LOCUS       NM_001039580            7328 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens microtubule associated protein 9 (MAP9), mRNA.
ACCESSION   NM_001039580
VERSION     NM_001039580.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7328)
  AUTHORS   Tran,M.V., Khuntsariya,D., Fetter,R.D., Ferguson,J.W., Wang,J.T.,
            Long,A.F., Cote,L.E., Wellard,S.R., Vazquez-Martinez,N.,
            Sallee,M.D., Genova,M., Magiera,M.M., Eskinazi,S., Lee,J.D.,
            Peel,N., Janke,C., Stearns,T., Shen,K., Lansky,Z., Magescas,J. and
            Feldman,J.L.
  TITLE     MAP9/MAPH-9 supports axonemal microtubule doublets and modulates
            motor movement
  JOURNAL   Dev Cell 59 (2), 199-210 (2024)
   PUBMED   38159567
  REMARK    GeneRIF: MAP9/MAPH-9 supports axonemal microtubule doublets and
            modulates motor movement.
REFERENCE   2  (bases 1 to 7328)
  AUTHORS   Xiao,H., Sun,J., Huang,W., Liu,W., Zhang,Y., Wang,H. and Luo,B.
  TITLE     Expression of MAP9 in Epstein-Barr virus-associated gastric
            carcinoma
  JOURNAL   Virus Res 293, 198253 (2021)
   PUBMED   33309912
  REMARK    GeneRIF: Expression of MAP9 in Epstein-Barr virus-associated
            gastric carcinoma.
REFERENCE   3  (bases 1 to 7328)
  AUTHORS   Mok,E.H.K., Leung,C.O.N. and Lee,T.K.W.
  TITLE     MAP9/ERCC3 signaling cascade: A new insight on understanding the
            chromosomal instability in hepatocellular carcinoma
  JOURNAL   EBioMedicine 54, 102709 (2020)
   PUBMED   32268270
  REMARK    GeneRIF: MAP9/ERCC3 signaling cascade: A new insight on
            understanding the chromosomal instability in hepatocellular
            carcinoma.
REFERENCE   4  (bases 1 to 7328)
  AUTHORS   Zhang,J., Huang,J.Z., Zhang,Y.Q., Zhang,X., Zhao,L.Y., Li,C.G.,
            Zhou,Y.F., Wei,H. and Yu,J.
  TITLE     Microtubule associated protein 9 inhibits liver tumorigenesis by
            suppressing ERCC3
  JOURNAL   EBioMedicine 53, 102701 (2020)
   PUBMED   32151798
  REMARK    GeneRIF: Microtubule associated protein 9 inhibits liver
            tumorigenesis by suppressing ERCC3.
REFERENCE   5  (bases 1 to 7328)
  AUTHORS   Wang,S., Huang,J., Li,C., Zhao,L., Wong,C.C., Zhai,J., Zhou,Y.,
            Deng,W., Zeng,Y., Gao,S., Zhang,Y., Wang,G., Guan,X.Y., Wei,H.,
            Wong,S.H., He,H.H., Shay,J.W. and Yu,J.
  TITLE     MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal
            Tumorigenesis, and Is Associated with Poor Survival of Patients
            with Colorectal Cancer
  JOURNAL   Clin Cancer Res 26 (3), 746-757 (2020)
   PUBMED   31662330
  REMARK    GeneRIF: MAP9 Loss Triggers Chromosomal Instability, Initiates
            Colorectal Tumorigenesis, and Is Associated with Poor Survival of
            Patients with Colorectal Cancer.
REFERENCE   6  (bases 1 to 7328)
  AUTHORS   Rouquier,S., Pillaire,M.J., Cazaux,C. and Giorgi,D.
  TITLE     Expression of the microtubule-associated protein MAP9/ASAP and its
            partners AURKA and PLK1 in colorectal and breast cancers
  JOURNAL   Dis Markers 2014, 798170 (2014)
   PUBMED   24876664
  REMARK    GeneRIF: MAP9 downregulation is associated with colorectal
            malignancy.
REFERENCE   7  (bases 1 to 7328)
  AUTHORS   Basbous,J., Knani,D., Bonneaud,N., Giorgi,D., Brondello,J.M. and
            Rouquier,S.
  TITLE     Induction of ASAP (MAP9) contributes to p53 stabilization in
            response to DNA damage
  JOURNAL   Cell Cycle 11 (12), 2380-2390 (2012)
   PUBMED   22672907
  REMARK    GeneRIF: ASAP stabilizes p53 both by alleviating MDM2-mediated p53
            ubiquitination and by enhancing its p300-dependent acetylation.
