LOCUS       NM_001324366            4268 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens N6-Methyl-AMP deaminase (MAPDA), transcript variant 5,
            mRNA.
ACCESSION   NM_001324366 XM_005254204
VERSION     NM_001324366.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4268)
  AUTHORS   Lee,I.H. and Kong,S.W.
  TITLE     ADGR: Admixture-Informed Differential Gene Regulation
  JOURNAL   Genes (Basel) 14 (1), 147 (2023)
   PUBMED   36672888
  REMARK    GeneRIF: ADGR: Admixture-Informed Differential Gene Regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4268)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4268)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4268)
  AUTHORS   Frey,C.R., Andrei,G., Votruba,I., Cannizzaro,C., Han,B., Fung,W.,
            Hung,M., Liu,X., Geleziunas,R., Fiten,P., Opdenakker,G., Snoeck,R.
            and Cihlar,T.
  TITLE     Mutations in adenosine deaminase-like (ADAL) protein confer
            resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP
            and GS-9219
  JOURNAL   Anticancer Res 33 (5), 1899-1912 (2013)
   PUBMED   23645737
  REMARK    GeneRIF: Mutations in adenosine deaminase-like (ADAL) protein
            confer drug resistance in Uterine Cervical Neoplasms.
REFERENCE   5  (bases 1 to 4268)
  AUTHORS   Murakami,E., Bao,H., Mosley,R.T., Du,J., Sofia,M.J. and Furman,P.A.
  TITLE     Adenosine deaminase-like protein 1 (ADAL1): characterization and
            substrate specificity in the hydrolysis of N(6)- or
            O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
  JOURNAL   J Med Chem 54 (16), 5902-5914 (2011)
   PUBMED   21755941
  REMARK    GeneRIF: Data indicated that ADAL1 specifically acts at the
            6-position of purine and 2-aminopurine nucleoside monophosphates.
REFERENCE   6  (bases 1 to 4268)
  AUTHORS   Maier,S.A., Galellis,J.R. and McDermid,H.E.
  TITLE     Phylogenetic analysis reveals a novel protein family closely
            related to adenosine deaminase
  JOURNAL   J Mol Evol 61 (6), 776-794 (2005)
   PUBMED   16245011
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009852.9 and AC018924.9.
            
            On Jun 2, 2019 this sequence version replaced NM_001324366.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.185594.1,
                                           SRR1803611.189916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000562188.7/ ENSP00000456242.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC009852.9         164464-164651
            189-289             AC009852.9         165692-165792
            290-413             AC009852.9         167103-167226
            414-639             AC009852.9         168737-168962
            640-770             AC009852.9         169488-169618
            771-831             AC009852.9         170418-170478
            832-919             AC009852.9         174057-174144
            920-1001            AC009852.9         176786-176867
            1002-1128           AC018924.9         16187-16313
            1129-1209           AC018924.9         17349-17429
            1210-1348           AC018924.9         19240-19378
            1349-1449           AC018924.9         21274-21374
            1450-4268           AC018924.9         22084-24902
FEATURES             Location/Qualifiers
     source          1..4268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..4268
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="N6-Methyl-AMP deaminase"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
     exon            1..188
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            189..289
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            290..413
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            414..639
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1644
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /EC_number="3.5.4.-"
