wang,G., Liu,M., Han,S., Dong,M., Peng,M., Wang,W.,
            Wang,Y., Xu,Y. and Liu,L.
  TITLE     Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic
            insight into IQGAP1 phosphorylation and pancreatic Cancer
            progression
  JOURNAL   J Transl Med 22 (1), 602 (2024)
   PUBMED   38943117
  REMARK    GeneRIF: Deciphering the SOX4/MAPK1 regulatory axis: a
            phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic
            Cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5881)
  AUTHORS   Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P.,
            Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H.
  TITLE     Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance
            via the PAK1-ERK1/2 axis in hepatocellular carcinoma
  JOURNAL   Int J Biol Sci 20 (9), 3269-3284 (2024)
   PUBMED   38993552
  REMARK    GeneRIF: Deubiquitination of CIB1 by USP14 promotes lenvatinib
            resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5881)
  AUTHORS   Hu,S., Xie,Z., Onishi,A., Yu,X., Jiang,L., Lin,J., Rho,H.S.,
            Woodard,C., Wang,H., Jeong,J.S., Long,S., He,X., Wade,H.,
            Blackshaw,S., Qian,J. and Zhu,H.
  TITLE     Profiling the human protein-DNA interactome reveals ERK2 as a
            transcriptional repressor of interferon signaling
  JOURNAL   Cell 139 (3), 610-622 (2009)
   PUBMED   19879846
  REMARK    GeneRIF: ERK2 acts as a transcriptional repressor for interferon
            gamma-induced genes.
REFERENCE   7  (bases 1 to 5881)
  AUTHORS   Goedert,M., Cohen,E.S., Jakes,R. and Cohen,P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 5881)
  AUTHORS   Rossomando,A.J., Wu,J., Michel,H., Shabanowitz,J., Hunt,D.F.,
            Weber,M.J. and Sturgill,T.W.
  TITLE     Identification of Tyr-185 as the site of tyrosine
            autophosphorylation of recombinant mitogen-activated protein kinase
            p42mapk
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5779-5783 (1992)
   PUBMED   1378617
REFERENCE   9  (bases 1 to 5881)
  AUTHORS   Gonzalez,F.A., Raden,D.L., Rigby,M.R. and Davis,R.J.
  TITLE     Heterogeneous expression of four MAP kinase isoforms in human
            tissues
  JOURNAL   FEBS Lett 304 (2-3), 170-178 (1992)
   PUBMED   1319925
REFERENCE   10 (bases 1 to 5881)
  AUTHORS   Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
  TITLE     Extracellular signal-regulated kinases in T cells: characterization
            of human ERK1 and ERK2 cDNAs
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1416-1422 (1992)
   PUBMED   1540184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017832.1, BC099905.1,
            AP000555.1, AP000554.1 and AP000553.1.
            
            On Nov 20, 2019 this sequence version replaced NM_002745.4.