REFERENCE   8  (bases 1 to 7328)
  AUTHORS   Eot-Houllier,G., Venoux,M., Vidal-Eychenie,S., Hoang,M.T.,
            Giorgi,D. and Rouquier,S.
  TITLE     Plk1 regulates both ASAP localization and its role in spindle pole
            integrity
  JOURNAL   J Biol Chem 285 (38), 29556-29568 (2010)
   PUBMED   20615875
  REMARK    GeneRIF: Results highlight dual ASAP regulation by Plk1 and further
            confirm the importance of ASAP for spindle pole organization,
            bipolar spindle assembly, and mitosis.
REFERENCE   9  (bases 1 to 7328)
  AUTHORS   Venoux,M., Basbous,J., Berthenet,C., Prigent,C., Fernandez,A.,
            Lamb,N.J. and Rouquier,S.
  TITLE     ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A:
            phosphorylation on Ser625 is essential to spindle formation and
            mitosis
  JOURNAL   Hum Mol Genet 17 (2), 215-224 (2008)
   PUBMED   17925329
  REMARK    GeneRIF: Study demonstrates that AurA-mediated phosphorylation of
            ASAP is essential to spindle formation and mitosis.
REFERENCE   10 (bases 1 to 7328)
  AUTHORS   Saffin,J.M., Venoux,M., Prigent,C., Espeut,J., Poulat,F.,
            Giorgi,D., Abrieu,A. and Rouquier,S.
  TITLE     ASAP, a human microtubule-associated protein required for bipolar
            spindle assembly and cytokinesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (32), 11302-11307 (2005)
   PUBMED   16049101
  REMARK    GeneRIF: ASAP is a human microtubule-associated protein required
            for bipolar spindle assembly and cytokinesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY690636.1, BC022852.1, CF144347.1 and AC097467.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001039580.1.
            
            Summary: ASAP is a microtubule-associated protein required for
            spindle function, mitotic progression, and cytokinesis (Saffin et
            al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146864.1, AY690636.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311277.9/ ENSP00000310593.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AY690636.1         6-792
            788-1558            BC022852.1         618-1388
            1559-1572           AY690636.1         1564-1577
            1573-1973           CF144347.1         15-415
            1974-1981           AY690636.1         1979-1986
            1982-2027           CF144347.1         424-469
            2028-2266           AY690636.1         2033-2271
            2267-7328           AC097467.1         109416-114477       c
FEATURES             Location/Qualifiers
     source          1..7328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..7328
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /note="microtubule associated protein 9"
                     /db_xref="GeneID:79884"
                     /db_xref="HGNC:HGNC:26118"
                     /db_xref="MIM:610070"
     exon            1..195
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            196..334
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2203
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /note="aster-associated protein"
                     /codon_start=1
                     /product="microtubule-associated protein 9"
                     /protein_id="NP_001034669.1"
                     /db_xref="CCDS:CCDS35493.1"
                     /db_xref="GeneID:79884"
                     /db_xref="HGNC:HGNC:26118"
                     /db_xref="MIM:610070"
                     /translation="MSDEVFSTTLAYTKSPKVTKRTTFQDELIRAITARSARQRSSEY
                     SDDFDSDEIVSLGDFSDTSADENSVNKKMNDFHISDDEEKNPSKLLFLKTNKSNGNIT
                     KDEPVCAIKNEEEMAPDGCEDIVVKSFSESQNKDEEFEKDKIKMKPKPRILSIKSTSS