                     /note="isoform 3 is encoded by transcript variant 5;
                     adenosine deaminase-like protein; N6-mAMP deaminase;
                     N6-methyl-AMP aminohydrolase; adenosine deaminase like"
                     /codon_start=1
                     /product="N6-Methyl-AMP deaminase isoform 3"
                     /protein_id="NP_001311295.1"
                     /db_xref="CCDS:CCDS81868.1"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
                     /translation="MIEAEEQQPCKTDFYSELPKVELHAHLNGSISSHTMKKLIAQKP
                     DLKIHDQMTVIDKGKKRTLEECFQMFQTIHQLTSSPEDILMVTKDVIKEFADDGVKYL
                     ELRSTPRRENATGMTKKTYVESILEGIKQSKQENLDIDVRYLIAVDRRGGPLVAKETV
                     KLAEEFFLSTEGTVLGLDLSGDPTVGQAKDFLEPLLEAKKAGLKLALHLSEIPNQKKE
                     TQILLDLLPDRIGHGTFLNSGEGGSLDLVDFVRQHRIPLELCLTSNVKSQTVPSYDQH
                     HFGFWYSIAHPSVICTDDKGVFATHLSQEYQLAAETFNLTQSQVWDLSYESINYIFAS
                     DSTRSELRKKWNHLKPRVLHI"
     exon            640..770
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            771..831
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            832..919
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1001
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1128
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1209
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1348
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1449
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..4268
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1865..1870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="hexamer: ATTAAA"
     polyA_site      1888
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="hexamer: AATAAA"
     polyA_site      3597
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="major polyA site"
     regulatory      4080..4085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="hexamer: AGTAAA"
     polyA_site      4108
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
     regulatory      4175..4180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="hexamer: AATATA"
     regulatory      4184..4189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /note="hexamer: AATGAA"
     polyA_site      4199
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
     polyA_site      4203
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
ORIGIN      
        1 gtagccagtg ctaagttcgc ttgcggctga cctttctttg gaatgtcgtg agttccattt
       61 gtcccagaat acggtccgct accgctgtga catgagtgtt agggaaggcg ggttgtcacg
      121 tttctacaag ccttccagtc aaaagggaaa ccttgcctaa gtccttgtag ttgagaaatc
      181 tctaagaggt ggaagcaaat actgcacatg cgtgttggtc ctgtgaggga aaccagctag
      241 tggagaggga gaggttgaag gaacagaaaa atgagaagac aactcactgg aggctgaagt
      301 gggaggatcg cttgagtctg gaagcttgag actgcagcaa gctgtgatcg tgacactgca
      361 ctccagcctg ggcaacaaag taagatcctg tctcaaaaga aaaaaaaaaa aaggtgaagc
      421 tgaacccaga tctacacata cagctaatct taccaaaatg tgtggaagta aagcaatctg
      481 aaggaaattc agtaccatac aatttactga ctgaaataca tcatattgct catactaaga
      541 ataagagtgg agaagaatca tttttttcct gctaaaatga tagaggcaga agagcaacag
      601 ccttgcaaga cagacttcta ttctgaattg ccaaaagtgg aacttcatgc ccacttgaat
      661 ggatccatta gttctcatac catgaagaaa ttaatagccc agaagccaga tcttaaaatc
      721 cacgatcaga tgactgtgat tgacaaggga aagaaaagaa ctttggaaga atgtttccag
      781 atgtttcaaa ctattcatca gcttactagt agccctgaag atattctaat ggtcacaaaa
      841 gatgtcataa aagaatttgc agatgacggc gtcaagtacc tggaactaag gagcacaccc
      901 agaagagaaa atgctactgg aatgactaaa aagacttatg tggaatctat acttgaaggt
      961 ataaaacagt ccaaacaaga aaacttggac attgatgtta ggtatttgat agcagttgac
     1021 agaagaggtg gccctttagt agccaaggag actgtaaaac ttgccgagga gttcttcctt
     1081 tctactgagg gtacagttct tggccttgac ctcagtggag accctactgt aggacaagca
     1141 aaagacttct tggaacctct tttagaagct aagaaagcag gtctgaagtt agcattgcat