            
            Summary: This gene encodes a member of the MAP kinase family. MAP
            kinases, also known as extracellular signal-regulated kinases
            (ERKs), act as an integration point for multiple biochemical
            signals, and are involved in a wide variety of cellular processes
            such as proliferation, differentiation, transcription regulation
            and development. The activation of this kinase requires its
            phosphorylation by upstream kinases. Upon activation, this kinase
            translocates to the nucleus of the stimulated cells, where it
            phosphorylates nuclear targets. One study also suggests that this
            protein acts as a transcriptional repressor independent of its
            kinase activity. The encoded protein has been identified as a
            moonlighting protein based on its ability to perform
            mechanistically distinct functions. Two alternatively spliced
            transcript variants encoding the same protein, but differing in the
            UTRs, have been reported for this gene. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099905.1, SRR14038193.3108135.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000215832.11/
                                               ENSP00000215832.7
            multifunctional gene product(s) :: PMID: 19879846
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1297              BC017832.1         36-1332
            1298-3250           BC099905.1         1298-3250
            3251-3393           AP000555.1         587-729             c
            3394-4792           AP000554.1         358-1756            c
            4793-5881           AP000553.1         163858-164946       c
FEATURES             Location/Qualifiers
     source          1..5881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..5881
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="mitogen-activated protein kinase 1"
                     /db_xref="GeneID:5594"
                     /db_xref="HGNC:HGNC:6871"
                     /db_xref="MIM:176948"
     exon            1..324
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..507
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..697
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..814
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..929
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1061
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1171
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1297
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..5881
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="hexamer: AATAAA"
     polyA_site      2949
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="major polyA site"
     regulatory      5189..5194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="hexamer: ATTAAA"
     polyA_site      5216
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="major polyA site"
     polyA_site      5245
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
     polyA_site      5273
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
     regulatory      5859..5864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="hexamer: AGTAAA"
     polyA_site      5881
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38;
                     p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
ORIGIN      
        1 agtctggcag gcaggcaggc aatcggtccg agtggctgtc ggctcttcag ctctcccgct
       61 cggcgtcttc cttcctcctc ccggtcagcg tcggcggctg caccggcggc ggcgcagtcc
      121 ctgcgggagg ggcgacaaga gctgagcggc ggccgccgag cgtcgagctc agcgcggcgg