                     AENNSLDTDDHFKPSPRPRSMLKKKSHMEEKDGLEDKETALSEELELHSAPSSLPTPN
                     GIQLEAEKKAFSENLDPEDSCLTSLASSSLKQILGDSFSPGSEGNASGKDPNEEITEN
                     HNSLKSDENKENSFSADHVTTAVEKSKESQVTADDLEEEKAKAELIMDDDRTVDPLLS
                     KSQSILISTSATASSKKTIEDRNIKNKKSTNNRASSASARLMTSEFLKKSSSKRRTPS
                     TTTSSHYLGTLKVLDQKPSQKQSIEPDRADNIRAAVYQEWLEKKNVYLHEMHRIKRIE
                     SENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAAR
                     KGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEK
                     KEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRH
                     SFLESEALPPWSPPSRTVFAKVF"
     exon            335..419
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            420..740
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            741..967
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1061
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1309
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1380
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1549
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1639
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1801
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1947
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2080
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..7328
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /note="hexamer: AATAAA"
     polyA_site      2565
                     /gene="MAP9"
                     /gene_synonym="ASAP"
     regulatory      7304..7309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /note="hexamer: AATAAA"
     polyA_site      7328
                     /gene="MAP9"
                     /gene_synonym="ASAP"
                     /note="major polyA site"
ORIGIN      
        1 cttcgtctgg gtggttgccc cagcgacacg ttgggccgaa gagcggtgtt gggtacccga
       61 gagacccggc ggtggggaag tcacttcctc ccgaagacgc tgtttcctag caaccgccct
      121 ccgcctctgt tattagcccc tcctcctcgc tcggtccagg accggctctg cgggcgccgc
      181 caggcccaga ccaagctact atcagaagtt gaattctaat aattagctat tttataaagg
      241 taacgagaaa aaatacacta tgtctgatga agtttttagc accactttgg catatacaaa
      301 gagtccaaaa gttaccaaaa gaactacttt ccaggatgag ctaataagag caattacagc
      361 tcgctcagcc agacaaagga gttctgaata ctcagatgac tttgacagtg atgagattgt
      421 ttctttaggt gatttttctg acacttcagc agatgaaaat tcagttaata aaaaaatgaa
      481 tgactttcat atatcagatg atgaagaaaa gaatccttca aaactattgt ttttgaaaac
      541 caataaatca aacggtaaca taaccaaaga tgagccagtg tgtgccatca aaaatgaaga
      601 ggaaatggca cctgatgggt gtgaagacat tgttgtaaaa tctttctctg aatctcaaaa
      661 taaggatgag gaatttgaaa aagacaaaat aaaaatgaaa cctaaaccca gaattctttc
      721 aattaaaagc acatcttcag cagaaaacaa cagccttgac acagatgatc actttaaacc
      781 atcacctcgg ccaaggagta tgttgaaaaa gaaaagtcac atggaggaga aggatggact
      841 agaagataaa gaaactgccc tcagtgaaga attggagtta cattctgcac cttcttccct
      901 tccaacgccg aatggcatac aattagaagc tgagaaaaaa gcattctctg aaaaccttga
      961 tcctgaggat tcatgcttaa caagtctagc atcatcatca cttaaacaaa ttcttggaga
     1021 ttctttttca ccaggatctg agggaaacgc atctggaaaa gatccaaatg aagaaatcac
     1081 tgaaaaccat aattccttga aatcagatga aaataaagag aattcatttt cagcagacca
     1141 tgtgactact gcagttgaga aatccaagga aagtcaagtg actgctgatg accttgaaga
     1201 agaaaaggca aaagcggaac tgattatgga tgatgacaga acagttgatc cactactatc
     1261 taaatctcag agtatcttaa tatctaccag tgcaacagca tcttcaaaga aaacaattga
     1321 agatagaaat ataaagaata aaaagtcaac aaataataga gcatccagtg catctgccag
     1381 attaatgacc tctgagtttt tgaagaaatc tagttctaaa aggagaactc catcgacaac