     1201 ctttcagaga ttccaaacca aaaaaaagaa acacaaatac tcctggatct gcttcctgac
     1261 agaatcgggc atggaacatt tctcaactcc ggtgagggag gatccctgga tctggtggac
     1321 tttgtgaggc aacatcggat accactggaa ctctgtttga cctcaaacgt caaaagtcag
     1381 acagttccat cttatgacca gcaccatttc ggattctggt acagcattgc ccatccttct
     1441 gtgatctgta ctgatgataa gggtgttttt gcaacacacc tttctcaaga gtaccagctg
     1501 gcagctgaaa catttaattt gacccagtct caggtgtggg atctgtctta tgaatccatc
     1561 aactacatct ttgcttctga cagcaccaga tctgaactga ggaagaaatg gaatcacctg
     1621 aagcccagag tgttacatat ttaagctata atgaggtgaa ctacttctga gtatgtgttt
     1681 caatcaagtt cctgccatat cccacttagt aaaacagtcc accactcctt tgaagcatag
     1741 caaccaagtt ccttgggctc tatcaccagc accttacaca tggcaggtac tcagtaaata
     1801 cgtgtcttca actgactcac aagctctcag gtgcttactg ggtgggactt gactgttgtt
     1861 gctaattaaa tccccattcc accagtgatt attgtgactc agcagtcctt ccctattagt
     1921 gatcataaaa tttcagggaa atcgaagttt ctcatcagga aatgttttgg aattactagt
     1981 ataaagttag gaaagtgggg aaattaggtt actgccgaga cctttaagcc ttctaaacag
     2041 ctttatattt tattgtgcat actttaatca gactcccttc actcgcttta agtttttaaa
     2101 agtattcccc agccggatgt gatggctcat gcctgtaatc ccagcacttt gggaagccaa
     2161 agtgggcaga ttgcttgatc ctaggagttc agtagcagcc taggcaacat ggagaaaccc
     2221 tgtctctaca aaaacaaaaa aacaaaaaac cggaaattag tcaggcacgg tggtacacac
     2281 ctgtagtccc agccaccagg gaggctaagg tgggaggaga cctgatccca gggatgtttg
     2341 aggctgcagt gagctgtgat gctacagcac tccagcctgg gcaacagagt gaaaccctgt
     2401 ttcaagaaaa agaaaagtat tctccaagat cccaagacca ttgacaccag gccacattgt
     2461 ataccaggga tttatgtgaa tgcctaggga tgaccgtagt gacagataaa gctaggtgct
     2521 gagatctggt tttgccctct ttatgattgt cccatcggta ctagaaagtg aagtcattgc
     2581 tccaattttg gaagaggaga gaataactgg ctgaggggtg agaaagacag aaatagctgc
     2641 agctctcttt tttttttttt tcaacaaagg ctctcactct gttccccagg ctggagtgca
     2701 gtgacatgat cacagatcac tgcagctttc agttttaaaa cagcttttat tacattttct
     2761 ttgtggaagc tgtatttcta ccttagtact cactttctgc ttggtctgaa agatacctct
     2821 agtagtggca acattgtgtt aagtagagtt cattgggtct cttgtaaccc tacccctaca
     2881 taatggacca ctggtgcagg cttacataaa cacacatact gtggccactt cagctgaaga
     2941 caagggacaa actaagatag ttctgaaagg taaaaaaaca aacaaacaaa caaaaaacaa
     3001 aaacaaaatt attagatacc aagttatgct tgaattgctt tgctctttag aatgtgtgtt
     3061 tttccctggt atcagaagaa gttaaggctg atgacacccc taatttaaat tactaaggat
     3121 ttctgatagg ttttctgtct ttctgtgata tcgtaaagta tttatttggt ctttgaccct
     3181 gtttcctggc atactgctcc taaaatcctt agagtctcca gagtgatggc tttttgtatc
     3241 taatgagttg actgctggct ggcagcccct aggggctggt cactggaaag acaaatgcat
     3301 gattagagtt gggactttca gtcctccccc aaactcttgg gagaagggct gaaggttaag
     3361 ttgatcacca gtgaccagtg gtaatcatac cttcataatg aagcctccat aaaactccag
     3421 aagaacagat tttggagcat ttccaggtaa ctgaacatat ggaggtccct agagggtgct
     3481 gtacctgaag agggtagagg gtataggagc tccctgtccc ttcccacatg ccttgctcta
     3541 tccatttctt catctctatc ctttgtactg tcctttataa taaaccagtg aacctaagtg
     3601 tttccctgag ttctgtgagc tttactagca aattaaactc aaggaggggt catgggaacc
     3661 ctgatttata ggtttggtca gaagcacagg taaaaccacc tggggtttga acttggcact
     3721 ggaagtgggc agcagtcttg tgggactggg ccctcaatct gtgggatcaa atgccatctc
     3781 taggggatag catgggaaac tggaggacac ctagctggta tctgctgcaa aattgattgc
     3841 ttgcttgatg gtggggaaaa aactccacac atttggtcag agaagttttc tgtctttatt
     3901 gtggtgtgag agcagaggaa aaaagtttgt tttttccgct cagactttgt tttaaggaac
     3961 aggggagagg gaagttctgt ggtttttgaa gttcttagat acgtgtgtgt agctttgtgt
     4021 ggcattatat atagcattat attattttct acccttatct actcatacag aaattgcaca
     4081 gtaaaaacat caaagtttat tcataaaatg tggatctatt gcagtcacta aaaatgttgc
     4141 agaacagatt ttaatgactg aaagtgttca tgataatata ttcaatgaaa atatggttat
     4201 aaagttttat agtccttttt ttgtttaata tctatacaaa agctattgaa gtgtatgatt
     4261 ttaattta
//