      181 aggcggcggc ggcccggcag ccaacatggc ggcggcggcg gcggcgggcg cgggcccgga
      241 gatggtccgc gggcaggtgt tcgacgtggg gccgcgctac accaacctct cgtacatcgg
      301 cgagggcgcc tacggcatgg tgtgctctgc ttatgataat gtcaacaaag ttcgagtagc
      361 tatcaagaaa atcagcccct ttgagcacca gacctactgc cagagaaccc tgagggagat
      421 aaaaatctta ctgcgcttca gacatgagaa catcattgga atcaatgaca ttattcgagc
      481 accaaccatc gagcaaatga aagatgtata tatagtacag gacctcatgg aaacagatct
      541 ttacaagctc ttgaagacac aacacctcag caatgaccat atctgctatt ttctctacca
      601 gatcctcaga gggttaaaat atatccattc agctaacgtt ctgcaccgtg acctcaagcc
      661 ttccaacctg ctgctcaaca ccacctgtga tctcaagatc tgtgactttg gcctggcccg
      721 tgttgcagat ccagaccatg atcacacagg gttcctgaca gaatatgtgg ccacacgttg
      781 gtacagggct ccagaaatta tgttgaattc caagggctac accaagtcca ttgatatttg
      841 gtctgtaggc tgcattctgg cagaaatgct ttctaacagg cccatctttc cagggaagca
      901 ttatcttgac cagctgaacc acattttggg tattcttgga tccccatcac aagaagacct
      961 gaattgtata ataaatttaa aagctaggaa ctatttgctt tctcttccac acaaaaataa
     1021 ggtgccatgg aacaggctgt tcccaaatgc tgactccaaa gctctggact tattggacaa
     1081 aatgttgaca ttcaacccac acaagaggat tgaagtagaa caggctctgg cccacccata
     1141 tctggagcag tattacgacc cgagtgacga gcccatcgcc gaagcaccat tcaagttcga
     1201 catggaattg gatgacttgc ctaaggaaaa gctcaaagaa ctaatttttg aagagactgc
     1261 tagattccag ccaggataca gatcttaaat ttgtcaggac aagggctcag aggactggac
     1321 gtgctcagac atcggtgttc ttcttcccag ttcttgaccc ctggtcctgt ctccagcccg
     1381 tcttggctta tccactttga ctcctttgag ccgtttggag gggcggtttc tggtagttgt
     1441 ggcttttatg ctttcaaaga atttcttcag tccagagaat tcctcctggc agccctgtgt
     1501 gtgtcaccca ttggtgacct gcggcagtat gtacttcagt gcacctactg cttactgttg
     1561 ctttagtcac taattgcttt ctggtttgaa agatgcagtg gttcctccct ctcctgaatc
     1621 cttttctaca tgatgccctg ctgaccatgc agccgcacca gagagagatt cttccccaat
     1681 tggctctagt cactggcatc tcactttatg atagggaagg ctactaccta gggcacttta
     1741 agtcagtgac agccccttat ttgcacttca ccttttgacc ataactgttt ccccagagca
     1801 ggagcttgtg gaaatacctt ggctgatgtt gcagcctgca gcaagtgctt ccgtctccgg
     1861 aatccttggg gagcacttgt ccacgtcttt tctcatatca tggtagtcac taacatatat
     1921 aaggtatgtg ctattggccc agcttttaga aaatgcagtc atttttctaa ataaaaagga
     1981 agtactgcac ccagcagtgt cactctgtag ttactgtggt cacttgtacc atatagaggt
     2041 gtaacacttg tcaagaagcg ttatgtgcag tacttaatgt ttgtaagact tacaaaaaaa
     2101 gatttaaagt ggcagcttca ctcgacattt ggtgagagaa gtacaaaggt tgcagtgctg
     2161 agctgtgggc ggtttctggg gatgtcccag ggtggaactc cacatgctgg tgcatatacg
     2221 cccttgagct acttcaaatg tgggtgtttc agtaaccacg ttccatgcct gaggatttag
     2281 cagagaggaa cactgcgtct ttaaatgaga aagtatacaa ttctttttcc ttctacagca
     2341 tgtcagcatc tcaagttcat ttttcaacct acagtataac aatttgtaat aaagcctcca
     2401 ggagctcatg acgtgaagca ctgttctgtc ctcaagtact caaatatttc tgatactgct
     2461 gagtcagact gtcagaaaaa gctagcacta actcgtgttt ggagctctat ccatatttta
     2521 ctgatctctt taagtatttg ttcctgccac tgtgtactgt ggagttgact cggtgttctg
     2581 tcccagtgcg gtgcctcctc ttgacttccc cactgctctc tgtggtgaga aatttgcctt
     2641 gttcaataat tactgtaccc tcgcatgact gttacagctt tctgtgcaga gatgactgtc
     2701 caagtgccac atgcctacga ttgaaatgaa aactctattg ttacctctga gttgtgttcc
     2761 acggaaaatg ctatccagca gatcatttag gaaaaataat tctattttta gcttttcatt
     2821 tctcagctgt ccttttttct tgtttgattt ttgacagcaa tggagaatgg gttatataaa
     2881 gactgcctgc taatatgaac agaaatgcat ttgtaattca tgaaaataaa tgtacatctt
     2941 ctatcttcac attcatgtta agattcagtg ttgctttcct ctggatcagc gtgtctgaat