     1441 tacctcttct cactatttag ggactttaaa agtcttggac caaaaacctt cacagaaaca
     1501 gagcatagaa cctgatagag cagataacat aagggcagct gtttatcagg agtggttaga
     1561 aaagaaaaat gtgtatttac atgaaatgca cagaataaaa agaattgaaa gtgaaaactt
     1621 aaggatccaa aatgaacaga aaaaagctgc taaaagagaa gaagcattag catcatttga
     1681 ggcctggaag gctatgaaag aaaaggaagc aaagaaaata gctgccaaaa agaggcttga
     1741 agaaaaaaac aagaagaaaa ctgaagaaga aaatgctgca agaaaaggag aagcactaca
     1801 agcttttgaa aaatggaaag agaaaaagat ggaatatctt aaagagaaaa atagaaagga
     1861 gagagaatat gaaagagcaa agaaacagaa agaggaggaa actgttgccg agaaaaagaa
     1921 agataattta actgctgttg agaaatggaa tgaaaaaaag gaagcttttt tcaagcaaaa
     1981 ggaaaaagaa aaaataaatg agaaaagaaa ggaagaactg aaaagagctg agaaaaaaga
     2041 taaagataaa caagctatta atgaatatga aaaatggctg gaaaataagg aaaaacaaga
     2101 aagaattgaa cgaaaacaga agaaacgtca ttcctttctt gaaagtgagg cacttcctcc
     2161 gtggagccct ccaagcagaa ctgtgttcgc aaaagtgttt tgataattct agttcttaca
     2221 ttatttggtt atttatcggt ttgccaatat tagccataga tttaaaacca ttcaattatt
     2281 tatagttaga ggaatatatt ttaattaaat gccagacact cctgctgaca atgaaagaaa
     2341 tactttggaa tgtaatcagt gaaagcattt ttttgaactg tagataaact gcctcaaaca
     2401 aagacctaat aatcagattg tttttaccat taagatacat aagattttat catgtcctga
     2461 taattcttat ggtggagtga ttcatgatct ttttcattaa gctctgtatg ttatttaagt
     2521 atatttaatt ccagtaataa aaaggaaatc atctaggtac cataatgata gaaattattc
     2581 cttttgtgga tgattgtgaa tctagattca ggtttttaaa tgaagggtcg ctgggaagtg
     2641 cgcatatatt attccttctg aaactgatgt ttagctcaaa gcagttgcat ttgtactgtg
     2701 ctagttagaa ttttcatcag ttgaggcagt agctcagtag aactctaatc atcaaggctt
     2761 tttatttaag aattttgcct tatgttttaa tatgagtgta ctttatctgt tccaggctta
     2821 tgtgataatc ataggtactt tataatgagt ccacctctga aatttttctt tctgaattct
     2881 atctcacttt attatttcag tgataccaaa agacatcaat gtcacagtag tgatatactt
     2941 atgtattagt tatggaaatt ccacaggagt tcaaggtcat tatcactata attattttcc
     3001 tgactaaagc cataaaggtg atttaggcaa ttattgtcat cttagctagt cctgttttat
     3061 agcttatatt cagcagacag ctgtatggga aggtaaatat gttgacaatg tccacaaagc
     3121 ctttatttat ttatttattt gatctctgca tgtcctcgta gtaactggtc tcatacttga
     3181 cctggtcatc tggtttaaga cagaccaagt gtatgctcac ggagctgaaa tgcattagtc
     3241 agttgtgcaa tgaggagatg atggatgaga atatatagtt cctatttatt gagcatctaa
     3301 tatataatct ctactggacc tttacaaatg tatttaacat ctttacaaca acttttcagg
     3361 gtaggtgtta ccggcttcat cttacatata aaaatactgg cgctcagata aaccaagtaa
     3421 cttaccgtcc atctggagtg tgcctgagtt gagatcaaac gggattcagt acgtctgact
     3481 gaatctgcct ccttctgaaa tctctatgct ctttttcaca cttctctgta gcctcagaga
     3541 ctgccaagtt ctgtcaagac ctctgcataa tatcaacgtt acaaacacgt tttaactttt
     3601 agagcctaaa atcatgtatt gttatccaaa gatgatcttt ctctacagaa atagctgctt
     3661 gttcttagag atggtggagg tcattaaatc tataaagtga gataaaaatc cataagattt
     3721 catgagttac tcaggcatct tataactact atcagaatat cagaaaactc agcaagttat
     3781 gtgacaaagg ctttgagatg atcactccag acgttccaca tactgagcat cagccttctt
     3841 gctgcagtgc atgtgcaaga taagatgtca taggcagctt tgtaagattg tatcagtgct
     3901 atagacaatt aagagaaatt tcatagataa aactagaacc ctttctatat ggccagaact
     3961 gtaatacttt atgaaattga tctgattatc agcaatatgt agtatcagca tggaatttag
     4021 gacctctctt actcattcct gtgtccccca tagtaccaaa aacagtgcct gccaaaatag
     4081 attaaaagtg tttattgtat tagctgttta gagctgaaaa gatatttaca aattccaggg
     4141 aagtaaaagg aaaaaaactg aaaaaggtac agctactttt ggggatgtga gatcatggat
     4201 gtgtatctta tagatttcac attatttatt tactttccat tattttcttc tacattatca
     4261 tatttagtgg ctaaccatta ttacttctta ggttgttgtg agaaccgagt taattaatgt
     4321 aaactatttg acacataata aggacttaaa tgttcattgt tgtcattatt gatttattac