     3001 ggacagtcag gttcaggttg tgctgaacac agaaatgctc acaggcctca ctttgccgcc
     3061 caggcactgg cccagcactt ggatttacat aagatgagtt agaaaggtac ttctgtaggg
     3121 tcctttttac ctctgctcgg cagagaatcg atgctgtcat gttcctttat tcacaatctt
     3181 aggtctcaaa tattctgtca aaccctaaca aagaagcccc gacatctcag gttggattcc
     3241 ctggttctct ctaaagaggg cctgcccttg tgccccagag gtgctgctgg gcacagccaa
     3301 gagttgggaa gggccgcccc acagtacgca gtcctcacca cccagcccag ggtgctcacg
     3361 ctcaccactc ctgtggctga ggaaggatag ctggctcatc ctcggaaaac agacccacat
     3421 ctctattctt gccctgaaat acgcgctttt cacttgcgtg ctcagagctg ccgtctgaag
     3481 gtccacacag cattgacggg acacagaaat gtgactgtta ccggataaca ctgattagtc
     3541 agttttcatt tataaaaaag cattgacagt tttattactc ttgtttcttt ttaaatggaa
     3601 agttactatt ataaggttaa tttggagtcc tcttctaaat agaaaaccat atccttggct
     3661 actaacatct ggagactgtg agctccttcc cattcccctt cctggtactg tggagtcaga
     3721 ttggcatgaa accactaact tcattctaga atcattgtag ccataagttg tgtgcttttt
     3781 attaatcatg ccaaacataa tgtaactggg cagagaatgg tcctaaccaa ggtacctatg
     3841 aaaagcgcta gctatcatgt gtagtagatg catcattttg gctcttctta catttgtaaa
     3901 aatgtacaga ttaggtcatc ttaattcata ttagtgacac ggaacagcac ctccactatt
     3961 tgtatgttca aataagcttt cagactaata gcttttttgg tgtctaaaat gtaagcaaaa
     4021 aattcctgct gaaacattcc agtcctttca tttagtataa aagaaatact gaacaagcca
     4081 gtgggatgga attgaaagaa ctaatcatga ggactctgtc ctgacacagg tcctcaaagc
     4141 tagcagagat acgcagacat tgtggcatct gggtagaaga atactgtatt gtgtgtgcag
     4201 tgcacagtgt gtggtgtgtg cacactcatt ccttctgctc ttgggcacag gcagtgggtg
     4261 tagaggtaac cagtagcttt gagaagctac atgtagctca ccagtggttt tctctaagga
     4321 atcacaaaag taaactaccc aaccacatgc cacgtaatat ttcagccatt cagaggaaac
     4381 tgttttctct ttatttgctt atatgttaat atggttttta aattggtaac ttttatatag
     4441 tatggtaaca gtatgttaat acacacatac atacgcacac atgctttggg tccttccata
     4501 atacttttat atttgtaaat caatgttttg gagcaatccc aagtttaagg gaaatatttt
     4561 tgtaaatgta atggttttga aaatctgagc aatccttttg cttatacatt tttaaagcat
     4621 ttgtgcttta aaattgttat gctggtgttt gaaacatgat actcctgtgg tgcagatgag
     4681 aagctataac agtgaatatg tggtttctct tacgtcatcc accttgacat gatgggtcag
     4741 aaacaaatgg aaatccagag caagtcctcc agggttgcac caggtttacc taaagcttgt
     4801 tgccttttct tgtgctgttt atgcgtgtag agcactcaag aaagttctga aactgctttg
     4861 tatctgcttt gtactgttgg tgccttcttg gtattgtacc ccaaaattct gcatagatta
     4921 tttagtataa tggtaagtta aaaaatgtta aaggaagatt ttattaagaa tctgaatgtt
     4981 tattcattat attgttacaa tttaacatta acatttattt gtggtatttg tgatttggtt
     5041 aatctgtata aaaattgtaa gtagaaaggt ttatatttca tcttaattct tttgatgttg
     5101 taaacgtact ttttaaaaga tggattattt gaatgtttat ggcacctgac ttgtaaaaaa
     5161 aaaaaactac aaaaaaatcc ttagaatcat taaattgtgt ccctgtatta ccaaaataac
     5221 acagcaccgt gcatgtatag tttaattgca gtttcatctg tgaaaacgtg aaattgtcta
     5281 gtccttcgtt atgttcccca gatgtcttcc agatttgctc tgcatgtggt aacttgtgtt
     5341 agggctgtga gctgttcctc gagttgaatg gggatgtcag tgctcctagg gttctccagg
     5401 tggttcttca gaccttcacc tgtggggggg ggggtaggcg gtgcccacgc ccatctcctc
     5461 atcctcctga acttctgcaa ccccactgct gggcagacat cctgggcaac cccttttttc
     5521 agagcaagaa gtcataaaga taggatttct tggacatttg gttcttatca atattgggca
     5581 ttatgtaatg acttatttac aaaacaaaga tactggaaaa tgttttggat gtggtgttat
     5641 ggaaagagca caggccttgg acccatccag ctgggttcag aactaccccc tgcttataac
     5701 tgcggctggc tgtgggccag tcattctgcg tctctgcttt cttcctctgc ttcagactgt
     5761 cagctgtaaa gtggaagcaa tattacttgc cttgtatatg gtaaagatta taaaaataca
     5821 tttcaactgt tcagcatagt acttcaaagc aagtactcag taaatagcaa gtctttttaa
     5881 a
//