     4381 catgagccct acatttcccc attcatgagt gtgcgaacat taacatagat agggttgata
     4441 atggttattt gacattacac atttttagga agaagaaatt tctgtcttgc tggccagtcc
     4501 aggctgtaac actcaaaaaa acaaaacaaa acaaaacaaa acaaaaaaac agaaagatgc
     4561 cttgtattag ggccttccta aaaagaaagc taagtaagta ttaatttctt aggattgctt
     4621 ctgaggtagg atgaggtgtt tgcatagacc caacaagtca ttcacttcaa attttttttg
     4681 tcttactatg ataaataaca tattatttcc tgtttacagc aacctgcact gaaattaact
     4741 agttgaataa aatcacctct tctagcacaa ataaagctga gttcggggag gtgggtgaaa
     4801 atacagtact gttgtttact tcctaagatc caagggagag aatcaagctt ggtaatattc
     4861 tcttgaatat acatttacct atttaaaagg tatgattttc ccatatttcc ttaggaagta
     4921 tgtcatgtca atatagatat ttactcatta ggtttacatt aatttgtatt ataagggaat
     4981 gtttaattca aattaaggac attaaaagta tatagacttt catataaaag ttccggtttt
     5041 ataaattgcg ttgatcactt aaagaatgca gagatctcaa agtaaagaaa acaaatttta
     5101 tgaatatttt aaaacattac ttaaaacaag tttccttaga aagcacattt gtggataaat
     5161 ttaaatatta atactaaata ataaagtagt atacagaatt taaatttcat aataatgaag
     5221 aaagtggtaa tgctatttaa cttaaaagat gcaatatggc attttagatc aagaggttaa
     5281 agttttctta atgaaagaaa gtaacgattt atgggataaa aatattccag tggtttgtat
     5341 ttgcttcata cttcaaaagt gttagtccat ttattgttta aagttatatt gaaactgata
     5401 ttttcactgc tgccaaagca gtacctgaca gtagataggt atccacagtc ttatgttcct
     5461 tagagttata gaactatgcc tctgaaaggg gttttaatac tttaataaac ctggcctaaa
     5521 ctgttttatt tctaagttga agaaactgat tgtcaagtac tttgacttgt ccaatctcat
     5581 acaactaact atggtacatc tagagttaga tctcagtatc aggggtccca gttgtattct
     5641 gctcaccatt ccacaatttc gatattgata aaactttcac actaactttt gaactgtggt
     5701 tattattaat ttagttgatt catgtcctct tatttatctc cttactcctc cactgctgcc
     5761 ttcataactg tccaccagat caaagctatt tgggtaccta cactttaaag tgaggggaaa
     5821 taatgaagtt tcttaaatcc tgtgtcatgg actaagatac aataaagaaa aggaatttca
     5881 caaagtaggg gaaattacgt gttagttata atcattccca agaataaact agtaaaagaa
     5941 acttagattt ccctaattta atcttgactc cgattttgat agtgctatat aaaaaggtat
     6001 ttaaacccat atgcttcctt ttacataaaa gaaagatatc aactttccta gtttgcattt
     6061 acactggcta ataggataat aaaatgctgt gtaaatgtta aactggaagt ttctctgagt
     6121 tatttttact ttaaaatttc atgtgattat gccattttga atatgtatat tacatgtaat
     6181 tgtataatgt taactcgggt aggcaaaatt cttggtatta aatttaggat gttttaaaaa
     6241 ttattaagaa gatattaatg tctgcttttt gatagcatat attttcatgt aatgtttagt
     6301 gtattaaaat caaccattca agatttattt tattgggtga cactattgac tgtgttccaa
     6361 aatgcccata gtgttaggaa atgtggtgtg agttttattt gtgggctaag gataaaataa
     6421 tcatatgcta atataccttt tattataaat gactaaaaat ttggatataa aactgatgtt
     6481 ttactacaca aattacagag agagataata taattatata attattaaat aattagaaaa
     6541 tgcaaataag caaaagtcac ccatgttccc agttctcatc tcctgaagat agttataact
     6601 aacatattat tttgtactct tcctgttaat tagtttctag tgtactttct cctgtagctg
     6661 aaattaagct gagaaaaaag gaagagatag ttcctccctc ctctttctct ctcccactct
     6721 gtctctctcc tgtgctatct gtgtgtatat acaaatatgt atgcatatat atataatgat
     6781 gtacataata tatataaaat acaaatacta atgtgcatat tttcaaacat acacatattt
     6841 tttattattt gaaataagaa tgagtcagac tacatatttg gtagccagat ttttttcact
     6901 cagtgatata tcatgaacat atttccatgc taatataatt ttctaataat tttagatgct
     6961 gtaactacaa tttcattgtt aatgggcaat ttgttgcttt acaaatggta aattatatga
     7021 taaataatat gatcattatt cttgtagcca atatcattat tagaaatgat ggaccgcatt
     7081 aaagctataa aattaaataa gaatttataa atgtaaggag ttattcagac atcttgtatc
     7141 tagtattaca atatcagaaa actcagcagg ttatatgaca tatacacttt gagatagtca
     7201 ctcagaggtt ttcacataca ggattaacct tgctgcagtg cgtgtgcaag attaaaaaag
     7261 atgtcacggg tcactttgta atgtcatatc gttgctgttg ataaataaag gaaatgttat
     7321 aaataaaa
//
